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  • Protein
  • sites for other proteins. For instance, SH3 domains typically bind to short PxxP motifs (i.e. 2 prolines [P], separated by two unspecified amino acids [x]

  • P53
  • genes. This domain is followed by the proline rich domain (PXXP), whereby the motif PXXP is repeated (P is a proline and X can be any amino acid). It

  • SH3BP4
  • gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation

  • Protein–protein interaction
  • recognize proline enriched sequences, as polyproline type II helical structure (PXXP motifs)[verification needed] in cell signaling proteins like protein tyrosine

  • HCK
  • PMC 230587. PMID 7791757. Saksela K, Cheng G, Baltimore D (1995). "Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are

  • ARMH3
  • largest mRNA variant of c10orf76 encodes a proline-rich motif containing two PxxP domains, where "P" represents a proline residue and "x" represents any other

  • DLG4
  • again a protein-protein interaction domain. Its family generally bind to PXXP sites, but in MAGUKs it is known to bind to other sites as well. One of the

  • SH3GLB1
  • with a wide variety of proteins through a canonical SH3 domain that enables PxxP motif-containing protein interactions, including Beclin-1, amphiphysin-1

  • Membrane-associated guanylate kinase
  • again a protein–protein interaction domain. Its family generally bind to PXXP sites, but in MAGUKs it is known to bind to other sites as well. One of the

  • USP8
  • Tanaka N (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain"

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Astrological/horoscope meaning of pxxp. pxxp means: With a Life Path 8, your numbers are (8, 17/8, 26/8, 35/8). The Life Path 8 suggests that you entered this life armed with a plan to manage, organize and govern. They are very ambitious and goal oriented. They want to use your goals, their organizational skills and efficient approach to carve a satisfying niche for themselves. If you are a positive 8 equipped with enormous potential to develop large programs and ideas, and also possess the toughness and independence, you follow to the end. In short, you are born to be a leader.They know how to manage themselves and their environment. Your ability to judge the character and potential of the people around you works to your advantage. Much of the success in life comes from, how hard you work.This way of life is most likely to produce workaholics. But your ability to recognize and attack tasks in your efforts makes you able to draw the right people. It is a quality of inspiration in your makeup that you can be a great leader. They are practical and stable in their pursuit of great goals, and you have the courage, when it comes to taking on great responsibilities and opportunities to strive forward.With the life path number 8 you are focused on learning the satisfactions that are in the material world. The Life Path 8 produces many powerful people, confident and materially successful. Most of your concerns relate to money and learning the power that it brings. With the proper handling of your financial resources, you have the potential of becoming extremely wealthy.This way of life is perhaps their most concern as they are desirous of status as the ultimate measure of success. You want to be recognized for your hard work and achievements. Reaching the honors and acceptance in the management of the club is very important. Given these, you are suitable for doing very well and competing in the business world or the political arena.In relationships you are frank, honest and firm. You can be very romantic, but are careful that you are not too busy and preoccupied to show it. Lavish gifts is not always an adequate replacement for your dedication and personal affection. You have to mitigate a great need for close personal relationships and to somehow soften your style. You need time for love and keep it as a major project in your life.The negative 8 is dictatorial and often suppresses the enthusiasm of colleagues and others around your efforts. Often the strength of their own personality excludes close feelings for other people with whom they come into contact. Gains and material rewards are often issues of the utmost importance, even at the expense of family, home and rest. Dedication to success can become an obsession. Emotional feelings are often suppressed by the negative 8, isolation and loneliness are paramount. All Life Path 8 people must avoid discounting the opinions of others.

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    P: Meaning of P in the acronym pxxp means: P has a heavy top standing on just a point to show it's strenght. It means strong, the ability tp perceive weakness and opportunities easily and clear-sightedness. By standing on its own, it shows self-centeredness, a thriving attitude and rigorousness. P also shows disconnection, strong will to go even alone and impartiality.

    X: Meaning of X in the acronym pxxp means: X is a cross bettween two arms of exactly the same lenght. It also balances on two ends at the bottom. It looks like Y with the bottom ends merged in the middle. X is stable, responsible, gorgeous, and spiritual as it opens upwards. X also shows enlightenment as it seeks to explore by extending its arms.

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