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MARIMASTAT

Marimastat

Chemical compound

Marimastat was a proposed antineoplastic drug developed by British Biotech. It acted as a broad-spectrum matrix metalloproteinase inhibitor. Marimastat

Marimastat

British Biotech

British based Biotechnology company

$2.5 billion, largely on the basis of its two main development drugs: marimastat (a novel matrix metalloprotease inhibitor for cancer treatment) and lexipafant

British Biotech

British_Biotech

Metalloprotease inhibitor

Enzyme

called "hydroxamate-based MMP inhibitors“. An example can be seen in Marimastat, a first generation inhibitor, which has a similar backbone and sidechain

Metalloprotease inhibitor

Metalloprotease_inhibitor

Matrix metalloproteinase

Family of zinc-dependent metalloendopeptidases

suspected to be involved in (see above). However, most of these, such as marimastat (BB-2516), a broad-spectrum MMP inhibitor, and cipemastat (Ro 32-3555)

Matrix metalloproteinase

Matrix_metalloproteinase

Matrix metalloproteinase inhibitor

as anticancer drugs. Examples include: Batimastat Cipemastat Ilomastat Marimastat Prinomastat Rebimastat Tanomastat Metalloproteinase inhibitors are found

Matrix metalloproteinase inhibitor

Matrix_metalloproteinase_inhibitor

Batimastat

Chemical compound

administered orally (as opposed to the newer and chemically similar MMPI marimastat), and injection into the peritoneum caused peritonitis. It is well-known

Batimastat

MMP2

Protein-coding gene in humans

generally safe with minimal adverse side effects. Additionally, trials with marimastat did show a slight increase in survival of patients with gastric or pancreatic

MMP2

Exopeptidase inhibitor

inhibitors, DPP-4 inhibitors, and exogenous MMP inhibitors like batimastat and marimastat. Various enkephalinase inhibitors, such as ketalorphan, spinorphin, and

Exopeptidase inhibitor

Exopeptidase_inhibitor

Tanomastat

Chemical compound

with these compounds have to date produced equivocal results. Batimastat Marimastat Coussens, L. M. (2002). "Matrix Metalloproteinase Inhibitors and Cancer--Trials

Tanomastat

Index of oncology articles

lymphoma – mammary – mammogram – mammography – Mammotome – mantle field – marimastat – mast cell – mastectomy – mastocytoma – matrix metalloproteinase – MDL

Index of oncology articles

Index_of_oncology_articles