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  • Tet methylcytosine dioxygenase 1
  • translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene. Its function, regulation, and

  • TET enzymes
  • perception. The three related TET genes, TET1, TET2 and TET3 code respectively for three related mammalian proteins TET1, TET2, and TET3. All three proteins

  • Epigenetics
  • recruits the demethylating enzyme TET1 to an association, and brings TET1 to about 600 locations on the genome where TET1 can then demethylate and activate

  • Reactive oxygen species
  • expression of a gene. A major enzyme involved in demethylating 5mCpG is TET1. However, TET1 is only able to act on 5mCpG if an ROS has first acted on the guanine

  • Transcription (biology)
  • EGR1 proteins are up-regulated and they bind to (recruit) the pre-existing TET1 enzymes that are produced in high amounts in neurons. TET enzymes can catalyse

  • DNA repair
  • guanine within a methylated CpG site it recruits TET1 to the 8-OHdG lesion (see Figure). This allows TET1 to demethylate an adjacent methylated cytosine

  • CpG site
  • without immediate excision. OGG1, present at a 5mCp-8-OHdG site recruits TET1 and TET1 oxidizes the 5mC adjacent to the 8-OHdG. This initiates demethylation

  • Tet methylcytosine dioxygenase 2
  • tissues and Tahiliani et al. demonstrated the TET1-dependent conversion of 5mC to 5hmC. A role for TET1 in cancer was reported in 2003 showing that it

  • DNA damage (naturally occurring)
  • 5mCp-8-OHdG site recruits TET1, and TET1 oxidizes the 5mC adjacent to the 8-OHdG. This initiates de-methylation of 5mC. TET1 is a key enzyme involved in

  • 8-Oxo-2'-deoxyguanosine
  • form 8-oxo-dG is an important first step. TET1 is a key enzyme involved in demethylating 5mCpG. However, TET1 is only able to act on 5mCpG if an ROS has

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Astrological/horoscope meaning of tet1. tet1 means: undefined

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    T: Meaning of T in the acronym tet1 means: T is a vertical strand crossed at the top by a horizontal strand. With the top strand balanced in the middle by the vertical strand, T shows balance and stability in its ways. It is also forgoing and spiritual. With the top strand projected up by the bottom strand, T is highly ambitious, but also kind to others as it can let others rest on its horizontal top. This makes T selfless, cooperative, womanly and dutiful. It also displays a high degree of generosity and liberalism.

    E: Meaning of E in the acronym tet1 means: The letter E has three branches of equal lenghts. These all extend from it's left side. The equal lenghts show a degree of fairness to the outside world. They extend outwards indicating a willingness to learn, think broadly and be more vigorous in understanding. B also implies endowed with good writing abilities, eloquence, resourcefulness. It displays a unique artistic nature and strong enthusaism to get out and know more.

    1: Meaning of 1 in the acronym tet1 means: undefined

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