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TAF15

TAF15

Protein-coding gene in the species Homo sapiens

protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene. Initiation of transcription by RNA polymerase II requires the activities

TAF15

Proteinopathy

Diseases caused by abnormal protein structure

Vidal R, Apostolova LG, Lashley T, Ghetti B, Ryskeldi-Falcon B (2024). "TAF15 amyloid filaments in frontotemporal lobar degeneration". Nature. 625 (7994):

Proteinopathy

FET protein family

Family of RNA-binding proteins

at band 16 on the short arm of chromosome 16; and 3) the TAF15 protein encoded by the TAF15 gene (also termed the TATA-box binding protein associated

FET protein family

FET_protein_family

RNA-binding protein FUS

Human protein and coding gene

TATA-binding protein TBP-associated factor TAFII68/TAF15, and the Drosophila cabeza/SARF protein. FUS/TLS, EWS and TAF15 have a similar structure, characterised

RNA-binding protein FUS

RNA-binding_protein_FUS

Hsp104

Fungal protein found in Saccharomyces cerevisiae S288c

It is known to reverse toxicity of mutant α-synuclein, TDP-43, FUS, and TAF15 in yeast cells. Conserved in prokaryotes (ClpB), fungi, plants and as well

Hsp104

Extraskeletal myxoid chondrosarcoma

Type of abnormal growth in the body

described, including: EWSR1 (22q12.2), TAF15 (17q12), FUS (16p11.2), TCF12 (15q21), and TFG (3q12.2). The EWSR1, TAF15 (i.e. TAF2N), and FUS proteins are

Extraskeletal myxoid chondrosarcoma

Extraskeletal_myxoid_chondrosarcoma

Transcription factor II D

General transcription factors

(TAFII31L) TAF10 (TAFII30) TAF11 (TAFII28) TAF12 (TAFII20/15) TAF13 (TAFII18) TAF15 (TAFII68) Eukaryotic transcription General transcription factor Preinitiation

Transcription factor II D

Transcription_factor_II_D

ZNF384

Protein-coding gene in the species Homo sapiens

gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have

ZNF384

Stress granule

Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress

Semb H, Stenman G, et al. (July 2008). "The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement

Stress granule

Stress_granule

TBP-associated factor

Protein domains

(TAFII31L) TAF10 (TAFII30) TAF11 (TAFII28) TAF12 (TAFII20/15) TAF13 (TAFII18) TAF15 (TAFII68) TAF domains are spread out across many digital signatures: Xie

TBP-associated factor

TBP-associated_factor

RNA-binding protein EWS

Human protein and coding gene

EWS gene encodes an RNA binding protein closely related to FUS (gene) and TAF15, all of which have been associated to amyotrophic lateral sclerosis. The

RNA-binding protein EWS

RNA-binding_protein_EWS

TATA-binding protein

Protein-coding gene in the species Homo sapiens

RELA, NR2B1, TAF1, TAF4, TAF5, TAF6, TAF7, TAF9. TAF10, TAF11, TAF13, and TAF15. The TATA-box binding protein (TBP) is required for the initiation of transcription

TATA-binding protein

TATA-binding_protein

List of human protein-coding genes 8

A0A1W2PPL8 16267 TAF12 HGNC:11545; Q16514 16268 TAF13 HGNC:11546; Q15543 16269 TAF15 HGNC:11547; Q92804 16270 TAFA1 HGNC:21587; Q7Z5A9 16271 TAFA2 HGNC:21589;

List of human protein-coding genes 8

List_of_human_protein-coding_genes_8

Acral myxoinflammatory fibroblastic sarcoma

Soft tissue tumor

diagnostic fusion genes involving the NR4A3 gene fused with either the EWSR1 or TAF15 gene. Some nodular fasciitis and proliferative fasciitis lesions may have

Acral myxoinflammatory fibroblastic sarcoma

Acral_myxoinflammatory_fibroblastic_sarcoma

RNA recognition motif

Protein domain

SLIRP; SLTM; SNRP70; SNRPA; SNRPB2; SPEN; SR140; SRRP35; SSB; SYNCRIP; TAF15; TARDBP; THOC4; TIA1; TIAL1; TNRC4; TNRC6C; TRA2A; TRSPAP1; TUT1; U1SNRNPBP;

RNA recognition motif

RNA_recognition_motif

SAFB

Protein-coding gene in the species Homo sapiens

been shown to interact with: Estrogen receptor alpha, HNRPD, SAFB2, and TAF15. GRCh38: Ensembl release 89: ENSG00000160633 – Ensembl, May 2017 GRCm38:

SAFB

TAF5

Protein-coding gene in the species Homo sapiens

the TFIID complex. TAF5 has been shown to interact with: TAF6, TAF9, and TAF15, TATA binding protein. GRCh38: Ensembl release 89: ENSG00000148835 – Ensembl

TAF5

Anne Bertolotti

Neurological disease researcher

PhD from the Louis Pasteur University for the discovery of hTAFII68 (now TAF15) while working with Laszlo Tora and Pierre Chambon at Institut de Genetique

Anne Bertolotti

Anne_Bertolotti

POLR2C

Protein-coding gene in the species Homo sapiens

POLR2B, POLR2E and POLR2F, POLR2G, POLR2H, POLR2J, POLR2K, POLR2L, and TAF15. GRCh38: Ensembl release 89: ENSG00000102978 – Ensembl, May 2017 GRCm38:

POLR2C

TAF11

Protein-coding gene in the species Homo sapiens

histone H3. TAF11 has been shown to interact with: GTF2F1, POLR2A and TAF13, TAF15, TATA binding protein, and Transcription Factor II B. GRCh38: Ensembl release

TAF11

TAF7

Protein-coding gene in the species Homo sapiens

required for proper production of TAF1 TAF7 has been shown to interact with: TAF15, TAF1, and TATA binding protein. GRCh38: Ensembl release 89: ENSG00000178913

TAF7

List of OMIM disorder codes

Chondrosarcoma; 215300; EXT1 Chondrosarcoma, extraskeletal myxoid; 612237; TAF15 Chondrosarcoma, extraskeletal myxoid; 612237; TFG Chondrosarcoma, extraskeletal

List of OMIM disorder codes

List_of_OMIM_disorder_codes

TAF13

Protein-coding gene in the species Homo sapiens

pseudogene located on chromosome 6. TAF13 has been shown to interact with TAF15, TAF11, TAF10 and TATA binding protein. GRCh38: Ensembl release 89: ENSG00000197780

TAF13

POLR2E

Protein-coding gene in the species Homo sapiens

pseudogene is located on chromosome 11. POLR2E has been shown to interact with TAF15, POLR2C, POLR2G, POLR2H, POLR2A, POLR2B, POLR2L and GTF2F2. GRCh38: Ensembl

POLR2E