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Class of intracellular transport proteins
Ryanodine receptors (RyR) are classified as high-conductance, intracellular calcium release channels, typically present in the membrane of the sarcoplasmic
Ryanodine_receptor
Chemical compound
Ryanodine is a poisonous diterpenoid found in the South American plant Ryania speciosa (Salicaceae). It was isolated by Merck chemists in the 1940s from
Ryanodine
Protein and coding gene in humans
Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is one of a class of ryanodine
Ryanodine_receptor_1
Transport protein and coding gene in humans
Ryanodine receptor 2 (RYR2) is one of a class of ryanodine receptors and a protein found primarily in cardiac muscle. In humans, it is encoded by the RYR2
Ryanodine_receptor_2
Transport protein and coding gene in humans
Ryanodine receptor 3 is one of a class of ryanodine receptors and a protein that in humans is encoded by the RYR3 gene. The protein encoded by this gene
Ryanodine_receptor_3
Medical condition
RYR2, which encodes a protein included in an ion channel known as the ryanodine receptor; this channel releases calcium from a cell's internal calcium
Catecholaminergic polymorphic ventricular tachycardia
Catecholaminergic_polymorphic_ventricular_tachycardia
Activation of tension-generating sites in muscle
proximity to ryanodine receptors in the adjacent sarcoplasmic reticulum. The activated dihydropyridine receptors physically interact with ryanodine receptors
Muscle_contraction
Severe reaction to general anesthesia
typically located on the long arm of chromosome 19 (19q13.2) involving the ryanodine receptor. More than 25 different mutations in this gene are linked with
Malignant_hyperthermia
Carcass quality condition
glycolysis and a low pH within the muscle fibers. A mutation point in the ryanodine receptor gene (RYR1) in pork, associated to stress levels prior to slaughter
PSE_meat
Calcium-storing organelle in muscle cells
SR/terminal cisternae through a ryanodine receptor (RyR) and is known as a calcium spark. There are three types of ryanodine receptor, RyR1 (in skeletal muscle)
Sarcoplasmic_reticulum
Class of insecticide
active mainly against lepidoptera (caterpillars), which act on the insect ryanodine receptor. They are diamides of either phthalic acid or anthranilic acid
Diamide_insecticides
Higher release of Calcium in cells
occurs through an ion channel within the membrane of the SR, known as a ryanodine receptor (RyR), which opens upon activation. This process is important
Calcium_sparks
Species of flowering plant
family Salicaceae. The species is significant partly because the alkaloid ryanodine was originally isolated from this South American tree. The tree was used
Ryania_speciosa
Antiarrhythmic medication
flecainide is useful to break a tachyarrhythmia. Flecainide also inhibits ryanodine receptor 2 (RyR2), a major regulator of sarcoplasmic release of stored
Flecainide
Chemical compound
Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. It is the primary drug used for the treatment and prevention
Dantrolene
Repeating unit of a myofibril in a muscle cell
with ryanodine receptors present on the sarcoplasmic reticulum. The inward flow of calcium from the L-type calcium channels activates ryanodine receptors
Sarcomere
Chemical compound
Chlorantraniliprole opens muscular calcium channels, in particular the ryanodine receptor, rapidly causing paralysis and ultimately death of sensitive
Chlorantraniliprole
Pesticide used against insects
of rice to planthopper attacks. Diamides selectively activate insect ryanodine receptors (RyR), which are large calcium release channels present in cardiac
Insecticide
Peptide toxin from the venom of the scorpion Hadrurus gertschi
the venom of the scorpion Hadrurus gertschi. Hadrucalcin modifies the Ryanodine receptor channels RyR1 and RyR2, found in the sarcoplasmic reticulum,
Hadrucalcin
American horse breed
stressors such as overwork or excitement. Caused by a mutated allele, ryanodine receptor 1 gene (RyR1) at nucleotide C7360G, generating a R2454G amino
American_Quarter_Horse
Extensions in cell membrane of muscle fibres
known as a ryanodine receptor, located on the cell's own internal calcium store, the sarcoplasmic reticulum. Activation of the ryanodine receptor causes
T-tubule
Drug for skeletal muscle function
with the release of calcium by binding to the ryanodine receptor and blocking the endogenous ligand ryanodine by competitive inhibition. Muscle that contracts
Muscle_relaxant
Protein-coding gene in the species Homo sapiens
SplA/ryanodine receptor domain and SOCS box containing 3 is a protein that in humans is encoded by the SPSB3 gene. GRCh38: Ensembl release 89: ENSG00000162032
SplA/ryanodine receptor domain and SOCS box containing 3
SplA/ryanodine_receptor_domain_and_SOCS_box_containing_3
Chemical compound
partners (e.g. TRPV4, ryanodine receptors,...). For example, it is a potent inhibitor of intracellular calcium release by ryanodine receptors (Kd ~20 nM)
Ruthenium_red
One of three major types of muscle
close to ryanodine receptors in the adjacent sarcoplasmic reticulum. The activated dihydropyridine receptors physically interact with ryanodine receptors
Skeletal_muscle
Toxin
peptide (CPP); it binds with high affinity and specificity to skeletal ryanodine receptor 1 (RYR1) of the sarcoplasmic reticulum, thereby triggering calcium
Vejocalcin
Structure of muscle tissue
influx of calcium and 2) a mechanical interaction with calcium-conducting ryanodine receptors (RyRs) on the adjacent SR membrane. Activation of RyRs causes
Triad_(anatomy)
Chemical compound used as insecticide
Flubendiamide is the first insecticide of the diamide class. It acts on the ryanodine receptor. A environmentally persistent metabolite of flubendiamide is
Flubendiamide
Chemical compound
cytoplasm. In heart muscle cells this increase in Ca2+ activates the ryanodine receptor-operated channel on the SR, results in further increases in Ca2+
Inositol_trisphosphate
Chemical compound
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Bistrifluron
Breed of fast-growing chicken
Abdi-Hachesoo, B. (2019-06-25). "Sequence and expression analysis of cardiac ryanodine receptor 2 in broilers that died from sudden death syndrome". Avian Pathology
Cobb_500
Species of scorpion
Valdivia; Lourival D. Possani (1997). "The mechanism of inhibition of ryanodine receptor channels by imperatoxin I, a heterodimeric protein from the scorpion
Emperor_scorpion
Protein and coding gene in humans
"Differential functional interaction of two Vesl/Homer protein isoforms with ryanodine receptor type 1: a novel mechanism for control of intracellular calcium
HOMER1
Family of transport proteins
triggers calcium release from the sarcoplasmic reticulum by activating ryanodine receptor 2 (RyR2) (calcium-induced-calcium-release). Phosphorylation of
L-type_calcium_channel
Protein-coding gene in humans
encoding different isoforms. Defective interaction between FKB1B and the ryanodine receptor is thought to be a potential mechanism underlying the arrhythmias
FKBP1B
Calcium ATPase-type P-ATPase
Ca2+-ATPase from skeletal muscle heavy sarcoplasmic reticulum: the role of ryanodine Ca2+ channel". Biochim. Biophys. Acta. 1768 (6): 1498–505. doi:10.1016/j
SERCA
Chemical compound
are at least six genetic loci of interest, the most prominent being the ryanodine receptor gene (RYR1). MH susceptibility is phenotype and genetically related
Suxamethonium_chloride
Short peptide toxin
one of a group of short, basic peptides called calcins, which bind to ryanodine receptors (RyRs) and thereby trigger calcium release from the sarcoplasmic
Intrepicalcin
Mexican beaded lizard, Heloderma horridum horridum. Helothermine inhibits ryanodine receptors, calcium channels and potassium channels. Helothermine can cause
Helothermine
Group of membrane channel proteins
The ryanodine-inositol 1,4,5-triphosphate receptor Ca2+ channel (RIR-CaC) family includes Ryanodine receptors and Inositol trisphosphate receptors. Members
Ryanodine-Inositol 1,4,5-triphosphate receptor calcium channels
Ryanodine-Inositol_1,4,5-triphosphate_receptor_calcium_channels
Medication and insecticide
Sulfluramid Tebufenozide Tebufenpyrad Veracevine Xanthone Metaflumizone Ryanodine Ryanodol Metabolites Oxon Malaoxon Paraoxon TCPy Schradan N-oxide Biopesticides
Permethrin
Species of shark
relative to other sharks. Their homeothermy may also rely on SERCA2 and ryanodine receptor 2 protein expression, which may have a cardioprotective effect
Salmon_shark
Type of ion channel transmembrane protein
(biochemistry) Inositol trisphosphate receptor Metabotropic receptor Ryanodine receptor "Gene Family: Ligand gated ion channels". HUGO Gene Nomenclature
Ligand-gated_ion_channel
Initially normal, then declining ability of a muscle to generate force
that occur in vivo with sustained exercise. It has been found that the ryanodine receptor present in skeletal muscle undergoes a conformational change
Muscle_fatigue
Local anaesthetic drug
tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores
Tetracaine
Breed of fast-growing chicken
growth, Cardiovascular risk, and Polymorphism in Targeted Regions of Ryanodine Receptor 2 (RYR2) gene in Three Breeds of Chickens., doi:10.21203/rs.3
Ross_308
Condition in pigs
It is an inherited, autosomal recessive disorder due to a defective ryanodine receptor leading to huge calcium influx, muscle contracture and increase
Porcine_stress_syndrome
Chemical compound
CH2(CH=CR)2NR' → C5H3R2NR' + H− Hantzsch ester Dihydropyridine receptor Ryanodine receptor "1,4-dihydropyridine - Compound Summary". Pubchem Compound. US:
1,4-Dihydropyridine
Class of organic chemical compounds with insecticidal properties
Sulfluramid Tebufenozide Tebufenpyrad Veracevine Xanthone Metaflumizone Ryanodine Ryanodol Metabolites Oxon Malaoxon Paraoxon TCPy Schradan N-oxide Biopesticides
Pyrethrin
Protein
Pandinus imperator. IpTx A acts by modifying the activity of the type 1 ryanodine receptor of skeletal muscle. RyR controls the intracellular Ca2+ permeability
Maurocalcine
Biological process
channels) are activated. CICR occurs when the resulting Ca2+ influx activates ryanodine receptors on the SR membrane, which causes more Ca2+ to be released into
Calcium-induced calcium release
Calcium-induced_calcium_release
Species of scorpion
described. Two peptides from the venom, BmK AS and AS1, are known to act on ryanodine receptors. Apart from having analgesic properties, BmK AS is also the
Olivierus_martensii
Family of enzymes
directed to specific sub-cellular locations after tethering to AKAPs. Ryanodine receptor (RyR) co-localizes with the muscle AKAP and RyR phosphorylation
Protein_kinase_A
Toxin
structure. The molecular weight of the toxin is 3.7 kDa. IpTxa acts on the Ryanodine receptors (RyR), which are intracellular Ca2+ release channels mainly
Imperatoxin
Chemical compound
provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels". Molecular Pharmacology. 74 (4): 980–9. doi:10.1124/mol
Paraxanthine
Protein and coding gene in humans
"Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane"
ASPH
Part of SR around T-tubules in muscle
is not actually an ionotropic channel. Instead, it serves to activate ryanodine, which will let calcium ions pass into the sarcoplasmic reticulum, and
Terminal_cisternae
Genus of flowering plants
Flacourtiaceae. The genus is significant partly because the alkaloid ryanodine was originally extracted from Ryania speciosa. The Catalogue of Life includes
Ryania
Mammalian protein found in Homo sapiens
calcium ion negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel
GSTO1
Pest worm of tomato, potato, and others
receptor agonists (18), volgate-gated sodium channel blockers (22A and 22B), ryanodine receptor modulators (28), and azadirachtin (of unknown action, UN). Experiments
Tuta_absoluta
Chemical compound
Sulfluramid Tebufenozide Tebufenpyrad Veracevine Xanthone Metaflumizone Ryanodine Ryanodol Metabolites Oxon Malaoxon Paraoxon TCPy Schradan N-oxide Biopesticides
Imidacloprid
Mammalian protein found in humans
transverse tubule of muscles. In skeletal muscle it associates with the ryanodine receptor RyR1 of the sarcoplasmic reticulum via a mechanical linkage.
Cav1.1
Group of voltage-gated ion channels permeable to Ca2+
channel, which is mechanically gated to a calcium-release channel (a.k.a. ryanodine receptor, or RYR) in the sarcoplasmic reticulum (SR), causes opening of
Voltage-gated_calcium_channel
Organelle in eukaryotic cells responsible for respiration
Pivneva T, Voitenko N, Fedirko N (May 2008). "Functional coupling between ryanodine receptors, mitochondria and Ca(2+) ATPases in rat submandibular acinar
Mitochondrion
Chemical compound
Sulfluramid Tebufenozide Tebufenpyrad Veracevine Xanthone Metaflumizone Ryanodine Ryanodol Metabolites Oxon Malaoxon Paraoxon TCPy Schradan N-oxide Biopesticides
Prallethrin
Drug
provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels". Molecular Pharmacology. 74 (4): 980–989. doi:10.1124/mol
Phosphodiesterase_inhibitor
Family of ion channel proteins
tetrameric ion channels. These include the sodium, potassium, calcium, ryanodine receptor, HCN, CNG, CatSper, and TRP channels. This large group of ion
Cation_channel_superfamily
Protein molecule receiving signals for a cell
cGMP (vision), cAMP and cGTP (olfaction) Na+, K+ IP3 receptor IP3 Ca2+ Intracellular ATP receptors ATP (closes channel) K+ Ryanodine receptor Ca2+ Ca2+
Receptor_(biochemistry)
Topics referred to by the same term
Agency, a repository of contributed programs for IBM computers. Spla/ryanodine receptor domain and socs box containing 3, a protein encoded by the SPSB3
SPLA
Medical drug
rhodopsin, the A1 adenosine receptor, the D2 receptor, the P2 receptor, and ryanodine receptors. Suramin is also an inhibitor of ABC-type and P-type ATPases
Suramin
Peptide hormone
increased by calcium release from intracellular stores via activation of ryanodine receptors. The calcium ion concentration in the cytosol of the beta cells
Insulin
Chemical compound
produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores". Neuropharmacology. 48 (8): 1086–96. doi:10.1016/j.neuropharm
CP_55,940
Another study was done for molecular autopsy on the RyR2-encoded cardiac ryanodine receptor in SUDS. There were 49 cases in this study, 30 of which were
Molecular_autopsy
Chemical compound which is reduced and oxidized
does this by binding to and opening a class of calcium channels called ryanodine receptors, which are located in the membranes of organelles, such as the
Nicotinamide adenine dinucleotide
Nicotinamide_adenine_dinucleotide
Chemical compound
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Imidaclothiz
Central nervous system stimulant
trisphosphate receptor 1 antagonist and a voltage-independent activator of the ryanodine receptors (RYR1, RYR2, and RYR3). It is also a competitive antagonist
Caffeine
Medication class with multiple uses
messenger in the cardiac cell is that it phosphorylates the LTCC and the ryanodine receptor to increase intracellular calcium levels and cause contraction
Beta_blocker
Chemical compound
Sulfluramid Tebufenozide Tebufenpyrad Veracevine Xanthone Metaflumizone Ryanodine Ryanodol Metabolites Oxon Malaoxon Paraoxon TCPy Schradan N-oxide Biopesticides
Acetamiprid
Topics referred to by the same term
Robert Yates Racing, a NASCAR NEXTEL Cup and Busch Series racing team Ryanodine receptor, a class of intracellular calcium channels RYR, the ICAO code
RYR
Chest discomfort due to disorder of the heart muscles
heart muscle cells. cAMP, which plays a vital role in phosphorylating the ryanodine receptor and LTCC, will usually increase Ca+2 levels in the heart muscle
Angina
Type of ion channel transmembrane protein
voltage-gated ion channels, including: inwardly rectifying K+ channels, ryanodine-inositol 1,4,5-triphosphate receptor Ca2+ channels, transient receptor
Voltage-gated_ion_channel
Intracellular communication process
1016/S0092-8674(00)81904-2. ISSN 0092-8674. PMID 9054501. Lu, Yun-Fei (September 2002). "Ryanodine receptors contribute to cGMP-induced late-phase LTP and CREB phosphorylation
Calcium_signaling
Thermogenic muscle cells in some fishes
releases heat. Heater cells are rich in the SR calcium-release channel, the ryanodine receptor (RyR), and the SR calcium pump, the Ca2+-ATPase (SERCA). The
Heater_cell
Episodes of muscular weakness due to low blood potassium levels
Cav1.1 as well as from the sarcoplasmic reticulum through the associated ryanodine receptor RyR1. This causes contraction (tensing) of the muscle. Depolarisation
Hypokalemic periodic paralysis
Hypokalemic_periodic_paralysis
rafoxanide renofluthrin resmethrin rhodojaponin-III [Wikidata] rotenone ryania ryanodine sabadilla sanguinarine sarolaner schradan selamectin semiamitraz [Wikidata]
List_of_insecticides
Protein-coding gene in the species Homo sapiens
September 2008). "S100A1 and calmodulin compete for the same binding site on ryanodine receptor". The Journal of Biological Chemistry. 283 (39): 26676–26683
S100A1
Protein-coding gene in the species Homo sapiens
is encoded by the SRI gene. SRI (gene) has been shown to interact with Ryanodine receptor 2, ANXA7 and GCA. GRCh38: Ensembl release 89: ENSG00000075142
SRI_(gene)
Class of insecticides
Sulfluramid Tebufenozide Tebufenpyrad Veracevine Xanthone Metaflumizone Ryanodine Ryanodol Metabolites Oxon Malaoxon Paraoxon TCPy Schradan N-oxide Biopesticides
Pyrethroid
Chemical compound
Sulfluramid Tebufenozide Tebufenpyrad Veracevine Xanthone Metaflumizone Ryanodine Ryanodol Metabolites Oxon Malaoxon Paraoxon TCPy Schradan N-oxide Biopesticides
Lotilaner
Family of transport proteins
Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα 1.1 1.2 1.3 1.4 N-type/Cavα2
Voltage-gated_sodium_channel
Protein found in humans
(LTCC) Cav1.2, the sarcoplasmic reticulum calcium release channel, and the ryanodine receptor 2 (RyR2). CALM1 disease mutations are often diagnosed in patients
Calmodulin_1
Chemical compound
Sulfluramid Tebufenozide Tebufenpyrad Veracevine Xanthone Metaflumizone Ryanodine Ryanodol Metabolites Oxon Malaoxon Paraoxon TCPy Schradan N-oxide Biopesticides
Piperonyl_butoxide
Protein-coding gene in the species Homo sapiens
Second messengers IP3 NAADP cADPR Intracellular channels IP3 receptor Ryanodine receptor Calcium-induced calcium release Intracellular pumps SERCA ATP2A1
Sarcalumenin
Mammalian protein found in Homo sapiens
Second messengers IP3 NAADP cADPR Intracellular channels IP3 receptor Ryanodine receptor Calcium-induced calcium release Intracellular pumps SERCA ATP2A1
Osteocalcin
Protein and coding gene in humans
intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital
FKBP1A
Class of transport proteins
"Structural and functional conservation of key domains in InsP3 and ryanodine receptors". Nature. 483 (7387): 108–112. Bibcode:2012Natur.483..108S.
Inositol trisphosphate receptor
Inositol_trisphosphate_receptor
Experimental oral insecticide for mosquitos
Sulfluramid Tebufenozide Tebufenpyrad Veracevine Xanthone Metaflumizone Ryanodine Ryanodol Metabolites Oxon Malaoxon Paraoxon TCPy Schradan N-oxide Biopesticides
Attractive_toxic_sugar_baits
Protein family
reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor calcium signalling. It contains 10 conserved cysteines which
Cysteine-rich secretory protein superfamily
Cysteine-rich_secretory_protein_superfamily
Chemical compound used as an insecticide
(February 15, 2023). "Comprehensive Overview of Diamide Derivatives Acting as Ryanodine Receptor Activators". Journal of Agricultural and Food Chemistry. 71 (8):
Cyantraniliprole
Pyrethroid used as an insect repellent
Sulfluramid Tebufenozide Tebufenpyrad Veracevine Xanthone Metaflumizone Ryanodine Ryanodol Metabolites Oxon Malaoxon Paraoxon TCPy Schradan N-oxide Biopesticides
Metofluthrin
RYANODINE
RYANODINE
RYANODINE
RYANODINE
Female
Native American
Native American Navajo name SAHKYO means "mink."
Girl/Female
Hindu, Indian
Beautiful
Girl/Female
American, Australian, British, Danish, English, German, Greek, Romanian
Divine; From the Sacred Spring; Variant of Dione; Follower of Dionysius
Surname or Lastname
English (Devon)
English (Devon) : variant spelling of Coker.
Boy/Male
Indian
The victorious
Surname or Lastname
English
English : variant of Fern 1.
Boy/Male
Australian, French, Latin
Chalice
Boy/Male
Arabic, Muslim
Star
Girl/Female
American, Australian, British, English, German
Hazelnut; Evelyn; Life
Girl/Female
Hindu, Indian, Marathi
Full of Kindness
RYANODINE
RYANODINE
RYANODINE
RYANODINE
RYANODINE