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ARNT2

ARNT2

Protein-coding gene in the species Homo sapiens

receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene. This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim

ARNT2

Amhara people

Semitic-speaking ethnic group in Ethiopia

involvement in high-altitude adaptation in Ethiopia, including CBARA1, VAV3, ARNT2 and THRB. Although most of these genes have not been identified in previous

Amhara people

Amhara_people

High-altitude adaptation in humans

adaptation of Ethiopians, including CBARA1, VAV3, ARNT2 and THRB. Two of these genes (THRB and ARNT2) are known to play a role in the HIF-1 pathway, a

High-altitude adaptation in humans

High-altitude_adaptation_in_humans

Tigrayans

Semitic-speaking ethnic group in Ethiopia

under positive selection in northern highlanders include CBARA1, VAV3, ARNT2, and THRB, all of which are associated with HIF‑1 pathways. Interestingly

Tigrayans

Basic helix–loop–helix

Protein structural motif

for C or T, R is A or G, M is A or C and K is G or T. AHR; AHRR; ARNT; ARNT2; ARNTL; ARNTL2; ASCL1; ASCL2; ASCL3; ASCL4; ATOH1; ATOH7; ATOH8; BHLHB2;

Basic helix–loop–helix

Basic_helix–loop–helix

Hypoxia-inducible factor

Protein that responds to low oxygen

aryl-hydrocarbon receptor nuclear translocator 2 Identifiers Symbol ARNT2 Alt. symbols HIF2B, KIAA0307, bHLHe1 NCBI gene 9915 HGNC 16876 OMIM 606036 RefSeq

Hypoxia-inducible factor

Hypoxia-inducible_factor

NPAS3

Protein-coding gene in the species Homo sapiens

proteins in the superfamily. It functions as an heterodimer by binding ARNT2, another member of the bHLH-PAS superfamily. NPAS3 harbors the largest cluster

NPAS3

List of human transcription factors

Known motif – from protein with 100% identical DBD – in vitro [31] KCACGTGM ARNT2 ENSG00000172379 bHLH Known motif – High-throughput in vitro [32] RDCACGTGM

List of human transcription factors

List_of_human_transcription_factors

Neuronal PAS domain protein 4

Protein-coding gene in the species Homo sapiens

helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function". PLOS ONE. 9 (1) e85768. Bibcode:2014PLoSO...985768B.

Neuronal PAS domain protein 4

Neuronal_PAS_domain_protein_4

Organisms at high altitude

Organisms capable of living at high altitudes

other genes appear to be involved in Ethiopians, including CBARA1, VAV3, ARNT2 and THRB, which are known to play a role in HIF genetic functions. The EPAS1

Organisms at high altitude

Organisms_at_high_altitude

List of human protein-coding genes 1

HGNC:19846; Q86TY3 1064 ARMS2 HGNC:32685; P0C7Q2 1065 ARNT HGNC:700; P27540 1066 ARNT2 HGNC:16876; Q9HBZ2 1067 ARPC1A HGNC:703; Q92747 1068 ARPC1B HGNC:704; O15143

List of human protein-coding genes 1

List_of_human_protein-coding_genes_1

Bruce Beutler

American immunologist and geneticist

Russell, Jamie; Beutler, Bruce (December 18, 2018). "A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis". Disease

Bruce Beutler

Bruce_Beutler

Sarah Tishkoff

American geneticist (born 1965)

different gene candidates underlying adaptation to high altitude (CBARA1, VAV3, ARNT2, and THRB). This study demonstrates another example of convergent evolution

Sarah Tishkoff

Sarah_Tishkoff