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Protein-coding gene in the species Homo sapiens
Signal peptide peptidase-like 2B, also known as SPPL2B, is a human gene. This gene is a member of the signal peptide peptidase-like protease (SPPL) family
SPPL2B
Protein family
plays a role in transplant rejection The homologous proteases SPPL2A and SPPL2B promote the intramembrane cleavage of TNFα in activated dendritic cells
Signal_peptide_peptidase
Immune system messenger protein which induces inflammation
to be secreted. After cleavage, the remaining tmTNF is cleaved again by SPPL2B, causing the intracellular portion to translocate to the nucleus. There
Tumor_necrosis_factor
Protein-coding gene in the species Homo sapiens
PMID 21896273. Friedmann E, Hauben E, Maylandt K, et al. (2006). "SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells
SPPL2A
Intramembrane cellular enzymes
Kuhn, PH; Stauffer, D; Rovelli, G; Martoglio, B (August 2006). "SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells
Intramembrane_protease
P10451 15745 SPP2 HGNC:11256; Q13103 15746 SPPL2A HGNC:30227; Q8TCT8 15747 SPPL2B HGNC:30627; Q8TCT7 15748 SPPL2C HGNC:28902; Q8IUH8 15749 SPPL3 HGNC:30424;
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
Protein-coding gene in the species Homo sapiens
suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3". J. Biol. Chem. 280 (47): 39515–23. doi:10.1074/jbc.M501645200
UNQ1887
Protein-coding gene in humans
addition, it has interactions with proteins such as COX17, COX1, LMNA, COA3, SPPL2B, and others. GRCh38: Ensembl release 89: ENSG00000178449 – Ensembl, May
COX14
Protein-coding gene in the species Homo sapiens
C15orf32 and PKD2, ALG9, DISP1, NPC1, FZD2, FAM69A, ATP6V1G2, ASIC1, DPY19L4, SPPL2B, and HGSNAT. Variants of C15orf32 has been linked to several traits through
Uncharacterized protein C15orf32
Uncharacterized_protein_C15orf32
SPPL2B
SPPL2B
SPPL2B
SPPL2B
Boy/Male
Indian
One who laughs often
Boy/Male
Hungarian
Peacekeeper.
Boy/Male
Hindu, Indian, Modern
Sign of Beauty
Boy/Male
Indian, Sanskrit
Endowing with Goodness; Purity
Girl/Female
Tamil
Descendant from Puru
Boy/Male
Tamil
Lord
Boy/Male
Arabic, French
Helper
Boy/Male
French American Anglo Saxon English Shakespearean
Prosperous protector.
Surname or Lastname
English
English : variant spelling of Rasberry.
Girl/Female
Muslim
Hail
SPPL2B
SPPL2B
SPPL2B
SPPL2B
SPPL2B