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Search references for EML4. Phrases containing EML4
See searches and references containing EML4!EML4
Protein-coding gene in the species Homo sapiens
microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene. This protein is involved in cancers when spliced with the anaplastic
EML4
Medical condition
most frequently, the echinoderm microtubule-associated protein-like 4 (EML4) gene is fused to the anaplastic lymphoma kinase (ALK) gene. Less frequently
ALK_positive_lung_cancer
Protein found in humans
5' fusion partners, such as TFG, ATIC, CLTC1, TPM4, MSN, ALO17, MYH9. The EML4-ALK fusion gene is responsible for approximately 3–5% of non-small-cell lung
Anaplastic_lymphoma_kinase
Class of pharmaceutical drugs
on tumours with variations of anaplastic lymphoma kinase (ALK) such as an EML4-ALK translocation. They fall under the category of tyrosine kinase inhibitors
ALK_inhibitor
Any type of epithelial lung cancer other than small-cell lung carcinoma
States in January 2026. Up to 7% of non-small-cell lung cancer patients have EML4-ALK translocations or mutations in the ROS1 gene; these patients may benefit
Non-small-cell_lung_cancer
Medication
Cobimetinib Avutometinib (+defactinib) Mirdametinib Selumetinib Trametinib EML4-ALK Crizotinib Entrectinib Lorlatinib Bruton's (BTK) Acalabrutinib Ibrutinib
Elranatamab
Short protein motif that forms a solenoid domain
DNCI1, DTL, DYNC1I1, DYNC1I2, EDC4, EED, EIF3S2, ELP2, EML1, EML2, EML3, EML4, EML4-ALK, EML5, ERCC8, FBXW10, FBXW11, FBXW2, FBXW4, FBXW5, FBXW7, FBXW8, FBXW9
WD40_repeat
City in Chūgoku, Japan
Mano, (1959 – ) Japanese doctor. Discovery of the lung cancer-causing gene EML4-ALK. "Takahashi city official statistics" (in Japanese). Japan. 気象庁 / 平年値（年・月ごとの値）
Takahashi,_Okayama
Substance or process that is indicative of the presence of cancer in the body
PMID 18768784. Li Y, Ye X, Liu J, Zha J, Pei L (January 2011). "Evaluation of EML4-ALK fusion proteins in non-small cell lung cancer using small molecule inhibitors"
Cancer_biomarker
ALK inhibitor for treatment of non-small-cell lung cancer
carcinoma have a chromosomal rearrangement that generates a fusion gene between EML4 ('echinoderm microtubule-associated protein-like 4') and ALK ('anaplastic
Crizotinib
Public school in Japan
Mano, (1959 – ) Japanese doctor. Discovery of the lung cancer-causing gene EML4-ALK. Arao Itano, (1887 – 1972) Honorary Doctor of the Imperial University
Okayama Prefectural Takahashi High School
Okayama_Prefectural_Takahashi_High_School
lung tumor typing system. Adenocarcinomas: EGFR Mutations K-ras Mutations EML4-ALK Fusions and Mutations Signet ring cell Acinar Papillary Micropapillary
HOHMS
Lung cancer of glandular origin or characteristics
adenocarcinomas of the lung. In ALK rearrangements, the most common partner gene is EML4. The respiratory tract can be divided into two main components: the conducting
Adenocarcinoma_of_the_lung
Monoclonal antibody
Cobimetinib Avutometinib (+defactinib) Mirdametinib Selumetinib Trametinib EML4-ALK Crizotinib Entrectinib Lorlatinib Bruton's (BTK) Acalabrutinib Ibrutinib
Mosunetuzumab
Medical intervention
cell lung cancer that is characterized by the EML4-ALK fusion oncogene, and is approved by the FDA. EML4-ALK is found in some relatively young, never or
Treatment_of_lung_cancer
Medical intervention
source?] Inhibitor of EML4-ALK crizotinib shows benefit in a subset of non-small cell lung cancer that is characterized by the EML4-ALK fusion oncogene
Targeted therapy of lung cancer
Targeted_therapy_of_lung_cancer
fusion of ALK tyrosine kinase domain with the promoter and 5’ region of EML4 in lung cancer. ALK-positive tumors are a clinically relevant subgroup as
Chromogenic in situ hybridization
Chromogenic_in_situ_hybridization
these proteins, Rikova performed RT-PCR and discovered ALK to be fused to EML4, a microtubule protein, triggering perpetual activation of the ALK tyrosine
Klarisa_Rikova
Medical condition
activity. Other genes that fuse with AKT found in IMT include: TFG, DCTN1, EML4, TPM3, TPM4, ATIC RANBP2 (most if not all RAMB2-ALK chimeric genes occur
Inflammatory myofibroblastic tumour
Inflammatory_myofibroblastic_tumour
HGNC:3330; O00423 4929 EML2 HGNC:18035; O95834 4930 EML3 HGNC:26666; Q32P44 4931 EML4 HGNC:1316; Q9HC35 4932 EML5 HGNC:18197; Q05BV3 4933 EML6 HGNC:35412; Q6ZMW3
List of human protein-coding genes 3
List_of_human_protein-coding_genes_3
EML4
EML4
EML4
EML4
Boy/Male
Hindu
A God, Deity
Female
English
Variant spelling of English Millicent, MELICENT means "strong worker."
Boy/Male
Hindu
Surname or Lastname
English
English : variant of Dowland.
Boy/Male
Tamil
Institution
Boy/Male
Muslim/Islamic
Name of an authority of Hadith
Girl/Female
Hindu
Goddess Durga
Girl/Female
Muslim
(Daughter of the prophet (SAW))
Boy/Male
Tamil
Snehit | ஸà¯à®¨à¯‡à®¹à®¿à®¤Â
A friend, Be friendly
Surname or Lastname
English
English : habitational name from any of various places named in Old English from bēan ‘beans’ (collective singular) + feld ‘field’, ‘open land’, as for example Benville in Dorset.Irish : variant of the Norman family name Banville (see Bonfield), associated primarily with county Wexford.
EML4
EML4
EML4
EML4
EML4