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Chemical compound
some media sources claimed that the designer drug Ivory Wave contained WIN 35428. However, these reports at the time were poorly researched and sensationalized:
WIN-35428
values for displacement of [3H]WIN 35428 with ligand tricarbonyltechnetium replaced with rhenium. (IC50 for WIN 35428 were 2.62 ± 1.06 @ high affinity
List_of_phenyltropanes
of high affinity cocaine analogues. ɑIC50 (nM) for displacement of [3H]WIN 35428 See N-front & back bridged phenyltropanes. Back-bridged cocaine analogues
List_of_cocaine_analogues
Chemical compound
compound 4F-EPH. 4F-MPH was reported as having the following values: [3H]WIN 35428 binding of 35.0 ± 3.0 (2) and [3H]dopamine 142 ± 2.0 (2). 4-Fluoromethylphenidate
4-Fluoromethylphenidate
Appetite suppressant
alphanumeric assignation (name) R R′ R′′ IC50 (nM) (Inhibition of [3H]WIN 35428 binding) IC50 (nM) (Inhibition of [3H]DA uptake) Selectivity uptake/binding
Mazindol
Chemical compound
first known published synthesis of troparil and the related compound WIN 35428 is by Clarke and co-workers during the 1970s. Apparently, it was their
Troparil
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
Tesofensine
Chemical compound
cocaine in terms of its potency to elicit self-administration in monkeys. WIN 35428 was 6 times weaker than RTI-31, whereas RTI-51 was 2.6 times weaker than
RTI-31
Class of drug
with different effects: (1) typical or conventional DRIs like cocaine, WIN-35428 (β-CFT), and methylphenidate that produce potent psychostimulant, euphoric
Dopamine_reuptake_inhibitor
Mammalian protein found in Homo sapiens
Methylphenidate Orphenadrine Pethidine (meperidine) Pipradrol RTI-55 Troparil (WIN-35065) WIN-35428 (β-CFT) These agents may actually act as dopamine releasing agent-esque
Dopamine_transporter
Chemical compound
4-fluorophenyl containing compounds, such as the pesticide Flusilazole. WIN-35428 SCH-57871 Tefludazine & Irindalone Seganserin Setoperone Citalopram Paroxetine
1-Bromo-4-fluorobenzene
Chemical compound
phenyltropanes with high NET/DAT selectivity ratios Compound DAT [3H]WIN-35428 5-HTT [3H]Paroxetine NET [3H]Nisoxetine Selectivity 5-HTT/DAT Selectivity
RTI-83
Singh's alphanumeric assignation (name) R1 R2 IC50 (nM) (Inhibition of [3H]WIN 35428 binding) IC50 (nM) (Inhibition of [3H]DA uptake) Selectivity uptake/binding
List of methylphenidate analogues
List_of_methylphenidate_analogues
'-phenylisoxazol-5'-yl)tropane (β-CPPIT) • Altropane • Brasofensine • WIN 35428 (β-CFT) • Cocaine • Dichloropane • Difluoropine •
List_of_dopaminergic_drugs
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
NS-2359
Chemical compound
cocaine and semi-synthetic derivative o-hydroxy-cocaine Compound DAT [3H]WIN 35428 5-HTT [3H]Paroxetine NET [3H]Nisoxetine Selectivity 5-HTT/DAT Selectivity
Salicylmethylecgonine
Chemical compound
cocaine and semi-synthetic derivative o-acetoxy-cocaine Compound DAT [3H]WIN 35428 5-HTT [3H]Paroxetine NET [3H]Nisoxetine Selectivity 5-HTT/DAT Selectivity
2′-Acetoxycocaine
Class of compounds
been grouped into two types, typical or conventional DRIs like cocaine, WIN-35428 (β-CFT), and methylphenidate that produce potent psychostimulant, euphoric
Monoamine_releasing_agent
Class of chemical compounds
dependence liability. The first simple phenyltropanes to be made (WIN 35065-2 and WIN 34,428) were shown to be active in behavioral assays only for the
Phenyltropane
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-32
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
2α-(Propanoyl)-3β-(2-(6-methoxynaphthyl))-tropane
2α-(Propanoyl)-3β-(2-(6-methoxynaphthyl))-tropane
Cocaine analogue
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
FE-β-CPPIT
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
Ioflupane_(123I)
Cocaine analogue
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
FP-β-CPPIT
Chemical compound
1050 (45) 177 cf. 112 Troparil 23 49.8 920 (550) 37.2 1960 (178) 173 WIN 35428 13.9 23.0 835 (503) 38.6 692 (63) 101 RTI-31 1.1 3.68 37 (22) 5.86 44
RTI-113
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
Brasofensine
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
2β-Propanoyl-3β-(2-naphthyl)-tropane
2β-Propanoyl-3β-(2-naphthyl)-tropane
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-177
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-352
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-336
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-171
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
Dichloropane
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
2-Propanoyl-3-(4-isopropylphenyl)-tropane
2-Propanoyl-3-(4-isopropylphenyl)-tropane
Chemical compound
rearrangement product, the original synthesis had to be modified as follows; WIN 35428 was N-demethylated and then the NH amine was reacted with a suitable protecting
RTI-274
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-51
Stimulant drug
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
Altropane
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
2β-Propanoyl-3β-(4-tolyl)-tropane
2β-Propanoyl-3β-(4-tolyl)-tropane
Chemical compound
favored because they are very-high-energy γ-ray emitters. Compared to the "WIN" compounds, extremely low Ki values are attainable. RTI-55 is mainly used
RTI-55
Synthetic stimulant and triple reuptake inhibitor
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-112
Pharmaceutical drug
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-126
Chemical compound
powerful than many of the potent phenyltropane derived stimulant drugs such as WIN 35,428 and RTI-55. It showed promising effects in alleviating the symptoms
Difluoropine
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-229
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-353
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-150
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-121
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-371
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
RTI-120
Chemical compound
t e Phenyltropanes (classifications) 2-Carboxymethyl Esters Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83 (3,4-Disubstituted Phenyl)-tropanes
Tropoxane
Infinite binary sequence generated by repeated complementation and concatenation
Computer Science. Vol. 4036. Springer-Verlag. pp. 280–291. ISBN 978-3-540-35428-4. Zbl 1227.68074. Levine, Lionel; Stange, Katherine E. (2012). "How to
Thue–Morse_sequence
American journalist (born 1967)
(13). (Hardback ed.) Three Rivers Press, 2008; ISBN 0-307-35428-8 (10); ISBN 978-0-307-35428-0 (13). (Paperback ed.) 2008 Great American Hypocrites: Toppling
Glenn_Greenwald
Historical period
(2013). Les Paris de l'industrie 1750–1920. CREASPHIS Editions. ISBN 978-2-35428-079-6. Marchand, Bernard (1993). Paris, histoire d'une ville (XIX-XX siecle)
Paris_in_the_Belle_Époque
Philippine television network
Gold Medal for its newscast, the first Filipino news program to do so. This win, along with the Peabody Award in 1999, earned the network a commendation
GMA_Network
(1911–1912), Créaphis, 2018, 480 pages and 230 photographs. ISBN 978-2-35428-141-0.[1] History of Libya | Libya Connected (archived 20 April 2007) Libya
History_of_Libya
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