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Anion exchange protein
Pendrin is an anion exchange protein that in humans is encoded by the SLC26A4 gene (solute carrier family 26, member 4). Pendrin was initially identified
Pendrin
Kidney system
Kirsten M.; Nielsen, Søren (2002-10-01). "Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney". American Journal
Collecting_duct_system
Endocrine gland in the neck
then travels from within the cell into the lumen, through the action of pendrin, an iodide-chloride antiporter. In the follicular lumen, the iodide is
Thyroid
Medical condition
It has been linked to mutations in the PDS gene, which codes for the pendrin protein (solute carrier family 26, member 4, SLC26A4). The gene is located
Pendred_syndrome
Chemical compound
α-ketoglutarate's binding to, and thereby inhibits its activation of OXGR1. The pendrin protein promotes the electroneutral exchange of tissue chloride (Cl−) for
Α-Ketoglutaric_acid
Diuretics that act along the loop of Henle in the kidneys
tubule, epithelial sodium channels, and chloride-bicarbonate exchanger pendrin. This will promote sodium reabsorption and fluid retention, causing diuretic
Loop_diuretic
Hormones produced by the thyroid gland
is moved across the apical membrane into the colloid of the follicle by pendrin. Hydrogen peroxide is also introduced into the follicle by the action of
Thyroid_hormones
Enzyme expressed mainly in the thyroid gland
side, iodide is shuttled across the apical membrane into the colloid via pendrin after which thyroid peroxidase oxidizes iodide to atomic iodine (I) or
Thyroid_peroxidase
Chemical compound
Resting and IL-4-Stimulated Human Bronchial Epithelial Cells: Role of Pendrin and Anion Channels". Journal of Immunology. 178 (8): 5144–5153. doi:10
Thiocyanate
Human chromosome
2025-12-25. Grimaldi R, Capuano P, Miranda N, Wagner C, Capasso G (2007). "[Pendrin: physiology, molecular biology and clinical importance]". Giornale Italiano
Chromosome_7
Increase in blood pH resulting from fluid loss
attributable entirely to chloride depletion, which leads to a failure of pendrin, a chloride/bicarbonate exchanger in the collecting duct. Diagnosis of
Contraction_alkalosis
Hormone-producing cell in the thyroid gland
iodide is secreted into the colloid by the chloride/iodide transporter pendrin. Thyroid diverticulum List of human cell types derived from the germ layers
Thyroid_follicular_cell
Study of the physiology of the kidney
reabsorption (thick ascending) – reabsorption (intercalated cells, via band 3 and pendrin) Protons Uses vacuolar H+ATPase – – – secretion (intercalated cells) Potassium
Renal_physiology
Chemical compound
resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels". J. Immunol. 178 (8): 5144–53. doi:10.4049/jimmunol
Hypothiocyanite
Academic department in the UK
Alan W.; Fong, Peying; Gray, Michael A. (2011-11-25). "Novel Role for Pendrin in Orchestrating Bicarbonate Secretion in Cystic Fibrosis Transmembrane
Department of Pharmacology, University of Oxford
Department_of_Pharmacology,_University_of_Oxford
Protein-coding gene in the species Homo sapiens
caused by mutations in which compromise the function of the encoded protein pendrin - an anion Cl−/HCO3 − exchanger expressed in the inner ear. The loss of
TRPV6
Protein found in humans
Greeley T, Petrovic S, Wang Z, Amlal H, Kopp P, Burnham CE (February 2001). "Pendrin: an apical Cl−/OH−/HCO3− exchanger in the kidney cortex". American Journal
Anion_exchange_protein_2
Protein-coding gene in the species Homo sapiens
M, Greeley T, Petrovic S, Wang Z, Amlal H, Kopp P, et al. (Feb 2001). "Pendrin: an apical Cl−/OH−/HCO3− exchanger in the kidney cortex". American Journal
Anion_exchange_protein_3
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