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Chemical compound
Pyrazole is an organic compound with the formula (CH)3N2H. It is a heterocycle characterized as an azole with a 5-membered ring of three carbon atoms and
Pyrazole
Chemical reaction
an amino-ketone and a ketone. Also reported by Knorr is a synthesis of pyrazoles from 1,3-dicarbonyls and hydrazines, hydrazides, or semibicarbazides.
Paal–Knorr_synthesis
Chemical compound
Propylpyrazoletriol (PPT) is a synthetic, nonsteroidal agonist of ERα with 400-fold selectivity over ERβ that is used widely in scientific research to
Propylpyrazoletriol
Compounds that inhibit or block the activity of cannabinoid receptors
requires a para-substituted phenyl ring at the pyrazole 5-position. The 5-substituent of the pyrazole is involved in receptor recognition and antagonism
Cannabinoid receptor antagonist
Cannabinoid_receptor_antagonist
Two chemical isomers, imidazole and pyrazole
atoms and two nitrogen atoms. The two isomers are: Imidazole (1,3-diazole) Pyrazole (1,2-diazole) Diazole Archived 24 December 2013 at the Wayback Machine
Diazole
Chemical reaction
instead can cyclize at that site via a substitution reaction to give a pyrazole. This process is a key part of the synthesis of pyraclofos [de] and related
Japp–Klingemann_reaction
Chemical fungicide
their brand name Miravis. The compound is an methoxyamide which combines a pyrazole acid with a substituted amphetamine to give an inhibitor of succinate dehydrogenase
Pydiflumetofen
are characterized by a central pyrazole ring with a phenyl group attached to one of the nitrogen atoms of the pyrazole. Phenylpyrazole insecticides were
Phenylpyrazole_insecticides
Chemical compound
Methylpiperidinopyrazole (MPP) is a synthetic, nonsteroidal, and highly selective antagonist of ERα that is used in scientific research to study the function
Methylpiperidinopyrazole
Chemical compound
the formula (CH3C)2CHN2H. It is one of several isomeric derivatives of pyrazole that contain two methyl substituents. The compound is unsymmetrical but
3,5-Dimethylpyrazole
Chemical compound
3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid is a chemical compound which is used commercially as an intermediate to seven fungicides which
3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic_acid
Chemical compound
N-(1-Amino-3-methyl-1-oxoButan-2-yl)-1-(CycloHexylmethyl)-3-(4-FlUorophenyl)-1H-PYrazole-5-CarboxAmide. There are two known regioisomers of AB-CHFUPYCA: 3,5-AB-CHMFUPPYCA
AB-CHFUPYCA
pyrazolylalanine synthase (EC 4.2.1.50) catalyzes the chemical reaction L-serine + pyrazole ⇌ {\displaystyle \rightleftharpoons } 3-(pyrazol-1-yl)-L-alanine + H2O
Pyrazolylalanine_synthase
Chemical compound
related to stanozolol, differing only in having an isoxazole instead of pyrazole ring fused to the A ring, and is also related to furazabol, prostanozol
Androisoxazole
Method of catalysis
environment, nanotechnology, and wastewater treatment. Consider the example of pyrazole, a compound that has antimicrobial, antihypertensive, anti-inflammatory
Sonocatalysis
Tridentate ligand which "pinches" the central metal atom
as: utilizing pyrrole, imidazole, or indole compounds in place of the pyrazole rings²;[citation needed] the possibility of tripodal heptadentate ligands
Scorpionate_ligand
Weed control herbicide
broadleaf weeds in what and barley. It is a selective benzoylpyrazolone, pyrazole compound, registered in Canada and Australia in 2004, and the USA in 2007
Pyrasulfotole
Chemical compound
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)pyrazole-3-carbonitrile) is a white, solid powder with a moldy odor. It is degraded
Fipronil
Chemical entity that reversibly binds ions
ionophores are based on crown ethers, cryptands, and calixarenes. Pyrazole-pyridine and bis-pyrazole derivatives have also been synthesized. These synthetic species
Ionophore
Cyclic nitrogen compound with formula HN5
containing one to five nitrogen atoms. This set contains pyrrole, imidazole, pyrazole, triazoles, tetrazole, and pentazole. Substituted analogs of pentazole
Pentazole
Chemical compound
6,7,8-tetrahydro-3H,5H,10H-spiro[dipyrrolo[1,2-a:1′,2′-d]pyrazole-2,3′-indole]-5,10-dione Identifiers CAS Number 182234-26-0 N 3D model (JSmol)
Spirotryprostatin_B
Chemical compound
Fluxapyroxad is a broad-spectrum pyrazole-carboxamide fungicide used on a large variety of commercial crops. It stunts fungus growth by inhibiting the
Fluxapyroxad
Chemical compound
containing two adjacent nitrogen atoms. It can be viewed as a derivative of pyrazole possessing an additional carbonyl (C=O) group. Compounds containing this
Pyrazolone
Chemical compound
using their brand name Vibrance. The compound is an amide which combines a pyrazole acid with an aryl amine to give a succinate dehydrogenase inhibitor (SDHI)
Sedaxane
Chemical compound
Deuruxolitinib, sold under the brand name Leqselvi, is a medication used for the treatment of alopecia areata. It is a Janus kinase inhibitor selective
Deuruxolitinib
Class of enzymes
51) is an enzyme that catalyzes the chemical reaction O-acetylserine + pyrazole CH3CO2H β-pyrazolyl-L-alanine It was first characterised from
Beta-pyrazolylalanine synthase
Beta-pyrazolylalanine_synthase
Chemical compound
Eganelisib (USAN), codenamed IPI-549, is an experimental drug being investigated as a possible treatment for cancer. It is a highly selective phosphoinositide
Eganelisib
Chemical compound
compound. This bicyclic compound consists of the fusion of benzene and pyrazole. Indazole is an amphoteric molecule which can be protonated to an indazolium
Indazole
Chemical compound
5F-AB-FUPPYCA (also known as AZ-037) is a pyrazole-based synthetic cannabinoid that is presumed to be an agonist of the CB1 receptor and has been sold
5F-AB-FUPPYCA
Nonsteroidal anti-inflammatory medication
relationship of celecoxib. A para-sulfamoylphenyl at position 1 of the pyrazole was found to have a higher potency for COX-2 selective inhibition than
Celecoxib
Species of cockroach
carbamates, synthetic pyrethroids, neonicotinoids, oxadiazines, and phenyl pyrazoles. German cockroach resistance was first observed with chlordane in 1952
German_cockroach
Anti-cancer medication
Zidesamtinib, sold under the brand name Jideytro, is an anti-cancer medication used for the treatment of non-small cell lung cancer. Zidesamtinib is a
Zidesamtinib
Chemical compound
backbone of DNA. Imidazole, an analog with two nonadjacent nitrogen atoms Pyrazole, an analog with two adjacent nitrogen atoms Tetrazole, an analog with four
Triazole
Chemical compound
Baricitinib, sold under the brand name Olumiant among others, is an immunomodulatory medication used for the treatment of rheumatoid arthritis, alopecia
Baricitinib
Pesticide used to kill molluscs
"Synthesis and Molluscicidal Activity of New Chromene and Pyrano[2,3- c ]pyrazole Derivatives". Archiv der Pharmazie. 340 (10): 543–548. doi:10.1002/ardp
Molluscicide
Chemical compound
stanozolol, differing from it only by having a furazan ring system instead of pyrazole. Furazabol has a relatively high ratio of anabolic to androgenic activity
Furazabol
Chemical compound
AM-251, the p-chloro group attached to the phenyl substituent at C-5 of the pyrazole ring is replaced with a p-iodo group. The resulting compound exhibits slightly
AM-251_(drug)
Protein-coding gene in the species Homo sapiens
)-2-(3-methylcyclohexylidene)hydrazine 2-Thiazolylhydrazone 3,5-Diaryl pyrazole Pyrazoline derivatives Several coumarin derivatives and #C19* (see 3d model)
Monoamine_oxidase_B
German chemist (1850–1902)
discovery of diazomethane in 1894. Pechmann condensation and Pechmann pyrazole synthesis. He also first prepared 1,2-diketones (e.g., diacetyl), acetonedicarboxylic
Hans_von_Pechmann
Chemical compound
antidepressant in the 1980s. The isomeric N,N-dimethyl-4,5-diphenyl-1H-pyrazole-1-propanamine was completely inactive in the primary antidepressant screens
Fezolamine
Concentration of chemical that stops bacterial growth
Ansar M, Faouzi ME (November 2022). "Identification of the new progress on pyrazole derivatives molecules as antimicrobial and antifungal agents". West African
Minimum inhibitory concentration
Minimum_inhibitory_concentration
Experimental drug
Pimicotinib (ABSK021), an oral, highly potent and selective small molecule blocker of the colony-stimulating factor 1 receptor (CSF-1R) independently discovered
Pimicotinib
Anti-cancer medication
Lazertinib, sold under the brand names Lazcluze and Leclaza among others, is an anti-cancer medication used for the treatment of non-small cell lung cancer
Lazertinib
Agricultural fungicide, QoI, strobilurin
Pyraclostrobin is a quinone outside inhibitor (QoI)-type fungicide used in agriculture. Among the QoIs, it lies within the strobilurin chemical class.
Pyraclostrobin
Chemical compound
borohydride and 3,5-dimethylpyrazole. Hydrogen gas is evolved as each of the pyrazole reacts at the boron. The rate of B-N bond formation becomes more difficult
Potassium tris(3,5-dimethyl-1-pyrazolyl)borate
Potassium_tris(3,5-dimethyl-1-pyrazolyl)borate
Chemical compound
M.; Cotesta, Simona (22 December 2022). "JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS G12C for the Treatment of Solid Tumors"
Opnurasib
Pharmaceutical compound
Enerisant (INNTooltip International Nonproprietary Name; developmental code name TS-091) is an experimental drug under investigation as a potential treatment
Enerisant
Herbicide classification system
pyruvate dioxygenase Isoxaflutole, Pyrasulfotole, Mesotrione Soxazoles, Pyrazoles, Triketones I O 4 Auxin mimic Dicamba, Halauxifen, Picloram, 2,4-D, MCPA
HRAC_classification
Protein-coding gene in the species Homo sapiens
long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase
ADH4
Class of enzymes
protease is in the market yet, but inhibitors such as rupintrivir and pyrazoles show promising targeting in broad range of picornaviruses. Acheson, Nicholas
Picornain_3C
Chemical compound
Zabadinostat is an experimental epigenetic drug being investigated as a potential treatment for advanced or metastatic cancers. It is an orally available
Zabadinostat
Pharmaceutical compound
6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide CAS Number 898044-15-0 PubChem CID 25227462 IUPHAR/BPS 8937
PF-3758309
but might plausibly be likely to appear in future (e.g. "Quinolinoyl pyrazole carboxylate", "Naphthoylimidazole" etc); "(a) In this section: (1) “Core
Structural scheduling of synthetic cannabinoids
Structural_scheduling_of_synthetic_cannabinoids
Organic compounds derived from coumarin
is the backbone of the neoflavones, a type of neoflavonoids. Coumarin-pyrazole hybrids have been synthesized from hydrazones, carbazones and thiocarbazones
Coumarin_derivatives
Pharmaceutical compound
Camonsertib is an investigational new drug that is being evaluated for the treatment of cancer. It is a selective oral small molecule inhibitor of ATR
Camonsertib
Pharmaceutical drug
Gumarontinib is a pharmaceutical drug used for the treatment of cancer. In China, it was conditionally approved in 2023 for the treatment of adult patients
Gumarontinib
Protein-coding gene in the species Homo sapiens
5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester 1y2c: Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylic
PDE4D
Class of organic compounds
Michel; Bentiss, Fouad (2008). "New one step synthesis of 3,5-disubstituted pyrazoles under microwave irradiation and classical heating". Journal of Heterocyclic
Hydrazone
Colorless flammable liquid with an ammonia-like odor
applications involve conversion of hydrazine to heterocyclic rings such as pyrazoles and pyridazines. Examples of commercialized bioactive hydrazine derivatives
Hydrazine
pyridine-carboxamide fluopyram, a pyrimide (pyridinyl ethylbenzamide) fluxapyroxad, a pyrazole-carboxamide oxycarboxin, oxathiin-carboxamide Strobylurines kresoxim-methyl
Wheat_diseases
Class of heterocyclic compounds
core of many biomolecules, such as histidine. Nitrogen only Imidazole Pyrazole 1,2,3-Triazole 1,2,4-Triazole Tetrazole Pentazole N,O compounds Oxazole
Azole
ALK inhibitor for treatment of non-small-cell lung cancer
Crizotinib, sold under the brand name Xalkori among others, is an anti-cancer medication used for the treatment of non-small cell lung carcinoma (NSCLC)
Crizotinib
and kidney cancer. The copper complex of a synthetic salicylaldehyde pyrazole hydrazone (SPH) derivative induced human umbilical endothelial cell (HUVEC)
Copper_in_biology
Quinoline Acridine Pyrazine Quinoxaline Phenazine Imidazole Benzimidazole Purine Pyrimidine Quinazoline Pteridine Pyrazole Indazole Pyridazine Cinnoline
Basic_aromatic_ring
Medication
(about 80 to 85% of an administered dose). Other metabolites include the pyrazoles 4-hydroxymethylpyrazole and the N -glucuronide conjugates of 4-carboxypyrazole
Fomepizole
Chemical compound
Erdafitinib, sold under the brand name Balversa, is an anti-cancer medication. It is a small molecule inhibitor of fibroblast growth factor receptor (FGFR)
Erdafitinib
Chemical compound
cyclizing agent in the synthesis of aziridine, oxadiazole, isoxazole and pyrazoles. It is inexpensive, has low toxicity, and acts as a oxidizing agent. In
Chloramine-T
Pharmaceutical compound
S6821 is a food additive that acts as a potent and selective antagonist of the bitter taste receptor TAS2R8. It has been approved as a food additive to
S6821
is low-spin. The Tp ligands are usually prepared from the reaction of pyrazole with potassium borohydride: KBH4 + 3 C3H3N2H → K[HB(C3N2H3)3] + 3H2 Intermediates
Trispyrazolylborate
Investigational drug
N-myristoyltransferase inhibitors are small molecules that target and inhibit N-myristoyltransferases, which block the addition of myristic acid to the
N-myristoyltransferase inhibitors
N-myristoyltransferase_inhibitors
Chemical compound
other 1,3-diketones, it is used as a precursor to heterocycles, e.g. pyrazoles, and metal chelates. It is prepared by condensation of esters of trifluoroacetic
1,1,1-Trifluoroacetylacetone
Fungicide
AG in 2006 and is used for crop protection from fungi. Penflufen is a pyrazole-amide based succinate-dehydrogenase inhibitor, which blocks the electron
Penflufen
Aromatic organic compounds consisting only of a conjugated planar ring system
Thiophene Benzothiophene Dibenzothiophene Imidazole Benzimidazole Purine Pyrazole Indazole Oxazole Benzoxazole Thiazole Benzothiazole 1,2,3-Triazole
Simple_aromatic_ring
Pharmaceutical compound
Investigational Identifiers IUPAC name 5-(1,3-benzodioxol-5-yl)-3-(3-bromophenyl)-1H-pyrazole CAS Number 882697-00-9 PubChem CID 44608289 DrugBank DB13927 ChemSpider
Emrusolmin
Medication used for postpartum depression
13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl)-1H-pyrazole-4-carbonitrile CAS Number 1632051-40-1 PubChem CID 86294073 DrugBank DB15490
Zuranolone
Chemical compound
substrates contain O-H, N-H, S-H bonds, including alcohols, phenols, pyrazoles, and thiols.[citation needed] NaH notably deprotonates carbon acids (i
Sodium_hydride
Chemical compound synthesized in the body via a mitochondrial enzyme
Effect of 2,2-bipyridyl, 2,2-dipyridyl amine, 1-methyl-3-(2-pyridyl) pyrazole, phenanthroline and 2,9-dimethyl-1,10-phenanthroline upon structure". Inorganica
Orotic_acid
Chemical compound
alcohols, and water. The synthesis of KTp involves potassium borohydride and pyrazole without a solvent. KBH4 + 3 C3N2H4 → KHB(C3N2H3)3 + 3 H2 The tris(pyrazolyl)borate
Potassium_trispyrazolylborate
Chemical compound
compounds. XXXVI. Synthesis of furo[3,2-c]pyrazole derivatives. (4) Synthesis of 1,3-diphenylfuro[3,2-c]pyrazole-5-carboxaldehyde and its derivatives (author's
Riociguat
Chemical compound
Regadenoson, sold under the brand name Lexiscan among others, is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used
Regadenoson
Chemical compound with the group –N+≡C–
1]Cycloaddition of Isocyanides to 1,2,4,5-Tetrazines: A Novel Synthesis of Pyrazole". Angewandte Chemie International Edition. 21 (4): 284. doi:10.1002/anie
Isocyanide
reaction Kishner cyclopropane synthesis Knoevenagel condensation Knorr pyrazole synthesis Knorr pyrrole synthesis Knorr quinoline synthesis Koch–Haaf reaction
List_of_organic_reactions
Chemical compound
Omesdafexor (MET409) is a small-molecule farnesoid X receptor (FXR) agonist developed for nonalcoholic steatohepatitis and colitis. Harrison, S. A.; Bashir
Omesdafexor
Drug discovery
appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen
Discovery and development of direct Xa inhibitors
Discovery_and_development_of_direct_Xa_inhibitors
Chemical compound
"Clinical trial of 3-methyl-5-(beta-N'-(N-m-chlorophenylpiperazino)ethyl)-pyrazole dihydrochloride (Mepiprazol) in the therapy of psychovegetative disorders"
Mepiprazole
Chemical compound
Lorediplon (INN) is a nonbenzodiazepine of the pyrazolopyrimidine family that is being pursued as a treatment for insomnia but has not completed development
Lorediplon
Chemical compound
CHK-336 is a small molecule lactate dehydrogenase inhibitor developed by Chinook Therapeutics (a Novartis Company). CHK-336 is a first-in-class, orally
CHK-336
Chemical compound
Alcohol dehydrogenase Cimetidine Ethanol Fomepizole (4-methylpyrazole) Pyrazole ALDHTooltip Aldehyde dehydrogenase Acetaldehyde Cimetidine Cyanamide Disulfiram
Γ-Butyrolactone
Pharmaceutical compound
Alcohol dehydrogenase Cimetidine Ethanol Fomepizole (4-methylpyrazole) Pyrazole ALDHTooltip Aldehyde dehydrogenase Acetaldehyde Cimetidine Cyanamide Disulfiram
JZP-386
Pharmaceutical compound
Zemprocitinib is an investigational new drug that is be evaluated by Lynk Pharmaceuticals for the treatment of ankylosing spondylitis and rheumatoid arthritis
Zemprocitinib
Overview of and topical guide to organic chemistry
Indolizines Isoquinolines Olympicenes Oxazoles Purines Xanthines Pyrans Pyrazoles Pyrazines Pyridazines Pyridines Pyrimidines Pyrroles Quinolines Thiazoles
Outline_of_organic_chemistry
Medication
Omidenepag, sold under the brand name Eybelis among others, is a medication used for the treatment of glaucoma and ocular hypertension. Omidenepag was
Omidenepag
Molecule with one or more rings composed of different elements
Unsaturated (and partially unsaturated) 2 × Nitrogen Pyrazolidine Imidazolidine Pyrazole (Pyrazoline) Imidazole (Imidazoline) Nitrogen + Oxygen Oxazolidine Isoxazolidine
Heterocyclic_compound
major use is in heterocyclic synthesis. E.g. with alkynes they generate pyrazoles in a 1,3-dipolar cycloaddition. Due to their high energy, they are usually
Nitrilimine
Medication for nausea, psychosis, and anxiety
Alcohol dehydrogenase Cimetidine Ethanol Fomepizole (4-methylpyrazole) Pyrazole ALDHTooltip Aldehyde dehydrogenase Acetaldehyde Cimetidine Cyanamide Disulfiram
Prochlorperazine
Chemical compound
Identifiers IUPAC name 2-([1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl]amino)adamantane-2-carboxylic acid CAS Number 146362-70-1 Y
Meclinertant
Discontinued steroid for heart treatment
5α-dihydrotestosterone (DHT) with a methyl group at the C17α position and a pyrazole ring attached to the A ring of the steroid nucleus. Various chemical syntheses
Stanozolol
Atypical antipsychotic and antiemetic medication
Alcohol dehydrogenase Cimetidine Ethanol Fomepizole (4-methylpyrazole) Pyrazole ALDHTooltip Aldehyde dehydrogenase Acetaldehyde Cimetidine Cyanamide Disulfiram
Amisulpride
Chemical compound
Alcohol dehydrogenase Cimetidine Ethanol Fomepizole (4-methylpyrazole) Pyrazole ALDHTooltip Aldehyde dehydrogenase Acetaldehyde Cimetidine Cyanamide Disulfiram
Γ-Hydroxybutyric_acid
Chemical compound
trispyrazolylborate (KTp). The procedure involves heating potassium borohydride and pyrazole without a solvent. KBH4 + 3 C3N2H4 → KHB(C3N2H3)3 + 3 H2 Diborane is produced
Potassium_borohydride
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