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Severing of the axon of a neuron
In cellular neuroscience, an axotomy (from axo- 'axon' and -tomy 'surgery') is the cutting or otherwise severing of an axon. This type of denervation
Axotomy
Dissolution of a neuron's Nissl bodies
of a neuron. It is an induced response of the cell usually triggered by axotomy, ischemia, toxicity to the cell, cell exhaustion, virus infections, and
Chromatolysis
Diagnostic test for nerve function
peripheral nervous system Cranial and peripheral nerves Nerve block Vagotomy Axotomy Neurectomy Sympathetic nervous system Ganglionectomy Sympathectomy Endoscopic
Nerve_conduction_study
Medical condition
"Cyclosporin-A treatment attenuates delayed cytoskeletal alterations and secondary axotomy following mild axonal stretch injury". Developmental Neurobiology. 67 (14):
Diffuse_axonal_injury
Ganglionectomy · Sympathectomy/Endoscopic thoracic sympathectomy · Neurectomy Axotomy · Vagotomy Nerve biopsy Endocrine Hypophysectomy · Thyroidectomy · Parathyroidectomy ·
List_of_surgical_procedures
Cellular response to brain injury involving glial cells
Studies have shown that in cases of reversible neuronal injury, such as axotomy, neuron signals cause microglia to produce trophic factors, which promote
Gliosis
Damage to nervous tissue
neurotrophic factor receptor alpha in sciatic motor neurons following axotomy". Neuroscience. 91 (4): 1401–13. doi:10.1016/S0306-4522(98)00717-9. PMID 10391446
Nerve_injury
Family of biomolecules
neurons of embryonic rats and is suggested to aid development and to reduce axotomy. The ephrins are a family of neurotrophic factors that signal through eph
Neurotrophic_factors
Protein found in humans
culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF is synthesized as a 211 amino acid-long protein precursor, pro-GDNF
Glial cell line-derived neurotrophic factor
Glial_cell_line-derived_neurotrophic_factor
Pharmaceutical compound
neuroprotective activity as its biosynthesis is increased 2-10 fold upon axotomy in the peripheral nervous system as well as when seizure activity occurs
Galanin
Connections between dendrites
dendrodendritic synapses to compensate. In experiments where deafferentation or axotomy was performed in the lateral geniculate nucleus (LGN) of cats it was found
Dendrodendritic_synapse
Death of a cell mediated by intracellular program, often as part of development
et al. (July 1996). "Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2". The
Programmed_cell_death
German neuromorphologist (1932–2019)
the experimental model provided by the facial motor nucleus following axotomy Kreutzberg and his fellow workers discovered essential parameters of the
Georg_Kreutzberg
Biomedical engineer
(1 December 2004). "Neurosurgery: functional regeneration after laser axotomy". Nature. 432 (7019): 822. Bibcode:2004Natur.432..822Y. doi:10.1038/432822A
Adela_Ben-Yakar
Professor of neuroimmunology
protect neurons from secondary degeneration after central nervous system axotomy". Nature Medicine. 5 (1): 49–55. doi:10.1038/4734. PMID 9883839. S2CID 8877114
Michal_Schwartz
Protein-coding gene in the species Homo sapiens
1021/bi991614n. PMID 10545197. Liu XH, Collier RJ, Youle RJ (2002). "Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion
ANTXR1
Biological process of axonal degeneration
protects motor axons but not their cell bodies after avulsion and neonatal axotomy". The European Journal of Neuroscience. 24 (8): 2163–8. doi:10.1111/j.1460-9568
Wallerian_degeneration
Physiologist (1929–2023)
Muller, Kenneth J.; Adams, William B.; Nicholls, John G. (30 May 2002). "Axotomy of single fluorescent nerve fibers in developing mammalian spinal cord
John_Graham_Nicholls
Enzyme in mammals and humans
Angelov DN, Neiss WF, Gunkel A, Guntinas-Lichius O, Stennert E (1994). "Axotomy induces intranuclear immunolocalization of neuron-specific enolase in facial
Enolase_2
American neurobiologist
receptor expression and the survival of laryngeal motor neurons after axotomy, J. Neurosci. 16: 6625 - 6633. Robertson, J. and Kelley, D. 1996. Thyroid
Darcy_Kelley
American neurologist and neuroscientist
embryonic but not adult spinal sensory neurons, and is re-expressed following axotomy. Journal of Neurophysiology, 72:466-471,1994. doi:10.1152/jn.1994.72.1
Stephen_Waxman
British neuroscientist (1954–2021)
"The Expression of P2X3Purinoreceptors in Sensory Neurons: Effects of Axotomy and Glial-Derived Neurotrophic Factor". Molecular and Cellular Neuroscience
Stephen_Brendan_McMahon
Chinese-American neurobiologist
Yishi; Ben-Yakar, Adela (2004). "Functional regeneration after laser axotomy". Nature. 432 (7019): 822. doi:10.1038/432822a. ISSN 1476-4687. PMID 15602545
Yishi_Jin
Chemical compound
preservation and reactive gliosis attenuation following neonatal sciatic nerve axotomy by a fluorinated cannabidiol derivative". Neuropharmacology. 140: 201–208
4'-Fluorocannabidiol
American neuroscientist
circuitry formation. This was previously thought impossible, due to neuronal axotomy/dendritotomy. The lab employed this neuronal FACS first for studies of
Jeffrey_Macklis
populations, chromosome dissection, cytoskeleton disruption, organelle ablation, axotomy, or the optical tweezing or isolation of intracellular material. Terms
Optical_transfection
Medication
2002). "Upregulation of heat shock proteins rescues motoneurones from axotomy-induced cell death in neonatal rats". Exp. Neurol. 176 (1): 87–97. doi:10
Arimoclomol
Protein-coding gene in the species Homo sapiens
1158/0008-5472.CAN-04-2865. PMID 15833836. Weishaupt JH, Klöcker N, Bähr M (2005). "Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a
POU4F2
American geneticist (born 1958)
deposition/tangle formation induces microglial activation and synaptic pruning/axotomy beginning with the astrocytic release of MCP1. 2018: Showed that the amyloid
Rudolph_E._Tanzi
protect neurons from secondary degeneration after central nervous system axotomy". Nature Medicine. 5 (1): 49–55. doi:10.1038/4734. PMID 9883839. S2CID 8877114
Protective_autoimmunity
Dutch biologist (born 1973)
concentration of vesicles to restricted sites of regenerating neurons after axotomy". J Cell Biol. 176 (4): 497–507. doi:10.1083/jcb.200607098. PMC 2063984
Casper_Hoogenraad
Protein-coding gene in the species Homo sapiens
Kitamura T (July 1995). "A novel RING-H2 motif protein downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic
PJA2
Protein-coding gene in the species Homo sapiens
Expression is also increased after axonal injury, such as peripheral axotomy in motor neurons and dorsal root ganglia. This upregulation implies that
Peripherin
Protein-coding gene in the species Homo sapiens
"Drebrin expression is increased in spinal motoneurons of rats after axotomy". Neurosci. Lett. 311 (3): 165–8. doi:10.1016/S0304-3940(01)02155-3. PMID 11578820
DBN1
Receptor modulators
THX-B, which inhibits NGF-p75NTR binding and prevents the death of RGCs in axotomy and glaucoma. In addition, in combination with LM22A-24, THX-B delays the
Neurotrophin_mimetics
Migration of cells in the direction of cellular adhesion along a surface
(1986). "Induction of nerve growth factor receptor in Schwann cells after axotomy". Proceedings of the National Academy of Sciences. 83 (11): 4094–4098.
Haptotaxis
Protein
function for Aurora B kinase has recently been reported in neurons. Following axotomy of cultured neurons, significant upregulation in Aurora B kinase gene expression
Aurora_kinase_B
Drug developed by Novartis
about 10−9 M. Omigapil prevents neurodegeneration in facial motor neuron axotomy animal models as well as mouse models of progressive motor neuronopathy
Omigapil
significant upregulation of a number of trophic factors after undergoing axotomy. One major difference in motor and sensory pathways is the difference in
Preferential motor reinnervation
Preferential_motor_reinnervation
Human protein-coding gene
"Purkinje cell degeneration (pcd) phenotypes caused by mutations in the axotomy-induced gene, Nna1". Science. 295 (5561): 1904–6. Bibcode:2002Sci...295
AGTPBP1_(gene)
British-American biochemist
nervous system) and in response to injury (e.g. excitotoxic stress and axotomy). JNK also contributes to tumor cell death and can suppress tumorigenesis
Roger_J._Davis
MeSH E04.525.210.080.800.800 – sympathectomy, chemical MeSH E04.525.210.145 – axotomy MeSH E04.525.210.210 – cordotomy MeSH E04.525.210.380 – ganglionectomy
List_of_MeSH_codes_(E04)
AXOTOMY
AXOTOMY
AXOTOMY
AXOTOMY
Male
Dutch
, Christ-bearer.
Boy/Male
English
Lives on a narrow passage.
Girl/Female
Indian
Captivating, Clever, Smart, Fascinating
Boy/Male
Arabic
Street Light
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Tamil, Telugu
Handsome
Girl/Female
Hindu, Indian, Marathi, Parsi
Lovely; Beautiful
Boy/Male
Hindu, Indian, Traditional
Love for Brightness
Girl/Female
Tamil
Sabine
Girl/Female
Australian, French, German, Greek, Latin
Constancy; Steadfastness
Surname or Lastname
English (Kent)
English (Kent) : unexplained; possibly a variant of Leeson.
AXOTOMY
AXOTOMY
AXOTOMY
AXOTOMY
AXOTOMY