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Chemical compound
6-MAPB (1-(benzofuran-6-yl)-N-methylpropan-2-amine) is an entactogen of the benzofuran family which is structurally related to 6-APB and MDMA. It is known
6-MAPB
Pharmaceutical compound
βk-6-MAPB, or BK-6-MAPB, also known as NM-PrBF6 or as 6-[2-(methylamino)propanoyl]benzofuran, is a putative entactogen of the benzofuran and cathinone
BK-6-MAPB
Chemical compound
5-MAPB, also known as 5-(N-methyl-2-aminopropyl)benzofuran, is an entactogen and designer drug of the amphetamine family that is similar to MDMA in its
5-MAPB
Class of psychoactive drugs that produce empathic experiences
MDA, MDEA, MDOH, MBDB, and methylone, the benzofurans 5-APB, 5-MAPB, 6-APB, and 6-MAPB, the cathinone mephedrone, the 2-aminoindane MDAI, and the α-alkyltryptamine
Entactogen
Psychoactive drug, often called ecstasy
MDEA, MDOH, MDMOH (FLEA), N-t-BOC-MDMA, methylone (MDMC), MBDB, 5-MAPB, 6-MAPB, 5-MAPBT, 6-MAPBT, SDMA, ODMA, SeDMA, TDMA, MDAI, and MDAT, among many others
MDMA
Designer drug combination mimicking MDMA
described as an MDMA-like entactogen. It is a mixture of the entactogen 5-MAPB or MDAI, the stimulant 2-fluoromethamphetamine (2-FMA), and the serotonergic
Borax_combo
Psychedelic drug
5-chloro-DMT, 5-bromo-DMT, 6-fluoro-DMT, 5,6-dibromo-DMT, 4,5-MDO-DMT, 4,5-DHP-DMT, 5,6-MDO-DMT, 5-MeS-DMT, 6-methyl-DMT, 6-HO-DMT, 6-MeO-DMT, 7-methyl-DMT
Dimethyltryptamine
Chemical compound found in some species of mushrooms
peak effects occur in about 1 to 2 hours, and its duration is about 4 to 6 hours. Psilocybin mushrooms were used ritualistically in pre-Columbian Mexico
Psilocybin
Antidepressant medication
most commonly prescribed medication in the United States, with more than 6 million prescriptions. Mirtazapine is approved by the United States Food and
Mirtazapine
Central nervous system stimulant
the treatment of methamphetamine dependence". BMC Res Notes. 6 220. doi:10.1186/1756-0500-6-220. PMC 3679734. PMID 23734766. Newton TF, Roache JD, De La
Methamphetamine
Recreational drug
reduced (producing 3), or the tolyl group can be oxidised (producing 6). Both 5 and 6 are thought to be further metabolised by conjugation to the glucuronide
Mephedrone
Chemical compound
2-MAPB is a recreational designer drug with empathogenic effects. As with other related substituted benzofuran derivatives such as 6-APB and 5-MAPB, 2-MAPB
2-MAPB
Trace amine
Constants of Adrenergic Amines". Journal of the American Chemical Society. 73 (6): 2611–3. Bibcode:1951JAChS..73.2611L. doi:10.1021/ja01150a055. Boulton AA
Phenethylamine
Weight loss medication
and has a ratio of norepinephrine release versus dopamine release of about 6.6:1 compared to dextroamphetamine's ratio of about 3.5:1. It is more than 3-fold
Phentermine
Atypical antipsychotic medication
agonist". Expert Opinion on Investigational Drugs. 16 (6): 771–775. doi:10.1517/13543784.16.6.771. PMID 17501690. S2CID 42171115. Kegeles LS, Slifstein
Aripiprazole
Psychoactive substance found in plants in the family Apocynaceae
Academic Press. pp. 249–281. doi:10.1016/S0099-9598(01)56018-6. ISBN 978-0-12-469556-6. OCLC 119074996. PMID 11705112. Archived from the original (PDF)
Ibogaine
Central nervous system stimulant prodrug
ISBN 978-0-07-182770-6. The ARAS consists of several different circuits including the four main monoaminergic pathways discussed in Chapter 6. The norepinephrine
Lisdexamfetamine
Antidepressant medication
phase's half-life (distribution) is 3 to 6 hours, and the following phase's half-life (elimination) is 4.1 to 14.6 hours. The elimination half-life of extended-release
Trazodone
Psychedelic drug
Springer-Verlag Berlin Heidelberg. pp. 1–5. doi:10.1007/978-3-642-27772-6_43-2. ISBN 978-3-642-27772-6. In contrast to the users of other substances of abuse, hallucinogen
LSD
Medication mainly used for depression and smoking cessation
therapy, bupropion increases the likelihood of quitting smoking approximately 1.6-fold as compared to placebo. In this respect, bupropion is as effective as
Bupropion
Drug mixture used mainly to treat ADHD and narcolepsy
2020. Retrieved 6 February 2020. "Generic Adderall XR Availability". Drugs.com. Archived from the original on 6 February 2020. Retrieved 6 February 2020
Adderall
Topical nasal decongestant
eliminated in urine and recovery of levomethamphetamine is 20 to 60% (or about 2–6 mg) while that of levoamphetamine is 9 to 30% (or about 1–3 mg). Levomethamphetamine
Levomethamphetamine
Class of chemical compounds
receptor agonists. In addition, some benzofurans, including 5-MAPB, 6-MAPB, BK-5-MAPB, and BK-6-MAPB, have unexpectedly been found to be potent serotonin 5-HT1B
Substituted_benzofuran
Topical nasal decongestant
inhalations (two inhalations per nostril) every two hours for adults and children 6–12 years of age. Each inhalation delivers 0.4 to 0.5 mg (400 to 500 μg) in
Propylhexedrine
CNS stimulant and isomer of amphetamine
ISBN 978-0-07-182770-6. The ARAS consists of several different circuits including the four main monoaminergic pathways discussed in Chapter 6. The norepinephrine
Dextroamphetamine
Medication used to treat dyskinesia
South Korea, and the United States, respectively. By 2006, 90.6% of H3N2 strains and 15.6% of H1N1 were amantadine resistant. A majority of the amantadine-resistant
Amantadine
Tricyclic antidepressant
can be used for the treatment of nocturnal enuresis in children older than 6 after other treatments have failed. Amitriptyline is effective for depression
Amitriptyline
South American psychoactive decoction
1 Part 2. Springer Science & Business Media. p. 199. ISBN 978-3-7643-5165-6. Gorman, Peter (2010). Ayahuasca in My Blood: 25 Years of Medicine Dreaming
Ayahuasca
Entactogen drug
following oral administration of doses of 50 to 200 mg ranged from 5.8 to 6.9 hours. The onset of action and duration of action of methylone in humans
Methylone
Antihistamine medication
human histamine H3 receptor". Molecular Pharmacology. 55 (6): 1101–7. doi:10.1124/mol.55.6.1101. PMID 10347254. S2CID 25542667. Liu C, Ma X, Jiang X,
Diphenhydramine
Sympathomimetic agent
Psychopharmacology: Clinical and Experimental. 12 (6): 527–546. doi:10.1002/(SICI)1099-1077(199711/12)12:6<527::AID-HUP932>3.0.CO;2-U. ISSN 0885-6222. "Adderall
Phenylpropanolamine
Medication, stimulant and decongestant
(range 53–79%) excreted unchanged. The elimination half-life of ephedrine is 6 hours. Its duration of action orally is 2 to 4 hours and via intravenous or
Ephedrine
Codrug of amphetamine and theophylline
bust in Dubai, 5.6 tonnes of captagon seized". Khaleej Times. 26 February 2020. Archived from the original on 31 March 2020. Retrieved 6 May 2020. "Saudi
Fenethylline
Naturally occurring psychedelic compound
of 2 to 4 hours, and a duration that increases with dose and ranges from 6 to 14 hours. Mescaline primarily acts as a partial agonist at serotonin 5-HT2A
Mescaline
Chemical compound
(2-methyl-6-amino-2-heptanol), iproheptine (N-isopropyl-1,5-dimethylhexylamine), isometheptene (2-methyl-6-methylamino-2-heptene), octodrine (2-amino-6-methylheptane
Methylhexanamine
Psychedelic drug
described an effective dose range of 8 to 10 mg orally and a duration of 6 to 8 hours. Threshold effects occur at a dose of 4 mg orally. A wider recreational
2C-B
Chemical compound
Phenethylamines: 2-OH-PEA 4-CAB 4-FA 4-FMA 4-MA 4-MMA 5-APB 5-APBT 5-MAPB 6-APB 6-APBT 6-MAPB Alfetamine Amfecloral Amfepentorex Amfepramone Amphetamine (Dextroamphetamine
Indanorex
Substituted cathinone designer drug
pigs in relation to pharmacodynamics". Journal of Psychopharmacology. 29 (6): 734–43. doi:10.1177/0269881115576687. PMID 25804420. S2CID 26012927.
3-Methylmethcathinone
SSRI antidepressant
Overview". Retrieved 15 June 2009. "Lilly Menstrual drug OK'd – Jul. 6, 2000". Money.cnn.com. 6 July 2000. Archived from the original on 5 May 2016. Retrieved
Fluoxetine
Medication to prevent nausea and vomiting
16 of the 123 children treated with ondansetron vomited in the following 6 hours. A retrospective review found that ondansetron was used commonly for
Ondansetron
Monoamine neurotransmitter
"Phytoserotonin: a review". Plant Signaling & Behavior. 6 (6): 800–809. Bibcode:2011PlSiB...6..800A. doi:10.4161/psb.6.6.15242. PMC 3218476. PMID 21617371. Erspamer
Serotonin
Class of compounds based upon the amphetamine structure
(NBNA) and Phenyl (EDA, PMEA, 2-APN) Sites". Biomolecules & Therapeutics. 25 (6): 578–585. doi:10.4062/biomolther.2017.141. ISSN 2005-4483. PMC 5685426. PMID 29081089
Substituted_amphetamine
Decongestant medication
epinephrine's prevalence in the US". J Dent Anesth Pain Med. 23 (6): 293–302. doi:10.17245/jdapm.2023.23.6.293. PMC 10703557. PMID 38076507. Phenylephrine, a synthetic
Phenylephrine
Pharmaceutical compound
Phenethylamines: 2-OH-PEA 4-CAB 4-FA 4-FMA 4-MA 4-MMA 5-APB 5-APBT 5-MAPB 6-APB 6-APBT 6-MAPB Alfetamine Amfecloral Amfepentorex Amfepramone Amphetamine (Dextroamphetamine
Isocyclamine
Species of psychoactive cactus
alkaloids—primarily mescaline—at concentrations of about 0.4% when fresh and up to 6% when dried. Peyote is a slow-growing cactus that can be cultivated more rapidly
Peyote
Medication used to treat anxiety disorders
metabolites of buspirone include 5-hydroxybuspirone, 6-hydroxybuspirone, 8-hydroxybuspirone, and 1-PP. 6-Hydroxybuspirone has been identified as the predominant
Buspirone
Colourless non-flammable greenhouse gas
309 psi (21 atmospheres). At 600 psi, the required ignition energy is only 6 joules, whereas at 130 psi a 2,500-joule ignition energy input is insufficient
Nitrous_oxide
Synthetic opioid pain medication
elimination half-life of 9 hours, compared with 6 hours for tramadol itself. As with codeine, in the 6% of the population who have reduced CYP2D6 activity
Tramadol
Psychedelic drug
(Tryptamines I Have Known and Loved), Alexander Shulgin lists 5-MeO-DMT's dose as 6 to 20 mg smoked or 2 to 3 mg by intravenous injection and its duration as
5-MeO-DMT
Active ingredient in fermented drinks
drinking venue. The US Department of Agriculture (USDA) uses a figure of 6.93 kilocalories (29.0 kJ) per gram of alcohol (5.47 kcal or 22.9 kJ per mL)
Alcohol_(drug)
Psychedelic drug found in toads, mushrooms and plants
Addictions. 28 (6): 521–538. doi:10.3109/10826089309039645. PMID 8486435. The Dog Who Loved to Suck on Toads. NPR. Accessed on May 6, 2007. Psychoactive
Bufotenin
Chemical element with atomic number 54 (Xe)
Press. p. 48. ISBN 978-0-8493-2172-6. Ball P (May 1, 2002). "Xenon outs WIMPs". nature. doi:10.1038/news020429-6. Retrieved October 8, 2007. Saccoccia
Xenon
Entactogen, stimulant, and psychedelic drug of the amphetamine family
the serotonin 5-HT2A receptor. It has a duration of 5 to 8 hours or around 6 hours typically. MDA has a long history of psychotherapeutic and recreational
3,4-Methylenedioxyamphetamine
Chemical compound
developmental code name MY400. Substituted benzothiophene 6-MAPBT BK-5-MAPBT 5-MAPDI BK-5-MAPB IBF5MAP MDMA Methamnetamine TDMA Mydecine (5 January 2024)
5-MAPBT
Muscle relaxant medication
and 43 nM), adrenergic α-1A (5.6 and 34 nM), α-2B (Ki = 21 and 150 nM) and α-2C (Ki = 21 and 48 nM,); H1 (1.3 and 5.6 nM); and M1 (7.9 and 30 nM). Like
Cyclobenzaprine
Beta blocker drug
found to increase peak and area-under-the-curve levels of nifedipine by 1.6-fold and 1.8-fold, respectively. Propranolol decreases theophylline clearance
Propranolol
Chemical compound
active ingredient of khat (Catha edulis)". East African Medical Journal. 77 (6): 329–332. doi:10.4314/eamj.v77i6.46651. PMID 12858935. Widler P, Mathys K
Cathinone
Chemical compound
6-Chloro-2-aminotetralin (6-CAT) is a drug which acts as a selective serotonin releasing agent (SSRA) and is a putative entactogen in humans. It is a
6-CAT
Drug class
monoamine transporter substrates". Current Topics in Medicinal Chemistry. 6 (17): 1845–1859. doi:10.2174/156802606778249766. PMID 17017961. Heal DJ, Smith
Norepinephrine–dopamine releasing agent
Norepinephrine–dopamine_releasing_agent
Antihistamine drug
tomography (PET) study found that brain occupancy of the H1 receptor was 67.6% for a single 30 mg dose of hydroxyzine. In addition, subjective sleepiness
Hydroxyzine
Mushrooms containing psychoactive indole alkaloids
(116 species), Gymnopilus (14), Panaeolus (13), Copelandia (12), Pluteus (6) Inocybe (6), Pholiotina (4) and Galerina (1). Guzmán increased his estimate of
Psilocybin_mushroom
Chemical compound
located outside of the benzene ring. The protonated form has a pKa of −3.6. The sensitivity of many indolic compounds (e.g., tryptamines) under acidic
Indole
Species of amphibian
streams, temporary pools or man-made structures that hold water. Eggs are 1.6 mm in diameter, 5–7 mm apart, and encased in a long single tube of jelly with
Colorado_River_toad
Trace amine
approximately 10 to 25 mg of tyramine is required for a severe reaction, compared to 6 to 10 mg for a mild reaction. Tyramine, like phenethylamine, is a monoaminergic
Tyramine
Chemical compound
βk-5-MAPB, or BK-5-MAPB, is an entactogen of the benzofuran and cathinone groups which is related to both 5-MAPB and methylone. It was patented by Matthew
BK-5-MAPB
Atypical antipsychotic medication
metabolic consequences: A retrospective review". The Mental Health Clinician. 6 (6): 308–313. doi:10.9740/mhc.2016.11.308. PMC 6007538. PMID 29955487. Højlund
Quetiapine
Common name for more than 1,000 species of flowering plants in the family Convolvulaceae
Argyreia nervosa. A case-orientated demonstration]". Der Nervenarzt. 73 (9): 892–6. doi:10.1007/s00115-002-1374-4. PMID 12215884. Vargas, Theresa (2006-05-03)
Morning_glory
Atypical antipsychotic medication
difficult to determine, as more than half of people in trials quit before the 6-week completion date. Treatment with olanzapine (like clozapine) may result
Olanzapine
Atypical antipsychotic medication
mirror image cohort study". Psychopharmacology. 236 (6). Berl: 1931–1935. doi:10.1007/s00213-019-5179-6. PMID 30715572. S2CID 59603040. Archived from the
Clozapine
American pharmaceutical company
These include benzofurans like 5-MAPB, 6-MAPB, 5-MBPB, 6-MBPB, BK-5-MAPB, and BK-6-MAPB, benzothiophenes like 5-MAPBT, 6-MAPBT, and BK-5-MAPBT, α-alkyl-
Tactogen
Psychoactive drug
2:1 ratio of succinate to 6-APB. Analogues of 6-APB include MDA, 6-APDB, 6-MAPB, 5-APB, 6-APBT, and 6-API, among others. 6-APB, along with 5-APB, was
6-APB
Medication used to treat Alzheimer's disease
Hypoglycemic N-Arylsulfonyl-N'-adamantylureas". Journal of Medicinal Chemistry. 6 (6): 760–763. doi:10.1021/jm00342a029. PMID 14184942. Elks J (2014). The Dictionary
Memantine
Serotonin modulator antidepressant
side effects include nausea, dry mouth, diarrhea, constipation, vomiting (3-6% of people), and sexual dysfunction. Serious side effects may include suicide
Vortioxetine
Pharmaceutical compound
SSRI 6 hours after MDMA is partially protective, while administration 12 hours after MDMA is ineffective. The duration of MDMA in humans is 3 to 6 hours
MDMA/citalopram
Type of drug
pharmacological and clinical perspective". Journal of Psychopharmacology. 27 (6): 479–496. doi:10.1177/0269881113482532. PMC 3666194. PMID 23539642. Reith
Dopamine_releasing_agent
Medication used for high blood pressure and ADHD
attention deficit hyperactivity disorder, for instance 73% with guanfacine versus 6% with placebo in one trial. Guanfacine may worsen sleep in children with attention
Guanfacine
Trace amine
serotonin, dopamine, and norepinephrine, in that order of potency (EC50 = 32.6 nM, 164 nM, and 716 nM, respectively). That is, it acts as a
Tryptamine
Central nervous system stimulant
ISBN 978-0-07-182770-6. The ARAS consists of several different circuits including the four main monoaminergic pathways discussed in Chapter 6. The norepinephrine
Amphetamine
Chemical class of organic compounds
Aporphines like aporphine, apomorphine, glaucine, and nuciferine Others like 6-AB, 2-ADN, 2C-B-PYR, 2C-B-5-hemiFLY-α6 (BNAP), 2CB7 (2C-B-5-hemiFLY-β7), 2CBecca
Substituted_phenethylamine
Phytocannabinoid discovered in 1940
Drug Administration (FDA). February 6, 2024. Archived from the original on October 1, 2019. Retrieved February 6, 2024. "FDA Approves New Indication for
Cannabidiol
Tricyclic antidepressant
Disorder. Jason Aronson, Incorporated. pp. 61–. ISBN 978-1-4616-3230-6. Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties
Clomipramine
Class of chemical compounds
associated with impaired working memory and cognitive flexibility". PLOS ONE. 6 (6) e20602. Bibcode:2011PLoSO...620602C. doi:10.1371/journal.pone.0020602. PMC 3115937
Substituted_cathinone
Pharmaceutical compound
have been disclosed, but it may be a benzofuran like 5-MAPB, 6-MAPB, BK-5-MAPB, or BK-6-MAPB. TACT411 TACT908 1Z2MAP1O List of investigational hallucinogens
TACT833
Atypical antidepressant classified primarily as a melatonin receptor agonist
(EMA). 18 November 2006. Archived from the original (PDF) on 6 August 2010. Retrieved 6 July 2009. "CHMP Assessment Report for Valdoxan" (PDF). European
Agomelatine
Chemical compound
6-(2-Aminopropyl)tetralin (6-APT), also sometimes called tetralinylaminopropane (TAP), is a drug of the amphetamine class which acts as a selective serotonin
6-APT
CHCl3, historical anaesthetic and common solvent
phosgene into water and aqueous solutions". AIChE Journal. 6 (3): 494–500. Bibcode:1960AIChE...6..494M. doi:10.1002/aic.690060329. ISSN 0001-1541. "American
Chloroform
Sedating antidepressant
of 0.23 to 0.44). Doses of doxepin used for sleep normally range from 3 to 6 mg, but high doses of up to 25 to 50 mg may be used as well. A 2010 review
Doxepin
Antipsychotic medication
schizophrenic patients". The American Journal of Psychiatry. 156 (6): 869–875. doi:10.1176/ajp.156.6.869. PMID 10360125. Seeman P (2013). "Clozapine, a Fast-Off-D2
Risperidone
Blood pressure medication
borderline blood pressure: the DETECT Study". Journal of Human Hypertension. 27 (6): 362–367. doi:10.1038/jhh.2012.54. PMID 23190794. Reiberger T, Ulbrich G
Carvedilol
Psychedelic drug
regardless of form, was listed as 10 to 20 mg orally and the duration as 3 to 6 hours. The onset, in the case of psilocin specifically, was 15 to 40 minutes
Psilocin
Species of flowering plant
hydroxyvalerenic acid and acetoxyvalerenic acid Flavanones: hesperidin, 6-methylapigenin, and linarin The chief constituent of valerian is a yellowish-green
Valerian_(herb)
Medication used to treat seizures
6. PMID 11489456. S2CID 23374227. Roth BL (January 2007). "Drugs and valvular heart disease". The New England Journal of Medicine. 356 (1): 6–9. doi:10
Fenfluramine
Medication mainly used to treat gout
(NSAIDs) when treating gout. Low doses (1.2 mg in one hour, followed by 0.6 mg an hour later) appear to be well tolerated and may reduce gout symptoms
Colchicine
Chemical compound
Toxicology and Applied Pharmacology. 7 (4): 566–78. doi:10.1016/0041-008x(65)90042-6. PMID 4378772. "World Anti-Doping Agency 2008 Prohibited List" (PDF). World
Cyclazodone
Chemical compound
Elsevier. pp. 272–273. doi:10.1016/c2013-0-12543-3. ISBN 978-1-4832-3296-6. LCCN 66030086. OCLC 332437. OL 35255701M. Schayer, Richard W. (1952). "Synthesis
Adrenochrome
Chemical compound
monoamine transporter substrates". Current Topics in Medicinal Chemistry. 6 (17): 1845–1859. doi:10.2174/156802606778249766. PMID 17017961. Archived from
Phenmetrazine
Psychoactive stimulant
methcathinone (Ephedrone) abuse". Archives of Neurology. 64 (6): 886–9. doi:10.1001/archneur.64.6.886. PMID 17562938. "Convention on Psychotropic Substances
Methcathinone
Drug class
Phenethylamines: 2-OH-PEA 4-CAB 4-FA 4-FMA 4-MA 4-MMA 5-APB 5-APBT 5-MAPB 6-APB 6-APBT 6-MAPB Alfetamine Amfecloral Amfepentorex Amfepramone Amphetamine (Dextroamphetamine
Serotonin–norepinephrine releasing agent
Serotonin–norepinephrine_releasing_agent
Chemical compound
aftereffects such as tachycardia, hypertension, and mild stimulation lasting from 6 to 8 hours. High doses have been observed to cause intense, prolonged panic
Methylenedioxypyrovalerone
Chemical compound
compounds 90–95, all bearing a 3,4-(difluoromethylenedioxy) moiety (Figure 6, B).[96] It was hoped that this introduction of fluorine could lower the formation
DFMDA
travel, tourism, insurance
6 MAPB
6 MAPB
6 MAPB
6 MAPB
6 MAPB
6 MAPB
6 MAPB
6 MAPB
6 MAPB
travel, tourism, insurance