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PDE6

PDE6

Photoreceptor phosphodiesterase 6 (PDE6 or PDE-6) is a protein complex family, which is highly concentrated in the retina. cGMP PDE6A PDE6B PDE6C PDE6D

PDE6

PDE6B

Protein-coding gene in the species Homo sapiens

subunit beta is the beta subunit of the protein complex PDE6 that is encoded by the PDE6B gene. PDE6 is crucial in transmission and amplification of visual

PDE6B

Tadalafil

Medication used to treat erectile dysfunction

treating pulmonary arterial hypertension. Sildenafil and vardenafil inhibit PDE6, an enzyme found in the eye, more than tadalafil. Some sildenafil users see

Tadalafil

Vardenafil

Chemical compound

similar ocular side effects due to their similar selectivity overlap with PDE6, an enzyme found in the eye. Beyond its indications for erectile dysfunction

Vardenafil

CGMP-specific phosphodiesterase type 5

Mammalian protein found in humans

mechanism of action of E4021 on both the nonactivated and activated forms of rod PDE6 because both states are relevant to understanding how PDE5-selective inhibitors

CGMP-specific phosphodiesterase type 5

CGMP-specific_phosphodiesterase_type_5

PDE5 inhibitor

Vasodilating drug

influences their side effect profile. For example, sildenafil also inhibits PDE6 which is present in the retina of the eye; this reaction is thought to be

PDE5 inhibitor

PDE5_inhibitor

Sildenafil

Drug for erectile dysfunction and hypertension

because sildenafil, while selective for PDE5, does have some affinity for PDE6, which is the phosphodiesterase found in the retina. Patients thus taking

Sildenafil

Cyanopsia

Medical term for seeing everything tinted in blue

interfere with enzymes in the retina, particularly phosphodiesterase-6 (PDE6). This disruption affects how the retina processes light, leading to temporary

Cyanopsia

Zaprinast

Chemical compound

market. It is a phosphodiesterase inhibitor, selective for the subtypes PDE5, PDE6, PDE9 and PDE11. IC50 values are 0.76, 0.15, 29.0, and 12.0 μM, respectively

Zaprinast

Cyclic guanosine monophosphate

Chemical compound

used as a treatment for erectile dysfunction. However, the drug can inhibit PDE6 in retina (albeit with less affinity than PDE5). This has been shown to result

Cyclic guanosine monophosphate

Cyclic_guanosine_monophosphate

GAF domain

Protein domain

of the cyclic nucleotide phosphodiesterase superfamily: PDE2, PDE5, and PDE6 which bind cGMP to the GAF domain, PDE10 which binds cAMP, and PDE11 which

GAF domain

GAF_domain

Retina

Part of the eye

turn causes the Ga-subunit of the protein to activate a phosphodiesterase (PDE6), which degrades cGMP, resulting in the closing of Na+ cyclic nucleotide-gated

Retina

Visual phototransduction

Process by which light activates retinal cells

The alpha subunit-GTP complex activates phosphodiesterase, also known as PDE6. It binds to one of two regulatory subunits of PDE (which itself is a tetramer)

Visual phototransduction

Visual_phototransduction

PDE10A

Enzyme and protein-coding gene in humans

modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3". Cellular Signalling. 13 (10): 735–741. doi:10

PDE10A

Discovery and development of phosphodiesterase 5 inhibitors

Drug discovery

unintended effects of PDE5 inhibitors against other PDE isozymes, such as PDE1, PDE6 and PDE11. It is theorised that improved selectivity of PDE5 inhibitors may

Discovery and development of phosphodiesterase 5 inhibitors

Discovery_and_development_of_phosphodiesterase_5_inhibitors