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ENDOTYPE

  • Endotype
  • Subtype of a health condition

    An endotype is a subtype of a health condition, which is defined by a distinct functional or pathobiological mechanism. This is distinct from a phenotype

    Endotype

    Endotype

  • Cause (medicine)
  • Reason for or origin of a disease or pathology

    nasopharyngeal carcinoma, or Burkitt's lymphoma.[citation needed] An endotype is a subtype of a condition, which is defined by a distinct functional

    Cause (medicine)

    Cause_(medicine)

  • Heterogeneous condition
  • Descriptor of disease

    into endotypes based on etiology. Where necessary to determine appropriate treatment, differential diagnosis procedures are employed. An endotype is a

    Heterogeneous condition

    Heterogeneous_condition

  • Asthma
  • Long-term inflammatory disease of the airways of the lungs

    main endotypes there are subpopulations (phenotypes), some of which overlap or can be categorized under both of the two endotypes. The two endotypes are

    Asthma

    Asthma

    Asthma

  • Asthma phenotyping and endotyping
  • Medical classification of asthma

    Asthma phenotyping and endotyping is a novel approach to asthma classification inspired by precision medicine. It seeks to separate the clinical presentations

    Asthma phenotyping and endotyping

    Asthma_phenotyping_and_endotyping

  • Microvascular angina
  • Medical condition

    dysfunction endotype (inability to dilate) tend to have a high vascular tone at rest and high vascular tone at stress. Patients with this endotype typically

    Microvascular angina

    Microvascular_angina

  • Chronic obstructive pulmonary disease
  • Lung disease involving long-term poor airflow

    clinical practice. An endotype links such observable traits to underlying mechanisms. One phenotype may be related to multiple endotypes. A genotype is based

    Chronic obstructive pulmonary disease

    Chronic obstructive pulmonary disease

    Chronic_obstructive_pulmonary_disease

  • Dupilumab
  • Drug used to treat allergic diseases

    August 2025. Platt MP, Gray ST, Peters AT (August 2025). "Phenotype to Endotype-The Future of Chronic Rhinosinusitis". JAMA. 334 (11): 955. doi:10.1001/jama

    Dupilumab

    Dupilumab

    Dupilumab

  • Phenotype (clinical medicine)
  • Presentation of a disease

    presentation of a disease. The complementary concept in this regard is endotype, which refers to the pathogenesis of the disease ignoring its presentation

    Phenotype (clinical medicine)

    Phenotype_(clinical_medicine)

  • Odontogenic sinusitis
  • Infectious disease

    Keller, Christian; Bobbitt, Kevin R.; Ramesh, Mayur (2023). "Inflammatory endotype of odontogenic sinusitis". International Forum of Allergy & Rhinology.

    Odontogenic sinusitis

    Odontogenic sinusitis

    Odontogenic_sinusitis

  • Hypersensitivity
  • Overreaction of the immune system to an antigen

    Usually days–weeks; often chronic relapsing. Atopic dermatitis endotypes asthma/CRS T2 endotypes eosinophilic esophagitis DRESS Cell-mediated Type IVc (cell-mediated

    Hypersensitivity

    Hypersensitivity

    Hypersensitivity

  • Pectinase
  • Class of enzymes

    alcohol + acetate RG-I PUL PL9 EC4.2.2.23 Rhamnogalacturonan endolyase Endotype eliminative cleavage of L-α-rhamnopyranosyl-(1 → 4)-α-D-galactopyranosyluronic

    Pectinase

    Pectinase

  • Nosology
  • Branch of medicine that deals with classification of diseases

    understood as a nonspecific finding shared by a group of disease entities or endotypes. For example, concepts such as murrain and the grippe that were formerly

    Nosology

    Nosology

  • Allergy
  • Immune system response to a substance that most people tolerate well

    immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes". Paediatric Respiratory Reviews. 36: 118–127. doi:10.1016/j.prrv.2019

    Allergy

    Allergy

    Allergy

  • Sinusitis
  • Inflammation of the sinus' membranes

    heterogeneous, each with the ability to demonstrate three inflammatory endotypes, the third being a Th17 response. Sinusitis (or rhinosinusitis) is defined

    Sinusitis

    Sinusitis

    Sinusitis

  • Danielle Belgrave
  • Trinidadian-British computer scientist

    providing a framework for endotype discovery using probabilistic modelling. She uses statistical models to identify the underlying endotypes of a condition from

    Danielle Belgrave

    Danielle_Belgrave

  • Hidradenitis suppurativa
  • Human disease

    Ocker L, Stockfleth E, Haven Y, Myszkowski D, et al. (21 March 2025). "Endotyping Insulin–Glucose Homeostasis in Hidradenitis Suppurativa: The Impact of

    Hidradenitis suppurativa

    Hidradenitis suppurativa

    Hidradenitis_suppurativa

  • Airway remodelling
  • Asthma complication

    remodelling, or airway remodeling, is a potential complication of certain endotypes (subtypes) of asthma. It is the sum of changes that occur in the airways

    Airway remodelling

    Airway remodelling

    Airway_remodelling

  • Rhamnogalacturonan endolyase
  • -D-galactopyranosyluronate endolyase. catalyses the following process: Endotype eliminative cleavage of L-α-rhamnopyranosyl-(1→4)-α-D-galactopyranosyluronic

    Rhamnogalacturonan endolyase

    Rhamnogalacturonan_endolyase

  • Embryonal rhabdomyosarcoma
  • Most common soft-tissue cancer in children

    Rudzinski ER, et al. (2020). "Defining an embryonal rhabdomyosarcoma endotype". Cold Spring Harbor Molecular Case Studies. 6 (2) a005066. doi:10.1101/mcs

    Embryonal rhabdomyosarcoma

    Embryonal_rhabdomyosarcoma

  • Health eResearch Centre
  • research. Projects are grouped broadly into the following six themes: Endotype Discovery. By combining clinical and genetic data researchers are able

    Health eResearch Centre

    Health_eResearch_Centre

  • Functional endoscopic sinus surgery
  • Surgery to enlarge the paranasal sinus drainage pathways

    Zele T, Cardell LO, Arebro J, Olze H, et al. (May 2016). "Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers". Journal

    Functional endoscopic sinus surgery

    Functional endoscopic sinus surgery

    Functional_endoscopic_sinus_surgery

  • Disposition index
  • L, Stockfleth E, Haven Y, Myszkowski D, Bechara FG (21 March 2025). "Endotyping Insulin-Glucose Homeostasis in Hidradenitis Suppurativa: The Impact of

    Disposition index

    Disposition index

    Disposition_index

  • Cezmi Akdis
  • Medical Researcher

    regulatory NK Cells, 2008 Journal of Immunology. First studies mentioning endotypes of asthma and other allergic inflammatory diseases. Demonstration of human

    Cezmi Akdis

    Cezmi_Akdis

  • Mark G. Lebwohl
  • American professor of dermatology

    Lebwohl, Mark; Krueger, James G.; Guttman-Yassky, Emma (June 2019). "Blood endotyping distinguishes the profile of vitiligo from that of other inflammatory

    Mark G. Lebwohl

    Mark_G._Lebwohl

  • SPINA-GR
  • Insulin receptor gain, biomarker

    Haven, Yannik; Myszkowski, Daniel; Bechara, Falk G. (21 March 2025). "Endotyping Insulin–Glucose Homeostasis in Hidradenitis Suppurativa: The Impact of

    SPINA-GR

    SPINA-GR

  • SPINA-GBeta
  • Calculated biomarker

    Haven, Yannik; Myszkowski, Daniel; Bechara, Falk G. (21 March 2025). "Endotyping Insulin–Glucose Homeostasis in Hidradenitis Suppurativa: The Impact of

    SPINA-GBeta

    SPINA-GBeta

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