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Transmembrane carrier protein
Glucose transporter 2 (GLUT2) also known as solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2) is a transmembrane carrier protein
GLUT2
Transport that does not require energy
meal, the cell is signaled to move GLUT2 into membranes of the cells lining the intestines called enterocytes. With GLUT2 in place after a meal and the relative
Passive_transport
Simple ketonic monosaccharide found in many plants
the enterocyte across the basolateral membrane by either GLUT2 or GLUT5, although the GLUT2 transporter has a greater capacity for transporting fructose
Fructose
Naturally produced monosaccharide
basolateral side of the intestinal epithelial cells via the glucose transporter GLUT2, as well uptake into liver cells, kidney cells, cells of the islets of Langerhans
Glucose
Glycogen storage disease
and Horst Bickel, who first described it in 1949. It is associated with GLUT2, a glucose transport protein which, when functioning normally, allows glucose
Fanconi–Bickel_syndrome
Chemical compound
glucose to be transported into the cell by the glucose transport protein GLUT2, but is not recognized by the other glucose transporters. This explains
Streptozotocin
Type of brain cell
to changes in extracellular glucose. GP astrocytes possess high-capacity GLUT2-type glucose transporter proteins and appear to modulate the neuronal responses
Astrocyte
Type of cell found in pancreatic islets
Rodent beta cells primarily express the GLUT2 isoform, whereas human beta cells, although also expressing GLUT2, mainly make use of GLUT1 and GLUT3 isoforms
Beta_cell
Short-chain carbohydrates poorly absorbed in the small intestine
intestine (e.g., GLUT5), and to the basal membrane, contacting the blood (e.g., GLUT2). Improper absorption of these FODMAPs in the small intestine leaves them
FODMAP
Chemical compound
because it preferentially accumulates in beta cells through uptake via the GLUT2 glucose transporter. Studies suggest alloxan does not cause diabetes in
Alloxan
Family of monosaccharide transport proteins
virtually every cell type. Cotransport Cotransporter GLUT1 deficiency syndrome GLUT2 deficiency syndrome Maier A, Völker B, Boles E, Fuhrmann GF (December 2002)
Glucose_transporter
Form of diabetes mellitus
In both cases, it is a cytotoxic analog of glucose that passes through GLUT2 transport and accumulates in β-cells, causing their destruction. The chemically
Type_1_diabetes
Type of intestinal cell
enterocyte via the basolateral membrane (into the blood capillary) using GLUT2. Galactose uses the same transport system. Fructose, on the other hand,
Enterocyte
Physiological process in the kidney
2% Reabsorption (mmol/day) Concentration Apical transport proteins SGLT2 SGLT1 Basolateral transport proteins GLUT2 GLUT1 Other reabsorption features
Renal_glucose_reabsorption
Glucose being transported from the blood into cells
bloodstream, ensuring a steady supply to tissues that rely on glucose. GLUT2 in contrast has a high Km value (15-20mM) and therefore a low affinity for
Glucose_uptake
Breakdown of glycogen
which is not present in myocytes, and the free glucose exits the cell via GLUT2 facilitated diffusion channels in the hepatocyte cell membrane. Glycogenolysis
Glycogenolysis
Chemical compound
of glucose and fructose through the function of glucose transporter 2 (GLUT2) in sugar absorption. In addition, daily injections of myricetin into rats
Myricetin
Chemical compound
the endoplasmic reticulum via GLUT7 and released into the bloodstream via GLUT2 for uptake by other cells. Muscle cells lack this enzyme, so myofibers use
Glucose_6-phosphate
Protein-coding gene in humans
and diabetes has been reported, including the involvement in GLUT1 and GLUT2 transporter expression in pancreatic β-cells and angiotensin-converting
HNF1A
Medical condition
phosphorylase-b kinase deficiency. GSD type XI (GSD 11): Fanconi-Bickel syndrome (GLUT2 deficiency), hepatorenal glycogenosis with renal Fanconi syndrome, no longer
Glycogen_storage_disease
Chemical compound
do not take up 2-NBDG. In mammalian cells, one transporter for 2-NBDG is GLUT2. In T cells, 2-NBDG was transported by another, unidentified transporter
2-NBDG
Protein-coding gene in the species Homo sapiens
fructose uptake are not explained by alterations in the abundance of GLUT5 or GLUT2". J. Nutr. Biochem. 15 (10): 630–7. doi:10.1016/j.jnutbio.2004.06.003. PMID 15542355
GLUT5
Protein involved in the pancreas and duodenum differentiation
Thompson N, Nicod P, Bonny C (1997). "Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor". Mol. Endocrinol. 10 (11):
PDX1
Medical condition
among others, the genes for insulin, the principal glucose transporter (GLUT2), and several proteins involved in glucose and mitochondrial metabolism
MODY_1
Medical condition
blood-brain barrier. Fanconi-Bickel syndrome (GLUT2 deficiency, formally known as GSD-XI) is a deficiency of GLUT2, which is needed for the transport of glucose
Inborn errors of carbohydrate metabolism
Inborn_errors_of_carbohydrate_metabolism
Protein-coding gene in the species Homo sapiens
Rab11 recycling endosomes, where it plays an important role in GLP1R and GLUT2 recycling. Overexpression of VAMP8 in β-cells results in decreased insulin
Vesicle-associated membrane protein 8
Vesicle-associated_membrane_protein_8
Class of membrane transport proteins
GLUT2. GLUT1 is found in various tissues like the red blood cells, brain, and blood-brain barrier and is responsible for basal glucose uptake. GLUT2 is
Uniporter
Protein
capacity than GLUT1 or GLUT4, as well as a higher glucose affinity than GLUT1, GLUT2 or GLUT4. This is significant as glucose levels surrounding the neurons
GLUT3
American cell biologist, born 1941
sequence mRNAs encoding a mammalian glucose transport protein, GLUT1, and then GLUT2 and the insulin- responsive GLUT4, an anion exchange protein, a transporter
Harvey_Lodish
Type of membrane transport proteins
diabetes mellitus, defect in glucose transport across the blood-brain barrier GLUT2, SLC2A2 low CNS glucose causing seizures, Fanconi-Bickel syndrome, Glycogen
Cotransporter
Medical condition
continues to play a role in the regulation and expression of genes for insulin, GLUT2, glucokinase, and somatostatin. MODY 4 is so rare that only a single family
MODY_4
Glucosephosphate isomerase deficiency Glucosidase acid-1,4-alpha deficiency Glut2 deficiency Glutamate decarboxylase deficiency Glutamate-aspartate transport
List_of_diseases_(G)
Protein-coding gene in the species Homo sapiens
chains. Furthermore, it is involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation with controlling cell-surface expression of SLC2A2 in pancreatic
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
Alpha-1,3-mannosyl-glycoprotein_4-beta-N-acetylglucosaminyltransferase_A
Protein-coding gene in the species Homo sapiens
nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter". Diabetes. 51 (5): 1409–1418. doi:10.2337/diabetes.51.5.1409
EP300
Protein-coding gene in the species Homo sapiens
also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression
MAPK8IP1
Protein family
Matsubara Y, Narisawa K, Iinuma K (November 2000). "Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome". Pediatric Research. 48 (5):
Major_facilitator_superfamily
Canadian medical researcher
revealed how acute and chronic hyperglycemia affects the expression of GLUT2 gene and protein in diabetes. Vranic pioneered new concepts of the role
Mladen_Vranic
GLUT2
GLUT2
GLUT2
GLUT2
Girl/Female
Indian, Telugu
Good Knowledge; Knows Everything; Cleverer
Girl/Female
Muslim
Happy. Lucky.
Boy/Male
Hindu, Indian, Marathi
Ecstasy; Merriment
Girl/Female
Australian, Christian, Irish
Leaping Water
Boy/Male
Indian, Sanskrit
Immovable; Steady
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Name of a sage, Clever, Receptacle of glory
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French, Hebrew, Hindu, Indian, Tamil, Telugu
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Girl/Female
Bengali, Gujarati, Hindu, Indian, Kannada, Telugu
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Boy/Male
Hindu
Vijayram
Girl/Female
Australian, British, Christian, English, French, Greek, Hebrew
Twin
GLUT2
GLUT2
GLUT2
GLUT2
GLUT2