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Drug that reduces excitement without inducing sleep
A sedative, or tranquilizer, is a substance that induces sedation by reducing irritability or excitement. They are central nervous system (CNS) depressants
Sedative
Topics referred to by the same term
up sedative in Wiktionary, the free dictionary. A general anaesthetic is also known as a sedative. Other uses of the term sedative include: Sedative (band)
Sedative_(disambiguation)
Drug whose use induces sleep
fibromyalgia as well. This group of drugs is related to sedatives. Whereas the term sedative describes drugs that serve to calm or relieve anxiety, the
Hypnotic
Australian band
Sedative is an Australian deathcore band from Perth, formed in 2021. The band currently consists of vocalist Matthew Daly (Blanche Dubrah),guitarists Benjamin
Sedative_(band)
of sedative, hypnotic or anxiolytic Harmful pattern of use of sedative, hypnotic or anxiolytic Sedative, hypnotic or anxiolytic dependence Sedative, hypnotic
List_of_mental_disorders
Obsolete sedative–hypnotic drug
Methaqualone is a sedative-hypnotic medication that was widely prescribed during the mid-20th century. It was marketed under various brand names, including
Methaqualone
Class of depressant drugs derived from barbituric acid
effects. They have been used recreationally for their anti-anxiety and sedative effects, and are thus controlled in most countries due to the risks associated
Barbiturate
Medical aid in dying
someone's life to relieve pain and suffering Palliative sedation, the use of sedative medications to relive symptoms, which may accelerate the death of the patient
Assisted_dying
Benzodiazepine medication
carbamazepine, sedative antihistamines, opioids, antipsychotics, and alcohol, when taken with lorazepam, may result in enhanced sedative effects. Lorazepam
Lorazepam
Syndrome caused by a dangerous level of a toxin
Substances that may cause this toxidrome are opioids. The symptoms of sedative/hypnotic toxidrome include ataxia, blurred vision, coma, confusion, delirium
Toxidrome
Antihistamine medication
sold under the brand name Benadryl among others, is an antihistamine and sedative. Although generally considered sedating, diphenhydramine can cause paradoxical
Diphenhydramine
Medical condition
neurological condition which results from repeated withdrawal episodes from sedative–hypnotic drugs such as alcohol and benzodiazepines. Each withdrawal leads
Kindling (sedative–hypnotic withdrawal)
Kindling_(sedative–hypnotic_withdrawal)
Pharmaceutical compound
Mephenaqualone is an analogue of the sedative and hypnotic drug methaqualone which has been sold as a designer drug. It was reported in Germany in 2025
Mephenaqualone
Alcoholic drink created for sharing
began to treat afflicted soldiers with large doses of a sedative called sodium amytal. The sedative would induce a deep sleep lasting up to three weeks.
Jungle_juice
American singer and actor (1935–1977)
eight months of 1977 alone, he had [prescribed] more than 10,000 doses of sedatives, amphetamines, and narcotics: all in Elvis' name." Nichopoulos' license
Elvis_Presley
Short-acting barbiturate
Pentobarbital is a short-acting barbiturate typically used as a sedative, a preanesthetic, and to control convulsions in emergencies. It can also be used
Pentobarbital
Benzodiazepine drug
Marcen, Sedatival, Sedotime, Solatran and Unakalm) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal
Ketazolam
Spice Effect Aniseed anti-spasmodic, expectorant, sedative Caraway diuretic, anti-spasmodic, galactagogue Cardamom antiseptic Cilantro antibacterial, anti-inflammatory
Spice_use_in_antiquity
2026 film by Nia DaCosta
sacrifice to Old Nick, claiming that Satan is his father. Running low on sedatives, Kelson prepares to euthanise Samson, but is overjoyed when Samson says
28 Years Later: The Bone Temple
28_Years_Later:_The_Bone_Temple
Chemical compound
allylisopropylacetylurea or allylisopropylacetylcarbamide, is a hypnotic/sedative drug of the ureide (acylurea) group synthesized in 1926 by Hoffmann-La
Apronal
Sedative, hypnotic, or anxiolytic use disorder, mild F13.11 Sedative, hypnotic, or anxiolytic use disorder, mild, in early remission F13.11 Sedative,
List of mental disorders in the DSM-5 and DSM-5-TR
List_of_mental_disorders_in_the_DSM-5_and_DSM-5-TR
disorder NOS 304.10 Sedative, hypnotic, or anxiolytic dependence 305.40 Sedative, hypnotic, or anxiolytic abuse 292.89 Sedative, hypnotic, or anxiolytic
List of mental disorders in the DSM-IV and DSM-IV-TR
List_of_mental_disorders_in_the_DSM-IV_and_DSM-IV-TR
American singer-songwriter (born 1948)
that she might relapse, she visited a psychiatrist, who prescribed the sedative Klonopin to help her remain free from cocaine. In late 1985, Fleetwood
Stevie_Nicks
Benzodiazepine medication
temazepam, and has moderate amnesic, anxiolytic, anticonvulsant, hypnotic, sedative, and skeletal muscle relaxant properties compared to other benzodiazepines
Oxazepam
Sedative-hypnotic drug
Ethchlorvynol is a GABAA receptor positive allosteric modulator with hypnotic and sedative properties, first developed by Pfizer in the 1950s. In the United States
Ethchlorvynol
Alpha-adrenergic agonist
Kapvay, among others, is an α2-adrenergic receptor agonist, hypotensive, sedative and anxiolytic drug used to treat high blood pressure, attention deficit
Clonidine
Chemical sedative and hypnotic drug
is a geminal diol with the formula Cl3C−CH(OH)2. It was first used as a sedative and hypnotic in Germany in the 1870s. Over time it was replaced by safer
Chloral_hydrate
Benzodiazepine medication
Chlordiazepoxide sold under the brand name Librium, is a sedative and hypnotic medication of the benzodiazepine class. It is used to treat anxiety, insomnia
Chlordiazepoxide
Class of drugs
Many GABA analogues are used as drugs, especially as anticonvulsants, sedatives, and anxiolytics. Butyric acid (butanoic acid) – histone deacetylase inhibitor
GABA_analogue
Medical condition
tolerance reported that "tolerance develops relatively quickly for the sedative and anticonvulsant actions of benzodiazepines, whereas tolerance to anxiolytic
Benzodiazepine_dependence
Birth defects linked to thalidomide use
trouble sleeping, tension, and morning sickness. It was introduced as a sedative and medication for morning sickness without having been tested on pregnant
Thalidomide_scandal
Sedative/Hypnotic medication for alcohol withdrawal
Clomethiazole (also called chlormethiazole) is a sedative and hypnotic originally developed by Hoffmann-La Roche in the 1930s. The drug is typically used
Clomethiazole
Pharmaceutical compound
femerazol or 5-phenyl-3-methylpyrazole, is a sedative drug and arylpyrazole derivative. It produces sedative, hypnotic, hypolocomotive, antiaggressive,
Phemerazole
Barbiturate
anxiolytic, sedative, and hypnotic properties. In the United Kingdom, it was known as quinalbarbitone. Secobarbital is considered to be an obsolete sedative–hypnotic
Secobarbital
Chemical compound
central nervous system depressant developed in 1949 as a non-barbiturate sedative-hypnotic drug. An improved method of manufacture was patented by Hoffmann-La
Pyrithyldione
as qualones, are a group of 4-quinazolinone derivatives typified by the sedative and hypnotic drug methaqualone (former brand name Quaalude). They are known
List of methaqualone analogues
List_of_methaqualone_analogues
Experimental psychiatric drug
modulator with a wider separation between antidepressant-like activity and sedative effects in preclinical research than related drugs like zuranolone. It
PRAX-114
Allergy medication
antagonist (antihistamine) with anticholinergic properties (drying) and sedative side effects. Like all first-generation antihistamines, it is sedating
Clemastine
Antihistamine drug
tract.[better source needed] Use of hydroxyzine for premedication as a sedative has no effects on tropane alkaloids, such as atropine, but may, following
Hydroxyzine
2016 film by Damien Leone
carries is her infant child. Art attacks Dawn and subdues Tara with a sedative. Tara awakens, bound to a chair, to see Dawn suspended upside down wearing
Terrifier
Medical intervention
assessment, determine any contraindications to PSA, choose the most appropriate sedative agent, and monitor the patient for potential complications both during
Procedural sedation and analgesia
Procedural_sedation_and_analgesia
Crown Prince of Saudi Arabia since 2017
seeks death penalty for Khashoggi murder, says journalist was killed by sedative overdose". CNN. 15 November 2018. Archived from the original on 15 November
Mohammed_bin_Salman
Nykopp-Koski Finland 2004–2009 5 Nurse who killed five elderly patients using sedatives and opiates in Finland. Kimberly Clark Saenz United States 2008 5 Killed
List of serial killers by number of victims
List_of_serial_killers_by_number_of_victims
Medical condition
differential diagnosis should include intoxication by other substances with sedative effects, such as benzodiazepines, anticonvulsants (carbamazepine), alcohols
Barbiturate_overdose
Pharmaceutical compound
is an analogue of the sedative and hypnotic drug methaqualone first synthesised in the 1980s, though not identified as a sedative drug until 2020. It is
PPQ_(drug)
Triazolobenzodiazepine sleep medication
generally only used as a sedative to treat severe insomnia. In addition to the hypnotic properties, triazolam's amnesic, anxiolytic, sedative, anticonvulsant,
Triazolam
Chemical compound
half-life) fluorinated analogue of temazepam that has powerful hypnotic, sedative, amnesiac, anxiolytic, anticonvulsant and skeletal muscle relaxant properties
Flutemazepam
Sedation of the terminally ill
usually by means of a continuous intravenous or subcutaneous infusion of a sedative drug, or by means of a specialized catheter designed to provide comfortable
Palliative_sedation
Group of chemical compounds
bioactive. They are responsible for the psychoactive, analgesic, euphoric and sedative effects of kava. Kava extract interacts with many pharmaceuticals and herbal
Kavalactone
Chemical compound
has neuroprotective and anticonvulsant, anxiolytic, antinociceptive and sedative / hypnotic effects in animal models. Pilot human clinical trials in the
HA-966
Pharmaceutical compound
MCPPQ, is an analogue of the sedative and hypnotic drug methaqualone which has been sold as a designer drug. It is one of a number of "next generation"
MCPPQ
Benzodiazepine medication
a benzodiazepine medication. It possesses anxiolytic, anticonvulsant, sedative, hypnotic, and skeletal muscle relaxant properties. Clorazepate is an unusually
Clorazepate
Chemical compound
Phenyltoloxamine is an antihistamine with sedative and analgesic effects. It is available in combination with other drugs such as paracetamol (acetominophen)
Phenyltoloxamine
Reduction of irritability or agitation by administration of sedative drugs
Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure
Sedation
Muscle relaxant medication
effects and safety profile associated with baclofen when it is combined with sedative drugs (e.g., alcohol, barbiturates, and benzodiazepines) range depending
Baclofen
Benzodiazepine drug
anxiolytic effects, yet without any notable sedative or amnestic effects. In fact, imidazenil blocks the sedative effects of diazepam, yet without lowering
Imidazenil
Psychoactive fluid secreted by lettuce
from the base of the stems. It is known as lettuce opium because of its sedative and analgesic properties. It has also been reported to promote a mild sensation
Lactucarium
Chemical compound
Romifidine is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses, although it may be used in a wide variety
Romifidine
Chemical compound
Lactucopicrin (Intybin) is a bitter substance that has a sedative and analgesic effect, acting on the central nervous system. It is a sesquiterpene lactone
Lactucopicrin
American UFO religion (1974–1997)
began on March 22–23 in three waves. Members took lethal doses of the sedative drug phenobarbital mixed into apple sauce or pudding. They also consumed
Heaven's Gate (religious group)
Heaven's_Gate_(religious_group)
Species of plant
the Lactuca (lettuce) genus, often ingested for its mild analgesic and sedative effects. It is related to common lettuce (L. sativa), and is often called
Lactuca_virosa
American musician (1964–2017)
prescription medications in therapeutic doses were found in Cornell's system: the sedative butalbital (5.4 μg/mL), commonly prescribed for the treatment of headache;
Chris_Cornell
Hypnotic medication
positive allosteric modulation at GABAA neurons. Zopiclone is considered a sedative and CNS depressant. Zopiclone and other benzodiazepine-like drugs like
Zopiclone
German physician
suspicion. Josef von Mering helped to discover barbiturates, a class of sedative drugs used for insomnia, epilepsy, anxiety, and anesthesia. In 1903, he
Joseph_von_Mering
2018 American film
watch her die. He leaves with Clark's parent's address and a syringe of sedative. At Clark's parents' house, Forrester finds the corpses of Clark's parents
The_Dead_Center
Neologism from online manosphere communities
Lyrica) is a drug used to treat epilepsy and other nervous damages, and has sedative effects. 1,4-Butanediol (with street names like "Bute", "One Comma Four"
Looksmaxxing
1951 film by Robert Wise
confesses that he murdered Sophia and that he has mixed an overdose of sedatives into her drink. Karin informs him that he has poisoned himself. She tries
The_House_on_Telegraph_Hill
Benzodiazepine medication
mania due to bipolar disorder. It possesses anxiolytic, anticonvulsant, sedative, hypnotic, and skeletal muscle relaxant properties. It is typically taken
Clonazepam
Chemical compound
eczema or poison ivy, by acting as an antihistamine). It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. Despite being
Alimemazine
Class of psychoactive drugs
drugs begin with the letter "z"), are a class of psychoactive, depressant, sedative, hypnotic, anxiolytic drugs that are benzodiazepine-like in uses. Nonbenzodiazepine
Nonbenzodiazepine
Category of drug
an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant
GABA_receptor_agonist
Chemical compound
solvents. It reacts with water to form chloral hydrate, a once widely used sedative and hypnotic substance. Chloral was first prepared, and named, by the German
Chloral
Chemical compound
Petrichloral (pentaerythritol chloral, brand name Periclor) is a sedative and hypnotic chloral hydrate prodrug. It is a Schedule IV drug in the USA. US
Petrichloral
Opioid analgesic and recreational drug
point similar to that of heroin. Sedatives, specifically benzodiazepines such as diazepam, are added to enhance the sedative effects of heroin. The hallucinogenic
Heroin
Chemical compound
Medetomidine is a veterinary anesthetic medication with potent sedative effects. As of December 2025[update], it is an emerging illicit drug adulterant
Medetomidine
Miles Laboratories sedative patent medicine (1884–ca.1970)
Nervine was a patent medicine tonic with sedative effects introduced in 1884 by Dr. Miles Medical Company (later Miles Laboratories which was absorbed
Nervine
Mixture of different psychoactive drugs
different ketamine is from cocaine. Cocaine is a stimulant and ketamine is a sedative-hallucinogenic anesthetic. It does not mix well with alcohol. The effects
Tusi_(drug)
Spray that delivers medicine in the nostrils
pharmaceutical drugs exist as nasal sprays for systemic administration (e.g. sedative-analgesics, treatments for migraine, osteoporosis and nausea). Other applications
Nasal_spray
Topics referred to by the same term
drug with typical sedative and anxiolytic effects Ro5-4864, or 4'-Chlorodiazepam, an atypical benzodiazepine derivative with sedative yet also convulsant
Chlorodiazepam
Peoples Temple cult settlement in Guyana, led by Jim Jones
that day's lunch of grilled cheese sandwiches may have been tainted with sedatives. The crowd was surrounded by armed guards, offering members the basic
Jonestown
Triazolobenzodiazepine medication
with a triazole ring. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Estazolam is an intermediate-acting
Estazolam
Drink laced with drugs
and murderers at drinking establishments who lace alcoholic drinks with sedative drugs. The "Mickey Finn" is most likely named after the manager and bartender
Mickey_Finn_(drugs)
Class of chemical compounds formally derived from the acylation of urea
chlorphenacemide, and acetylpheneturide (which are phenylureides), and the sedatives acecarbromal, bromisoval, and carbromal (which are bromoureides). Others
Acylurea
Medication used to treat anxiety disorders
antidepressant-induced sexual dysfunction, and bruxism. Buspirone is not effective as a sedative–hypnotic or muscle relaxant and does not have anticonvulsant properties
Buspirone
Anxiolytic medication
5-substituted,[clarification needed] tofisopam does not have anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties
Tofisopam
2020 film by Dean Craig
ex-girlfriend, an uninvited guest with a secret about Hayley, a misplaced sleep sedative, and a woman he has been pining for for years in alternate versions of
Love_Wedding_Repeat
Ionic compound (KBr)
Potassium bromide (KBr) is a salt, widely used as an anticonvulsant and a sedative in the late 19th and early 20th centuries, with over-the-counter use extending
Potassium_bromide
Chemical compound
2-Methyl-2-propyl-1,3-propanediol (MPP) is a simple alkyl diol which has sedative, anticonvulsant and muscle relaxant effects. It is both a synthetic precursor
2-Methyl-2-propyl-1,3-propanediol
2-Methyl-2-propyl-1,3-propanediol
Sedating antihistamine
brand name Phenergan among others, is a first-generation antihistamine, sedative, and antiemetic used to treat allergies, nausea, and vomiting. It may also
Promethazine
Drug-induced relaxation of dental patients
and appropriate sedative measures while incorporating anxiety-reducing procedures. Adherence to safety protocols while performing sedative procedures in
Sedation_dentistry
Benzodiazepine sedative
effects of alcohol, other hypnotics/sedatives (e.g., barbiturates), other muscle relaxants, certain antidepressants, sedative antihistamines, opioids, and antipsychotics
Diazepam
American serial killer (1960–1994)
administered sleeping pills to his partners, giving them liquor laced with sedatives. He then waited for his partner to fall asleep before performing various
Jeffrey_Dahmer
Pharmaceutical compound
Veralipride Zicronapine Ziprasidone Zotepine Antiemetics/gastroprokinetics/sedatives: Aceprometazine AS-8112 Alimemazine Alizapride Benzquinamide Bromopride
13-Hydroxylergotrile
Chemical compound
Trional (Methylsulfonal) is a sedative-hypnotic and anesthetic drug with GABAergic actions[citation needed]. It has similar effects to Sulfonal, except
Trional
Medical condition
(1995) study found oxazepam less toxic and less sedative, and temazepam more toxic and more sedative, than most benzodiazepines in overdose. Following
Benzodiazepine_overdose
Chemical compound
benzoxepin, several of which are the subject of research due to their apparent sedative-hypnotic effects. "4-CPB". Compendium of Pesticide Common Names. British
4-(4-Chlorophenoxy)butanoic acid
4-(4-Chlorophenoxy)butanoic_acid
Plants that induce psychotropic effects upon ingestion
the mind or alter the state of consciousness. Psychoactivity may include sedative, stimulant, euphoric, deliriant, and hallucinogenic effects. Several hundred
Psychoactive_plant
Antipsychotic medication
as an antipsychotic, but is now almost exclusively used on animals as a sedative and antiemetic. A closely related analogue, chlorpromazine, is still used
Acepromazine
Chemical compound
Prenderol (Diethylpropanediol) is a simple alkyl diol which has sedative, anticonvulsant and muscle relaxant effects. It is closely related in structure
Prenderol
Sedative medication
adults may reduce time to extubation and ICU stay. Compared with other sedatives, some studies suggest dexmedetomidine may be associated with less delirium
Dexmedetomidine
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