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How an organism receives and responds to painful stimuli
In physiology, nociception /ˌnəʊsɪˈsɛpʃ(ə)n/, also nocioception (from Latin nocere 'to harm/hurt'), is the sensory nervous system's process of encoding
Nociception
Type of unpleasant bodily feeling
postherpetic neuralgia. Nociplastic pain is pain characterized by a changed nociception (but without evidence of real or threatened tissue damage, or without
Pain
Test to measure pain
A nociception assay (nocioception or nocioperception assay) evaluates the ability of an animal, usually a rodent, to detect a noxious stimulus such as
Nociception_assay
flinching or withdrawal of a limb. Nociception is found, in one form or another, across all major animal taxa. Nociception can be observed using modern imaging
Pain_in_fish
Sensory neuron that detects pain
body part, so the threat can be mitigated; this process is called nociception. Nociception and pain are usually evoked only by pressures and temperatures
Nociceptor
Cluster of neurons in a dorsal root of a spinal nerve
expressed by DRG sensory neurons and might play a role in acid-induced nociception. The nerve endings of dorsal root ganglion neurons have a variety of
Dorsal_root_ganglion
numerous definitions of pain, almost all involve two key components. First, nociception is required. This is the ability to detect noxious stimuli which evokes
Pain_in_invertebrates
been shown to be expressed in small-diameter neurons responsible for nociception where they may play a role in acid-induced pain sensation. Acid-sensing
Proton-sensing G protein-coupled receptors
Proton-sensing_G_protein-coupled_receptors
cord and not involving the brain. Nociception is found, in one form or another, across all major animal taxa. Nociception can be observed using modern imaging
Pain_in_crustaceans
Human protein for regulating body temperature
In addition, TRPV1 provides a sensation of scalding heat and pain (nociception). In primary afferent sensory neurons, it cooperates with TRPA1 (a chemical
TRPV1
Sensation and perception of temperature
Mechanoreceptor – Sensory receptor cell responding to mechanical pressure or strain Nociception – How an organism receives and responds to painful stimuli Proprioception –
Thermoception
Degeneration of a weight-bearing joint due to loss of sensation
swelling around a joint in the presence of neuropathy with impaired nociception. Although counterintuitive, deep dull pain may be present upon load bearing
Neuropathic_arthropathy
Protein-coding gene in the species Homo sapiens, named for ketazocine
for mediating the effects of these compounds. These include altering nociception, mood, reward system, and motor control. KOR is one of the two opioid
Κ-opioid_receptor
Chronic disease caused by bacterial infection
respiratory tract, skin, and eyes. This nerve damage may result in the loss of nociception, which can lead to the loss of parts of a person's extremities from repeated
Leprosy
British neurobiologist
Nicholas Wood FRS is a British neurobiologist, and Head of the Molecular Nociception Group, at University College London. John N. Wood B.Sc., M.Sc., Ph.D
John_Nicholas_Wood
Nerve system for sensing touch, temperature, body position, and pain
special senses of sight, smell, taste, hearing, and balance. One for the nociception detection of pain and temperature. Nociceptory information is that received
Somatosensory_system
Pentapeptide
An enkephalin is a pentapeptide involved in regulating nociception (pain sensation) in the body. The enkephalins are termed endogenous ligands, as they
Enkephalin
Neurological condition involving the crossing of senses
traditional senses, though it can also include other perceptions, such as nociception, thermoception, chronoception, and interoception. People with synesthesia
Synesthesia
Physiological capacity
humans include spatial orientation, proprioception (body position) and nociception (pain). Further internal senses lead to signals such as hunger, thirst
Sense
Type of nerve fiber carrying sensory signals
temperature, mechanical stimuli (touch, pressure, stretch) or danger (nociception). Thus, different free nerve endings work as thermoreceptors, cutaneous
Free_nerve_ending
the oldest examples is probably the Greeks' theory of beneception and nociception. They believed that these two principles decided the motivation in all
Hedonic_motivation
Three columns of grey matter within the spinal cord
important in nociception, laminae III and IV are not involved nociception, and lamina V is involved in both nociception and non-nociception. The function
Grey_columns
studying nociception. Many other vertebrate and invertebrate animals also show nociceptive reflex responses similar to our own. Nociception usually involves
Pain_in_animals
Chemical compound
and modulates GABAA receptor activity. Yangonin significantly reduces nociception and inflammatory hyperalgesia via spinal CB1 receptors in rats, highlighting
Yangonin
Points on body used in traditional Chinese and Ayurvedic medicine
death have been harshly criticized.[failed verification] Chakra Dantian Nociception Chinese: 穴位; pinyin: xuéwèi Japanese: 急所, romanized: kyūsho, lit. 'tender
Pressure_point
Layer of connective tissue in the body
these features enable fascia to participate in repair, inflammation, and nociception. Examples of deep fascia are fascia lata, fascia cruris, brachial fascia
Fascia
Conversion of sensory stimuli
also includes the sensory transduction related to thermoception and nociception. Lodish, Harvey F. (2000). Molecular cell biology (4th ed.). New York:
Transduction_(physiology)
Drugs that lower neurotransmission levels, reducing brain activity
protein-coupled receptor. The nociception receptor controls a wide range of biological functions, including nociception, food intake, memory processes
Depressant
Family of translocation methylcytosine dioxygenases
article Nociception, nociception is the sensory nervous system's response to harmful stimuli, such as a toxic chemical applied to a tissue. In nociception, chemical
TET_enzymes
flinching or withdrawal of a limb. Nociception is found, in one form or another, across all major animal taxa. Nociception can be observed using modern imaging
Pain_in_cephalopods
The enteric glial cells play a variety of roles, such as modulating nociception (pain sensation), exerting immune functions, and coordinating gastrointestinal
Enteric_glia
Ability to experience feelings and sensations
and send signals to the brain. Nociception is widespread among animals, even among insects. The presence of nociception indicates an organism's ability
Sentience
Neurological pain disorder
data such as tactition (pressure), thermoception (temperature), and nociception (pain) originating from the face above the jawline; it is also responsible
Trigeminal_neuralgia
Stimulus that may damage tissue
organism. The ability to perceive noxious stimuli is a prerequisite for nociception, which itself is a prerequisite for nociceptive pain. A noxious stimulus
Noxious_stimulus
flinching or withdrawal of a limb. Nociception is found, in one form or another, across all major animal taxa. Nociception can be observed using modern imaging
Pain_in_amphibians
Species of wasp
abundant venom peptide found in D.occidentalis venom is Do6a, which induces nociception in Drosophila larvae. Both sexes make a squeaking noise (stridulation)
Dasymutilla_occidentalis
(1994) H. Robert Horvitz, biologist, Nobel Prize (2002) David Julius, nociception, Nobel Prize (2021) Eric Kandel, biologist, Nobel Prize (2000) C. Henry
List of Jewish American biologists and physicians
List_of_Jewish_American_biologists_and_physicians
Nerve cell that converts environmental stimuli into corresponding internal stimuli
by sending signals to the spinal cord and brain. This process, called nociception, usually causes the perception of pain. They are found in internal organs
Sensory_neuron
Comparison of equivalent doses of pain medications
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for
Equianalgesic
American mass murderer (1992–2012)
blunted affect, alogia, anhedonia, sensory sensitivities, and decreased nociception. Because of concerns that published accounts of Lanza's autism could
Adam_Lanza
Excessive focus on distressing physical symptoms
sensations. Pain is a multifaceted experience, not just a sensation. While nociception refers to afferent neural activity that transmits sensory information
Somatic_symptom_disorder
Drugs used to achieve relief from pain
(December 1995). "Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance". Neurology. 45 (12 Suppl 8). NEUROLOGY, 2005:
Analgesic
Chemical compound
antinociceptive and anti-inflammatory properties in 2 models of persistent nociception via activation of the cannabinoid receptors CB1 and CB2 and by inhibiting
Amyrin
Protein-coding gene in the species Homo sapiens
small-diameter sensory neurons called C-fibres, and is involved in nociception. C-fibres can be activated by noxious thermal or mechanical stimuli and
Nav1.8
Class of transmembrane proteins
Cardiovascular Function Emesis Heart Rate Impulsivity Memory Mood Nausea Nociception Penile Erection Pupil Dilation Respiration Sexual Behavior Sleep Sociability
5-HT_receptor
Common strain of laboratory mouse
et al. (March 1999). "Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception". Pain. 80 (1–2): 67–82. doi:10
C57BL/6
Neuron cluster of the medulla
brain areas that are important for controlling autonomic activity and nociception. Jeffrey D Blaustein (2006). Handbook of Neurochemistry and Molecular
Nucleus_paragigantocellularis
Sensory system that receives and integrates information from the body
stimuli, like light, touch, sound, and odor. He classified temperature and nociception as exteroceptive sensations as well, though these are now regarded as
Interoception
Pain that lasts longer than three months
Chronic pain is pain that persists or recurs for longer than 3 months. It is also described as burning, electrical, throbbing, or nauseating pain. This
Chronic_pain
French culinary dish
gavage" (PDF). FAF SAS. Serviere, J, Bernadet, MD and Guy, G. 2003. "Is nociception a sensory component associated with force-feeding? Neurophysiological
Foie_gras
Core tendency of sadomasochism
Algolagniacs may have DNA errors such as SCN9A, causing inaccurate nociception to occur. At least one researcher in the 1900s, Albert Freiherr von Schrenck-Notzing
Algolagnia
Complete separation of the head from the body
in EEG indices over a period of 10 seconds that have been linked to nociception across a number of different species of animals, including rats. Some
Decapitation
Stimulant
1996). "The effects of systemic procaine, lidocaine and dimethocaine on nociception in mice". General Pharmacology. 27 (4): 647–50. doi:10.1016/0306-3623(95)02079-9
Dimethocaine
Reflex of the human foot
beyond age 2–3 indicates a problem in the brain or spinal cord. Afferent: Nociception detected in the S1 dermatome and travels up the tibial nerve to the sciatic
Plantar_reflex
Peptide hormone in animals
a potent peptide vasodilator and can function in the transmission of nociception. In the spinal cord, the function and expression of CGRP may differ depending
Calcitonin gene-related peptide
Calcitonin_gene-related_peptide
Genus of flowering plants
extract of Narcissus bulbs was found effective in one mouse model of nociception, para-benzoquinone induced abdominal constriction, but not in another
Narcissus_(plant)
Type of passive movement of a skeletal joint
arthrokinematic joint play. Activates Type I mechanoreceptors that inhibit nociception and provide information regarding joint position. They have a low threshold
Joint_mobilization
American physiologist and Nobel laureate 2021
chemicals. David Julius's lab has also made contributions to the study of nociception by discovering toxins that modulate these channels, describing unique
David_Julius
Chemical compound
(TRPV1) in a subpopulation of primary afferent sensory neurons involved in nociception, the transmission of physiological pain. TRPV1 is an ion channel in the
Resiniferatoxin
innocence, innocent, innocuity, innocuous, innoxious, nocebo, nocent, nociception, nociceptive, nocifensor, nocument, nocuous, noxious, nuisance, obnoxious
List of Greek and Latin roots in English/N
List_of_Greek_and_Latin_roots_in_English/N
Area of applied ethics
considerable. Jones reviews neurophysiological and behavioural work on nociception and opioid systems, distinguishes moral considerability from degrees
Ethics_of_uncertain_sentience
Regulation of neurons by neurotransmitters
spinal cordbehavior behavior mood satiety body temperature sleep decrease nociception rostral dorsal raphe nucleus Serotonin receptors in: thalamus striatum
Neuromodulation
Protein-coding gene in the species Homo sapiens
recent research has highlighted its involvement in itch and pain, or nociception. The nociceptive activity of cathepsin S results from its role as a signaling
Cathepsin_S
Species of mammal
Le Bars D, Gozariu M, Cadden SW (December 2001). "Animal models of nociception". Pharmacological Reviews. 53 (4): 597–652. doi:10.1016/S0031-6997(24)01514-X
House_mouse
Medical condition for inability to feel pain
Ebner D, Tracey I, Serra J, Bennett DL (March 2019). "V1.7 in Human Nociception". Neuron. 101 (5): 905–919.e8. doi:10.1016/j.neuron.2019.01.047. PMC 6424805
Congenital insensitivity to pain
Congenital_insensitivity_to_pain
Senses with specialized organs
includes mechanoreception (pressure, vibration and proprioception), pain (nociception) and heat (thermoception), and such information is carried in general
Special_senses
State of medically-controlled temporary loss of sensation or awareness
inadequate anxiolysis or sedation rather than a failure of the block itself. Nociception (pain sensation) is not hard-wired into the body. Instead, it is a dynamic
Anesthesia
Chemical substance that enables neurotransmission
homeostasis medullary control of respiration negative emotional memory nociception (perception of pain) reward (minor role) Dopamine system Dopaminergic
Neurotransmitter
Dopamine agonist medication
chronic pain, which is mediated through three different mechanisms: nociception, neuropathy and nociplasty. In animal models, it was shown that pramipexole
Pramipexole
Chemical compound
osteoarthritis isovaline restored mobility, suggesting inhibition of nociception by isovaline in the synovial membrane of the mouse knee. Isovaline does
Isovaline
Pain response test
proposed by Eddy and Leimbach in 1953. They used a behavioral model of nociception where behaviors such as jumping and hind paw-licking are elicited following
Hot_plate_test
Species of plant
with a vanilloid receptor on primary sensory neurons mediating pain (nociception) and neurogenic inflammation. The pain sensing cation channel is TRPV1
Euphorbia_resinifera
Organic compound involved in immune responses
nerves • CNS: Sleep-wake cycle (promotes wakefulness), body temperature, nociception, endocrine homeostasis, regulates appetite, involved in cognition •
Histamine
American radio broadcaster and writer
a double-blind randomised trial using audiotapes for intra-operative nociception control". Anaesthesia. 54 (8): 769–73. doi:10.1046/j.1365-2044.1999.00958
Robert_Monroe
Action used to slow down the heart rate by stimulating the vagus nerve
decrease temporary pain through sinoaortic baroreceptor mediated anti-nociception (inhibition of pain conduction, release of substance P and noradrenaline)
Vagal_maneuver
Hyperirritable spots in skeletal muscle
widespread pain and tenderness and is described as a central augmentation of nociception giving rise to deep tissue tenderness that includes muscles. Myofascial
Myofascial_trigger_point
Physiology and biochemistry of insect organ systems
and transmit sensations of pain) in insects, though recent findings of nociception in larval fruit flies challenges this and proves that all insects are
Insect_physiology
Medication used for migraines & cluster headaches
medication overuse headache in patients with migraine: An unsolved riddle in nociception". Neurobiology of Pain. 17 100179. doi:10.1016/j.ynpai.2025.100179. ISSN 2452-073X
Sumatriptan
humans can sense balance and acceleration (equilibrioception), pain (nociception), body and limb position (proprioception or kinesthetic sense), and relative
List of common misconceptions about science, technology, and mathematics
List_of_common_misconceptions_about_science,_technology,_and_mathematics
Synthetic opioid analgesic
although an increase in the dosage in cats can achieve analgesia and anti-nociception. Hyperalgesia and tolerance has been demonstrated in rodents and rabbits
Remifentanil
Type of data
modalities Gustation (taste) Olfaction (smell) Thermoception (heat) Nociception (pain) Equilibrioception (balance) Any human sense can be used as a computer
Modality (human–computer interaction)
Modality_(human–computer_interaction)
sheath of axons that allow for saltatory conduction of action potentials. Nociception The sensory perception of pain, including detection of noxious stimuli
Glossary_of_neuroscience
Species of fish
exposure to warm water causes instant behavioural responses indicative of nociception or pain in Atlantic salmon". Veterinary and Animal Science. 8 100076
Atlantic_salmon
Raising and breeding insects as livestock
nociception. According to Lars Chittka, "almost every time scientists search for insect nociception, they find it." Insects shown to have nociception
Insect_farming
Decreased movement due to basal ganglia dysfunction
nociception FQ peptide (NOP) receptor antagonists. This treatment has been shown to reduce hypokinesia in animal studies when increasing nociception FQ
Hypokinesia
Mouse used for scientific research
Marshall (March 1999). "Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception". Pain. 80 (1): 67–82. doi:10
Laboratory_mouse
Mating practice in invertebrates
2009. Retrieved 2009-04-07. In the majority of examples of invertebrate nociception noted above, there seems to be little, if any, evidence that the animals'
Traumatic_insemination
Terrestrial invertebrate, order Opisthopora
a nervous system is essential for an animal to be able to experience nociception or pain. However, other physiological capacities are also required such
Earthworm
Chemical compound (polypeptide neurotransmitter)
dendritic arborisation, respiratory rhythm, neurotoxicity, pain, and nociception. In 2014, it was found that substance P played a role in male fruit fly
Substance_P
Region of the brain which processes touch
contralateral hemihypesthesia and astereognosis. It could also reduce nociception, thermoception, and crude touch, but, since information from the spinothalamic
Primary_somatosensory_cortex
Pain affecting the somatosensory nervous system
central mechanisms of neuropathic pain involve several major pathways. Nociception is ordinarily transduced by a polysynaptic path through the spinal cord
Neuropathic_pain
Medical condition
feet have a dryness of the skin and a reduced ability to feel pain (nociception). Hence, minor injuries may remain undiscovered and subsequently progress
Diabetic_foot
Chemical compound
hypersensitivity, further validating the role of the CB2 receptor in nociception. MDMB-FUBINACA (similar structure but agonist at both CB1 and CB2 receptors)
Olorinab
Chemical compound
(February 2013). "Blockade of TRPA1 with HC-030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide
HC-030031
Technique to induce the absence of sensation in a specific part of the body
anesthetic is a drug that causes reversible local anesthesia and a loss of nociception. When it is used on specific nerve pathways (nerve block), effects such
Local_anesthesia
Ability of a firearm or other weapon to cause immediate incapacitation
killers, alcohol, and PCP have all been known to decrease the effects of nociception and increase a person's resistance to incapacitation, all while having
Stopping_power
Class of transport proteins
mechanical stimulation of the cuticle and sound detection) and cold nociception. TRPP, P for "polycistin", is named for polycystic kidney disease, which
Transient receptor potential channel
Transient_receptor_potential_channel
Medical symptom or condition
bulimia nervosa Depression Drug withdrawal Other Post-operative vomiting Nociception Altitude sickness Mast cell activation syndrome Drugs Chemotherapy Antibiotics
Nausea
Protein and coding gene in humans
sub-population of peripheral C-fibers are considered important sensors of nociception in humans, and their activation will under normal conditions give rise
TRPA1
Canadian neuroscientist (born 1966)
Greg I (1999). "Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception". Pain. 80 (1): 67–82. doi:10
Jeffrey_Mogil
NOCICEPTION
NOCICEPTION
NOCICEPTION
NOCICEPTION
Boy/Male
Indian
Radiant
Boy/Male
Welsh
Chief.
Boy/Male
English
From the bean field.
Female
German
 Pet form of German Elsabeth, ELSA means "God is my oath."
Girl/Female
Indian
Queen of Snakes
Girl/Female
Arabic, Muslim
Pleasant
Boy/Male
Indian
Lord of Gold
Boy/Male
Hindu, Indian, Marathi
Worthy of Praise
Male
African
seemed destined to die at birth.
Boy/Male
Biblical
Ancient, sleeping.
NOCICEPTION
NOCICEPTION
NOCICEPTION
NOCICEPTION
NOCICEPTION