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DERMATOFIBROSARCOMA PROTUBERANS

  • Dermatofibrosarcoma protuberans
  • Medical condition

    Dermatofibrosarcoma protuberans (DFSP) is a rare locally aggressive malignant cutaneous soft-tissue sarcoma. DFSP develops in the connective tissue cells

    Dermatofibrosarcoma protuberans

    Dermatofibrosarcoma protuberans

    Dermatofibrosarcoma_protuberans

  • Imatinib
  • Chemical compound

    malignancies. In 2006 the FDA expanded approved use to include dermatofibrosarcoma protuberans (DFSP), myelodysplastic/myeloproliferative diseases (MDS/MPD)

    Imatinib

    Imatinib

    Imatinib

  • Dermatofibrosarcoma protuberans, fibrosarcomatous
  • Medical condition

    Dermatofibrosarcoma protuberans, fibrosarcomatous (DFSP-FS), also termed fibrosarcomatous dermatofibrosarcoma protuberans, is a rare type of tumor located

    Dermatofibrosarcoma protuberans, fibrosarcomatous

    Dermatofibrosarcoma_protuberans,_fibrosarcomatous

  • Sarcoma
  • Cancer originating in connective tissue

    liposarcoma Atypical lipomatous tumor Dermatofibrosarcoma protuberans (includes pigmented varieties) Dermatofibrosarcoma protuberans, fibrosarcomatous Giant cell

    Sarcoma

    Sarcoma

    Sarcoma

  • Mohs surgery
  • Surgery used to treat skin cancers

    (cure rate 52%). Other indications for Mohs surgery include dermatofibrosarcoma protuberans, keratoacanthoma, spindle cell tumors, sebaceous carcinomas

    Mohs surgery

    Mohs surgery

    Mohs_surgery

  • Soft-tissue sarcoma
  • Malignant tumor that develops in soft tissue

    Fibrous tissue Undifferentiated pleomorphic sarcoma (UPS) Legs Dermatofibrosarcoma protuberans Trunk Synovial sarcoma Legs Fat Liposarcoma Arms, legs, trunk

    Soft-tissue sarcoma

    Soft-tissue sarcoma

    Soft-tissue_sarcoma

  • Down syndrome
  • Genetic disorder

    sarcoma t(11 FLI1; 22 EWS) Synovial sarcoma t(x SYT;18 SSX) Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid liposarcoma t(12 DDIT3; 16 FUS)

    Down syndrome

    Down syndrome

    Down_syndrome

  • Trent Williams
  • American football player (born 1988)

    done to remove a growth from his head that was diagnosed as dermatofibrosarcoma protuberans (DFSP), a type of cancer. The growth was first noticed in 2013

    Trent Williams

    Trent Williams

    Trent_Williams

  • Dermatofibroma
  • Medical condition

    histologically, from rare malignant fibrohistocytic tumours like dermatofibrosarcoma protuberans. Dermatofibromas typically have a positive buttonhole sign

    Dermatofibroma

    Dermatofibroma

    Dermatofibroma

  • Magic Dirt
  • Australian rock band

    their second extended play. Turner died in August 2009 of dermatofibrosarcoma protuberans (a soft tissue cancer). From 2010 to November 2018, the band

    Magic Dirt

    Magic Dirt

    Magic_Dirt

  • Turner syndrome
  • X chromosome monosomy

    sarcoma t(11 FLI1; 22 EWS) Synovial sarcoma t(x SYT;18 SSX) Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid liposarcoma t(12 DDIT3; 16 FUS)

    Turner syndrome

    Turner syndrome

    Turner_syndrome

  • Birth defect
  • Condition present at birth regardless of cause

    sarcoma t(11 FLI1; 22 EWS) Synovial sarcoma t(x SYT;18 SSX) Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid liposarcoma t(12 DDIT3; 16 FUS)

    Birth defect

    Birth defect

    Birth_defect

  • Skin sarcoma
  • Human disease

    sarcoma that can manifest on the skin include: Angiosarcoma Dermatofibrosarcoma protuberans Fibroxanthoma Kaposi's sarcoma Leiomyosarcoma Pleomorphic dermal

    Skin sarcoma

    Skin sarcoma

    Skin_sarcoma

  • Cartwheel pattern
  • Fibrous histiocytoma (dermatofibroma) Soft tissue perineurioma Dermatofibrosarcoma protuberans Stone, John H.; Zen, Yoh; Deshpande, Vikram (2012). "IgG4-Related

    Cartwheel pattern

    Cartwheel pattern

    Cartwheel_pattern

  • Basal-cell carcinoma
  • Most common type of skin cancer

    squamous-cell carcinoma, melanoma, atypical fibroxanthoma, dermatofibrosarcoma protuberans, Merkel cell carcinoma, microcystic adnexal carcinoma, and

    Basal-cell carcinoma

    Basal-cell carcinoma

    Basal-cell_carcinoma

  • Fibroblastic and myofibroblastic tumors
  • Tumors originating from fibroblast or muscle cell precursors

    fibroblastoma Dermatofibrosarcoma protuberans Fibrous hamartoma of infancy Intermediate (rarely metastasizing) FMTs Dermatofibrosarcoma protuberans, fibrosarcomatous

    Fibroblastic and myofibroblastic tumors

    Fibroblastic_and_myofibroblastic_tumors

  • Miscarriage
  • Natural premature termination of pregnancy

    sarcoma t(11 FLI1; 22 EWS) Synovial sarcoma t(x SYT;18 SSX) Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid liposarcoma t(12 DDIT3; 16 FUS)

    Miscarriage

    Miscarriage

    Miscarriage

  • Giant-cell fibroblastoma
  • Medical condition

    cells. GCF tumors are closely related to dermatofibrosarcoma protuberans (DFSP) and dermatofibrosarcoma protuberans, fibrosarcomatous (DFSP-FS) (also termed

    Giant-cell fibroblastoma

    Giant-cell_fibroblastoma

  • List of cancer types
  • Keratoacanthoma Sarcomas of primary cutaneous origin (e.g. dermatofibrosarcoma protuberans) Lymphomas of primary cutaneous origin (e.g. mycosis fungoides)

    List of cancer types

    List of cancer types

    List_of_cancer_types

  • Fryns–Aftimos syndrome
  • Medical condition

    sarcoma t(11 FLI1; 22 EWS) Synovial sarcoma t(x SYT;18 SSX) Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid liposarcoma t(12 DDIT3; 16 FUS)

    Fryns–Aftimos syndrome

    Fryns–Aftimos syndrome

    Fryns–Aftimos_syndrome

  • Fibrosarcoma
  • Malignant tumors composed of fibrous tissue

    within nine months of surgery. Benign fibrous histiocytoma Dermatofibrosarcoma protuberans Fibrous connective tissue Fibroma Malignant fibrous histiocytoma

    Fibrosarcoma

    Fibrosarcoma

    Fibrosarcoma

  • Low-grade fibromyxoid sarcoma
  • Medical condition

    peripheral nerve sheath tumora, low-grade myxofibrosarcoma, myxoid dermatofibrosarcoma protuberans, or in rare cases, extraskeletal myxoid chondrosarcoma, synovial

    Low-grade fibromyxoid sarcoma

    Low-grade fibromyxoid sarcoma

    Low-grade_fibromyxoid_sarcoma

  • Journal of Cutaneous Pathology
  • Academic journal

    malignancies, including cutaneous squamous cell carcinoma and dermatofibrosarcoma protuberans, and is also a publication venue for common skin lesions such

    Journal of Cutaneous Pathology

    Journal_of_Cutaneous_Pathology

  • Tumor marker
  • Proxy markers for certain cancers

    tumor, pleomorphic lipoma, gastrointestinal stromal tumor, dermatofibrosarcoma protuberans CD99 Ewing sarcoma, primitive neuroectodermal tumor,

    Tumor marker

    Tumor_marker

  • Kat Cressida
  • American actress

    public speaker. She shared her story about being diagnosed with Dermatofibrosarcoma protuberans in 2012 and the subsequent two years of life-threatening surgeries

    Kat Cressida

    Kat Cressida

    Kat_Cressida

  • Chromosomal translocation
  • Phenomenon that results in unusual rearrangement of an chromosomes

    Abbreviations: ALL – Acute lymphoblastic leukemia AML – Acute myeloid leukemia CML – Chronic myelogenous leukemia DFSP – Dermatofibrosarcoma protuberans

    Chromosomal translocation

    Chromosomal translocation

    Chromosomal_translocation

  • Skin cancer
  • Medical condition involving uncontrolled growth of skin cells

    keratoacanthoma, and skin sarcomas, such as angiosarcoma, dermatofibrosarcoma protuberans, Kaposi's sarcoma, leiomyosarcoma. BCC and SCC often carry

    Skin cancer

    Skin cancer

    Skin_cancer

  • Angiofibroma
  • Class of benign skin and mucous membrane lesions

    fibromas: distinctive CD34-positive lesions that may mimic dermatofibrosarcoma protuberans". Journal of Cutaneous Pathology. 32 (6): 413–8. doi:10.1111/j

    Angiofibroma

    Angiofibroma

    Angiofibroma

  • Etanercept
  • Biopharmaceutical for autoimmune diseases

    Soyer HP, Scharnagl E (October 1991). "Surgical treatment of dermatofibrosarcoma protuberans. A retrospective study of 20 cases with review of literature"

    Etanercept

    Etanercept

  • Lipofibromatosis
  • Medical condition

    tumor (lipofibromatosis-like neural tumor) mimicking pigmented dermatofibrosarcoma protuberans". Journal of Cutaneous Pathology. 48 (2): 290–294. doi:10.1111/cup

    Lipofibromatosis

    Lipofibromatosis

  • T(11:14)
  • Chromosomal translocation

    Abbreviations: ALL – Acute lymphoblastic leukemia AML – Acute myeloid leukemia CML – Chronic myelogenous leukemia DFSP – Dermatofibrosarcoma protuberans

    T(11:14)

    T(11:14)

    T(11:14)

  • Vulvar tumors
  • Neoplasm of the vulva

    epithelioid sarcoma Alveolar soft part sarcoma Liposarcoma Dermatofibrosarcoma protuberans Deep angiomyxoma Superficial angiomyxoma Angiomyofibroblastoma

    Vulvar tumors

    Vulvar_tumors

  • International Classification of Diseases for Oncology
  • Diagnosis classification

    lenticulare M8832/3 Dermatofibrosarcoma, NOS (C44._) Dermatofibrosarcoma protuberans, NOS M8833/3 Pigmented dermatofibrosarcoma protuberans Bednar tumor M8834/1

    International Classification of Diseases for Oncology

    International_Classification_of_Diseases_for_Oncology

  • CD34
  • Protein found in humans

    sarcoma, preB-ALL (positive in 75%), AML (40%), AML-M7 (most), dermatofibrosarcoma protuberans, gastrointestinal stromal tumors, giant cell fibroblastoma

    CD34

    CD34

    CD34

  • Lipofibromatosis-like neural tumor
  • Medical condition

    fibromatosis, congenital fibrosarcoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans (broad expression of the CD34 and/or S100 marker protein strongly

    Lipofibromatosis-like neural tumor

    Lipofibromatosis-like_neural_tumor

  • List of skin conditions
  • histiocytoma, nodular subepidermal fibrosis, sclerosing hemangioma) Dermatofibrosarcoma protuberans Desmoid tumor Diffuse cutaneous mastocytosis Diffuse infantile

    List of skin conditions

    List of skin conditions

    List_of_skin_conditions

  • Miscarriage and mental disorders
  • Medical condition

    sarcoma t(11 FLI1; 22 EWS) Synovial sarcoma t(x SYT;18 SSX) Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid liposarcoma t(12 DDIT3; 16 FUS)

    Miscarriage and mental disorders

    Miscarriage_and_mental_disorders

  • Birt–Hogg–Dubé syndrome
  • Rare autosomal dominant cancer syndrome

    colorectal cancer, sarcoma of the leg, lung cancer, melanoma, dermatofibrosarcoma protuberans, basal cell carcinoma, cutaneous leiomyosarcoma, and squamous

    Birt–Hogg–Dubé syndrome

    Birt–Hogg–Dubé syndrome

    Birt–Hogg–Dubé_syndrome

  • GRIA2
  • Mammalian protein found in Homo sapiens

    Among other CD34-positive tumours, GRIA2 is also expressed in dermatofibrosarcoma protuberans (DFSP); however, clinical and histologic features aid in their

    GRIA2

    GRIA2

    GRIA2

  • Koenen's tumor
  • Medical condition

    fibromas: distinctive CD34-positive lesions that may mimic dermatofibrosarcoma protuberans". Journal of Cutaneous Pathology. 32 (6): 413–8. doi:10.1111/j

    Koenen's tumor

    Koenen's tumor

    Koenen's_tumor

  • Targeted therapy
  • Type of therapy

    trials indicate that imatinib may be effective in treatment of dermatofibrosarcoma protuberans. Gefitinib (Iressa, also known as ZD1839), targets the epidermal

    Targeted therapy

    Targeted therapy

    Targeted_therapy

  • Dean Turner (musician)
  • Australian musician and record producer

    battled an extremely rare form of soft tissue cancer called dermatofibrosarcoma protuberans or (DFSP)... This cancer became life threatening after it began

    Dean Turner (musician)

    Dean Turner (musician)

    Dean_Turner_(musician)

  • Polysomy
  • Abnormal multiples of one or more chromosomes

    sarcoma t(11 FLI1; 22 EWS) Synovial sarcoma t(x SYT;18 SSX) Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid liposarcoma t(12 DDIT3; 16 FUS)

    Polysomy

    Polysomy

    Polysomy

  • Index of oncology articles
  • deoxyribonucleic acid – DepoFoam-encapsulated cytarabine – depsipeptide – dermatofibrosarcoma protuberans – dermatologist – dermis – DES – deslorelin – desmoid tumor

    Index of oncology articles

    Index_of_oncology_articles

  • List of acronyms: D
  • (ii) Discrete Field Model see Superluminal motion DFSP – (i) Dermatofibrosarcoma protuberans DfT– (i) Department for Transport DFTBA – (i) Don't Forget

    List of acronyms: D

    List_of_acronyms:_D

  • List of histologic stains that aid in diagnosis of cutaneous conditions
  • Desmoplastic trichoepithelioma Spindle cell lipoma Angiosarcoma Dermatofibrosarcoma protuberans Atypical fibroxanthoma Pleomorphic fibroma Intravascular large

    List of histologic stains that aid in diagnosis of cutaneous conditions

    List_of_histologic_stains_that_aid_in_diagnosis_of_cutaneous_conditions

  • Nodular fasciitis
  • Medical condition

    behavior. NF may resemble and therefore be misdiagnosed as dermatofibrosarcoma protuberans, fibrosarcoma, malignant fibrous histiocytoma, spindle-cell

    Nodular fasciitis

    Nodular fasciitis

    Nodular_fasciitis

  • PDGFB
  • Protein-coding gene in the species Homo sapiens

    tumors of the skin: giant cell fibroblastoma, dermatofibrosarcoma protuberans, and dermatofibrosarcoma protuberans, sarcomatous. Two splice variants have been

    PDGFB

    PDGFB

    PDGFB

  • Crenolanib
  • Chemical compound

    COL1A1 gene locus has been identified to be responsible for dermatofibrosarcoma protuberans (DFSP). In cancer cells, PDGFR promotes tumor development and

    Crenolanib

    Crenolanib

    Crenolanib

  • Adalita (album)
  • 2011 studio album by Adalita

    was completed in July 2009. Turner died on 21 August 2009 of dermatofibrosarcoma protuberans, a rare form of tissue cancer, and work on the album ceased

    Adalita (album)

    Adalita_(album)

  • Miscarriage risks
  • Factors that increase the chance of a miscarriage

    sarcoma t(11 FLI1; 22 EWS) Synovial sarcoma t(x SYT;18 SSX) Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) Myxoid liposarcoma t(12 DDIT3; 16 FUS)

    Miscarriage risks

    Miscarriage_risks

  • Apolipoprotein D
  • Protein-coding gene in the species Homo sapiens

    (August 2004). "Apo D in soft tissue tumors: a novel marker for dermatofibrosarcoma protuberans". The American Journal of Surgical Pathology. 28 (8): 1063–1069

    Apolipoprotein D

    Apolipoprotein D

    Apolipoprotein_D

  • Superficial acral fibromyxoma
  • Rare cutaneous condition

    sclerosing perineuroma, low grade fibromyxoid sarcoma, myxoid dermatofibrosarcoma protuberans, fibroma of tendon sheath, giant cell tumour, glomus tumour

    Superficial acral fibromyxoma

    Superficial_acral_fibromyxoma

  • Jonathan Lewis (oncologist)
  • American surgeon

    us Bowne WB, Antonescu CR, Leung DH, et al. (June 2000). "Dermatofibrosarcoma protuberans: A clinicopathologic analysis of patients treated and followed

    Jonathan Lewis (oncologist)

    Jonathan_Lewis_(oncologist)

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