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Two drug combination for the treatment of hepatitis C
Elbasvir/grazoprevir, sold under the brand name Zepatier, is a fixed-dose combination for the treatment of hepatitis C, containing elbasvir (an inhibitor
Elbasvir/grazoprevir
Chemical compound
Elbasvir is a drug approved by the FDA in January 2016 for the treatment of hepatitis C. It was developed by Merck and completed Phase III trials, used
Elbasvir
Group of isomeric bicyclic heterocyclic chemical compounds
a number of pharmaceutical drugs including, for example, apararenone, elbasvir, and etifoxine. Polybenzoxazines, also called benzoxazine resins, are a
Benzoxazine
Drug approved for the treatment of hepatitis C
trials, used in combination with the NS5A replication complex inhibitor elbasvir under the trade name Zepatier, either with or without ribavirin. Grazoprevir
Grazoprevir
Biochemist
led the development of antivirals for Hepatitis C Virus (HCV) including Elbasvir and Grazoprevir. She currently serves as Vice President for Infectious
Daria_Hazuda
Drug discovery
with ABT-530, and grazoprevir in combination with elbasvir, of which velpatasvir, ABT-530 and elbasvir are NS5A inhibitors. NS5A Hepatitis C Protease inhibitor
Discovery and development of NS5A inhibitors
Discovery_and_development_of_NS5A_inhibitors
Chemical compound
Vedroprevir§ Voxilaprevir NS5A inhibitors (–asvir) Coblopasvir Daclatasvir# Elbasvir Ledipasvir Netanasvir Odalasvir† Ombitasvir Pibrentasvir Ravidasvir† Ruzasvir†
Simeprevir
Pharmaceutical drug classification
Asunaprevir J05AP07 Daclatasvir J05AP08 Sofosbuvir J05AP09 Dasabuvir J05AP10 Elbasvir J05AP11 Grazoprevir J05AP12 Coblopasvir J05AP13 Ravidasvir J05AP14 Narlaprevir
ATC_code_J05
individuals with HIV/HCV co-infection as those with HCV mono-infection: Elbasvir/Grazoprevir The Phase 3, open-label, single-arm C-EDGE CO-INFECTION Study
Hepatitis C and HIV coinfection
Hepatitis_C_and_HIV_coinfection
Medication used to treat a viral infection
velpatasvir) Vosevi (sofosbuvir, velpatasvir, and voxilaprevir) Zepatier (elbasvir and grazoprevir) Mavyret (glecaprevir and pibrentasvir) Despite its historical
Antiviral_drug
Drug Manufacturer Indication Elbasvir/grazoprevir Merck Sharp & Dohme Hepatitis C Palbociclib Pfizer HR-positive, HER2-negative breast cancer Crizotinib
List of drugs granted breakthrough therapy designation
List_of_drugs_granted_breakthrough_therapy_designation
Class of pharmaceutical drugs
approved. Four other NS5A inhibitors of this class—daclatasvir, ombitasvir, elbasvir and velpatasvir—have been subsequently approved. All direct-acting antivirals
NS5B_inhibitor
Hepatitis C virus protein
ritonavir, co-packaged with dasabuvir Daclatasvir, approved on July 24, 2015 Elbasvir, approved on January 28, 2016 in a FDC with grazoprevir Velpatasvir, approved
Hepatitis C virus nonstructural protein 5A
Hepatitis_C_virus_nonstructural_protein_5A
ELBASVIR
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Boy/Male
Assamese, Hindu, Indian, Kannada, Sanskrit, Telugu
Spring
Girl/Female
Hindu, Indian, Marathi
Winning the Seven Elements
Boy/Male
Tamil
Beautiful
Girl/Female
Latin
Majestic.
Boy/Male
Australian, British, English, French
Form of Forrester; Of the Forest; Occupational Name; Woodsman; Place Name
Male
Egyptian
, a XIIIth dynasty monarch.
Girl/Female
Arabic, Muslim
Clean
Boy/Male
Tamil
Hridhaan | ஹà¯à®°à¯€à®¤à®¾à®¨
(Celebrity Name: Rhrithik Roshan)
Surname or Lastname
English
English : from the Middle English personal name Kit, a pet form of Christopher.English : metonymic occupational name for a maker or seller of wooden tubs and pails made of staves held together by a hoop, Middle English kitte.English : perhaps from Middle High German kīt ‘offshoot’, ‘sprout’, applied as a nickname for a junior member of a family; alternatively it may be from the old personal name Giddo.
Boy/Male
Australian, Celtic
Blond
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