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Chemical compound
Setmelanotide, sold under the brand name Imcivree, is a medication used for the treatment of genetic obesity caused by a rare single-gene mutation. The
Setmelanotide
Chemical compound
intake and lost weight. Another drug with a similar mechanism of action (setmelanotide) is approved for weight loss in rare types of obesity. Bremelanotide
Bremelanotide
Family of peptide hormones and neuropeptides
bremelanotide by Palatin Technologies. Others include modimelanotide and setmelanotide. Afamelanotide (brand name Scenesse) has been approved for the treatment
Melanocyte-stimulating hormone
Melanocyte-stimulating_hormone
Drug that never made it to the market
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Melanotan_II
Class of pharmacological agents
reducing energy intake or if they also increase energy expenditure. Setmelanotide is an agonist of the melanocortin 4 receptor and is used in people with
Anti-obesity_medication
Chemical compound
obesity, . Unlike the older drug with the same mechanism of action, setmelanotide, it can be taken orally. As of 9 Feb 2026, Rhythm Pharmaceuticals has
Bivamelagon
Peptides derived from pro-opiomelanocortin
premenopausal women. At therapeutic dose levels, it activates MC1R and MC4R. Setmelanotide (Imcivree) is an MC4R agonist approved for chronic weight management
Melanocortin
Ciliopathic recessive genetic disorder
multidisciplinary team manages patients with adequate supportive treatments.Setmelanotide (marketed as Imcivree) was approved for treatment of obesity and the
Bardet–Biedl_syndrome
Protein controlling mammalian coloration
peptide full agonist Modimelanotide - nonselective peptide full agonist Setmelanotide - nonselective peptide full agonist Agouti signalling peptide - nonselective
Melanocortin_1_receptor
Mammalian protein found in Homo sapiens
appetite and food intake. In rare cases of POMC deficiency, treatment with setmelanotide, a selective melanocortin-4 receptor agonist, has been effective. Two
Proopiomelanocortin
Mammalian protein found in humans
II Modimelanotide Setmelanotide was approved by FDA as first-ever therapy for chronic weight management (IMCIVREE).The setmelanotide was advanced first-in-class
Melanocortin_4_receptor
Chemical compound
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Semax
Medical condition
include bariatric surgery and melanocortin 4 receptor agonists such as setmelanotide. Dimitri, Paul (6 April 2022). "Treatment of Acquired Hypothalamic Obesity:
Hypothalamic_obesity
Pharmaceutical compound
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Atumelnant
Obesity caused by a mutation in a single gene
to POMC, PCSK1, or leptin receptor deficiency who were treated with setmelanotide, an MC4R agonist mimicking the POMC-derived alpha-MSH resulted in drastic
Monogenic_obesity
Pharmaceutical compound
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
LIB-01
Chemical compound
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Afamelanotide
Pituitary hormone
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Adrenocorticotropic_hormone
G protein-coupled receptor
β-MSH γ-MSH Afamelanotide Bremelanotide Melanotan II Modimelanotide Setmelanotide MC1-selective BMS-470,539 MC4-selective PF-00446687 PL-6983 THIQ Unknown
Melanocortin_receptor
Mammalian protein found in Homo sapiens
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Agouti-related_peptide
Pharmaceutical compound
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
RO-0282425
Obesity in children
was associated with a reduced risk for suicidal ideation or attempt. Setmelanotide is approved for children six years or older with certain types of secondary
Childhood_obesity
Protein-coding gene in mammals
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Agouti-signaling_protein
Chemical compound
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Adrenocorticotropic hormone (medication)
Adrenocorticotropic_hormone_(medication)
Chemical compound
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
PL-6983
Experimental erectile dysfunction drug
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
PF-00446687
Chemical compound
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
SNAP-7941
Chemical compound
pharmacodynamic profile. Afamelanotide Bremelanotide Melanotan II Modimelanotide Setmelanotide Kang L, McIntyre KW, Gillooly KM, et al. (October 2006). "A selective
BMS-470539
IDH1 mutation Baricitinib Eli Lilly and Company severe alopecia areata Setmelanotide Rhythm Pharmaceuticals Bardet–Biedl syndrome Dextromethorphan/bupropion
List of drugs granted breakthrough therapy designation
List_of_drugs_granted_breakthrough_therapy_designation
System involved in the regulation of weight and peripheral tissue such as hair and skin
are a target of choice for anti-obesity drugs development, such as setmelanotide and lorcaserin, but also diabetes, cachexia and eating disorders such
Central_melanocortin_system
Peptide hormone in mammals
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Α-Melanocyte-stimulating hormone
Α-Melanocyte-stimulating_hormone
Chemical compound
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Γ-Melanocyte-stimulating hormone
Γ-Melanocyte-stimulating_hormone
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
N-Terminal peptide of proopiomelanocortin
N-Terminal_peptide_of_proopiomelanocortin
Chemical compound
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Β-Melanocyte-stimulating hormone
Β-Melanocyte-stimulating_hormone
Mammalian protein found in humans
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Melanocortin_3_receptor
Pharmaceutical drug classification
Clobenzorex A08AA09 Mefenorex A08AA10 Sibutramine A08AA11 Lorcaserin A08AA12 Setmelanotide A08AA51 Phentermine and topiramate A08AA56 Ephedrine, combinations A08AA62
ATC_code_A08
Mammalian protein found in humans
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
ACTH_receptor
American biochemist, pharmaceutical scientist, and entrepreneur
Pharmaceuticals Announces Late-breaking Data from Phase 3 Trials of Setmelanotide in POMC and LEPR Deficiency Obesities at ObesityWeek 2019 | Rhythm Pharmaceuticals
Louis_Tartaglia
Chemical compound
pursued. Afamelanotide BMS-470,539 Bremelanotide Melanotan II PF-00446687 Setmelanotide Ramos AM, González-Guerrero C, Sanz A, Sanchez-Niño MD, Rodríguez-Osorio
Modimelanotide
Chemical compound
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
THIQ
Chemical compound
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Alsactide
Protein found in humans
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Melanocortin_5_receptor
Pharmaceutical compound
Modimelanotide PF-00446687 (PF-446687) PG-931 PL-6983 Ro 27-3225 RO-0282425 Setmelanotide THIQ Indirect agonists LIB-01 (DIC-2024; Libiguin) Antagonists AGRP
Mifomelatide
SETMELANOTIDE
SETMELANOTIDE
SETMELANOTIDE
SETMELANOTIDE
Boy/Male
British, English
From the Mountain Valley
Boy/Male
Arabic, Muslim
Servant of the Beautiful (Allah)
Boy/Male
Latin
Blessed.
Girl/Female
Muslim
Forehead, Intelligence
Boy/Male
Muslim/Islamic
Man of Qualities
Surname or Lastname
English
English : variant of Hebden.
Girl/Female
Tamil
Gods gift, Ankle bells, Brightness
Biblical
my furrow; that suspends the waters; heap of waters
Boy/Male
Australian, Danish, French, Hebrew, Polish, Spanish
Gift from God; Given by God; God has Given
Girl/Female
Greek American English
Reap; from Therasia.
SETMELANOTIDE
SETMELANOTIDE
SETMELANOTIDE
SETMELANOTIDE
SETMELANOTIDE