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FOSTEMSAVIR

  • Fostemsavir
  • Antiretroviral medication used to treat HIV

    Fostemsavir, sold under the brand name Rukobia, is an antiretroviral medication for adults living with HIV/AIDS who have tried multiple HIV medications

    Fostemsavir

    Fostemsavir

    Fostemsavir

  • Drug of last resort
  • Type of drug

    those caused by Pseudomonas; carries risk of kidney and nerve damage. Fostemsavir (an HIV attachment inhibitor) and lenacapavir (an HIV capsid inhibitor)

    Drug of last resort

    Drug_of_last_resort

  • Bristol Myers Squibb
  • American pharmaceutical company

    (BMS-582664) – development terminated Elotuzumab (BMS-901608) – phase III Fostemsavir (BMS-663068) – approved in the United States in July 2020 Lirilumab (BMS-986015)

    Bristol Myers Squibb

    Bristol Myers Squibb

    Bristol_Myers_Squibb

  • ViiV Healthcare
  • Pharmaceutical company

    delavirdine (brand name Rescriptor, no longer available) Attachment inhibitors fostemsavir (brand name Rukobia) Integrase strand transfer inhibitors (INSTIs): dolutegravir

    ViiV Healthcare

    ViiV_Healthcare

  • Entry inhibitor
  • Antiviral drug

    and prevents the viral transmission that occurs via cell-cell fusion. Fostemsavir, an attachment inhibitor that interferes with the interaction of CD4

    Entry inhibitor

    Entry_inhibitor

  • Envelope glycoprotein GP120
  • Glycoprotein exposed on the surface of the HIV virus

    extremely difficult due to its high degree of variability and shielding. Fostemsavir (BMS-663068) is a methyl phosphate prodrug of the small molecule inhibitor

    Envelope glycoprotein GP120

    Envelope glycoprotein GP120

    Envelope_glycoprotein_GP120

  • Dapivirine Ring
  • Antiretroviral vaginal ring

    Cenicriviroc†, Leronlimab†) CD4 (Ibalizumab (IBA), Semzuvolimab§) gp120 (Fostemsavir (FTR)) Integrase inhibitors (Integrase strand transfer inhibitors (INSTI))

    Dapivirine Ring

    Dapivirine Ring

    Dapivirine_Ring

  • ATC code J05
  • Pharmaceutical drug classification

    marboxil J05AX26 Amenamevir J05AX27 Favipiravir J05AX28 Bulevirtide J05AX29 Fostemsavir J05AX31 Lenacapavir J05AX32 Riamilovir J05AX33 Labuvirtide "ATC (Anatomical

    ATC code J05

    ATC_code_J05

  • List of drugs granted breakthrough therapy designation
  • carcinoma Inebilizumab Viela Bio neuromyelitis optica spectrum disorder Fostemsavir Viiv Healthcare multidrug-resistant HIV-1 Tafasitamab MorphoSys relapsed

    List of drugs granted breakthrough therapy designation

    List_of_drugs_granted_breakthrough_therapy_designation

  • Cabotegravir/rilpivirine
  • Co-packaged antiretroviral medication

    Cenicriviroc†, Leronlimab†) CD4 (Ibalizumab (IBA), Semzuvolimab§) gp120 (Fostemsavir (FTR)) Integrase inhibitors (Integrase strand transfer inhibitors (INSTI))

    Cabotegravir/rilpivirine

    Cabotegravir/rilpivirine

    Cabotegravir/rilpivirine

  • Semzuvolimab
  • Experimental antibody for HIV treatment

    Cenicriviroc†, Leronlimab†) CD4 (Ibalizumab (IBA), Semzuvolimab§) gp120 (Fostemsavir (FTR)) Integrase inhibitors (Integrase strand transfer inhibitors (INSTI))

    Semzuvolimab

    Semzuvolimab

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