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Chemical compound
Ipatasertib (RG7440) is an experimental cancer drug in development by Roche. It is a small molecule inhibitor of AKT, which is a key component of the
Ipatasertib
Cell cycle regulation pathway
least two prior therapies. AKT is downstream to PI3K and is inhibited by Ipatasertib. Akt is an AGC-family kinase and a central, integral signaling node of
PI3K/AKT/mTOR_pathway
Set of three serine threonine-specific protein kinases
solid tumors. with a study of AZD5363 with olaparib reporting in 2016. Ipatasertib is in phase II trials for breast cancer. Akt isoform activation is associated
Protein_kinase_B
Malaysian biologist
most recently for Tecentriq® (PD-L1 Ab), tiragolumb (TIGIT Ab), and ipatasertib (AKT inhibitor) in oncology, Ocrevus® (CD20 Ab) in multiple sclerosis
Ming_Tatt_Cheah
Chemical compound
leading to cell proliferation. Moreover, combination with an AKT inhibitor ipatasertib further enhanced apoptotic promotion in malignant R-CHOP-resistant lymphocytes
Nirogacestat
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Girl/Female
Tamil
Anantya | அநஂதா, அநஂதயா
Endless, Eternal
Boy/Male
Australian, Indian
Thought
Girl/Female
Assamese, Indian
River
Boy/Male
Hindu
Dawning, Exile, Bright
Boy/Male
Hindu
Lord Shiva
Surname or Lastname
English
English : variant of Job.South German : from the personal name, either a derivative of Hiob, the German form of Job, or a reduced form of Jakob.
Girl/Female
Native American
Butterfly showing beautiful wings.
Boy/Male
French American English
Raven.
Surname or Lastname
English
English : variant of Holton.
Male
Italian
Short form of Italian Giovanni, VANNI means "God is gracious."
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