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ACANTHOLYSIS

Acantholysis

Medical condition

Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, seen in diseases such as

Acantholysis

Pemphigus

Blistering autoimmune diseases

from each other and the epidermis becomes detached, a phenomenon called acantholysis. This causes blisters that slough off and turn into sores. In some cases

Pemphigus

Transient acantholytic dermatosis

Medical condition

pruritic, papulovesicular dermatosis characterized histologically by acantholysis with or without dyskeratosis. Once confirmed, most cases of Grover's

Transient acantholytic dermatosis

Transient_acantholytic_dermatosis

Squamous-cell carcinoma

Carcinoma that derives from squamous epithelial cells

carcinoma) is characterized by a tubular microscopic pattern and keratinocyte acantholysis. basaloid squamous-cell carcinoma is mostly found in or near the tongue

Squamous-cell carcinoma

Squamous-cell_carcinoma

Skin condition

Any medical condition that affects the integumentary system

Parakeratosis Hypergranulosis Acanthosis Papillomatosis Dyskeratosis Acantholysis Spongiosis Hydropic swelling Exocytosis Vacuolization Erosion Ulceration

Skin condition

Skin_condition

Hailey–Hailey disease

Medical condition

In addition to blistering, other symptoms which accompany HHD include acantholysis, erythema and hyperkeratosis. It typically begins in late teenage years

Hailey–Hailey disease

Hailey–Hailey_disease

Cantharidin

Chemical compound

cells together. The process leads to the loss of cellular connections (acantholysis), and ultimately results in blistering of the skin. Lesions heal without

Cantharidin

Pemphigus vulgaris

Chronic blistering skin disease

the clinical picture resembles a blister. These blisters are due to acantholysis, or the breaking apart of intercellular connections through an autoantibody-mediated

Pemphigus vulgaris

Pemphigus_vulgaris

Pemphigoid

Autoimmune blistering diseases

to pemphigus, however unlike pemphigus, pemphigoid does not feature acantholysis, a loss of connections between skin cells. Pemphigoid is more common

Pemphigoid

Pemphigus foliaceus

Autoimmune blistering disease

formed into a desmosome. This in turn causes a loss of adhesion with acantholysis as a result. The National Institute of Arthritis and Musculoskeletal

Pemphigus foliaceus

Pemphigus_foliaceus

Pemphigus erythematosus

Medical condition

skin layers, which causes the blisters. The separation itself is called acantholysis. Patients with pemphigus erythematosus have antibodies against desmoglein-1

Pemphigus erythematosus

Pemphigus_erythematosus

IgA pemphigus

Medical condition

histologically by intraepidermal bullae with neutrophils, some eosinophils, and acantholysis. Clinically, the pustules in the intraepidermal neutrophilic subtype

IgA pemphigus

IgA_pemphigus

Desmosome

Cell junction involved in cell-to-cell adhesion

Dsg3 (Desmoglein 3) and sometimes Dsg1. PV is manifested by suprabasal acantholysis, or blisters in the mucous membrane and blisters in the epidermis. PF

Desmosome

Bullous pemphigoid

Autoimmune disease of skin and connective tissue characterized by large blisters

ISBN 978-1-264-26850-4. Kumaran, MSendhil; Kanwar, AmrinderJ; Seshadri, Divya (2013). "Acantholysis revisited: Back to basics". Indian Journal of Dermatology, Venereology

Bullous pemphigoid

Bullous_pemphigoid

Vesiculobullous disease

Presence of fluid-filled lesions in the skin or mucous membranes

Name Acantholysis? Ig epidermolysis bullosa yes mostly IgG bullous pemphigoid no mostly IgG dermatitis herpetiformis no IgA

Vesiculobullous disease

Vesiculobullous_disease

Auspitz's sign

Dermatologic sign

v4.25046. doi:10.3402/jchimp.v4.25046. PMC 4120137. PMID 25147644. "Acantholysis or the Auspitz sign? A revelation of the life of Carl Heinrich Auspitz"

Auspitz's sign

Auspitz's_sign

Blister beetle dermatitis

Medical condition

results from the disruption of tonofilaments in the desmosomes with acantholysis and intra-epidermal blister formation. "Just the facts…Paederus Beetles"

Blister beetle dermatitis

Blister_beetle_dermatitis

Galli–Galli disease

Medical condition

Dowling-Degos disease but also associated with suprabasal, nondyskeratotic acantholysis. List of cutaneous conditions Skin lesion James, William; Berger, Timothy;

Galli–Galli disease

Galli–Galli_disease

Pemphigus herpetiformis

Medical condition

findings may include subcorneal pustules and eosinophilic spongiosis, while acantholysis may be minimal or absent compared with other forms of pemphigus. Because

Pemphigus herpetiformis

Pemphigus_herpetiformis

Histopathologic diagnosis of dermatitis

irregular Normal or thick Normal Spongiosis; lymphocytic infiltrate; rare acantholysis Occasional vacuolar change Pityriasis rosea Present Focal Irregular Normal

Histopathologic diagnosis of dermatitis

Histopathologic_diagnosis_of_dermatitis

Paraneoplastic pemphigus

Medical condition

a specific immunoprecipitation pattern Minor: Histologic evidence of acantholysis (loss of intercellular connections leading to breaking apart of the skin;

Paraneoplastic pemphigus

Paraneoplastic_pemphigus

Desmoglein-3

Protein found in humans

present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice". The Journal of Clinical Investigation. 102

Desmoglein-3

List of MeSH codes (C23)

The following is a partial list of the "C" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)

List of MeSH codes (C23)

List_of_MeSH_codes_(C23)

List of MeSH codes (C17)

800.862.952 – vasculitis, allergic cutaneous MeSH C17.800.865.070 – acantholysis MeSH C17.800.865.187 – blister MeSH C17.800.865.360 – dermatitis herpetiformis

List of MeSH codes (C17)

List_of_MeSH_codes_(C17)