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Simulations Plus, Inc. develops absorption, distribution, metabolism, excretion, and toxicity (ADMET) modeling and simulation software for the pharmaceutical
Simulations_Plus
Join S&P MidCap 400; Diversified Healthcare Trust, Palomar Holdings & Simulations Plus to Join S&P SmallCap 600" (PDF). May 27, 2020. Retrieved December 28
List_of_S&P_600_companies
Acronym for process of disposition of pharmaceutical compounds
five Parallel artificial membrane permeability assay Simcyp Simulator Simulations Plus Solubility Doogue, Matthew P.; Polasek, Thomas M. (2013). "The ABCD
ADME
2025 Mirrorless digital camera by Fujifilm
distinguishing feature is the dedicated film simulation dial that provides quick access to selected simulations plus three customizable "recipe" slots. Fuji
Fujifilm_X-E5
planning. Adaptive Simulations - cloud based and fully automated CFD simulations. Akselos - reduced-basis finite element-based simulation software for structural
List of computer simulation software
List_of_computer_simulation_software
Aspen Plus, Aspen HYSYS, ChemCad and MATLAB, PRO are the commonly used process simulators for modeling, simulation and optimization of a distillation process
Modeling and simulation of batch distillation unit
Modeling_and_simulation_of_batch_distillation_unit
Join S&P MidCap 400; Diversified Healthcare Trust, Palomar Holdings & Simulations Plus to Join S&P SmallCap 600" (PDF). Retrieved December 14, 2020. "Essent
List_of_S&P_400_companies
Whole-building energy simulation program
EnergyPlus is a whole-building energy simulation program that engineers, architects, and researchers use to model both energy consumption — for heating
EnergyPlus
Simulation method used in drug development
conditions, e.g., chronic kidney disease. Simcyp Simulator and GastroPlus (from Simulations Plus) are simulators that take account for individual variabilities
Pharmacokinetics_simulation
Retrieved 17 July 2023. QSP Special Interest Group at ISoP QSP as Simulations Plus QSP at Certara eBook: The Emerging Discipline of Quantitative Systems
Quantitative systems pharmacology
Quantitative_systems_pharmacology
Country in East Asia
Population Distribution. International Conference on Social Modeling and Simulation, plus Econophysics Colloquium 2014. Springer Proceedings in Complexity. pp
Japan
American technology company
/ Measurement / Tools category for significant strides in circuit simulation, plus overcoming challenges in accuracy, efficiency and scalability. In 2024
Qorvo
Software generating fractal images
2017. Röss, Dieter (2011). Learning and Teaching Mathematics using Simulations: Plus 2000 Examples from Physics. Walter de Gruyter. p. 56. ISBN 9783110250077
Fractal-generating_software
Tellurium [6] Metabolism PhysioLab (Entelos)[7] GastroPlus and ADMEPredictor (Simulations-Plus) [8] Certara's Simcyp physiologically based pharmacokinetics
Biosimulation
Mathematical technique used to solve a certain class of partial differential equations
1016/0021-9991(77)90099-7. Birdsall, C.K. (1991). "Particle-in-cell charged-particle simulations, plus Monte Carlo collisions with neutral atoms, PIC-MCC". IEEE Transactions
Particle-in-cell
1998 video game
Invasion of Normandy is a 1998 computer wargame developed by Interactive Simulations and published by Empire Interactive. Key members of the team had previously
101: The Airborne Invasion of Normandy
101:_The_Airborne_Invasion_of_Normandy
Virtual medium through which various types of skills can be acquired
workings of the sectors as a whole, making training simulations versatile. Training simulations are not just games; their aim is to educate and inform
Training_simulation
1997 video game
by critics. In Computer Games Strategy Plus, Phil Thé found it to be "probably one of the best Bulge simulations yet to appear on either paper or silicon
Decisive Battles of WWII: The Ardennes Offensive
Decisive_Battles_of_WWII:_The_Ardennes_Offensive
General-purpose programming language
Library wxWidgets x265 XGBoost C++ numerical libraries Adept Advanced Simulation Library ALGLIB Armadillo Blitz++ CAPD CGAL Class Library for Numbers deal
C++
Discovering chemical properties by physical simulations
presence of a solvent such as water. Simulations of systems in vacuum are referred to as gas-phase simulations, while those that include the presence
Molecular_modelling
British theoretical physicist
systems “with multiscale simulations, plus AI surrogates, plus simulations of the neutrons, simulations of the damage, and simulations of the engineering to
Steven_Cowley
Building automation
Cybernetic Building Systems". 2009-03-21. Retrieved 2009-04-29. "HVAC SIMulation PLUS other systems (HVACSIM+)". 2009-05-13. Retrieved 2009-05-13. "Concentrated
Virtual Cybernetic Building Testbed
Virtual_Cybernetic_Building_Testbed
1998 video game
combat flight simulation video game. Set in the European theatre of operations during World War II, it is part of the Jane's Combat Simulations franchise
Jane's_WWII_Fighters
1999 video game
Jane's also licensed to EA the "Jane's" name and the "Jane's Combat Simulations" logo, and the game was marketed under the "Jane's" name, much like the
Fleet_Command
Primary NATO organization for defence science and technology
standards in order to foster simulation interoperability and reuse, to crafting a map for the development of simulations in order to satisfy NATO needs
NATO Science and Technology Organization
NATO_Science_and_Technology_Organization
1999 video game
Bauman, Steve (January 28, 2000). "10 Best Sci-Fi Simulations". Computer Games Strategy Plus. Strategy Plus, Inc. Archived from the original on February 4
MechWarrior_3
1995 video game
the best simulation of 1995, although it lost to Apache. "Home". capitalismlab.com. Capitalism Plus Manual, page 20. Chapter 2 Capitalism Plus Manual,
Capitalism_(video_game)
1999 war video game
wargame developed by Atomic Games and published by Strategic Simulations Inc. (SSI). A simulation of the Battle of the Bulge during World War II, it is the
Close Combat: Battle of the Bulge
Close_Combat:_Battle_of_the_Bulge
2001 video game
This flight simulation video game article is a stub. You can help Wikipedia by adding missing information.
Air_Ranger:_Rescue_Helicopter
Simulation system language
General Purpose Simulation System (GPSS) is a simulation language used for discrete-event simulations. It is especially useful in the modelling of queuing
GPSS
Video game series
Sandbox is a series of simulation video games; users can see the effects of gravity on objects in the universe and run scale simulations of the Solar System
Universe_Sandbox
Individual who portrays a disaster victim
firefighters or EMT personnel. Crisis actors are used to create high-fidelity simulations of disasters in order to allow first responders to practice their skills
Crisis_actor
1996 video game
Battles is a 1996 computer wargame developed and published by Strategic Simulations. It is the sequel to Steel Panthers and the second entry in the Steel
Steel Panthers II: Modern Battles
Steel_Panthers_II:_Modern_Battles
1995 video game
combat flight simulator video game developed and published by Military Simulations. Back to Baghdad is a combat flight simulator: its gameplay involves
Back_to_Baghdad
Topics referred to by the same term
the free dictionary. Snooker may also refer to: Six-red snooker Snooker plus, a cue sport based on snooker Power Snooker, a 2010 variant of the cue sport
Snooker_(disambiguation)
operations of SolidSim made available in Aspen Plus. Seader, J.D., Seider, W.D. and Pauls, A.C.: Flowtran Simulation – An Introduction, 2nd Edition, CACHE (1977)
List of chemical process simulators
List_of_chemical_process_simulators
Cosmological model
than in Lambda-CDM simulations. The reason for the disagreement was tracked down to an issue of how to construct the simulations that are used to determine
Conformal_cyclic_cosmology
Cloud computing simulator
multi-cloud simulations, vertical and horizontal VM scaling, host fault injection and recovery, joint power- and network-aware simulations and more. Though
CloudSim
Video game subgenre of simulation games
Dating sims, also known as dating simulation games, are a video game subgenre of simulation games with romantic elements. While resembling the visual
Dating_sim
destroy Odin until Jin reminds him how Odin connects him to his father. This, plus some wise words from his mother, cause Ban to rebound. Jin is notified that
List of Danball Senki episodes
List_of_Danball_Senki_episodes
Japanese series of train simulation video games
(トレインシミュレーター, Torein Shimyurētā, or abbreviated "TS") is a Japanese train simulation game series produced by Ongakukan. The game is significant as it was one
Train_Simulator_(Ongakukan)
2017 video game
following. An expanded version of the game, titled Doki Doki Literature Club Plus!, was released as a premium game in 2021 for PCs as well as the Nintendo
Doki_Doki_Literature_Club!
Building information modeling software application suite
to create 3D geometry needed for EnergyPlus using the existing drawing tools. RunManager manages simulations and workflows and gives users access to
OpenStudio
occurred plus requires many more system recalculations during the course of the simulation. An exercise in learning how to build discrete-rate simulations is
Discrete_rate_simulation
1998 video game
Dynasty General) is a turn-based computer wargame developed by Strategic Simulations, Inc (SSI). It was released in September 1998 in North America and Europe
People's_General
1999 video game
GameRankings. Panzer Elite was a finalist for Computer Games Strategy Plus's 1999 "Simulation Game of the Year" award, which ultimately went to MiG Alley. The
Panzer_Elite
1997 video game
Games Strategy Plus gave it universal acclaim, over a month before the game was released Stateside. GameSpot wrote that F1 Racing Simulation is an extremely
F1_Racing_Simulation
1987 video game
business partner Bill Stealey was skeptical of producing non-vehicle simulations. With five successful years behind him, Microprose considered star designer
Sid_Meier's_Pirates!
Simulation language
military and air-traffic control simulations. SIMSCRIPT II.5 is a powerful, free-form, English-like, general-purpose simulation programming language. It supports
SIMSCRIPT
Video game genre
Simulator (DCS), a highly realistic simulator focused on study-level simulations of payware military aircraft. ELITE: Electronic IFR Training Environment
Flight_simulation_video_game
Standard for distributed simulation
standard for distributed simulation, used when building a simulation for a larger purpose by combining (federating) several simulations. The standard was developed
High_Level_Architecture
1997 video game
1939–1999 is a 1997 computer wargame developed and published by Strategic Simulations, Inc. It is the third game in the Steel Panthers series, following Steel
Steel Panthers III: Brigade Command 1939–1999
Steel_Panthers_III:_Brigade_Command_1939–1999
immortalibestia is derived from the Latin words immortali- ('immortal') plus bestia ('beast'), meaning 'the undying beast'. The name refers to the superhero
List of organisms named after works of fiction
List_of_organisms_named_after_works_of_fiction
1996 video game
Creatures is an artificial life simulation packaged as a video game developed by British studio Creature Labs for Windows, and was ported to Macintosh
Creatures_(1996_video_game)
called the Tasmanian tiger (with Rhys Nicholson); The Kardashians on Disney Plus in Australia (with Margaret Pomeranz); Cancellation of the 'Australian Bureau
List of The Weekly with Charlie Pickering episodes
List_of_The_Weekly_with_Charlie_Pickering_episodes
1998 video game
Champions is a licensed motorcycle racing game, developed by Intense Simulations Entertainment and Interactive Entertainment Ltd. and published by Midas
Castrol Honda SuperBike World Champions
Castrol_Honda_SuperBike_World_Champions
and texture mapping onto polygons, a main feature of transportation simulations; Bob Stone of the Advanced Robotics Research Centre at the University
List_of_Equinox_episodes
Video game series
Strategic Simulations 1996 Steel Panthers: Campaign Disk by Strategic Simulations 1997 Steel Panthers: Campaign Disk #2 by Strategic Simulations 1996 Steel
Steel_Panthers
1998 video game
(February 11, 1999). "The Best of 1998 (Simulation Game of the Year)". Computer Games Strategy Plus. Strategy Plus, Inc. Archived from the original on February
Jane's_F-15
troubles with him, but he fails to mention he knows his past again. Another plus is that Dr. Martin hires Candy as his nurse, though he pays for it by not
List_of_Candy_Candy_episodes
Replication of aspects of building performance
capability from whole-building simulations to model input calibration to building auditing. Among whole-building simulation software tools, it is important
Building performance simulation
Building_performance_simulation
Video game developer
the stock exchange via IPOs. • City Economic Simulation DLC (2016) features advanced economic simulations with detailed GDP modeling and lets players take
Trevor_Chan
Recreational military combat simulation
tactics, and rules of engagement. Most simulations strive for immersion and tension in players. MilSim simulations are usually smaller, and more frequent
MilSim
Video game developer and publisher
FunPlus is a video game developer and publisher headquartered in Switzerland, with operations in China, Singapore, Portugal and Spain. The company has
FunPlus
1996 video game
ZuluWar! is a 1996 computer wargame published by Incredible Simulations. Designed by Jeff Lapkoff and Dennis Bishop, it simulates the Anglo-Zulu War.
ZuluWar!
Class of thermodynamic models
here). The EOS itself was developed through comparisons with computer simulations and should capture the essential physics of size, shape, and hydrogen
Cubic_equations_of_state
(named after Loup Verlet) is a data structure in molecular dynamics simulations to efficiently maintain a list of all particles within a given cut-off
Verlet_list
2025 video game
Blippo+ is a full-motion video television simulation video game developed by Yacht, Telefantasy Studios, Noble Robot, and Dustin Mierau, and published
Blippo+
Electronic game with user interface and visual feedback
watching the results as a passive observer, such as with many computerized simulations of Conway's Game of Life. Most video games are intended for entertainment
Video_game
1999 video game
General 3D Assault is a 1999 computer wargame developed by Strategic Simulations, Inc (SSI) and published by The Learning Company. It is the third game
Panzer_General_3D_Assault
Software for simulating and modeling materials
drug discovery QSAR, QSAR Plus: to identify compounds with optimal physicochemical properties. Polymers and Classical Simulation: to construct and characterize
Materials_Studio
List of spaceflight games
This is a sourced index of commercial space flight simulation games. The list is categorized into four sections: space flight simulators, space flight
List of space flight simulation games
List_of_space_flight_simulation_games
1999 video game
that simulates hang gliding or paragliding. It was developed by Quality Simulations and published by Wilco Publishing for Windows in 1999. It was set for
Hangsim
Video game series
countless other space games wouldn't have existed if it weren't for Elite. Elite Plus was developed and published by Microplay Software in 1991. It was coded in
Elite_(video_game_series)
1997 video game
Panzer General II is a computer wargame by Strategic Simulations, Inc. Released October 15, 1997, Panzer General II is the sixth SSI game in the Panzer
Panzer_General_II
(2006) Jersey Shore: Family Vacation "12 Days of Jerzmas" (2021) Jon & Kate Plus 8 "Shopping For Ten" (2007) "Gosselin Family Christmas" (2008) "Puppies!"
List of United States Christmas television episodes
List_of_United_States_Christmas_television_episodes
1999 video game
combat flight simulation video game developed by Israeli studio Pixel Multimedia and released in 1999 as part of Jane's Combat Simulations series. The game
Jane's_USAF
Web-based EDA tool suite
design, simulate, share (publicly and privately) and discuss schematics, simulations and printed circuit boards, and to create a bill of materials, Gerber
EasyEDA
lie in the field of cosmology, studying galaxy formation and computer simulations of cosmic structure formation. Sigmund Freud (1856–1939): Austrian neurologist
List of atheists in science and technology
List_of_atheists_in_science_and_technology
2001 business simulation video game
It has two new campaigns (Capitalist Campaign and Entrepreneur Campaign) plus an in-depth tutorial. The gameplay is very similar to the original version
Capitalism_II
Chemical process simulator by AspenTech
Elsevier. p. 534. ISBN 9780080531298. Retrieved 10 December 2016. "Aspen Plus: Historical Footnotes". Chemical Engineering Junkie. Archived from the original
Aspen_HYSYS
2005 video game
Dangerous Waters, is a 2005 naval warfare simulation game developed by American studio Sonalysts Combat Simulations. It was released for Microsoft Windows
Dangerous_Waters_(video_game)
Pornographic company
webcam models, pornographic fiction and other media. Under the name Bellesa Plus, they have a tiered subscription service. The company was initially founded
Bellesa
Microprocessor by Sun Microsystems
servers based on the UltraSPARC T2 Plus processor, an SMP capable version of UltraSPARC T2. Sun released the UltraSPARC T2 Plus processor with the following
UltraSPARC_T2
2026. 地獄先生ぬ～べ～怪 3 (in Japanese). Shueisha. Retrieved May 19, 2026. 地獄先生ぬ～べ～PLUS (in Japanese). Shueisha. Retrieved March 28, 2026. 地獄先生ぬ〜べ〜 1（文庫版） (in Japanese)
List of Hell Teacher: Jigoku Sensei Nube chapters
List_of_Hell_Teacher:_Jigoku_Sensei_Nube_chapters
1998 video game
released in 1998. Developed by Ultimation Inc. and published by Strategic Simulations Inc. (SSI). The game is set in World War II as a tank simulator. In the
Panzer_Commander
Model-based representation of processes
Process simulation is used for the design, development, analysis, and optimization of technical process of simulation of processes such as: chemical plants
Process_simulation
video games for related lists. This is a comprehensive index of business simulation games, sorted chronologically. Information regarding date of release,
List of business simulation video games
List_of_business_simulation_video_games
Uncertainty in situational awareness
article Dave Arneson called fog of war "one of the biggest 'plus' factors in computer simulations", while Crawford concluded, using Tanktics as an example
Fog_of_war
1996 submarine simulator
War II submarine combat simulation for MS-DOS, developed by Aeon Electronic Entertainment and published by Strategic Simulations in 1996. The game takes
Silent_Hunter_(video_game)
1999 video game
2016. Dellinger, AJ (September 19, 2015). "5 mind-bending video game simulations pushed to their absolute limits". The Daily Dot. Archived from the original
RollerCoaster Tycoon (video game)
RollerCoaster_Tycoon_(video_game)
1998 video game
H. (May 30, 1999). "Monaco Grand Prix Racing Simulation 2". Computer Games Strategy Plus. Strategy Plus, Inc. Archived from the original on July 2, 2003
Monaco Grand Prix: Racing Simulation 2
Monaco_Grand_Prix:_Racing_Simulation_2
German electronics and software company
platform consisting of a processor and interfaces for sensors and actuators, plus the Simulink blocks needed to integrate the interfaces into the Simulink
DSPACE_(company)
Japanese dating simulation game & franchise
to December 23, 2010. An anime sequel titled Amagami SS+ plus, pronounced as "Amagami SS Plus", aired in Japan from January 6 to March 29, 2012. Seiren
Amagami
Military simulation board game
subtitled The Desert War, 1940–43, is a strategic board wargame published by Simulations Publications, Inc. (SPI) in 1978 that simulates the entire North African
The_Campaign_for_North_Africa
Collection of classes and functions used in the C++ programming language
Library wxWidgets x265 XGBoost C++ numerical libraries Adept Advanced Simulation Library ALGLIB Armadillo Blitz++ CAPD CGAL Class Library for Numbers deal
C++_Standard_Library
1996 video game
Sci-Fi Simulations". Computer Games Strategy Plus. Archived from the original on February 4, 2005. Staff (March 25, 1997). "Computer Games Strategy Plus announces
Archimedean_Dynasty
1999 video game
Computer Games Awards: The Best Games of 1999 (Simulation of the Year)". Computer Games Strategy Plus. Strategy Plus, Inc. Archived from the original on April
MiG_Alley_(video_game)
Software companies of the United Kingdom
Systems' component and fluids data plus Wylie and Streeter’s 'Fluid Transients in Systems' that both allow for simulations to be initiated before detailed
Flowmaster_Ltd.
1998 video game
Top Gun: Hornet's Nest is a 1998 combat flight simulation game developed by Zipper Interactive and published by MicroProse for Microsoft Windows. It is
Top_Gun:_Hornet's_Nest
SIMULATIONS PLUS
SIMULATIONS PLUS
Girl/Female
English
Blend of Deanne (divine) plus variants of Andrea (masculine) and Sandra (protector of man. ).
Boy/Male
English
Terran means 'Earthman.' Variants are contemporary rhyming blends of Ter- plus Darin.
Girl/Female
English
Blend of Deanne, meaning divine, plus variants of Andrea (masculine) and Sandra (protector of...
Girl/Female
English
Blend of Deanne: (divine) plus variants of Andrea: (masculine) and Sandra: (protector of man. ).
Girl/Female
English
Blend of Deanne (divine) plus variants of Andrea (masculine) and Sandra (protector of man. ).
Boy/Male
Muslim
Good habit, Plus point
Boy/Male
English
Terran means 'Earthman.' Variants are contemporary rhyming blends of Ter- plus Darin.
Girl/Female
English
Blend of Geri plus Erica.
Girl/Female
English
Blend of Geri plus Erica.
Girl/Female
English
Blend of Deanne: (divine) plus variants of Andrea: (masculine) and Sandra: (protector of man. ).
Girl/Female
English
Blend of Deanne: (divine) plus variants of Andrea: (masculine) and Sandra: (protector of man. ).
Surname or Lastname
English
English : habitational name from Plush in Dorset, originally named with an Old English word plysc ‘shallow pool’.
Boy/Male
Indian
Good habit, Plus point
Girl/Female
English
Blend of Geri plus Erica.
Boy/Male
English
Terran means 'Earthman.' Variants are contemporary rhyming blends of Ter- plus Darin.
Girl/Female
English
Blend of Geri plus Marilyn.
Boy/Male
American, British, English
Sovereign; Terran; Earth-man; Variants are Contemporary Rhyming Blends of Ter Plus Darin
Girl/Female
English
Blend of Deanne: (divine) plus variants of Andrea: (masculine) and Sandra: (protector of man. ).
Boy/Male
English
Terran means 'Earthman.' Variants are contemporary rhyming blends of Ter- plus Darin.
Boy/Male
English
Terran means 'Earthman.' Variants are contemporary rhyming blends of Ter- plus Darin.
SIMULATIONS PLUS
SIMULATIONS PLUS
Boy/Male
Bengali, Indian
Funny
Girl/Female
American, Anglo, Australian, Chinese
Child of Maud
Boy/Male
Indian
Apple in Persian also means great warrior
Boy/Male
Gaelic Irish Scottish American
Form of Michael 'Who is like God?'.
Boy/Male
Hindu, Indian, Marathi
Intelligent; Wise; Clever; Reproduction
Boy/Male
Indian
Eloquence
Girl/Female
French, German, Greek, Hungarian, Latin, Polish
Violet Blossom; Purple; Violet Flower
Girl/Female
Arabic, Australian, Gujarati, Hebrew, Hindu, Indian, Kannada, Marathi, Muslim
Full of Beauty; Peace; Full of Life
Girl/Female
Latin
Beautiful.
Boy/Male
Indian
Very Big
SIMULATIONS PLUS
SIMULATIONS PLUS
SIMULATIONS PLUS
SIMULATIONS PLUS
SIMULATIONS PLUS
n.
Any one of several of South African lizards of the genus Zonura, common in rocky situations.
n.
Stimulation.
a.
Of or pertaining to dying or death; as, dying bed; dying day; dying words; also, simulating a dying state.
n.
The act of producing excitement (stimulation); also, the excitement produced.
n.
The act of exciting, or the condition of being excited to action, by stimulation; -- as, the condition of an organ of sense, when its nerve is affected by some external body; esp., the act of exciting muscle fibers to contraction, by artificial stimulation; as, the irritation of a motor nerve by electricity; also, the condition of a muscle and nerve, under such stimulation.
a.
Causing dilation or relaxation of the blood vessels; as, the vasodilator nerves, stimulation of which causes dilation of the blood vessels to which they go. These nerves are also called vaso-inhibitory, and vasohypotonic nerves, since their stimulation causes relaxation and rest.
n.
A projecting ornament placed at the intersection of the ribs of ceilings, whether vaulted or flat, and in other situations.
p. pr. & vb. n.
of Simulate
n.
A pricking; stimulation.
a.
Feigning; simulating; pretending.
n.
The state of dying or the stimulation of such a state; extreme languor; languishment.
n.
The quality or state of being sincere; honesty of mind or intention; freedom from simulation, hypocrisy, disguise, or false pretense; sincereness.
a.
Producing epilepsy or epileptoid convulsions; -- applied to areas of the body or of the nervous system, stimulation of which produces convulsions.
n.
The irritating action of various agents (stimuli) on muscles, nerves, or a sensory end organ, by which activity is evoked; especially, the nervous impulse produced by various agents on nerves, or a sensory end organ, by which the part connected with the nerve is thrown into a state of activity; irritation.
n.
The act of stimulating, or the state of being stimulated.
n.
A painful affection of the side, simulating pleurisy, usually due to rheumatism.
n.
Stimulation.
n.
The act of simulating, or assuming an appearance which is feigned, or not true; -- distinguished from dissimulation, which disguises or conceals what is true.
n.
A mutual agreement of two or more persons or parties, or one of the stipulations in such an agreement.
n.
The theory of medical practice which regarded life as dependent upon stimulation, or excitation, and disease as caused by excess or deficiency in the amount of stimulation.