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Chemical compound
Halichondrin B is a polyether macrolide originally isolated from the marine sponge Halichondria okadai by Hirata and Uemura in 1986. In that report, the
Halichondrin_B
Pharmaceutical drug
synthetic macrocyclic ketone analog of the marine sponge natural product halichondrin B, a naturally occurring, potent mitotic inhibitor with a unique tubulin-based
Eribulin
Japanese chemistry professor (1937–2023)
including the Nozaki–Hiyama–Kishi reaction. Kishi's total synthesis of halichondrin B was pivotal for the discovery and development of the anticancer drug
Yoshito_Kishi
Cell division inhibitor
site nearby. The isolation of halichondrin B is from two unrelated genera of sponge, has led to speculate that halichondrin B is a microbial in reality,
Mitotic_inhibitor
Exploration of nature for material with commercial potential
simplified synthetic analogue. This was necessary with the natural product halichondrin B, its simplified analogue eribulin now approved and marketed as an anticancer
Bioprospecting
Genus of sponges
through the discovery of cell division limiting properties of the extract Halichondrin B, which inhibits cell mitosis. The drug Eribulin, a related compound
Halichondria
Animals of the phylum Porifera
Healing" (PDF). JEZ Part B: Molecular and Developmental Evolution. 344 (4): 214–235. Bibcode:2025JEZB..344..214A. doi:10.1002/jez.b.23295. PMID 40200856.
Sponge
anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.". Cancer Res. 61 (3): 1013–21. PMID 11221827. Zhang HJ, Yi YH, Yang
Sponge_isolates
Drug class
"Natural product drug discovery: the successful optimization of ISP-1 and halichondrin B". Current Opinion in Chemical Biology. 15 (4): 523–528. doi:10.1016/j
Sphingosine-1-phosphate receptor modulator
Sphingosine-1-phosphate_receptor_modulator
Professor
One particularly notable example is in Kishi's total synthesis of halichondrin B, where extensive application of the coupling was eventually adapted
Kazuhiko_Takai
been achieved for ET-743 with the production of the intermediate Safracin B from Pseudomonas fluoresens and the subsequent semisynthesis into ET-743.
Marine_pharmacognosy
Ditrisarubicin A 87399-21-1 C60H86O19 ciguatoxin CTX1B 11050-21-8 C60H86O19 halichondrin B 103614-76-2 C60H86N12O16 actinomycin F3 1402-46-6 C60H88N2O19 mepartricin
List of compounds with carbon numbers 50+
List_of_compounds_with_carbon_numbers_50+
Naturally occurring chemical compound
polyether metabolism. Alternatively, it may be bacterial in origin. Halichondrin B Yeung, Kap-Sun; Paterson, Ian (2005-10-21). "Advances in the Total Synthesis
Altohyrtin_A
Chemical compound
S.; Ai, Y.; Kishi, Y. (2017). "Unified Synthesis of Right Halves of Halichondrins A–C". J. Org. Chem. 82 (17): 8792–8807. doi:10.1021/acs.joc.7b01283
2-Methyl-6-nitrobenzoic anhydride
2-Methyl-6-nitrobenzoic_anhydride
HALICHONDRIN B
HALICHONDRIN B
Boy/Male
Biblical
Burning, foolish, mad.
Boy/Male
Basque German
Bear.
Boy/Male
Biblical
Bitter contrition, without judgment.
Boy/Male
British, English, Gaelic, Irish
Pale Bridge
Boy/Male
Biblical
Vine branches.
Boy/Male
Biblical
Building.
Boy/Male
Biblical
An evil; a son who beholds.
Boy/Male
Basque, French, German, Portuguese
Baptist; To Dip
Boy/Male
British, English, French, Italian
Son of a Farmer; Both Surname and Given Name
Boy/Male
British, English, French
Son of a Farmer; Both Surname and Given Name
Boy/Male
Biblical
That bows before God.
Boy/Male
Biblical
The first born.
Boy/Male
English American Biblical Hebrew
Son of a farmer. Both surname and given name.
Boy/Male
Biblical
Building me.
Boy/Male
British, English, Gaelic, Irish
Pale Bridge
Boy/Male
Biblical
Building; understanding.
Boy/Male
British, English
Barley Field
Boy/Male
Biblical
That bows before God.
Boy/Male
British, English
Bright Raven
Boy/Male
British, English
The Old English Variant of the German Bernard
HALICHONDRIN B
HALICHONDRIN B
Female
English
English name derived from the vocabulary word, from Latin libertas, LIBERTY means "freedom."
Boy/Male
Australian, Iranian, Parsi, Zoroastrian
A Character in Shahnameh
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Telugu
The Self
Boy/Male
Assamese, Gujarati, Hindu, Indian, Kannada, Punjabi, Sanskrit, Sikh, Tamil
Immortal; Super; One Having a Long Life; Lord Vishnu; Long Lived; Without Death
Boy/Male
Muslim
Surname or Lastname
Americanized spelling of German Buche.English
Americanized spelling of German Buche.English : see Book.
Boy/Male
Indian
Baby snake
Girl/Female
Hindu, Indian, Kannada, Marathi, Sindhi, Traditional
Goddess Durga
Boy/Male
Hindu
Daring & dashing
Male
Dutch
, the descender.
HALICHONDRIN B
HALICHONDRIN B
HALICHONDRIN B
HALICHONDRIN B
HALICHONDRIN B
a.
Having a low back and high neck, as a horse.
n.
The edible fruit of the Gaultheria Shallon, an ericaceous shrub found from California northwards. The berries are about the size of a common grape and of a dark purple color.
n.
See Saunders-blue.
n. pl.
An order of sponges, having simple siliceous spicules and keratose fibers; -- called also Keratosilicoidea.
a.
Having a large, protuberant belly, or one shaped like a tun; pot-bellied.
a.
Of inflexible honesty and fidelity; -- a term derived from the true, or Coventry, blue, formerly celebrated for its unchanging color. See True blue, under Blue.
n.
A kind of color prepared from calcined lapis lazuli; ultramarine; also, a blue prepared from carbonate of copper.
a.
Of genuine birth; having a right by birth to any title; as, a true-born Englishman.
n.
A low bed that is moved on trundles, or little wheels, so that it can be pushed under a higher bed; a truckle-bed; also, sometimes, a simiral bed without wheels.
a.
Of a genuine or right breed; as, a true-bred beast.
n.
Alt. of Sancte bell
a.
Being of real breeding or education; as, a true-bred gentleman.
n.
See Sanctus bell, under Sanctus.
n.
A low bed on wheels, that may be pushed under another bed; a trundle-bed.
n.
A kind of rural festival at the dedication of a church, when the parishioners brought rushes to strew the church.