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Pharmaceutical compound
4-Allyl-6-oxa-noribogainalog is a κ-opioid receptor (KOR) agonist of the oxa-ibogalog family related to oxa-noribogaine. It is a highly potent full agonist
4-Allyl-6-oxa-noribogainalog
Pharmaceutical compound
Analogues of noribogainalog include catharanthalog, ibogainalog, ibogaminalog, PNU-22394, tabernanthalog, 4-allyl-6-oxa-noribogainalog, and noribogaine
Noribogainalog
Species of plant
(18.6%), tachycardia (16.9%), drowsiness (13.6%), vomiting (11.2%), confusion (8.1%), seizures (6.1%), withdrawal symptoms (6.1%), hallucinations (4.8%)
Mitragyna_speciosa
Off-label, experimental use of the drug
"Low-Dose Naltrexone (LDN)—Review of Therapeutic Utilization". Medical Sciences. 6 (4). MDPI AG: 82. doi:10.3390/medsci6040082. ISSN 2076-3271. PMC 6313374. PMID 30248938
Low-dose_naltrexone
Chemical compound
Mitragynine Pseudoindoxyl, MGM-15, and MGM-16 in Schedule I". Federal Register. 6 July 2026. Retrieved 3 July 2026. "Office of Public Affairs | Justice Department
MGM-15
Opioid medication
CYP2D6 and 6-ketoreduction of oxycodone into 6-oxycodols represent relatively minor metabolic pathways, accounting for 11% ± 6% and 8% ± 6% of a dose
Oxycodone
Opioid receptor antagonist
Naloxone, also known as N-allylnoroxymorphone or as 17-allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one, is a synthetic morphinan derivative and was derived
Naloxone
Dissociative anesthetic and anti-depressant
Journal of Allergy, Asthma, and Immunology. 2 (4): 175–80. PMID 17301376. Archived from the original on 6 October 2014. Adams HA (December 1997). "[S-(+)-ketamine
Ketamine
Medication used to treat ADHD
fluid (CSF) with atomoxetine at a dosage of 80 mg/day were 6.6 ng/mL at 8 hours post-dose and 1.4 ng/mL at 24 hours post-dose following 2 weeks of administration
Atomoxetine
Tincture of opium
therapy (e.g., Imodium or Lomotil). The usual starting dose is 0.3 mL to 0.6 mL (about six to 12 drops) in a glass of water or juice four times a day.
Laudanum
Chemical compound
where it has antagonistic effects, and at the κ-opioid receptor (KOR) (Ki = 1.6 nM; EC50 = 483 nM; Emax = 95%) where it exerts high-efficacy partial agonist/near-full
Nalorphine
Opioid analgesic drug
half-lives of 0.4–1.6 h for the first phase and 6.3–21.8 h for the terminal phase. While in about 40% of patients, half-lives range from 1.5 to 4.7 h, in a
Dextromoramide
Opioid medication
fentanyl; most of the deaths were among adolescents (89.6%) (15–19 years) and children aged 0 to 4 years (6.6%). According to the UNODC, "the opioid crisis in
Fentanyl
Opioid analgesic and recreational drug
the United States, approximately 1.6 percent of people reported using heroin at some point in their lives and 0.4% of people aged 12 or older in 2021
Heroin
Chemical compound
inhibits enkephalinase enzymes in the intestinal epithelium with an IC50 of 6.1 nM, protecting enkephalins from being broken down by these enzymes. (Racecadotril
Racecadotril
Opioid drug used in pain relief
minutes and lasts about 4–8 hours. The manufacturer's information says onset of action is about 10–30 minutes and duration is about 4–6 hours. Recommended
Hydrocodone
Chemical compound
opioids. Brorphine was originally reported to be highly biased, with an EC50 of 4.8nM for GTPγS binding and 182nM for β-arrestin recruitment, however a more
Brorphine
Medication
Reports. 22 (6) 30. doi:10.1007/s11920-020-01153-4. PMID 32377953. S2CID 218527367. Archived (PDF) from the original on 6 January 2023. Retrieved 6 January
Naltrexone
Chemical compound
pretreated with PCPA]". Eksperimental'naia i Klinicheskaia Farmakologiia. 72 (4): 6–8. PMID 19803361. Inozemtseva LS, Karpenko EA, Dolotov OV, Levitskaya NG
Selank
Psychoactive substance found in plants in the family Apocynaceae
noribogaine, ibogamine, ibogaline, tabernanthine, voacangine, coronaridine, oxa-noribogaine, and pinoline, among others. A synthetic derivative of ibogaine
Ibogaine
Opioid used to treat pain and opioid use disorder
or intramuscular routes. Buprenorphine provides analgesia for 6–8 hours in dogs and 4–8 hours in cats when administered as an intramuscular or intravenous
Buprenorphine
Semi-synthetic opioid
opioid ligands at kappa opioid receptors". BMC Pharmacology. 6 (1) 3. doi:10.1186/1471-2210-6-3. PMC 1403760. PMID 16433932. Hawkinson JE, Acosta-Burruel
Etorphine
Medicine used to reduce diarrhea
fomulations" (PDF). WHO Drug Information. 4 (2): 73–74. 1990. Archived from the original (PDF) on 7 September 2014. Retrieved 6 September 2014. The leading international
Loperamide
Dried latex of the opium poppy containing narcotic compounds
Archived from the original on July 6, 2022. Retrieved May 4, 2007. "The devil's doctor". April 18, 2006. Retrieved May 4, 2007. "PARACELSUS, Five Hundred
Opium
Semi-synthetic opioid
in spite of major variation in DHM blood levels. DHC-6-G is half as potent as DHC. DHM and DHM-6-G display the highest affinity to μ-opioid receptors
Dihydrocodeine
Species of flowering plant in the poppy family
contains 51,213 genes encoding proteins distributed 81.6% in 11 individual chromosomes and 18.4% remaining in unplaced scaffolds. In addition, 70.9% of
Papaver_somniferum
Opiate and prodrug of morphine used to treat pain
Administration issued a warning about deaths in pediatric patients less than 6 years old after ingesting "normal" doses of paracetamol with codeine after
Codeine
Opioid treatment
Clinical Effectiveness". Canadian Agency for Drugs and Technologies in Health. 6 January 2017. PMID 28727399. Blazes CK, Morrow JD (11 September 2020). "Reconsidering
Buprenorphine/naloxone
Synthetic opioid painkiller
effect is reached in about 25-50 minutes. The duration of action is given as 4-6 hours. The elimination half-life for nortilidine is 3-5 hours. Tilidine is
Tilidine
5-F-MET), blixeprodil ((R)-4-FDCK, GM-1020), GM-3009 (an oxa-iboga), GM-5022, GM-2040, oxa-noribogaine, 4-allyl-6-oxa-noribogainalog Helus Pharma (Cybin) –
List of psychedelic pharmaceutical companies
List_of_psychedelic_pharmaceutical_companies
Pharmaceutical compound
Agonism Administered Alone and in Combination with Morphine". Biomolecules. 13 (6): 935. doi:10.3390/biom13060935. PMC 10295947. PMID 37371516. Schmid CL, Kennedy
SR-15099
Chemical compound
acid esters and amides]. Helvetica Chimica Acta (in German). 43 (6): 1727–1733. doi:10.1002/hlca.19600430634. Rossi A, Hunger A, Kebrle J, Hoffmann
Isotonitazene
Portion of opium poppy
Ukraine: a cross-sectional survey". Harm Reduction Journal. 6 23. doi:10.1186/1477-7517-6-23. PMC 2741433. PMID 19698166. Taracha E, Habrat B, Chmielewska
Poppy_straw
Chemical compound
etonitazene. This procedure is particularly useful in the preparation of the 4-, 5-, 6-, and 7-nitrobenzimidazoles. Varying the choice of the substituted phenylacetic
Etonitazene
Semi-mythical remedy
poison hurt. —I tell the tale that I heard told. Mithridates, he died old.[6] In the Diary of Samuel Pepys, entry for 9 April 1664; Pepys writes at the
Mithridate
Opioid analgesic
Parafluorofentanyl (4-fluorofentanyl, para-fluorofentanyl, pFF) is an opioid analgesic analogue of fentanyl developed by Janssen Pharmaceuticals in the
Parafluorofentanyl
Class of analgesic drug
illicitly (0.6–0.8% of the global population between the ages of 15 and 65). By 2021, that number rose to 60 million. In 2011, an estimated 4 million people
Opioid
Species of plant
ISBN 978-982-02-0160-6. Tomlinson M (2007). "Everything and Its Opposite: Kava Drinking in Fiji". Anthropological Quarterly. 80 (4): 1065–81. doi:10.1353/anq
Kava
Opioid analgesic
chemical used in the synthesis of R6890 is 1-phenyl-1,3,8-triazaspiro(4,5)decan-4-one (also known as spirodecanone), which is used in the synthesis of other
R6890
Opioid analgesic drug
ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe
Oliceridine
Species of plant
124 (5): 593–600. doi:10.1007/s10265-010-0394-6. PMID 21125306. S2CID 28382245. Marushia 2002, p. 4. Reisfield 1993, Distribution, Ecology, & Flower
Salvia_divinorum
Synthetic opioid pain medication
were undetectable. In cats oral tramadol at 6 mg/kg provides equivalent analgesia to intramuscular tramadol at 4 mg/kg. One study comparing tramadol to meperidine
Tramadol
Recreational drug beverage
1990s. Its use later spread to other States in the South. In June 2000, Three 6 Mafia's single "Sippin' on Some Syrup", featuring UGK, brought the term purple
Lean_(drug)
Synthetic opioid analgesic drug
York Times. Retrieved 2 November 2018. "dsuvia.com". 4 January 2025. Archived from the original on 4 January 2025. Silverman E (2 November 2018). "Despite
Sufentanil
Peptide hormone and neuropeptide
and other loci on chromosome 20". Molecular Endocrinology. 4 (6): 947–950. doi:10.1210/mend-4-6-947. PMID 1978246. Brownstein MJ, Russell JT, Gainer H (January
Oxytocin
Opioid agonist peptide compound
Multicellular Organisms. Vol. 85. pp. 57–71. doi:10.1007/978-3-0348-8837-0_4 (inactive 11 July 2025). ISBN 978-3-0348-9794-5. PMID 9949868. {{cite book}}:
Dermorphin
Norbinaltorphimine Oxilorphan PF-4455242 S-allyl-3-hydroxy-17-thioniamorphinan (SAHTM)[50] Samidorphan SR-16430 6'-Guanidinonaltrindole 7-Hydroxymitragynine
List_of_opioids
Opioid analgesic compound
The solubility of mitragynine in acidic water is higher (3.5 mg/ml at pH 4), however, this alkaloid can become unstable, so certain products, such as
Mitragynine
Opioid medication used for pain relief
the original on 4 March 2016. Retrieved 5 November 2015. Cohen MR (June 1992). "Doctor was thinking of the wrong drug". Nursing. 22 (6): 25. doi:10
Hydromorphone
Opioid analgesic
č. 4 psychotropních látek (příloha č. 4 k nařízení vlády č. 463/2013 Sb.)" [Substances added to list No. 4 of psychotropic substances (Annex No. 4 to
AH-7921
Medical condition
Bechand B, McIntosh S, Stallings L, Hodges A, et al. (20 September 2024). "Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models"
Opioid_use_disorder
Comparison of equivalent doses of pain medications
elimination half-lives of racemic tramadol and racemic M1 are 6.3 ± 1.4 and 7.4 ± 1.4 hours, respectively. The plasma elimination half-life of racemic
Equianalgesic
Opioid analgesic
maintained on methadone". Journal of Analytical Toxicology. 27 (6): 332–341. doi:10.1093/jat/27.6.332. PMID 14516485. Gerardy BM, Kapusta D, Dumont P, Poupaert
Methadone
Opioid analgesic drug
(preliminary report)". British Journal of Anaesthesia. 42 (4): 325–8. doi:10.1093/bja/42.4.325. PMID 4913411. de Vos JC, Rohof OJ, Bernsen PJ, Conemans
Bezitramide
Synthetic opioid analgesic
1007/s11419-017-0379-4. PMC 5754389. PMID 29367860. "Report on the risk assessment of methyl 1-(2-phenylethyl)-4-[phenyl(propanoyl) amino]piperidine-4-carboxylate
Carfentanil
Pain medication of the opiate family
Sciences. p. 571. ISBN 978-1-4557-0150-6. "Morphine Product information". Health Canada. 9 August 2005. Retrieved 4 April 2024. Macpherson G, ed. (2002)
Morphine
Herbal tea made out of poppy straw or poppy seeds
Home-Brewed Poppy Seed Tea by LC-MS/MS". Journal of Forensic Sciences. 63 (4): 1229–1235. doi:10.1111/1556-4029.13664. ISSN 0022-1198. PMID 28973785. S2CID 206919379
Poppy_tea
Opioid medication
Edition of Lumb and Jones. Wiley Blackwell. pp. 378–379. ISBN 978-1-119-83027-6. Pain-Killing Drug Approved By F.D.A., New York Times, June 27, 1967, pg.
Pentazocine
Chemical compound
Taxifolin Thienorphine κ-opioid (KOR) Agonists 3CS-nalmefene 4-Allyl-6-oxa-noribogainalog 6'-GNTI 8-CAC 18-MC 14-Methoxymetopon β-Chlornaltrexamine β-Funaltrexamine
SR-14968
Investigational antidepressant compound
proportionally with increasing doses. Steady-state concentrations are reached after 6 to 8 days of once-daily dosing. Aticaprant has been shown to reproducibly
Aticaprant
Atypical opioid analgesic
alpha-Hydroxy-7H-mitragynine, from Mitragyna speciosa in Thailand". Planta Medica. 60 (6): 580–581. Bibcode:1994PlMed..60..580P. doi:10.1055/s-2006-959578. PMID 17236085
7-Hydroxymitragynine
Metabolite of heroin
6-Monoacetylmorphine (6-MAM, 6-acetylmorphine, or 6-AM) is an opioid and also one of three active metabolites of heroin (diacetylmorphine), the others
6-Monoacetylmorphine
Compound medication
Behavioral Neurosciences. Vol. 34. pp. 59–75. doi:10.1007/7854_2015_422. hdl:1959.4/unsworks_62273. ISBN 978-3-319-60014-7. PMID 26768736. "Codeine Use While
Codeine/paracetamol
Dissociative hallucinogenic drug, mostly used recreationally
treatment of phencyclidine psychosis". Journal of Clinical Pharmacology. 24 (4): 202–4. doi:10.1002/j.1552-4604.1984.tb01831.x. PMID 6725621. S2CID 42278510
Phencyclidine
Pentapeptide
Library of Medicine Medical Subject Headings (MeSH) Nosek, Thomas M. "Section 6/6ch2/s6ch2_36". Essentials of Human Physiology. Archived from the original
Enkephalin
Chemical compound
synthetic analogue of a fragment of adrenocorticotropic hormone (ACTH), ACTH (4-10), of the following amino acid sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP
Semax
Medication
latency (about 4–7 weeks) [1]. Lacerda AL (2020). "Esketamine/ketamine for treatment-resistant depression". Braz J Psychiatry. 42 (6): 579–580. doi:10
Esketamine
Opioid analgesic
such as β-hydroxyfentanyl, ohmefentanyl, β-hydroxythiofentanyl and β-hydroxy-4-methylfentanyl. The development of such a wide structural family of novel
Α-Methylfentanyl
Toxicity due to excessive consumption of opiates
Substance Abuse Treatment, Prevention, and Policy. 14 (1) 6. doi:10.1186/s13011-019-0195-4. PMC 6379922. PMID 30777088. "NARCAN® (naloxone hydrochloride)
Opioid_overdose
Combination pain relief drug
man, rat, guinea pig, rabbit, and dog". Drug Metabolism and Disposition. 6 (4): 488–93. doi:10.1016/S0090-9556(25)06378-0. PMID 28931. Kaye AD (2015).
Hydrocodone/paracetamol
Centrally active opioid drug used for the treatment of diarrhea
cancer treatment-induced diarrhea". Seminars in Oncology Nursing. 19 (4 Suppl 3): 11–6. doi:10.1053/j.soncn.2003.09.009. PMID 14702928. Simon BT, Lizarraga
Diphenoxylate
Opioid analgesic
Discovery and Development of Naltrexone and Other Morphine Derivatives. Chapter 6 in Natural Products in Medicinal Chemistry, Volume 60 of Methods and Principles
Cyclorphan
Chemical compound
Substances: Temporary Placement of Mitragynine Pseudoindoxyl, MGM-15, and MGM-16 in Schedule I". Federal Register. 6 July 2026. Retrieved 3 July 2026.
MGM-16
Organic compound used as flavouring and analgesic
Current Allergy and Asthma Reports. 3 (3): 210–214. doi:10.1007/s11882-003-0041-6. ISSN 1534-6315. Butler DB, Ivy AC (1 October 1943). "Effects of Nasal Inhalers
Menthol
Impure form of heroin
type holds a variable admixture of morphine derivatives—predominantly 6-MAM (6-monoacetylmorphine), which is another result of crude acetylation. The
Black_tar_heroin
Class of peptides that bind to opioid receptors
analysis reveals that the conserved N-terminal region of the precursors contains 6 cysteines, which are probably involved in disulfide bond formation. It is
Opioid_peptide
Chemical compound
Taxifolin Thienorphine κ-opioid (KOR) Agonists 3CS-nalmefene 4-Allyl-6-oxa-noribogainalog 6'-GNTI 8-CAC 18-MC 14-Methoxymetopon β-Chlornaltrexamine β-Funaltrexamine
Zyklophin
Chemical compound
classically used in pain management". Neuropharmacology. 41 (4): 496–506. doi:10.1016/S0028-3908(01)00077-6. PMID 11543770. Noble F, Smadja C, Valverde O, Maldonado
RB-101
Atypical antidepressant
acid derivative). MC5 has a longer elimination half-life of approximately 7.6 hours, and takes about a week to reach steady-state concentration under daily-dosing
Tianeptine
Opioid analgesic
R-30490 (also known as 4-methoxymethylfentanyl) is an opioid analgesic related to the highly potent animal tranquilizer carfentanil, and with only slightly
R-30490
Opioid analgesic compound
Opioid Potency and Efficacy". ACS Pharmacology & Translational Science. 3 (6): 1063–1068. doi:10.1021/acsptsci.0c00075. PMC 7737207. PMID 33344889. Qu
Mitragynine_pseudoindoxyl
Opioid analgesic
analogs acetylfentanyl, 4-methoxybutyrfentanyl and furanylfentanyl: results from the Swedish STRIDA project". Clinical Toxicology. 54 (4): 324–32. doi:10.3109/15563650
Acetylfentanyl
Chemical compound
CID:134990386 (4). This compound cleaves when reacted with perchloric acid, releasing nitrogen molecules and forming a cyclopropane derivative, 6-deschloro
Cyproterone_acetate
Drug
Taxifolin Thienorphine κ-opioid (KOR) Agonists 3CS-nalmefene 4-Allyl-6-oxa-noribogainalog 6'-GNTI 8-CAC 18-MC 14-Methoxymetopon β-Chlornaltrexamine β-Funaltrexamine
Kendal_Black_Drop
Substance derived from opium
and 20 million people used opioids recreationally, representing 0.3% to 0.4% of the global population between the ages of 15 and 65. According to the
Opiate
Pharmaceutical compound
described in 2024. κ-Opioid receptor agonist Noribogaine Noribogainalog GM-3009 4-Allyl-6-oxa-noribogainalog Liu-Chen LY, Huang P (2025). "KOR agonists for the
Oxa-noribogaine
Traditional patent medicine
1000 mL, and contains the equivalent of 0.4 mg/mL of anhydrous morphine; one ounce of paregoric contains 129.6 mg (2 grains) of powdered opium, or the equivalent
Paregoric
Type of α-amino acid
1016/S0021-9258(19)34176-6. Thorpe TE (1913). A Dictionary of Applied Chemistry. Longmans, Green, and Co. pp. 191–193. Retrieved June 4, 2012. Plimmer RH (1912)
Phenylalanine
Substance use disorder services clinic
among patients receiving methadone". Drug and Alcohol Dependence Reports. 6 100138. doi:10.1016/j.dadr.2023.100138. ISSN 2772-7246. PMC 10040326. PMID 36994374
Methadone_clinic
Cough suppressant and dissociative drug
D". US Pharmacopeia. 2 May 2006. Archived from the original on 4 July 2017. Retrieved 6 May 2011. Schwartz AR, Pizon AF, Brooks DE (September 2008).
Dextromethorphan
Chemical compound
and curtails acute tolerance to morphine in rats". Neuropharmacology. 23 (6): 715–718. doi:10.1016/0028-3908(84)90171-0. PMID 6462377. S2CID 33168040
Proglumide
Drug class
Taxifolin Thienorphine κ-opioid (KOR) Agonists 3CS-nalmefene 4-Allyl-6-oxa-noribogainalog 6'-GNTI 8-CAC 18-MC 14-Methoxymetopon β-Chlornaltrexamine β-Funaltrexamine
Enkephalinase_inhibitor
Opioid analgesic drug
5α-epoxy-17-methylmorphinan-3,6β,14-triol (β-oxymorphol) which is different at position 6 on the morphine carbon skeleton. Hydromorphinol was developed in Austria in
Hydromorphinol
Medication used in the treatment for Opioid-Induced Constipation
(polyethylene glycol-modified) derivative of α-naloxol. Specifically, the 6-α-hydroxyl group of α-naloxol is connected via an ether linkage to the free
Naloxegol
Combination drug
Taxifolin Thienorphine κ-opioid (KOR) Agonists 3CS-nalmefene 4-Allyl-6-oxa-noribogainalog 6'-GNTI 8-CAC 18-MC 14-Methoxymetopon β-Chlornaltrexamine β-Funaltrexamine
Co-dydramol
Chemical compound
Taxifolin Thienorphine κ-opioid (KOR) Agonists 3CS-nalmefene 4-Allyl-6-oxa-noribogainalog 6'-GNTI 8-CAC 18-MC 14-Methoxymetopon β-Chlornaltrexamine β-Funaltrexamine
Thienorphine
Medieval medical concoction
Ritva (Pesahim 45b), Rabbenu Manoah (Mishneh Torah, Hilchot Chametz u'Matzah 4:10), and Shulchan Aruch, Orah Haim 442 Di Gennaro Splendore, Barbara (2025)
Theriac
Chemical compound
"Neutral amino acid therapy for the management of chronic pain". Cranio. 4 (2): 157–163. doi:10.1080/08869634.1986.11678141. PMID 3519793. Thanawala
D-Phenylalanine
Toxic chemical agent used by Russian special forces
Taxifolin Thienorphine κ-opioid (KOR) Agonists 3CS-nalmefene 4-Allyl-6-oxa-noribogainalog 6'-GNTI 8-CAC 18-MC 14-Methoxymetopon β-Chlornaltrexamine β-Funaltrexamine
Kolokol-1
Opioid analgesic
N-Benzyl-3-methyl-4-piperidone in a 2-stage Michael reaction, followed by Dieckmann cyclization as per usual.[citation needed] 3-Methylbutyrfentanyl 4-Fluorofentanyl
3-Methylfentanyl
travel, tourism, insurance
4 ALLYL-6-OXA-NORIBOGAINALOG
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4 ALLYL-6-OXA-NORIBOGAINALOG
4 ALLYL-6-OXA-NORIBOGAINALOG
4 ALLYL-6-OXA-NORIBOGAINALOG
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