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Search references for PARP2. Phrases containing PARP2
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Search references for PARP2. Phrases containing PARP2
See searches and references containing PARP2!PARP2
Protein-coding gene in the species Homo sapiens
[ADP-ribose] polymerase 2 is an enzyme that in humans is encoded by the PARP2 gene. It is one of the PARP family of enzymes. This gene encodes
PARP2
Pharmacological enzyme inhibitors of poly (ADP-ribose) polymerases
cancer are more dependent on PARP than regular cells, making PARP (PARP1, PARP2 etc.) an attractive target for cancer therapy. PARP inhibitors appear to
PARP_inhibitor
Family of proteins
putative). They vary greatly in structure and function within the cell. PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2)
Poly_(ADP-ribose)_polymerase
Anti-cancer medication
transporter proteins. Niraparib is an inhibitor of the enzymes PARP1 and PARP2. 73% of ingested niraparib is absorbed in the gut, and it reaches highest
Niraparib
Chemical compound
been part of many combination clinical trials. It inhibits both PARP1 and PARP2 and thereby induces synthetic lethality. It is still being evaluated for
Veliparib
Mammalian protein found in Homo sapiens
other plants), PARP2 plays more significant roles than PARP1 in protective responses to DNA damage and bacterial pathogenesis. The plant PARP2 carries PARP
PARP1
Addition of one or more ADP-ribose moieties to a protein
ADP-ribosylation which recruits repair factors to interact at the break site. PARP2 is a secondary responder to DNA damage but serves to provide functional
ADP-ribosylation
Process involved in DNA repair
is done by PARP1; similar systems exist in other eukaryotes: in plants, PARP2 seems to play this role. PARP binding then recruits the MRN complex to the
DNA_end_resection
Chemical compound
Schüler, H. (2010). "Crystal Structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888". Biochemistry. 49 (6): 1056–1058
3-Aminobenzamide
Protein
DNA-beta-Pol complex. XRCC1 has been shown to interact with: APEX1, APTX, OGG1, PARP2, PCNA, PNKP, POLB, and PARP1. GRCh38: Ensembl release 89: ENSG00000073050
XRCC1
Q6UWI2 11717 PARN HGNC:8609; O95453 11718 PARP1 HGNC:270; P09874 11719 PARP2 HGNC:272; Q9UGN5 11720 PARP3 HGNC:273; Q9Y6F1 11721 PARP4 HGNC:271; Q9UKK3
List of human protein-coding genes 6
List_of_human_protein-coding_genes_6
rheumatoid arthritis by inhibition of PI3K/Akt/mTOR signalling pathway via PARP2 targeting. By targeting transcripts of genes such as transcription factors
MiR-125
Type of congenital heart defect
smoker mothers who carry genetic variations in them include ERCC1, ERCC5, PARP2, and OSGEP. There are various ways of diagnosing this congenital heart defect
Pulmonary atresia with ventricular septal defect
Pulmonary_atresia_with_ventricular_septal_defect
PARP2
PARP2
PARP2
PARP2
Boy/Male
Bengali, Gujarati, Hindu, Indian, Malayalam, Marathi, Sindhi, Traditional
Friend of Poor; Humble and Merciful
Boy/Male
Indian, Punjabi, Sikh
Love for War
Surname or Lastname
English
English : unexplained.
Female
English
Variant form of English Tricia, TRESHA means "patrician, of noble descent."
Boy/Male
Tamil
Sarnavo | ஸரà¯à®¨à®¾à®µà¯‹
Glitters as gold
Female
English
English form of Italian Rosabella, ROSABEL means "beautiful rose."
Girl/Female
Muslim
Diminutive of Hishma, Modesty
Male
Greek
(ΕυφÏανωÏ) Greek name derived from the word euphraino, EUPHRANOR means "delightful."
Girl/Female
Arabic, Bengali, Indian, Modern
Poetry
Boy/Male
Muslim
The giver of dishonor
PARP2
PARP2
PARP2
PARP2
PARP2