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OLIG2

  • OLIG2
  • Protein found in humans

    Oligodendrocyte transcription factor (OLIG2) is a basic helix-loop-helix (bHLH) transcription factor encoded by the OLIG2 gene. The protein is of 329 amino

    OLIG2

    OLIG2

    OLIG2

  • Gloria Choi
  • South Korean neuroscientist and neuroimmunologist

    co-first author highlighted the finding that the transcription factor, Olig2, sequentially defines motor neuron and oligodendrocyte fate specification

    Gloria Choi

    Gloria Choi

    Gloria_Choi

  • Glioblastoma
  • Aggressive type of brain cancer

    biomarkers is unreliable. IDH-wildtype glioblastomas usually have lower OLIG2 expression compared with IDH-mutant lower grade astrocytomas. In patients

    Glioblastoma

    Glioblastoma

    Glioblastoma

  • Motor neuron
  • Nerve cell sending impulse to muscle

    Transcription factors here include Pax6, OLIG2, Nkx-6.1, and Nkx-6.2, which are regulated by sonic hedgehog (Shh). The OLIG2 gene being the most important due

    Motor neuron

    Motor neuron

    Motor_neuron

  • Oligodendrocyte
  • Neural cell type

    are typically identified by their expression of the transcription factor OLIG2. Most oligodendrocytes develop during embryogenesis and early postnatal

    Oligodendrocyte

    Oligodendrocyte

    Oligodendrocyte

  • Basic helix–loop–helix
  • Protein structural motif

    NEUROG2; NEUROG3; NHLH1; NHLH2; NPAS1; NPAS2; NPAS3; NPAS4; OAF1; OLIG1; OLIG2; OLIG3; PTF1A; SCL; SCXB; SIM1; SIM2; SOHLH1; SOHLH2; SREBF1; SREBF2; TAL1;

    Basic helix–loop–helix

    Basic helix–loop–helix

    Basic_helix–loop–helix

  • Human brain
  • Central organ of the human nervous system

    GFAP and S100B whereas myelin basic protein and the transcription factor OLIG2 are expressed in oligodendrocytes. Cerebrospinal fluid is a clear, colourless

    Human brain

    Human brain

    Human_brain

  • Oligodendroglioma
  • Medical condition

    differentiation obsolete in the future. Although, in normal brain tissue, OLIG2 expresses on oligodendrocytes but not on mature astrocytes, it expresses

    Oligodendroglioma

    Oligodendroglioma

    Oligodendroglioma

  • Neural tube
  • Developmental precursor to the central nervous system

    Retinoic acid is required ventrally along with Shh to induce Pax6 and Olig2 during differentiation of motor neurons. Three main ventral cell types are

    Neural tube

    Neural tube

    Neural_tube

  • OLIG1
  • Protein-coding gene in the species Homo sapiens

    humans is encoded by the OLIG1 gene. Oligodendrocyte Transcription factor OLIG2 GRCh38: Ensembl release 89: ENSG00000184221 – Ensembl, May 2017 GRCm38:

    OLIG1

    OLIG1

    OLIG1

  • Sonic hedgehog protein
  • Critical protein in embryonic development

    expresses a highly individualized combination of transcription factors—Nkx2.2, Olig2, Nkx6.1, Nkx6.2, Dbx1, Dbx2, Irx3, Pax6, and Pax7—that is regulated by the

    Sonic hedgehog protein

    Sonic hedgehog protein

    Sonic_hedgehog_protein

  • Chromosome 21
  • Human chromosome

    receptor-interacting protein 1 OLIG1: encoding oligodendrocyte transcription factor 1 OLIG2: encoding oligodendrocyte transcription factor 2 PAXBP1: encoding protein

    Chromosome 21

    Chromosome 21

    Chromosome_21

  • Mount Sinai Hospital (Manhattan)
  • Hospital and academic medical center in New York City

    Adolfo García-Sastre, Peter Palese and colleagues for modern research.   OLIG2 gene linked to schizophrenia is discovered. Proteins associated with ALS

    Mount Sinai Hospital (Manhattan)

    Mount Sinai Hospital (Manhattan)

    Mount_Sinai_Hospital_(Manhattan)

  • Stem-cell therapy
  • Use of stem cells to treat or prevent a disease or condition

    remyelination detected by Myelin Basic Proteins, positive differentiation into Olig2 positive oligodendrocytes, prevented the glial scar formation and restored

    Stem-cell therapy

    Stem-cell_therapy

  • Remyelination
  • Natural partial recreation of myelin sheaths in the brain

    dysregulation. Possible genes involved inside this pathway are TCF4 and OLIG2 which are both expressed in high amounts in areas where remyelination has

    Remyelination

    Remyelination

  • Oligodendrocyte progenitor cell
  • Subtype of glial cell in the central nervous system

    of Olig1 and Olig2 in neuroepithelial cells of the pMN and p3 domains of the ventral ventricular zone. Together, Nkx2.2 and Olig1/Olig2 drive OPC specification

    Oligodendrocyte progenitor cell

    Oligodendrocyte_progenitor_cell

  • List of human transcription factors
  • ENSG00000184221 bHLH Known motif – High-throughput in vitro [658] AVCATATGKT OLIG2 ENSG00000205927 bHLH Known motif – High-throughput in vitro [659] AMCATATGKY

    List of human transcription factors

    List_of_human_transcription_factors

  • David Rowitch
  • Neuroscientist and pediatrician

    and multiple sclerosis. His laboratory was the first to isolate Olig1 and Olig2, two related bHLH transcription factors which are essential for the differentiation

    David Rowitch

    David_Rowitch

  • Proneural genes
  • of scute (lsc) vertebrates E-12 Math1, Math5 Nato3 Beta3, Beta4, Olig1, Olig2, Olig3 NeuroD1 (NeuroD), NeuroD2 (Ndrf), NeuroD4 (Math3), NeuroD6 (Math2

    Proneural genes

    Proneural_genes

  • Neurogenins
  • Protein family

    reduced by inhibiting Nkx2.2 and Olig2 in neural progenitors while allowing the expression of Ngn2. The ability of Olig2 to induce expression of Ngn2 is

    Neurogenins

    Neurogenins

  • NKX2-2
  • Protein-coding gene in the species Homo sapiens

    Rowitch DH, Stiles CD (Oct 2003). "Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with

    NKX2-2

    NKX2-2

    NKX2-2

  • Rhombomere
  • Transient structure in animal development

    decrease in expression of Olig2, while when the Gli2 protein was mutated, the expression of Olig2 was not detected. Olig2 is normally expressed in the

    Rhombomere

    Rhombomere

  • C8orf48
  • Protein-coding gene in the species Homo sapiens

    Chemistry. 277 (30): 26761–8. doi:10.1074/jbc.M202078200. PMID 12004059. "OLIG2 oligodendrocyte lineage transcription factor 2 [Homo sapiens (human)] -

    C8orf48

    C8orf48

    C8orf48

  • List of human protein-coding genes 5
  • Q68BL8 11046 OLFML3 HGNC:24956; Q9NRN5 11047 OLIG1 HGNC:16983; Q8TAK6 11048 OLIG2 HGNC:9398; Q13516 11049 OLIG3 HGNC:18003; Q7RTU3 11050 OLR1 HGNC:8133; P78380

    List of human protein-coding genes 5

    List_of_human_protein-coding_genes_5

  • LMO1
  • Protein-coding gene in the species Homo sapiens

    PMC 528928. PMID 15489334. Lin YW, Deveney R, Barbara M, et al. (2005). "OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in

    LMO1

    LMO1

    LMO1

  • Myelinoid
  • Line of stem cells for research

    causing a substantial increase in their numbers which express SOX6, SOX10 and OLIG2, markers of glial induction and OPC specification. As the myelin organoid

    Myelinoid

    Myelinoid

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Online names & meanings

  • Abhaya Prada | அபயப்ரதா 
  • Boy/Male

    Tamil

    Abhaya Prada | அபயப்ரதா 

    Bestowed of safety, Another name of Lord Vishnu

  • Eish
  • Boy/Male

    Indian

    Eish

    God

  • DRACUL
  • Male

    Romanian

    DRACUL

     Romanian name DRACUL means "devil" or "dragon."

  • Payodhara | பயோதரா
  • Girl/Female

    Tamil

    Payodhara | பயோதரா

    Cloud

  • Nasuh |
  • Boy/Male

    Muslim

    Nasuh |

    Advised, Suggested, Sincere, Faithful

  • Wheelhouse
  • Surname or Lastname

    English (Yorkshire and East Midlands)

    Wheelhouse

    English (Yorkshire and East Midlands) : topographic name composed of Middle English whele ‘wheel’ + hous ‘house’. According to Reaney, the reference is often to a house near a dammed-up stream where a cutler ground his knives on a small water-wheel. The compound is not attested as a vocabulary word in this or any other sense before the 19th century, although the surname William de Whelehous is found in 1379.

  • parineetha | பரீநீதா
  • Girl/Female

    Tamil

    parineetha | பரீநீதா

    Married woman

  • Surina
  • Girl/Female

    Sikh

    Surina

    A Goddess

  • Tripp
  • Boy/Male

    American, British, English

    Tripp

    Traveler

  • Biboswan | பீபோஸ்வாந
  • Boy/Male

    Tamil

    Biboswan | பீபோஸ்வாந

    Sun God

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OLIG2

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OLIG2