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Search references for SETD2. Phrases containing SETD2
See searches and references containing SETD2!SETD2
Protein-coding gene in the species Homo sapiens
domain containing 2 is an enzyme that in humans is encoded by the SETD2 gene. SETD2 protein is a histone methyltransferase that is specific for lysine-36
SETD2
Congenital disorder
Luscan–Lumish syndrome (LLS), also known as SETD2-related overgrowth syndrome, is rare congenital disorder characterized by postnatal overgrowth, obesity
Luscan–Lumish_syndrome
Cancerous tumour in a bone
MYC, PIK3CA. In contrast, mutations in the histone methyltransferase gene SETD2 are rare in human osteosarcoma, but have been identified in 21% of canine
Osteosarcoma
Type of kidney cancer
Several frequently mutated genes were discovered in CCRCC: VHL, KDM6A/UTX, SETD2, KDM5C/JARID1C and MLL2. PBRM1 is also commonly mutated in CCRCC.[citation
Clear cell renal cell carcinoma
Clear_cell_renal_cell_carcinoma
French biopharmaceutical company
of the transaction, Ipsen also acquired Epizyme's first-in-class, oral SETD2 inhibitor development candidate. In January 2023, Ipsen announced it would
Ipsen
Project to catalogue genetic mutations responsible for cancer
profiles of type 2 tumors were heterogeneous, with alterations to CDKN2A, SETD2, TFE3, or increased expression of the NRF2–ARE pathway; loss of expression
The_Cancer_Genome_Atlas
British surgeon (born 1965)
Furthermore, his research linked the SET domain containing protein 2 (SETD2) gene to human breast cancer. He has also written 14 books in various disciplines
Kefah_Mokbel
Form of kidney cancer
five new frequently mutated genes were discovered in CCRCC; KDM6A/UTX, SETD2, KDM5C/JARID1C, and MLL2 CCRCC is derived from the proximal convoluted tubule
Renal_cell_carcinoma
Complication of celiac disease
SOCS1 (SOCS1 inhibits STAT signaling); tumor suppressor genes BCL11B and SETD2 (SETD2 is also involved in regulating lymphocyte development); another gene
Enteropathy-associated T-cell lymphoma
Enteropathy-associated_T-cell_lymphoma
Histone methylation on tail of histone H3 associated with gene bodies
damage such as double-strand breaks. The trimethylation is catalyzed by SETD2 methyltransferase. H3K36me3 acts as a mark for HDACs to bind and deacetylate
H3K36me3
Epigenitic modification to the protein histone H3
Histone-histone interactions play a role in this process. Regulation occurs via Setd2-dependent H3K36me3 deposition. H3K27me2 is broadly distributed within the
H3K27me3
Gene and protein involved in Huntington's disease
Huntingtin has also been shown to interact with: UBE2K, MAP3K10, OPTN, PRPF40A, SETD2, TRIP10, ZDHHC17. Huntington's disease (HD) is caused by a mutated form
Huntingtin
Nuclear protein
RR (July 2024). "A Phase II Trial of the WEE1 Inhibitor Adavosertib in SETD2 - Altered Advanced Solid Tumor Malignancies (NCI 10170)" (PDF). Cancer Research
Wee1
Protein-coding gene in the species Homo sapiens
histone methyltransferase (Huntingtin-interacting protein HYPB, also known as SETD2) to RNAPII during transcription elongation and is required for H3K36 trimethylation
IWS1
Medical condition
metastasis. Moreover, mutation of gene involved in chromatin remodeling (SETD2, BAP1, or PBRM) may lead to higher rate of TFE3/TFEB fusion. Additionally
Papillary renal cell carcinoma
Papillary_renal_cell_carcinoma
Protein family
EZH2 MLL, MLL2, MLL3, MLL5 NSD1, NSD2, NSD3 PRDM1, PRDM2, PRDM5 SETD1A, SETD2, SETD3, SETD4, SETD5, SETD6, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD1
SET_domain
Class of enzymes
EZH2 MLL, MLL2, MLL3, MLL4, MLL5 NSD1 PRDM2 SET, SETBP1, SETD1A, SETD1B, SETD2, SETD3, SETD4, SETD5, SETD6, SETD7, SETD8, SETD9, SETDB1, SETDB2 SETMAR
Histone_methyltransferase
Italian molecular and systems biologist
Vakoc, Christopher R. (18 May 2018). "MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity". Nature Communications. 9 (1): 1983. Bibcode:2018NatCo
Giulio_Superti-Furga
Medical condition
through Gα12-coupled receptors. Mutations in the chromatin remodeling gene, SETD2. This gene encodes SET domain containing 2, a protein that acts to reduce
Monomorphic epitheliotropic intestinal T cell lymphoma
Monomorphic_epitheliotropic_intestinal_T_cell_lymphoma
Q9Y6X0 14618 SETD1A HGNC:29010; O15047 14619 SETD1B HGNC:29187; Q9UPS6 14620 SETD2 HGNC:18420; Q9BYW2 14621 SETD3 HGNC:20493; Q86TU7 14622 SETD4 HGNC:1258;
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
as inhibitors and structure probes of protein lysine methyltransferase SETD2". Journal of the American Chemical Society. 134 (43): 18004–18014. doi:10
Minkui_Luo
American geneticist
PHIP, CDC42BPB, TKT, DHPS, PRUNE, EMC1, AHDC1, POGZ, PURA, ARID2, DDX3X, SETD2, KIF1A, and SPATA5. In April 2014, Chung spoke at TED2014, delivering a
Wendy_Chung
Medical condition
have mutations or other genetic abnormalities in their STAT5B, JAK3, TP53, SETD2, BRAF, KRAS, GNA12, CREBBP, and/or Myc genes. Indolent T cell lymphoproliferative
Natural killer cell enteropathy
Natural_killer_cell_enteropathy
Observation of the diversity of tumour cells
have shown that convergent mutations affecting H3K36 methyltransferase SETD2 and histone H3K4 demethylase KDM5C arose in spatially separated tumour sections
Tumour_heterogeneity
American biochemist and molecular biologist
lysine 4 (Set1), lysine 9 (SUV39H1), and lysine 36 of histone H3 (Set2/SETD2) and arginine 3 of histone H4 (PRMT1). Strahl also helped to develop the
Brian_D._Strahl
SETD2
SETD2
SETD2
SETD2
Boy/Male
Arabic, Muslim
Spring of Heaven
Boy/Male
Egyptian
Born on Sunday.
Girl/Female
Indian
Elated, Exultant, Flushed
Girl/Female
Hindu, Indian
Goddess Durga
Boy/Male
Tamil
Chitrannam | சிதà¯à®°à®¨à¯à®¨à®¾à®®
Pullannam
Girl/Female
Arabic, Muslim
Rays of Sun Light; Judging
Girl/Female
Arabic, Muslim
Name of a Sahabiyah
Girl/Female
Hindu, Indian
River
Surname or Lastname
English
English : unexplained. Compare Coppage.
Male
English
Short form of English Kameron, KAM means "crooked nose."
SETD2
SETD2
SETD2
SETD2
SETD2