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CYP4F3

CYP4F3

Protein-coding gene in the species Homo sapiens

omega-hydroxylase 2, is an enzyme that in humans is encoded by the CYP4F3 gene. CYP4F3 encodes two distinct enzymes, CYP4F3A and CYP4F3B, which originate

CYP4F3

Omega oxidation

Metabolic process in some animals

superfamily, members of the CYP4A and CYP4F subfamilies viz., CYP4A11, CYP4F2, CYP4F3, are considered the predominant cytochrome P450 enzymes responsible in most

Omega oxidation

Omega_oxidation

Omega hydroxy acid

Class of chemical compunds

(CYP450) microsome ω-hydroxylases such as CYP4A11, CYP4A22, CYP4F2, and CYP4F3 in humans, Cyp4a10 and Cyp4a12 in mice, and Cyp4a1, Cyp4a2, Cyp4a3, and

Omega hydroxy acid

Omega_hydroxy_acid

Cytochrome P450 (individual enzymes)

List of Cytochrome P450 enzymes

DHA to 22-hydroxy-DHA (i.e. 12-HDHA). CYP4F2, CYP4F3A, and CYP4F3B (see CYP4F3 for latter two CYPs) metabolize PUFAs to signaling molecules: they metabolize

Cytochrome P450 (individual enzymes)

Cytochrome_P450_(individual_enzymes)

Eicosanoid

Class of compounds

Cytochrome P450 microsome ω hydroxylases: CYP4A11, CYP4A22, CYP4F2, and CYP4F3 metabolize arachidonic acid primarily to 20-hydroxyeicosatetraenoic acid

Eicosanoid

CYP4A22

Protein-coding gene in the species Homo sapiens

chromosome 1p33. CYP4A22 was once considered, along with CYP4A11, CYP4F2, and CYP4F3, as active in metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic

CYP4A22

List of cytochrome P450 modulators

signaling modulators instead for eicosanoid-specific CYP450s, including: CYP4F3 (leukotriene-B4 ω-hydroxylase 2) CYP5A1 (thromboxane-A synthase) CYP8A1

List of cytochrome P450 modulators

List_of_cytochrome_P450_modulators

20-Hydroxyeicosatetraenoic acid

Chemical compound

stereoisomers. In humans, the CYP4 ω-hydroxylases include CYP4A11, CYP4F2, and CYP4F3 with the predominant 20-HETE-synthesizing enzymes being CYP4F2, which is

20-Hydroxyeicosatetraenoic acid

20-Hydroxyeicosatetraenoic_acid

CYP4F2

Human enzyme

makes the overall genomic organization of CYP4F2 very similar to that of CYP4F3. Gene polymorphisms (variants) in CYP4F2 affect liver mRNA levels and enzymatic

CYP4F2

5-Hydroxyeicosatetraenoic acid

Chemical compound

cell membranes in functionally important ways. A cytochrome P450, probably CYP4F3, to metabolize 5(S)-HETE to 5(S),20-dihydroxy-eicosatetraenoate (5,20-diHETE)

5-Hydroxyeicosatetraenoic acid

5-Hydroxyeicosatetraenoic_acid

List of human protein-coding genes 2

Q5TCH4 3888 CYP4B1 HGNC:2644; P13584 3889 CYP4F2 HGNC:2645; P78329 3890 CYP4F3 HGNC:2646; Q08477 3891 CYP4F8 HGNC:2648; P98187 3892 CYP4F11 HGNC:13265;

List of human protein-coding genes 2

List_of_human_protein-coding_genes_2

Epoxyeicosatrienoic acid

Class of fatty acids

(20-HETE). In humans, the major CYPs making 20-HETE are CYP4A11, CYP4F2, and CYP4F3. In animal models, 20-HETE raises blood pressure by contracting arteries

Epoxyeicosatrienoic acid

Epoxyeicosatrienoic_acid

CYP4A11

Protein-coding gene in the species Homo sapiens

modulating inflammation, potentially explaining the links between CYP4F2 and CYP4F3 variants and human Crohn's disease and Coeliac disease. GRCh38: Ensembl

CYP4A11

CYP2U1

Protein-coding gene in the species Homo sapiens

inflammatory responses and the reported associations of certain CYP4F2 and CYP4F3 single nucleotide variants with human Krohn's disease and Coeliac disease

CYP2U1

CYP4F8

Protein-coding gene in the species Homo sapiens

cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is located approximately 18 kb away. In addition to seminal vesicles, CYP4F8

CYP4F8