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METAP2

METAP2

Protein-coding gene in humans

Methionine aminopeptidase 2 is an enzyme that in humans is encoded by the METAP2 gene. Methionine aminopeptidase 2, a member of the dimetallohydrolase family

METAP2

Fumarranol

Chemical compound

which acts as an inhibitor of the type 2 methionine aminopeptidase enzyme METAP2. It was derived by structural modification of the natural product fumagillin

Fumarranol

BeOne Medicines

Global biotechnology company

Pharmaceuticals worked together to assess the efficacy and quality of Asieris's MetAP2 inhibitor and BeOne's PD-L1 inhibitor for bladder cancer patients. Novartis

BeOne Medicines

BeOne_Medicines

Methionyl aminopeptidase

Class of enzymes

and eukaryotes. Human proteins possessing this activity include METAP1, METAP2, METAP1D (mitochondrial), and RNPEPL1. Yoshida A, Lin M (1972). "NH2-terminal

Methionyl aminopeptidase

Methionyl_aminopeptidase

Nitroxoline

Antibiotic chemical compound

shown to have antiangiogenic properties. For example, nitroxoline inhibits MetAP2 activity, an enzyme associated with angiogenesis, and HUVEC proliferation

Nitroxoline

TNP-470

Chemical compound

TNP-470 is an methionine aminopeptidase 2 inhibitor. Although it was one of the first angiogenesis inhibitor tested in clinical trials, its potential was

TNP-470

Beloranib

Chemical compound

METAP2. It was originally designed as angiogenesis inhibitor for the treatment of cancer. However, once the potential anti-obesity effects of METAP2 inhibition

Beloranib

ZGN-1061

Chemical compound

ZGN-1061 is an experimental drug that was developed by Zafgen for treatment of obesity and type 2 diabetes. It has a similar mechanism of action as the

ZGN-1061

Protein kinase R

Human protein and coding gene

Protein kinase R has been shown to interact with: ASK1, DNAJC3, ILF3, METAP2, P53, PPP1CA, PRKRA, STAT1, and TARBP2. GRCh38: Ensembl release 89: ENSG00000055332

Protein kinase R

Protein_kinase_R

Stress granule

Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress

replication licensing factor MCM7 yes METAP1 METAP1 Methionine aminopeptidase METAP2 METAP2 Methionyl Aminopeptidase 2 MCRIP1 FAM195B/GRAN2 Granulin-2 MCRIP2 FAM195A/GRAN1

Stress granule

Stress_granule

List of human protein-coding genes 5

P08581 9473 METAP1 HGNC:15789; P53582 9474 METAP1D HGNC:32583; Q6UB28 9475 METAP2 HGNC:16672; P50579 9476 METRN HGNC:14151; Q9UJH8 9477 METRNL HGNC:27584;

List of human protein-coding genes 5

List_of_human_protein-coding_genes_5