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Protein-coding gene in the species Homo sapiens
pigmentosum, complementation group C, also known as XPC, is a protein which in humans is encoded by the XPC gene. XPC is involved in the recognition of bulky DNA
XPC_(gene)
Protein family
In molecular biology, the XPC binding domain is thought to play a role in DNA damage discrimination and in the enhancement of cell survival. They bind
XPC-binding
DNA repair mechanism
including the DNA-damage binding (DDB) and XPC-Rad23B complexes that constantly scan the genome and recognize helix distortions: the XPC-Rad23B complex is responsible
Nucleotide_excision_repair
Protein-coding gene in the species Homo sapiens
most studies have been performed with XPC-RAD23B, it is part of a trimeric complex with centrin-2, a calcium-binding protein of the calmodulin family. The
RAD23B
Protein-coding gene in the species Homo sapiens
C, Sugasawa K, Masutani C, Hanaoka F, Bootsma D, Hoeijmakers JH (1996). "XPC and human homologs of RAD23: intracellular localization and relationship
RAD23A
wildtype - wobble position - Wolfram syndrome - WWE protein domain - XPC-binding - XPG I protein domain - Xyloglucan endo-transglycosylase - YAC (yeast
Index of molecular biology articles
Index_of_molecular_biology_articles
Medical condition multisystem disorder
XPB(ERCC3) gene can lead to XP or XP combined with Cockayne syndrome. The XPC protein forms a complex with RAD23B protein to form the initial damage recognition
Xeroderma_pigmentosum
Protein-coding gene in the species Homo sapiens
to the sensitivities of cells defective in the other XP genes XPA, XPB, XPC, XPD, XPF and XPG. As shown by Wittschieben et al., when DDB2 is in a complex
DDB2
Mammalian protein found in humans
as OGG1 and MUTYH, nucleotide excision repair (NER) factors like DDB2 and XPC, mismatch repair (MMR) genes such as MSH2 and MLH1, and elements of homologous
P53
Type of genetic engineering
industrial-scale production of two meganucleases able to cleave the human XPC gene; mutations in this gene result in Xeroderma pigmentosum, a severe monogenic
Genome_editing
Protein-coding gene in humans
and segregation of the centrosome. CETN2 has been shown to interact with XPC and SFI1. GRCh38: Ensembl release 89: ENSG00000147400 – Ensembl, May 2017
Centrin_2
Protein-coding gene in humans
such as XPC and histones (see next section) near the damage site. Due to its ubiquitination of DNA damage-recognizing proteins DDB2 and XPC, CUL4A has
CUL4A
Mammalian protein found in Homo sapiens
ABCA1 has been shown to interact with: APOA1, APOE, FADD, SNTB2, and XPC. ATP-binding cassette transporter GRCh38: Ensembl release 89: ENSG00000165029 –
ABCA1
Damage in DNA which occurs naturally
H3, and H4, as well as the repair protein XPC, which has been attracted to the site of the DNA damage. XPC, upon ubiquitination, is activated and initiates
DNA damage (naturally occurring)
DNA_damage_(naturally_occurring)
(2007-08-03). "Engineered I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells". Journal
Meganuclease
Mammalian protein found in Homo sapiens
pigmentosum (XP) or XP combined with Cockayne syndrome (XPCS). Mutant XPB cells from individuals with the XPCS phenotype are sensitive to UV irradiation and acute
XPB
Protein-coding gene in the species Homo sapiens
Spektor A, Luciano DJ, et al. (2006). "CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability". Mol. Biol. Cell
Centrin_1
Xeroderma pigmentosa Trichothiodystrophy Xeroderma pigmentosum–Cockayne syndrome XPC Xeroderma pigmentosa XPD DNA helicase Xeroderma pigmentosa Trichothiodystrophy
List of genes mutated in cutaneous conditions
List_of_genes_mutated_in_cutaneous_conditions
Mammalian protein found in humans
combination of XP and TTD (XPTTD), or a combination of XP and Cockayne syndrome (XPCS). TTD and CS both display features of premature aging. These features may
ERCC2
Illuminated manuscript made in the Abbey of Saint Gail in Switzerland
separated by two bars. The bars bear the following inscription: HIC RESIDET XPC VIRTVTVM STEMMATE SEPTVS (Here Christ sits enthroned, surrounded by the wreath
Evangelium_Longum
Damage to the structure of a biological molecule
changes in the DNA helical structure. Bulky adducts seem to trigger NER. The XPC-RAD23-CETN2 heterotrimer involved with NER has a critical role in DNA lesion
Molecular_lesion
Cellular mechanism
ligase with UV-damaged DNA is independent of damage-recognition protein XPC". Journal of Cell Science. 120 (Pt 15): 2706–16. doi:10.1242/jcs.008367.
DNA_repair
Protein-coding gene in the species Homo sapiens
the DNA replicating licensing factor CDT1, DNA repairing proteins DDB2 and XPC, mitosis regulator Aurora B, and certain DNA polymerases in mammalian cells
Valosin-containing_protein
Medical condition
Wang Z, Gan N, Dai X, Wang Y (2014). "α-N-methylation of damaged DNA-binding protein 2 (DDB2) and its function in nucleotide excision repair". J. Biol
DNA repair-deficiency disorder
DNA_repair-deficiency_disorder
pigmentosum group B; 610651; ERCC3 Xeroderma pigmentosum group C; 278720; XPC Xeroderma pigmentosum group D; 278730; ERCC2 Xeroderma pigmentosum group
List_of_OMIM_disorder_codes
XPC BINDING
XPC BINDING
Boy/Male
Muslim/Islamic
Binding Fastening
Male
Iranian/Persian
Avestan myth name of the son of Ahura Mazda, derived from the proto-Indo-Iranian word *mitra, MITHRA means "contract, covenant, oath, promise, treaty," from the root mi- "to bind," all of which seems to indicate the basic meaning "alliance; contract; a means of binding."
Biblical
conclusion in pleading; binding
Girl/Female
Biblical
Conclusion in pleading, binding.
Boy/Male
Tamil
Binding, Attach together
Biblical
Making sweet; binding together
Surname or Lastname
English, German, and Jewish (Ashkenazic)
English, German, and Jewish (Ashkenazic) : metonymic occupational name for a maker of hoops and bands, etc., from Middle English band, bond, Middle High German, Middle Low German bant, German Band denoting something used for tying or binding: ‘hoop’, ‘metal band’, ‘fetter’, ‘shackle’.Old spelling of the Dutch cognates Bant, Bande, from Middle Dutch bant ‘band’.
Girl/Female
Biblical
Making sweet, binding together.
Girl/Female
Biblical
Hiding, binding.
Boy/Male
Arabic, Muslim, Sindhi
Binding; Fastening
Biblical
fearful; binding
Girl/Female
Biblical
Fearful, binding.
Biblical
hiding, binding
Male
Iranian/Persian
(Ù…â€ï®©â€Ø±) Persian name derived from Avestan Mithra, MIHR means "alliance; contract; a means of binding."
Boy/Male
Hindu, Indian
Binding; Attach Together
Boy/Male
Muslim
Binding, Fastening
XPC BINDING
XPC BINDING
Female
Dutch
, firm spear.
Girl/Female
Hindu, Indian
The Art of Home
Biblical
for all, or against all
Boy/Male
British, English
Rich War
Boy/Male
Irish
Serves Saint John. Surname.
Boy/Male
Biblical
Ancient heaps.
Surname or Lastname
French
French : from the Old French word goi (Latin gubia) denoting a type of bill hook or knife used by vine-growers or coopers, hence possibly a metonymic occupational name for a maker or user of such implements.English (of Norman origin) : habitational name from any of various places in France named Gouy, for example in Aisne or Pas-de-Calais.Galician : probably a habitational name from Goy in Lugo province, Galicia.German : northwestern variant of Gau.
Girl/Female
Hindu, Indian, Marathi, Sanskrit
Well Given; A Wife of Krishna
Male
English
Variant spelling of English Joshua, JOSHAWA means "God is salvation."
Boy/Male
Arabic, Muslim
Soothing Heart; Mind
XPC BINDING
XPC BINDING
XPC BINDING
XPC BINDING
XPC BINDING
n.
A fine kind of parchment, usually made from calfskin, and rendered clear and white, -- used as for writing upon, and for binding books.
n.
A binding.
n.
The condition or property of being binding; obligatory quality.
a.
Of or pertaining to a sacrament or the sacraments; of the nature of a sacrament; sacredly or solemnly binding; as, sacramental rites or elements.
a.
Not cut; not separated or divided by cutting or otherwise; -- said especially of books, periodicals, and the like, when the leaves have not been separated by trimming in binding.
n.
A North American shrub (Viburnum nudum) whose tough osierlike shoots are sometimes used for binding sheaves.
adv.
In a universal manner; without exception; as, God's laws are universally binding on his creatures.
v. t.
To cause to fail of effect, either wholly or in part; to make void; to destroy, as the validity or binding force of an instrument or transaction; to annul; as, any undue influence exerted on a jury vitiates their verdict; fraud vitiates a contract.
n.
A symbol representing ninety units, as 90 or xc.
n.
The act or process of binding or platting with twigs; also, the network so formed.
n.
Either of the ends of the conducting circuit of an electrical apparatus, as an inductorium, dynamo, or electric motor, usually provided with binding screws for the attachment of wires by which a current may be conveyed into or from the machine; a pole.
n.
A small cord, a line, a twine, or a slender strip of leather, or other substance, used for binding together, fastening, or tying things; a cord, larger than a thread and smaller than a rope; as, a shoe string; a bonnet string; a silken string.
n.
A surcingle, or strap of leather, used for binding a load upon the back of a beast; also, a leather tie; a short wagon rope.
v. t.
To unite, as spars, timbers, rails, etc., by lapping the two ends together, or by applying a piece which laps upon the two ends, and then binding, or in any way making fast.
a.
Made of the leather called roan; as, roan binding.
a.
Binding strongly; making strict requirements; restrictive; rigid; severe; as, stringent rules.
n.
The bindings of a hedge.
n.
A strong thread composed of two or three smaller threads or strands twisted together, and used for various purposes, as for binding small parcels, making nets, and the like; a small cord or string.
n.
A rope used for binding masts and spars.
n.
Sacredness; solemnity; inviolability; religious binding force; as, the sanctity of an oath.