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CYCLOL

Cyclol

Structural model of a folded, globular protein

The cyclol hypothesis is the now discredited first structural model of a folded, globular protein, formulated in the 1930s. It was based on the cyclol reaction

Cyclol

Protein tertiary structure

Three dimensional shape of a protein

the prediction of protein structures. Wrinch demonstrated this with the Cyclol model, the first prediction of the structure of a globular protein. Under

Protein tertiary structure

Protein_tertiary_structure

Dorothy Maud Wrinch

Mathematician and biochemical theorist

using mathematical principles. She was a champion of the controversial 'cyclol' hypothesis for the structure of proteins. Dorothy Wrinch was born in Rosario

Dorothy Maud Wrinch

Dorothy_Maud_Wrinch

Charles Frank (physicist)

British physicist (1911–1998)

the idea of the Frank–Read source of dislocations. He also proposed the cyclol reaction in the mid-1930s, and made many other contributions to solid-state

Charles Frank (physicist)

Charles_Frank_(physicist)

Claviceps purpurea

Species of fungus

alkaloid ergotamine, a complex molecule consisting of a tripeptide-derived cyclol-lactam ring connected via amide linkage to a lysergic acid (ergoline) moiety

Claviceps purpurea

Claviceps_purpurea

Protein primary structure

Linear sequence of amino acids in a peptide or protein

second hypothesis, the cyclol hypothesis advanced by Dorothy Wrinch, proposed that the linear polypeptide underwent a chemical cyclol rearrangement C=O +

Protein primary structure

Protein_primary_structure

Peptide bond

Covalent bond between amino acids in a protein chain

bond is a thiol, hydroxyl or amine, the resulting molecule may be called a cyclol or, more specifically, a thiacyclol, an oxacyclol or an azacyclol, respectively

Peptide bond

Peptide_bond

Protein

Biomolecule consisting of chains of amino acid residues

linear polymers of amino acids rather than branched chains, colloids, or cyclols. He won the Nobel Prize for this achievement in 1958. Christian Anfinsen's

Protein

Ergot

Fungi of the genus Claviceps

alkaloid ergotamine, a complex molecule consisting of a tripeptide-derived cyclol-lactam ring connected via amide linkage to a lysergic acid (ergoline) moiety

Ergot

Bromocriptine

Dopamine agonist medication

risk than certain other drugs. Like all ergopeptides, bromocriptine is a cyclol; two peptide groups of its tripeptide moiety are crosslinked, forming the

Bromocriptine

Ergoline

Chemical compound

structure consists of proline and two other α-amino acids, linked in an unusual cyclol formation >N-C(OH)< with the carboxyl carbon of proline, at the juncture

Ergoline

History of molecular biology

stabilize her cyclol structures. Although supported by J. D. Bernal and others, this (correct) hypothesis was rejected along with the cyclol hypothesis,

History of molecular biology

History_of_molecular_biology

Carl Niemann

American biochemist

periodic sequences of amino acids, and for contributing to the downfall of the cyclol model of protein structure. Niemann was born in St. Louis and attended the

Carl Niemann

Carl_Niemann

List of biologists

Dorothy Wrinch (1894–1976), British mathematical biologist who promoted the cyclol structure for proteins V. C. Wynne-Edwards (1906–1997), Scottish zoologist

List of biologists

List_of_biologists

Rollin Hotchkiss

American biochemist

multiples of 288 amino acids. (This would also be a feature of Dorothy Wrinch's cyclol hypothesis of protein structure). In 1946, in the wake of the Avery–MacLeod–McCarty

Rollin Hotchkiss

Rollin_Hotchkiss

Tetrahedral carbonyl addition compound

Chemical reaction intermediate

groups that are poorly conjugated with the potential carbonyl group (e.g. cyclol) compounds with sulfur atoms bonded to the anomeric centre (e.g., S-acylated-1

Tetrahedral carbonyl addition compound

Tetrahedral_carbonyl_addition_compound

Gladys Anslow

American physicist

Anslow, Gladys A. (1953-11-01). "The Sites of the Amino-Acid Residues on a Cyclol Model of Insulin". The Journal of Chemical Physics. 21 (11): 2083–2084.

Gladys Anslow

Gladys_Anslow

List of biochemists

biologist at Johns Hopkins University and Smith College who argued for the cyclol structure for proteins. António Xavier (1943–2006). Portuguese biophysicist

List of biochemists

List_of_biochemists