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Layout of proteins anchoring neurotransmitter receptors
The postsynaptic density (PSD) is a protein dense specialization attached to the postsynaptic membrane. PSDs were originally identified by electron microscopy
Postsynaptic_density
Mammalian protein found in Homo sapiens
PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs
DLG4
Biological junctions through which neurons' signals can be sent
Immediately behind the postsynaptic membrane is an elaborate complex of interlinked proteins called the postsynaptic density (PSD). Proteins in the PSD
Chemical_synapse
Protein-coding gene in the species Homo sapiens
synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein
SHANK2
Chemical substance that enables neurotransmission
Postsynaptic density Voltage- gated Ca++ channel Synaptic vesicle Neurotransmitter transporter Receptor Neurotransmitter Axon terminal Synaptic cleft Dendrite
Neurotransmitter
Protein-coding gene in humans
domain (SAM). Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other
SHANK3
American cell biologist (1918–2009)
cell membrane dynamics, and published extensively on the subject of postsynaptic density. Siekevitz was born on February 25, 1918, in Philadelphia to a working-class
Philip_Siekevitz
Part of an animal that coordinates actions and senses
proteins that cluster together to form a structure resembling a postsynaptic density (the signal-receiving part of a synapse). However, the function of
Nervous_system
Protein involved in multiple prion diseases
plasticity. It was further found that Aβ-oligomers bind to PrPC at the postsynaptic density, indirectly overactivating the NMDA receptor via the Fyn enzyme,
Major_prion_protein
Sort of synapse
membrane of the postsynaptic cell, and thus increases the probability of triggering an action potential in that cell. The postsynaptic cell—a muscle cell
Excitatory_synapse
Protein-coding gene in the species Homo sapiens
receptor complex postsynaptic density basolateral plasma membrane synapse glutamatergic synapse extrinsic component of postsynaptic density membrane Biological
SCRIB
Protein and coding gene in humans
neurons, Homer1 is concentrated in postsynaptic structures and constitutes a major part of the postsynaptic density. EVH1 domain interacts with PPXXF motif
HOMER1
Protein-coding gene in the species Homo sapiens
higher levels of the GluR1 subunit and increased miniature excitatory postsynaptic currents (mEPSCs) in addition to displaying deficiencies in long-term
Activity-regulated cytoskeleton-associated protein
Activity-regulated_cytoskeleton-associated_protein
Protein in Homo sapiens
knockout mice die perinatally. SynGAP1 is shown to localize at the postsynaptic density on the dendritic spines of excitatory synapses. Cultured neurons
SYNGAP1
Transmembrane protein family
PKA or SAP97 phosphorylation, receptors are then trafficked to the postsynaptic density (PSD). However, this process of trafficking to the PSD still remains
AMPA_receptor
Protein-coding gene in the species Homo sapiens
enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". The Journal of Neuroscience. 19 (11): 4189–99
GRIN2B
Protein-coding gene in the species Homo sapiens
"SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". The Journal of Biological Chemistry. 272 (18): 11943–51. doi:10
DLG1
Structure connecting neurons in the nervous system
close apposition with the membrane of the target (postsynaptic) cell. Both the presynaptic and postsynaptic sites contain extensive arrays of molecular machinery
Synapse
Chaperone protein
neurodegenerative diseases such as Alzheimer's disease. During healthy ageing, the density of sigma-1 receptors has been seen to increase. However, in diseases such
Sigma-1_receptor
Class of enzymes
it cannot remain active. After LTP induction, CaMKII moves to the postsynaptic density (PSD). However, if the stimulation does not induce LTP, the translocation
Ca2+/calmodulin-dependent protein kinase II
Ca2+/calmodulin-dependent_protein_kinase_II
Protein-coding gene in the species Homo sapiens
CD, Petralia RS, Wang YX, McGee AW, Bredt DS, et al. (May 1999). "Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel
GRID2
Persistent strengthening of synapses based on recent patterns of activity
and postsynaptic structures such as axonal bouton, dendritic spine and postsynaptic density. On the molecular level, an increase of the postsynaptic scaffolding
Long-term_potentiation
Human enzyme
activity Cellular component cytoplasm cytosol centrosome membrane postsynaptic density plasma membrane microtubule organizing center cytoskeleton cytoplasmic
MIB1
Mammalian protein found in Homo sapiens
vesicle membrane postsynaptic membrane cell projection endoplasmic reticulum membrane membrane synaptic vesicle postsynaptic density axonal spine plasma
GRIA1
Protein-coding gene in humans
"SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". J. Biol. Chem. 272 (18): 11943–51. doi:10.1074/jbc.272.18.11943
DLG3
Faculty of mind to store and retrieve data
and postsynaptic structures such as axonal bouton, dendritic spine and postsynaptic density. On the molecular level, an increase of the postsynaptic scaffolding
Memory
Protein-coding gene in the species Homo sapiens
component cytoplasm microprocessor complex nucleolus nucleus nucleoplasm postsynaptic density Biological process regulation of stem cell proliferation primary
Microprocessor complex subunit DGCR8
Microprocessor_complex_subunit_DGCR8
Small protrusion on a dendrite that receives input from a single axon
the spine contains an electron-dense region referred to as the "postsynaptic density" (PSD). The PSD directly apposes the active zone of its synapsing
Dendritic_spine
Protein-coding gene in the species Homo sapiens
exosome cytoskeleton nucleus cytosol presynapse glutamatergic synapse postsynaptic density, intracellular component Biological process actin cytoskeleton reorganization
TNIK
Protein-coding gene in the species Homo sapiens
granule lumen extracellular space nucleus postsynaptic density membrane cell junction synapse postsynaptic membrane Biological process epidermis development
FABP5
Protein-coding gene in the species Homo sapiens
action. It slows maturation of some neurons and increases neuronal spine density. SRGAP2 may also be involved in the development of some cancers. SRGAP2
SRGAP2
Protein-coding gene in the species Homo sapiens
known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the
DLG2
Protein-coding gene in the species Homo sapiens
signal transduction gephyrin clustering involved in postsynaptic density assembly postsynaptic density protein 95 clustering learning regulation of AMPA
NRXN1
Protein-coding gene in the species Homo sapiens
1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–1740. Bibcode:1995Sci
GRIN2A
Mammalian protein found in Homo sapiens
States B, et al. (Sep 1998). "Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP". Neuron. 21 (3): 581–591
GRIA2
Protein-coding gene in the species Homo sapiens
nuclear pore nucleoplasm dendrite nucleus cytoplasm cytosol host cell postsynaptic density glutamatergic synapse Biological process regulation of DNA recombination
Importin_subunit_alpha-5
Enclosing or separating membrane in organisms acting as selective semi-permeable barrier
different types of "supramembrane" structures such as caveolae, postsynaptic density, podosome, invadopodium, desmosome, hemidesmosome, focal adhesion
Biological_membrane
Protein
Neuroligins interact with other postsynaptic proteins to localize neurotransmitter receptors and channels in the postsynaptic density as the cell matures. Additionally
Neuroligin
Mammalian protein found in Homo sapiens
cytosol dendrite cell projection intracellular anatomical structure postsynaptic density nuclear periphery neuron projection soma dendritic shaft cell body
Microtubule-associated protein 2
Microtubule-associated_protein_2
Overview of and topical guide to the human nervous system
neurons. Membrane potential Ion channel Voltage-gated ion channels Postsynaptic density Voltage- gated Ca++ channel Synaptic vesicle Neurotransmitter transporter
Outline of the human nervous system
Outline_of_the_human_nervous_system
Protein-coding gene in the species Homo sapiens
(1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–40. Bibcode:1995Sci..
GRIN3A
Protein and coding gene in humans
Cellular component basal part of cell cell junction postsynaptic membrane synapse postsynaptic density membrane cytoplasm cytosol plasma membrane cellular
HOMER3
Protein-coding gene in the species Homo sapiens
of synaptic vesicle membrane integral component of postsynaptic density membrane postsynaptic density cell junction axon synaptic vesicle membrane cytoplasmic
PTPRS
Human protein and coding gene
metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome". The
FMR1
Highly modified saliva containing zootoxins
Both elapids and viperids may carry numerous other types of toxins. Postsynaptic density Voltage- gated Ca++ channel Synaptic vesicle Neurotransmitter transporter
Snake_venom
Protein-coding gene in the species Homo sapiens
assembly interleukin-1-mediated signaling pathway regulation of postsynaptic density assembly trans-synaptic signaling by trans-synaptic complex synaptic
IL1RAP
Protein found in humans
neuron projection synapse postsynaptic density membrane somatodendritic compartment cytosol cell surface postsynaptic density cerebellar mossy fiber Schaffer
CACNG2
Protein-coding gene in the species Homo sapiens
kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein
DLGAP1
Protein-coding gene in the species Homo sapiens
isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton". J. Biol. Chem. 276 (51): 48458–65. doi:10
DNM2
Protein-coding gene in the species Homo sapiens
growth cone Golgi apparatus intracellular membrane-bounded organelle postsynaptic density membrane plasma membrane axonal growth cone midbody ciliary membrane
PTCH1
Glutamate receptor and ion channel protein found in nerve cells
dorsolateral prefrontal cortex, GluN2B are exclusively within the postsynaptic density, and mediate higher cognitive operations such as working memory.
NMDA_receptor
Ability of a synapse to strengthen or weaken over time according to its activity
and postsynaptic structures such as axonal bouton, dendritic spine and postsynaptic density. On the molecular level, an increase of the postsynaptic scaffolding
Synaptic_plasticity
Protein-coding gene in the species Homo sapiens
endosome extracellular exosome mitochondrion lysosome endosome membrane postsynaptic density retromer, cargo-selective complex mitochondrion-derived vesicle neuron
VPS35
Mammalian protein found in humans
component of membrane G protein-coupled receptor dimeric complex postsynaptic density membrane G protein-coupled receptor homodimeric complex plasma membrane
Metabotropic glutamate receptor 1
Metabotropic_glutamate_receptor_1
Central nervous system stimulant
aminophylline, which are prescribed to relieve symptoms of asthma or COPD. Postsynaptic density Voltage- gated Ca++ channel Synaptic vesicle Neurotransmitter transporter
Caffeine
Protein-coding gene in humans
myofibril perikaryon dendritic spine synaptic membrane synapse M band postsynaptic density axon mitochondrion cytosol plasma membrane Z discdkac contractile
CRYAB
Protein-coding gene in the species Homo sapiens
protein kinase binding Cellular component cytosol Golgi apparatus postsynaptic density synaptic vesicle myelin sheath synapse synaptic vesicle membrane
Synapsin_I
Protein-coding gene in humans
membrane postsynaptic density integral component of plasma membrane excitatory synapse cell junction dendrite synaptic cleft terminal bouton postsynaptic density
GRIN1
Protein-coding gene in the species Homo sapiens
cytoplasm PML body centrosome postsynaptic membrane cell projection spindle pole nuclear body membrane postsynaptic density plasma membrane spindle dendritic
RGS14
aortic endothelial cells and cardiomyocytes. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the
Neurogranin
Protein found in humans
exosome cytoplasm nucleus endoplasmic reticulum cytosol membrane postsynaptic density postsynapse ribonucleoprotein complex dendrite synapse Biological
60S acidic ribosomal protein P0
60S_acidic_ribosomal_protein_P0
Protein found in humans
extracellular exosome polysome cytosolic large ribosomal subunit postsynaptic density ribonucleoprotein complex Biological process SRP-dependent cotranslational
60S_ribosomal_protein_L7
Formation of neuronal junctions in the nervous system
Wnt-11r contributes to acetylcholine receptor (AChR) clustering in the postsynaptic density of muscle cells. Wnt-3 is expressed by muscle fibers and is secreted
Synaptogenesis
Topics referred to by the same term
composing that signal. Protein S deficiency Post-stroke depression Postsynaptic density, a specialization of the cytoskeleton at the synaptic junction Psychiatric
PSD
Mammalian protein found in humans
membrane cell projection protein-containing complex chaperone complex postsynaptic density Biological process rRNA export from nucleus regulation of cell cycle
TSC1
Main receptor for most antipsychotic drugs
N-Propyldihydrexidine – analogue of the D1/D5 agonist dihydrexidine; Selective for postsynaptic D2 receptor over the presynaptic D2 autoreceptor. Piribedil – also D3
Dopamine_receptor_D2
Human gene and protein
FAM81A gene which is expressed in the postsynaptic density of the brain. It plays a pivotal role in forming postsynaptic protein agglomerations, essential
FAM81A
Protein-coding gene in the species Homo sapiens
cytoskeleton nucleus cytoplasm cytosol cytoplasmic side of plasma membrane postsynaptic density plasma membrane cell cortex region protein-containing complex basolateral
Protein_4.1
Protein-coding gene in the species Homo sapiens
Low-density lipoprotein receptor-related protein 4 (LRP-4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a protein that in
Low-density lipoprotein receptor-related protein 4
Low-density_lipoprotein_receptor-related_protein_4
Mammalian protein found in Homo sapiens
activity Cellular component cytoplasm cytosol endosome plasma membrane postsynaptic density glutamatergic synapse Biological process regulation of neuron projection
PAK3
Protein-coding gene in the species Homo sapiens
component axon terminus integral component of membrane postsynaptic membrane membrane postsynaptic density plasma membrane integral component of plasma membrane
Muscarinic acetylcholine receptor M1
Muscarinic_acetylcholine_receptor_M1
Mammalian protein found in humans
Gq-coupled G protein-coupled receptor predominantly expressed on the postsynaptic sites of neurons. In humans, it is encoded by the GRM5 gene. The amino
Metabotropic glutamate receptor 5
Metabotropic_glutamate_receptor_5
Mammalian protein found in Homo sapiens
cytoplasmic vesicle podosome postsynaptic density protein-containing complex glutamatergic synapse postsynaptic density, intracellular component Biological
ARHGEF2
Protein found in humans
neural cells, at certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by Cadherin-2. N-cadherins interact
Cadherin-2
Protein-coding gene in the species Homo sapiens
membrane axon Schaffer collateral - CA1 synapse integral component of postsynaptic density membrane Biological process dorsal/ventral axon guidance negative
Netrin_receptor_DCC
Protein domain
activator activity Cellular component cytoplasm cytosol postsynaptic membrane membrane postsynaptic density plasma membrane synapse cell junction extracellular
BCR_(gene)
Protein family
determinant of inhibitory postsynaptic membrane formation and plasticity. Gephyrin and collybistin are recruited to developing postsynaptic membranes of inhibitory
Collybistin
Protein-coding gene in the species Homo sapiens
endosome cytoplasm synapse cell junction nucleus neuron projection postsynaptic density membrane dendrite perinuclear region of cytoplasm slit diaphragm
MAGI2
Protein found in humans
extracellular exosome nucleus cytosolic large ribosomal subunit postsynaptic density polysomal ribosome Biological process viral transcription SRP-dependent
60S_ribosomal_protein_L10a
Mammalian protein found in Homo sapiens
proven that there is a high importance of nectin-3 for the dendritic spine densities (which simply represent the sites of synaptic contacts) on visual cortical
Nectin-3
Protein-coding gene in the species Homo sapiens
synaptic membrane soma glutamatergic synapse extrinsic component of postsynaptic density membrane Biological process positive regulation of peptidyl-serine
AKAP9
Protein-coding gene in the species Homo sapiens
projection cytoskeleton lamellipodium cytoplasm postsynaptic density actin cytoskeleton dendrite postsynaptic actin cytoskeleton glutamatergic synapse Biological
PPP1R9A
Protein-coding gene in the species Homo sapiens
cadherin binding Cellular component cytoplasm spindle pole membrane postsynaptic density cell-cell contact zone cell-cell junction spindle desmosome cell
Plakophilin-4
Cell surface receptor, part of the low-density lipoprotein receptor family
Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein that in humans is encoded
Low-density lipoprotein receptor-related protein 8
Low-density_lipoprotein_receptor-related_protein_8
Mitochondrial gene coding for a protein involved in the respiratory chain
glutamate receptor binding Cellular component respirasome membrane postsynaptic density integral component of membrane mitochondrion mitochondrial respiratory
MT-ND2
Mammalian protein found in Homo sapiens
mitochondrion mitochondrial inner membrane extracellular exosome nucleus postsynaptic density mitochondrial crista extrinsic component of mitochondrial outer membrane
Prohibitin
Protein-coding gene in the species Homo sapiens
Petralia RS, Wang YX, McGee AW, Bredt DS, Wenthold RJ (May 1999). "Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel
GRID1
Enzyme found in humans
projection membrane glutamatergic synapse integral component of postsynaptic density membrane Biological process Schwann cell differentiation adult locomotory
ADAM22
Protein
component cytoplasm cytosol endosome postsynaptic membrane endoplasmic reticulum membrane membrane postsynaptic density growth cone BLOC-1 complex plasma
Dysbindin
Protein-coding gene in humans
interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains". Journal of Cerebral
FYN
Protein-coding gene in the species Homo sapiens
complex cytoplasm cytosol membrane plasma membrane cytoskeleton postsynaptic density cytoplasmic vesicle plasma membrane raft Biological process barbed-end
ADD2
Mammalian protein found in Homo sapiens
TSC1-TSC2 complex perinuclear region of cytoplasm lysosome nucleus postsynaptic density Biological process regulation of endocytosis protein localization
TSC2
Protein-coding gene in the species Homo sapiens
synaptic vesicle membrane membrane cytoplasmic vesicle synaptic vesicle postsynaptic density glutamatergic synapse Biological process regulation of synaptic transmission
SYN3
Neuronal calcium sensory protein
levels Cellular component cytoplasm cytosol postsynaptic membrane Golgi apparatus membrane postsynaptic density intracellular membrane-bounded organelle
Neuronal_calcium_sensor-1
Protein-coding gene in the species Homo sapiens
domain specific binding Cellular component cell junction postsynaptic membrane postsynaptic density membrane plasma membrane synapse neuromuscular junction
DLGAP3
Cell surface receptor found in humans
filament endomembrane system postsynaptic density axon dendrite axolemma asymmetric synapse presynaptic membrane soma postsynaptic membrane presynaptic active
Adenosine_A2A_receptor
Large secreted extracellular matrix glycoprotein involved in neuronal migration
"Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex". Proceedings of the National Academy
Reelin
Protein-coding gene in the species Homo sapiens
is one of the membrane-associated guanylate kinases localized at postsynaptic density in neuronal cells. These kinases are a family of signaling molecules
DLGAP2
Protein-coding gene in the species Homo sapiens
of plasma membrane cell junction extracellular exosome presynapse postsynaptic density membrane glutamatergic synapse GABA-ergic synapse Biological process
ATP2B2
Protein and coding gene in humans
C (May 2012). "Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone
Muscarinic acetylcholine receptor M3
Muscarinic_acetylcholine_receptor_M3
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
Male
Swiss
, love.
Girl/Female
Indian, Sanskrit
Smile
Girl/Female
British, English
The Long Field
Boy/Male
Muslim/Islamic
Fearless
Girl/Female
Tamil
Fortunate
Boy/Male
Hindu, Indian
God
Girl/Female
American, British, English
Triumphant; Derived from Victoria
Boy/Male
Australian, German, Hungarian
Name of a Honour; Youth
Boy/Male
Greek Spanish
Sun or lordly.
Girl/Female
German
Famous Land
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
n.
The quality of being dense; density.
n.
The ratio of mass, or quantity of matter, to bulk or volume, esp. as compared with the mass and volume of a portion of some substance used as a standard.
n.
An instrument for determining the strength or purity of wine by measuring its density.
n.
A line or surface passing through those points in a medium, at which the density is the same.
n.
A measure of weight, being a thousand grams, equal to 2.2046 pounds avoirdupois (15,432.34 grains). It is equal to the weight of a cubic decimeter of distilled water at the temperature of maximum density, or 39¡ Fahrenheit.
n.
The curve formed by a rope or chain of uniform density and perfect flexibility, hanging freely between two points of suspension, not in the same vertical line.
n.
An instrument for ascertaining the specific gravity or density of a substance.
n.
The unit of weight in the metric system. It was intended to be exactly, and is very nearly, equivalent to the weight in a vacuum of one cubic centimeter of pure water at its maximum density. It is equal to 15.432 grains. See Grain, n., 4.
n.
The quality or state of being rare; rareness; thinness; as, the rarity (contrasted with the density) of gases.
n.
The state or quality of being solid; density; consistency, -- opposed to fluidity; compactness; fullness of matter, -- opposed to openness or hollowness; strength; soundness, -- opposed to weakness or instability; the primary quality or affection of matter by which its particles exclude or resist all others; hardness; massiveness.
n.
The science of the determination of the density of vapors and gases.
a.
Having equal density, as different regions of a medium; passing through points at which the density is equal; as, an isopycnic line or surface.
n.
The quality or state of being porous; -- opposed to density.
n.
A form of hydrometer, specially graduated, for finding the density of milk, and thus discovering whether it has been mixed with water or some of the cream has been removed.
n.
The change in the direction of ray of light, heat, or the like, when it enters obliquely a medium of a different density from that through which it has previously moved.
n.
The quality of being dense, close, or thick; compactness; -- opposed to rarity.
n.
To break the natural course of, as rays of light orr heat, when passing from one transparent medium to another of different density; to cause to deviate from a direct course by an action distinct from reflection; as, a dense medium refrcts the rays of light as they pass into it from a rare medium.
n.
Depth of shade.