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RRM2

  • RRM2
  • Protein-coding gene in humans

    ribonucleotide reductase small subunit, is an enzyme that in humans is encoded by the RRM2 gene. This gene encodes one of two non-identical subunits for ribonucleotide

    RRM2

    RRM2

    RRM2

  • TAR DNA-binding protein 43
  • Protein found in humans

    folded RNA recognition motifs spanning residues 106–176 (RRM1) and 191–259 (RRM2), respectively, required to bind target RNA and DNA; an unstructured C-terminal

    TAR DNA-binding protein 43

    TAR DNA-binding protein 43

    TAR_DNA-binding_protein_43

  • CCNF
  • Protein-coding gene in humans

    through RRM2 and CP110 control centrosome duplication and reduce the frequency of genomic mutations. So far, mutations in CCNF and increased RRM2 expression

    CCNF

    CCNF

    CCNF

  • Functional genomics
  • Field of molecular biology

    Deep mutational scan of the RNA recognition motif (RRM2) of a yeast PolyA binding protein (Pab1)

    Functional genomics

    Functional genomics

    Functional_genomics

  • Ribonucleotide reductase
  • Class of enzymes

    RRM1 gene while there are two isoforms of the beta subunit, encoded by the RRM2 and RRM2B genes: Each Class I alpha monomer consists of three domains: one

    Ribonucleotide reductase

    Ribonucleotide reductase

    Ribonucleotide_reductase

  • Gemcitabine
  • Chemical compound

    deaminase, and NT5C) and that express its other intracellular targets (RRM1, RRM2, and RRM2B) lead to variations in response to the drug. Research has also

    Gemcitabine

    Gemcitabine

    Gemcitabine

  • RNA interference
  • Biological process of gene regulation

    amyloidosis II Recruiting Alnylam Pharmaceuticals NCT01617967 CALAA-01 RRM2 Cyclodextrin NP Solid tumours I Active Calando Pharmaceuticals NCT00689065

    RNA interference

    RNA interference

    RNA_interference

  • List of enzymes
  • 4.4 Vitamin-K-epoxide reductase (warfarin-insensitive) EC 1.17.4.5 RRM1 RRM2 RRM2B Category:EC 1.17.5 Caffeine dehydrogenase EC 1.17.5.2 Category:EC 1

    List of enzymes

    List_of_enzymes

  • ELAV-like protein 1
  • Protein found in humans

    their secondary structure, a 20 amino-acid long N-terminus before RRM1 and RRM2, and a 12 amino acid linker connecting them. The hinge region connecting

    ELAV-like protein 1

    ELAV-like protein 1

    ELAV-like_protein_1

  • RNA silencing
  • Gene silencing by means of RNA

    Liver tumor PLK1 Cancer FANG Solid tumor Furin Cancer CALAA-01 Solid tumor RRM2 Cancer SPC2996 chronic lymphocytic leukemia BCL-2 Cancer ALN-VSP02 Solid

    RNA silencing

    RNA_silencing

  • ExPRESS Logistics Carrier
  • Module on the International Space Station

    and disposed of on Cygnus NG-16. ) (RRM3 was installed in 2018 to replace RRM2. Payload malfunctioned in 2019 and its payload of methane and ammonia was

    ExPRESS Logistics Carrier

    ExPRESS Logistics Carrier

    ExPRESS_Logistics_Carrier

  • RRM2B
  • Protein-coding gene in humans

    ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits". Cancer Research. 63 (5): 980–6. PMID 12615712. Zhou B, Liu X,

    RRM2B

    RRM2B

    RRM2B

  • GBP2
  • Protein-coding gene in the species Homo sapiens

    conserved. GBP2 gene can interact with the RNA via the domain RRM1 and RRM2. The RRM2 domain can recognize the core motif GGUC present in the RNA. Besides

    GBP2

    GBP2

    GBP2

  • Stephen Elledge
  • American geneticist

    increases when DNA is damaged. The human counterparts of RNR2, or homologs, are RRM2 and RRM2B. Over the next decade, he continued the search for genes and proteins

    Stephen Elledge

    Stephen_Elledge

  • Prp24
  • domain while the cleft between RRMs 1 and 2 including the beta-sheet face of RRM2 is a sequence-specific RNA binding site. The C-terminal motif is required

    Prp24

    Prp24

    Prp24

  • RRM1
  • Protein-coding gene in humans

    ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits". Cancer Res. 63 (5): 980–6. PMID 12615712. Gautam A, Li ZR, Bepler

    RRM1

    RRM1

    RRM1

  • U2AF2
  • Protein-coding gene in humans

    binding affinity to the Py tract on its adjacent 3’ splice site. The RRM1 and RRM2 are sufficient for specific RNA/protein binding, while RRM3 is responsible

    U2AF2

    U2AF2

    U2AF2

  • PABPC1
  • Protein-coding gene in the species Homo sapiens

    PABPC1 contains four RNA-recognition motifs (RRMs). The first two, RRM1 and RRM2, bind both α-importin and the poly(A) tail of processed mRNA. This feature

    PABPC1

    PABPC1

    PABPC1

  • PTBP1
  • Protein-coding gene in the species Homo sapiens

    Polypyrimidine Tract Binding Protein Isoform 1 (PTB1) 1sjr: NMR Structure of RRM2 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1) 2ad9: Solution

    PTBP1

    PTBP1

    PTBP1

  • RBM10
  • Protein-coding gene in the species Homo sapiens

    called RNA recognition motifs (RRMs). RBM10 contains two RRMs (RRM1 and RRM2) and other domains such as two zinc fingers (ZnFs), an octamer repeat (OCRE)

    RBM10

    RBM10

    RBM10

  • List of human protein-coding genes 7
  • Q92766 14109 RRH HGNC:10450; O14718 14110 RRM1 HGNC:10451; P23921 14111 RRM2 HGNC:10452; P31350 14112 RRM2B HGNC:17296; Q7LG56 14113 RRN3 HGNC:30346;

    List of human protein-coding genes 7

    List_of_human_protein-coding_genes_7

  • TMEM242
  • Protein-coding gene in the species Homo sapiens

    GPR42, BCL2L13, HEATR1, IZUMO4, ARID1B, SIAE, EDARADD, URB1, ZDHHC14, KIF11, RRM2, KCTD13, TMEM31, NDUFA3, SGPL1, CNR2, and GJA8. All of the listed proteins

    TMEM242

    TMEM242

    TMEM242

  • RBM4
  • Protein-coding gene in the species Homo sapiens

    mutation affecting both RNA binding domains is lethal, and a mutation in RRM2 leads to female infertility or developmental arrest in offspring. These two

    RBM4

    RBM4

    RBM4

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Online names & meanings

  • Polly
  • Girl/Female

    American, Australian, British, Christian, Danish, English, French, German, Hebrew, Irish, Latin

    Polly

    Bitterness; Rebelliousness; Form of Molly; From Mary; The Perfect One; Female Version of Paul; Little; Small

  • Wickens
  • Surname or Lastname

    English

    Wickens

    English : variant of Wicken, with the addition of the Middle English plural or genitive suffix -s.

  • HERBERT
  • Male

    German

    HERBERT

    Modern German form of Old High German Heribert, HERBERT means "bright army." 

  • Bazish
  • Boy/Male

    Indian

    Bazish

    Aggressive, Hardliner

  • Elan
  • Boy/Male

    Hebrew Native American

    Elan

    tree.

  • Inga
  • Boy/Male

    Australian, British, Dutch, English

    Inga

    A Meadow

  • Judaala |
  • Girl/Female

    Muslim

    Judaala |

    Distinct

  • Nimsad
  • Boy/Male

    Indian, Marathi

    Nimsad

    Joyful

  • Brannan
  • Boy/Male

    Irish

    Brannan

  • Zain
  • Girl/Female

    Arabic

    Zain

    Good

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RRM2

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RRM2