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Genetic polymorphism
5-HTTLPR (serotonin-transporter-linked promoter region) is a degenerate repeat (redundancy in the genetic code) polymorphic region in SLC6A4, the gene
5-HTTLPR
Mammalian protein found in humans
polymorphic region (5-HTTLPR) rs25531 — a single nucleotide polymorphism (SNP) in the 5-HTTLPR rs25532 — another SNP in the 5-HTTLPR STin2 — a variable
Serotonin_transporter
Branch of biology concerning depressive disorders in humans
fact that no candidate gene has reached genome-wide significance. The 5-HTTLPR, or serotonin transporter promoter gene's short allele, has been associated
Biology_of_depression
Three key elements of depression
Variant (5-HTTLPR), Stress, and Depression Meta-analysis Revisited: Evidence of Genetic Moderation". Archives of General Psychiatry. 68 (5): 444–454
Beck's_cognitive_triad
Personality trait of negativity
as 5-HTTLPR, which is transcribed into a serotonin transporter that removes serotonin. It has been found that compared to the long (l) variant of 5-HTTLPR
Neuroticism
Feeling of apprehension, discomfort or awkwardness in the presence of other people
correlations between shyness and specific variations of the DRD4 gene and the 5-HTTLPR (a region of the serotonin transporter gene). However, the influence of
Shyness
Personality trait of highly sensitive persons
evidence that higher levels of SPS are linked to the serotonin transporter 5-HTTLPR short/short genotype, polymorphisms in dopamine neurotransmitter genes
Sensory processing sensitivity
Sensory_processing_sensitivity
Deficiency in understanding, processing, or describing emotions
the Toronto Alexithymia Scale among those with the 5-HTTLPR homozygous long (L) allele. The 5-HTTLPR region on the serotonin transporter gene influences
Alexithymia
Monoamine neurotransmitter
levels below the baseline after chronic use, despite initial increases. The 5-HTTLPR gene codes for the number of serotonin transporters in the brain, with
Serotonin
Personality construct
extent, callous and remorseless traits. Bariş Yildirim theorizes that the 5-HTTLPR "long" allele, which is generally regarded as protective against internalizing
Psychopathy
Medical condition
between HA and components of the serotonin system, e.g. genetic variation in 5-HTTLPR in the serotonin transporter gene. Cheung, G (Aug 2007). "Stability of
Harm_avoidance
German clinical psychiatrist
foundation of personality traits. His 1996 paper on the association between the 5-HTTLPR polymorphism in the serotonin transporter gene and the personality trait
Klaus-Peter_Lesch
American scientist and academic
promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Archives of general psychiatry, 68(5), 444-454.
Margit_Burmeister
American psychologist
Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-analysis Revisited". Archives of General Psychiatry. 68 (5): 444–454. doi:10.1001/archgenpsychiatry
Terrie_E._Moffitt
Ability to understand or feel what another is feeling
activation of the amygdala when viewing emotionally arousing images. The gene 5-HTTLPR seems to influence sensitivity to negative emotional information and is
Empathy
Subtype of serotonin receptor
PS, Knudsen GM, Fisher PM (November 2020). "Common HTR2A variants and 5-HTTLPR are not associated with human in vivo serotonin 2A receptor levels". Human
5-HT2A_receptor
Pleasurable phenomenon elicited via direct stimulation of specific brain regions
2016). "Meta-analysis of the association between a serotonin transporter 5-HTTLPR polymorphism and smoking cessation". Psychiatric Genetics. 26 (2): 87–91
Brain_stimulation_reward
Israeli-American psychologist (born 1960)
1980s. Among Caspi's discoveries was that of an association between the 5-HTTLPR polymorphism and clinical depression. This discovery, originally reported
Avshalom_Caspi
Response to the same environmental variation differently by different genotypes
most recent criticisms were spurred by Moffitt and Caspi's studies on 5-HTTLPR and stress and its influence on depression. In contrast to previous debates
Gene–environment_interaction
Species of great ape
Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, et al. (June 2005). "5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility
Bonobo
Structure within the brain
region of the serotonin transporter (the SERT-long and -short allele: 5-HTTLPR) has been shown to affect the development of several regions of the thalamus
Thalamus
Neuroscientist and researcher
identified that the people who inherit two copies of the long variant of the 5-HTTLPR gene avoid negative imagery. She concluded that these people were ready
Elaine_Fox
Single nucleotide polymorphism in human BDNF gene
associated with introversion and interacts with 5-HTTLPR to influence neuroticism". Neuropsychopharmacology. 35 (5): 1083–1089. doi:10.1038/npp.2009.213. PMC 2840212
Rs6265
Big Five personality trait inventory
relationship between the serotonin transporter gene regulatory region (5-HTTLPR) and the neuroticism subscale. Individuals with a shorter allele had higher
Revised NEO Personality Inventory
Revised_NEO_Personality_Inventory
Mood disorder
Second, the correlation between depression risk and polymorphisms in the 5-HTTLPR gene, which codes for serotonin receptors, suggests a link. Third, decreased
Major_depressive_disorder
Flint J (February 2006). "Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder". Biological Psychiatry. 59
Heritability_of_autism
SSRI antidepressant
activity: influence of pindolol and 5-HTTLPR in delusional and nondelusional depression". Biological Psychiatry. 50 (5): 323–330. doi:10.1016/s0006-3223(01)01118-0
Fluvoxamine
Abnormally-thickened heart valve
mitral valve regurgitation (DMR), particularly in people with a specific 5-HTTLPR genotype ('long-long'). The researchers recommend genotyping DMR patients
Mitral_valve_prolapse
Memory loss caused by drugs
Feinn et al. found evidence for an association of the short allele of the 5-HTTLPR (SLC6A4) with AD, but the overall effect size estimated by odd ratios was
Blackout (drug-related amnesia)
Blackout_(drug-related_amnesia)
Class of antidepressant medication
degenerative mitral valve regurgitation (DMR), especially in individuals carrying 5-HTTLPR genotype. The study's authors suggest that genotyping should be performed
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Biological causes of variation in human personality
repeats in the gene for dopamine receptor D4 and serotonin transporter gene 5-HTTLPR, have both been found to influence the extraversion trait in adults. Specifically
Biological basis of personality
Biological_basis_of_personality
Endogenous enzyme
Lattuada E, Lorenzi C, et al. (May 2002). "Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders". American Journal
Monoamine_oxidase_A
Gene considered likely to be involved in a condition
meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression". Molecular Psychiatry
Candidate_gene
Ability to perceive and process information about one's surroundings
genetic factors (e.g., genetic variation in the serotonin transporter [5-HTTLPR short allele]). In other words, the model suggests that individuals carrying
Environmental_sensitivity
Study of the role of the genome in drug response
affecting HDL. In psychiatry, as of 2010, research has focused particularly on 5-HTTLPR and DRD2. Initiatives to spur adoption by clinicians include the Ubiquitous
Pharmacogenomics
Correlation between human biology and political tendencies
the 5-HTTLPR region being involved in numerous psychological and personality traits, yet Border et al. (2019) found that multiple associations with 5-HTTLPR
Biology and political orientation
Biology_and_political_orientation
System used in psychology
[citation needed] Gene variants that have been investigated are, e.g., 5-HTTLPR in the serotonin transporter gene and gene variants in XBP1. Cloninger
Temperament and Character Inventory
Temperament_and_Character_Inventory
Dutch doctor, author and academic
ADHD symptoms appears to be influenced by the interaction between the 5-HTTLPR gene and stress, with this gene-environment interaction mediated by gray
Jan_K._Buitelaar
Things associated with unlawful behavior
measuring the levels of the metabolite 5-HIAA in the urine; offenders often have lower levels of 5-HIAA. An 5-HTTLPR polymorphism, which lowers serotonin
Correlates_of_crime
Biological study Of bipolar disorder
LL (9 August 2013). "Meta-analysis confirms a functional polymorphism (5-HTTLPR) in the serotonin transporter gene conferring risk of bipolar disorder
Biology_of_bipolar_disorder
Psychological phenomenon
the effects of 5-HTTLPR genotypes within social anxiety disorder". European Archives of Psychiatry and Clinical Neuroscience. 264 (5): 433–439. doi:10
Social_buffering
Branch of psychology
under competitive pressure. The serotonin transporter gene polymorphism 5-HTTLPR has been connected with traits that are associated with stress response
Sport_psychology
Chemical compound
Wilson AA, Hussey D, Boovariwala A, Willeit M, et al. (August 2007). "Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen:
DASB
Protein-coding gene in the species Homo sapiens
Cristina S, Lilli R, et al. (2002). "Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders". Am. J. Med. Genet
TPH1
Medical condition
differences in stress response. Researchers at UCLA found that adults with the 5-HTTLPR S allele had higher cortisol levels, which can contribute both to the progression
Childhood_chronic_pain
American geneticist (born 1951)
Clifford J, Edwards S, et al. (2012). "Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology
Dean_Hamer
Chemical compound
used in scientific studies. It was originally believed to act as a selective 5-HT1A receptor antagonist, but subsequent research showed that it also acts
WAY-100635
The short allele of the promoter region of the serotonin transporter (5-HTTLPR) has been shown to be less efficient than the long allele and is associated
Genetics of post-traumatic stress disorder
Genetics_of_post-traumatic_stress_disorder
Protein-coding gene in the species Homo sapiens
of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis". Behavioral
SLC5A4
Canadian American academician and psychopharmacologist
concentrations. He established that elderly patients with the ll genotype of 5-HTTLPR showed faster symptom reduction with paroxetine than those with the s allele
Bruce_Pollock
5 HTTLPR
5 HTTLPR
Male
Japanese
(1-ç´€, 2-ä¿®, 3-ç†, 4-åŽ, 5-æ²», 6-çµ±) Japanese name OSAMU means 1) "chronicler," 2) "disciplined," 3) "logical," 4) "obtainer," 5) "to reign," 6) "ruler."
Surname or Lastname
English
English : variant spelling of Peak.Irish : variant of Peak 2.North German : metonymic occupational name for a spearmaker, from Middle Low German pēk ‘pike’. Compare Pike 4.Dutch : variant of Peck 4 and 5.
Surname or Lastname
English (Yorkshire)
English (Yorkshire) : unexplained.French : from a diminutive of Bard 5.Hungarian (Bárdy) : habitational name for someone from a place called Bárd in Somogy county or in Máramaros, (now Maramures in Romania).
Male
Japanese
(1-晋, 2-信, 3-紳, 4-心, 5-慎, 6-新, 7-進, 8-真) Japanese name SHIN means 1) "advancing," 2) "belief," 3) "gentleman," 4) "heart," 5) "humble," 6) "new," 7) "progressive," and 8) "true." Compare with another form of Shin.
Surname or Lastname
South German (Düll)
South German (Düll) : nickname for a stubborn man.German (Düll) : variant of Dill 5.English : unexplained.
Female
Japanese
(1-æµ, 2-æ…¶, 3-æ¡‚, 4-敬, 5-å•“, 6-åœ, 7-景) Japanese name KEI means 1) "blessed, lucky," 2) "happy," 3) "katsura tree," 4) "respectful," 5) "spring," 6) "square jewel," or "sunny."Â
Surname or Lastname
English
English : occupational name for a maker or seller of hoods, from Middle English hodestre, a feminine form of Hodder.German (also Höster) : habitational name for someone from either of two places called Host (see Host 5).
Girl/Female
Assamese, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
A Garland of 5 Types of Flowers
Male
Japanese
(1-æµ, 2-ä½³, 3-敬, 4-åœ, 5-æ…§) Japanese name KEI means 1) "blessed, lucky," 2) "excellent," 3) "respect," 4) "square jewel," or 5) "wise."
Surname or Lastname
English
English : variant spelling of Kay 4 and 5.
Surname or Lastname
English
English : variant of Wall.Swedish : ornamental name composed of the elements wall, an old spelling of vall ‘grassy bank’ + man ‘man’.German (Wallmann) : variant of Wall 4 and 5.
Surname or Lastname
English
English : patronymic from Kay 5.
Female
Japanese
(1-æ£, 2-é›…, 3-昌, 4-真, 5-政, 6-å°†) Unisex short form of Japanese names beginning with Masa-, MASA means 1) "correct, just," 2) "elegant," 3) "flourishing, prosperous" 4) "genuine, true," 5) "governing, political," 6) "military." Compare with strictly masculine Masa.
Boy/Male
Muslim
One who prays 5 times and fasts, Forever, Immortal
Surname or Lastname
English
English : nickname from Middle English dull + -ard ‘dull or stupid person’. Compare Doll 5.Irish : either an importation to Ireland of the English name or, possibly, a reduced and altered form of de la Hyde (see Dollarhide).
Female
Japanese
(1-æµå, 2-æ…¶å, 3-æ¡‚å, 4-敬å, 5-å•“å, 6-åœå, 7-景å) Japanese name KEIKO means 1) "blessed, lucky child," 2) "happy child," 3) "katsura tree child," 4) "respectful child," 5) "spring child," 6) "square jewel child," or 7) "sunny child."
Male
Japanese
(1-æ£, 2-é›…, 3-昌, 4-真, 5-政, 6-å°†) Unisex short form of Japanese names beginning with Masa-, MASA means 1) "correct, just," 2) "elegant, splendid" 3) "flourishing, prosperous" 4) "genuine, true," 5) "governing, political," 6) "military." Compare with another form of Masa.
Surname or Lastname
German
German : diminutive of Summer 5.English (Bedfordshire) : unexplained.
Boy/Male
Hindu, Indian, Tamil
5 Head of Snake
Male
Japanese
(1-æš, 2-æ‚Ÿ, 3-è¡, 4-知, 5-覚, 6-è«, 7-了, 8-智) Japanese name SATORU means 1) "daybreak," 2) "enlightened," 3) "fast learner," 4) "knowledgeable," 5) "perceptive," 6) "persuasive," 7) "understanding," or 8) "wise."
5 HTTLPR
5 HTTLPR
Girl/Female
Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Sindhi, Telugu
A Fair Woman; Goddess Parvati; Very Beautiful
Girl/Female
Tamil
Male
Icelandic
Icelandic form of Greek Petros, PÉTUR means "rock, stone."Â
Boy/Male
Danish, German, Norse
Son of Viking
Boy/Male
American, Australian, British, Chinese, Christian, Danish, English, French, German, Latin, Swiss
Young Lion; Form of Leonard; Like a Lion
Boy/Male
Muslim
Affectionate, Compassionate, Soft, Pardoning, Tender, Kind
Girl/Female
Hindu, Indian
Faith; Desire to Achieve
Girl/Female
Muslim
Prophet muhammads daughter
Girl/Female
Muslim
Blessing, Living An enjoyable life, Belonging to one
Girl/Female
Hindu
Princess, Noble lady, Precious
5 HTTLPR
5 HTTLPR
5 HTTLPR
5 HTTLPR
5 HTTLPR
n.
See 4th Trap, 5.
n.
See Flyer, n., 5.
n.
An umbilicus. See Umbilicus, 5 (b).
n.
The thorax of an insect. See Trunk, n., 5.
n.
Same as Reed, n., 5.
a.
Affected with the vapors. See Vapor, n., 5.
n.
See Closure, 5.
n.
See Tailing, n., 5.
n.
See Tread, n., 5.
v.
See Affected, 5.
n.
See Romance, 5.
n.
A morality play. See Morality, 5.
n.
Same as Placard, 4 & 5.
n.
Same as Gudgeon, 5.
n.
See Camp, n., 5.
n.
Same as Relief, n., 5.
n.
A way for passage; a hall. See Passage, 5.
n.
See Relief, n., 5.
n. & v.
See Prize, n., 5. Also Prize, v. t.
pref.
On; along; in traversing. Compare 5.