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TPH2

TPH2

Protein-coding gene in the species Homo sapiens

Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates. In humans, TPH2 is primarily expressed in the serotonergic

TPH2

Bipolar disorder

Disorder of depression and mood episodes

correction for multiple testing. On the other hand, two polymorphisms in TPH2 were identified as being associated with bipolar disorder. Due to the inconsistent

Bipolar disorder

Bipolar_disorder

TPH1

Protein-coding gene in the species Homo sapiens

TPH gene until 2003. A second form was found in the mouse (Tph2), rat and human brain (TPH2) and the original TPH was then renamed to TPH1. Tryptophan

TPH1

Attention deficit hyperactivity disorder

Neurodevelopmental disorder

genes associated with ADHD include SERT, HTR1B, SNAP25, GRIN2A, ADRA2A, TPH2, and BDNF. A common variant of a gene called latrophilin 3 is estimated to

Attention deficit hyperactivity disorder

Attention_deficit_hyperactivity_disorder

Tryptophan hydroxylase

Class of enzymes

chromosomes 11 and 12 and encode two different homologous enzymes TPH1 and TPH2 (sequence identity 71%). TPH1 is mostly expressed in tissues that express

Tryptophan hydroxylase

Tryptophan_hydroxylase

Serotonin

Monoamine neurotransmitter

has been shown to exist in two forms: TPH1, found in several tissues, and TPH2, which is a neuron-specific isoform. Serotonin can be synthesized from tryptophan

Serotonin

Biology of bipolar disorder

Biological study Of bipolar disorder

J; Jia, M; Qiao, D; Qiu, H; Sokolove, J; Zhang, J; Pan, Z (March 2016). "TPH2 gene polymorphisms and bipolar disorder: A meta-analysis". American Journal

Biology of bipolar disorder

Biology_of_bipolar_disorder

5-HT2C receptor

Serotonin receptor protein distributed mainly in the choroid plexus

receptors with a 5-HT2C agonist reduced cognitive deficits in mice with a TPH2 loss-of-function mutation. 5-HT2C receptors mediate the release and increase

5-HT2C receptor

5-HT2C_receptor

Genetics of aggression

of the Tph2 gene, which encodes tryptophan hydroxylase 2, the enzyme critical for brain serotonin synthesis. In a mouse model developed by, Tph2 knockout

Genetics of aggression

Genetics_of_aggression

Causes of mental disorders

Etiology of psychopathology

genes associated with ADHD include SERT, HTR1B, SNAP25, GRIN2A, ADRA2A, TPH2, and BDNF. A common variant of a gene called latrophilin 3 is estimated to

Causes of mental disorders

Causes_of_mental_disorders

Post-transcriptional regulation

Control of gene expression at the RNA level, between transcription and translation

receptor, the GABA-alpha3 receptor subunit, the tryptophan hydroxylase enzyme TPH2, the hepatitis delta virus and more than 16% of microRNAs. In addition to

Post-transcriptional regulation

Post-transcriptional_regulation

RNA editing

Molecular process

were also later seen alongside non-classic U-to-C alterations in brain cell TPH2 (tryptophan hydroxylase 2) transcripts. Although the reverse amination might

RNA editing

RNA_editing

Tryptophan 2,3-dioxygenase

Mammalian protein found in Homo sapiens

search: PDBe RCSB List of PDB id codes 4PW8 Identifiers Aliases TDO2, TDO, TO, TPH2, TRPO, tryptophan 2,3-dioxygenase, HYPTRP External IDs OMIM: 191070; MGI:

Tryptophan 2,3-dioxygenase

Tryptophan_2,3-dioxygenase

List of human protein-coding genes 8

Q6ZTW0 17258 TPGS2 HGNC:24561; Q68CL5 17259 TPH1 HGNC:12008; P17752 17260 TPH2 HGNC:20692; Q8IWU9 17261 TPI1 HGNC:12009; P60174 17262 TPK1 HGNC:17358; Q9H3S4

List of human protein-coding genes 8

List_of_human_protein-coding_genes_8

Rs1799913

Proudnikov, Scott Kellogg, Ann Ho, Jurg Ott & Mary Jeanne Kreek (March 2008). "TPH2 and TPH1: association of variants and interactions with heroin addiction"

Rs1799913

Jurgen Del-Favero

research group under the direction of Rolf Adolfsson, indicated that the TPH2 protein is involved in the development of depression and manic depression

Jurgen Del-Favero

Jurgen_Del-Favero