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PDS5A

PDS5A

Protein-coding gene in the species Homo sapiens

cohesion protein PDS5 homolog A is a protein that in humans is encoded by the PDS5A gene. GRCh38: Ensembl release 89: ENSG00000121892 – Ensembl, May 2017 GRCm38:

PDS5A

Cohesin

Protein complex that regulates the separation of sister chromatids during cell division

motifs for separase cleavage and a region that is competitively bound by PDS5A, PDS5B or NIPBL. The C-terminal domain of RAD21 forms a winged helix that

Cohesin

WAPAL

Protein-coding gene in the species Homo sapiens

single strand or a pair of sister chromosomes. WAPL forms a complex with PDS5A or PDS5B and releases cohesin from DNA by opening the interface between

WAPAL

Loop extrusion

Mechanism of nuclear organization

"The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism". Nature Structural & Molecular Biology. 29 (6): 586–591

Loop extrusion

Loop_extrusion

Establishment of sister chromatid cohesion

for the establishment of cohesion. In humans, the gene has two homologs, Pds5A and Pds5B. Pds5 interacts with chromatin-associated cohesin. Pds5 is not

Establishment of sister chromatid cohesion

Establishment_of_sister_chromatid_cohesion

List of human protein-coding genes 6

Q86YL7 11914 PDPR HGNC:30264; Q8NCN5 11915 PDRG1 HGNC:16119; Q9NUG6 11916 PDS5A HGNC:29088; Q29RF7 11917 PDS5B HGNC:20418; Q9NTI5 11918 PDSS1 HGNC:17759;

List of human protein-coding genes 6

List_of_human_protein-coding_genes_6

RAD21

Protein-coding gene in humans

and calpain to cleave, as well as a region that is competitively bound by PDS5A, PDS5B or NIPBL. The C-terminal domain of RAD21 forms a winged helix that

RAD21