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Genetic perturbation technique
CRISPR interference (CRISPRi) is a genetic perturbation technique that allows for sequence-specific repression of gene expression in prokaryotic and eukaryotic
CRISPR_interference
Family of DNA sequences found in prokaryotic organisms
CRISPR (/ˈkrɪspər/; acronym for clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic
CRISPR
Type of CRISPR tool
diseases. Like for CRISPR interference, the CRISPR effector is guided to the target by a complementary guide RNA. However, CRISPR activation systems are
CRISPR_activation
Gene editing method
such as RNA interference (RNAi) do not fully suppress gene function, CRISPR, ZFNs, and TALENs provide full, irreversible gene knockout. CRISPR can also target
CRISPR_gene_editing
Microbial protein found in Streptococcus pyogenes M1 GAS
Cas9 (CRISPR-associated protein 9) is a DNA cutting endonuclease that is part of the CRISPR immune system in bacteria and archaea. It has been adapted
Cas9
American molecular biologist
mechanisms of gene regulation, including pre-mRNA splicing, RNA interference (RNAi), and CRISPR–Cas adaptive immune systems, with implications for genome engineering
Erik_J._Sontheimer
Chemical and systems biology researcher
basis for CRISPR interference (CRISPRi). His laboratory subsequently developed CRISPR-Genome Organization (CRISPR-GO) based on dCas9 and CRISPR-Transcriptome
Lei_Stanley_Qi
Biological process of gene regulation
because the Dicer enzyme is not involved. It has been suggested that CRISPR interference systems in prokaryotes are analogous to eukaryotic RNAi systems,
RNA_interference
Single cell RNA sequencing method
repair pathway to introduce disruptive insertions or deletions. CRISPR interference (CRISPRi) on the other hand utilizes a catalytically inactive nuclease
Perturb-seq
RNA-guided transposition of their DNA. Unlike traditional CRISPR systems that contain interference mechanisms to degrade targeted DNA, CASTs lack proteins
CRISPR-associated_transposons
RNA transcript from the CRISPR locus
CRISPR RNA or crRNA is a RNA transcript from the CRISPR locus. CRISPR-Cas (clustered, regularly interspaced short palindromic repeats - CRISPR associated
CRISPR_RNA
Spanish microbiologist (born 1963)
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats). These were later developed into the first widespread genome editing tool, CRISPR-Cas9
Francisco_Mojica
Biological lab technique
patterning that mimic loss of wingless function. CRISPR/Cas is primarily used for reverse genetic screens. CRISPR has the ability to create libraries of thousands
Genetic_screen
DNA-editing technology
Cas12a (CRISPR-associated protein 12a, previously Cpf1) is a Class II Type V CRISPR-associated endonuclease-exonuclease. In bacteria such as F. novicida
Cas12a
Type of unintended effects of genetic modification techniques
technologies such as: clustered, regularly interspaced, short palindromic repeats (CRISPR)-Cas9, transcription activator-like effector nucleases (TALEN), meganucleases
Off-target_genome_editing
American biochemist and Nobel laureate (born 1964)
February 19, 1964) is an American biochemist who has pioneered work in CRISPR gene editing, and made other fundamental contributions in biochemistry and
Jennifer_Doudna
Subsystem of the immune system
Macmillan A.M. 2011. Recognition and maturation of effector RNAs in a CRISPR interference pathway. Nature Structural & Molecular Biology. 18 (6): 688–692.
Adaptive_immune_system
Group of proteins found in phages
nor the assembling of CRISPR molecules, so it was thought that those type I-F proteins directly affected the CRISPR–Cas interference. Further investigation
Anti-CRISPR
Gene thought to be critical for an organism's survival
the development of CRISPR, gene essentiality has also been determined through inhibition of gene expression through CRISPR interference. A summary of such
Essential_gene
Aspect of cell biology
larger CRISPR proteins. While the exact biological roles remain unclear, proposed functions include: Mobile genetic element (MGE) interference Gene regulation
TIGR-Tas
Research tool in genomics
Genome-wide CRISPR-Cas9 knockout screens aim to elucidate the relationship between genotype and phenotype by ablating gene expression on a genome-wide
Genome-wide CRISPR-Cas9 knockout screens
Genome-wide_CRISPR-Cas9_knockout_screens
RNA-targeting CRISPR effector
Cas13 is a family of orthologous CRISPR-associated endonucleases that target RNA (unlike Cas9 and Cas12). Cas13 utilizes a single RNA-guided endonuclease
Cas13
Phenotype of senescent cells which secrete certain substances
rapamycin reduces SASP production by senescent cells. Recent genome-wide CRISPR interference (CRISPRi) screens have identified genes whose selective inhibition
Senescence-associated secretory phenotype
Senescence-associated_secretory_phenotype
Kind of transposon
express large genetic sequences, such as a doxycicline-inducible CRISPR interference system. A novel member of the piggyBac family hyperactive Mage (MG)
PiggyBac_transposon_system
American Microbiologist
doi:10.1089/crispr.2020.29080.lma. Retrieved 2026-03-05. Marraffini, Luciano A.; Sontheimer, Erik J. (19 December 2008). "CRISPR Interference Limits Horizontal
Luciano_Marraffini
Biotechnology company
in discovering and developing antisense therapy, as well as RNA interference and CRISPR therapeutics. The company was founded in 1989 is based in Carlsbad
Ionis_Pharmaceuticals
RNA molecule that specifies a target sequence
CRISPR-associated protein to its nucleic acid sequence target by Watson-Crick base pairing. In bacteria and archaea, gRNAs are a part of the CRISPR-Cas
Guide_RNA
Type of immune cell
these sentinel cells take up and record target DNA sequences, using CRISPR interference for SNP differentiation and expression of target gene. This technology
Sentinel_cell
American biologist
identifying mechanisms in development and disease. Developed the first CRISPR interference (CRISPRi) mouse model, thereby enabling rapid and efficient gene
Michael T. McManus (biologist)
Michael_T._McManus_(biologist)
Use of laboratory and field experiments to explore evolutionary dynamics
transcription factors, globally altering the transcription machinery, CRISPR interference and activation. Also with yeast, transposons, loxP sequences, and
Experimental_evolution
Genetic technique
done through a variety of methods, including homologous recombination, CRISPR-Cas9, and TALENs. One of the main advantages of gene knockouts is that they
Gene_knockout
Genetic modification technique
acquired immunity, and this process is like a prokaryotic RNA interference mechanism. The CRISPR repeats are conserved amongst many species and have been demonstrated
Gene_knockdown
Engineering, in the Church lab. With the development of CRISPR technologies, construction of CRISPR interference strains in E. coli requires only one-step oligo
Recombineering
Indian microbiologist, biochemist, and professor
PMID 28673854. Zuberi, Azna; Misba, Lama; Khan, Asad U (2017). "CRISPR Interference (CRISPRi) Inhibition of luxS Gene Expression in E. Coli: An Approach
Asad_Ullah_Khan
Region of non-coding DNA between genes
Hatoum-Aslan, Asma; Mucida, Daniel; Marraffini, Luciano A. (2012-08-16). "CRISPR Interference Can Prevent Natural Transformation and Virulence Acquisition during
Spacer_DNA
Biochemist, microbiologist, and academic (born 1987)
metagenomics, gas chromatography, cryo-electron microscopy, and CRISPR interference. Greening co-discovered that atmospheric trace gases are major energy
Chris_Greening
Methodology for biomedical research
papers on OPS appeared the year after. One report described a small CRISPR interference screen that perturbed different components regulating a fluorescent
Optical_pooled_screening
Technologies to genetically improve human bodies
benefits of revolutionary tools like CRISPR are endless. For example, because it can be applied directly in the embryo, CRISPR/Cas9 reduces the time required
Human_genetic_enhancement
Protein used in CRISPR
Cas4 is an endonuclease found in some CRISPR systems that is used as part of the spacer acquisition stage. Cas4 family proteins belonging to the archaeon
Cas4
Protein used in CRISPR
enzymes. CRISPR-mediated adaptive immunity requires three stages: sequence acquisition, CRISPR RNA biogenesis, and target interference. CRISPR RNA-guided
Cas3
Gene editing technique
methodologies similar to precursor genome editing technologies, including CRISPR/Cas9 and base editors. Prime editing has been used on some animal models
Prime_editing
Introduction of foreign genetic material into a host
FA, Cox D, et al. (February 2013). "Multiplex genome engineering using CRISPR/Cas systems". Science. 339 (6121): 819–23. doi:10.1126/science.1231143.
Transgenesis
Transcription Activator-Like Effectors (TALEs) and nuclease deficient Cas9 fusions (CRISPR). Comparing genome-wide epigenetic maps with gene expression has allowed
Epigenome_editing
Elimination of mRNA with premature stop codons in eukaryotes
NMD are significant when designing CRISPR-Cas9 experiments, particularly those aimed at gene inactivation. CRISPR-Cas9 introduces double-strand breaks
Nonsense-mediated_decay
Process of editing the human genome so that the changes are inherited
Council of Europe. In November 2015, a group of Chinese researchers used CRISPR/Cas9 to edit single-celled, non-viable embryos to assess its effectiveness
Human_germline_engineering
German biologist
Beisel's research in the field of CRISPR biology and technologies aims to understand the functional diversity of CRISPR-Cas immune systems and to use these
Chase_Beisel
PMC 2238822. PMID 17932051. Marraffini, L. A.; Sontheimer, E. J. (2010). "CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea". Nature
MicrobesOnline
Optical biosensing technology
(2020-05-27). "Bio-Layer Interferometry Analysis of the Target Binding Activity of CRISPR-Cas Effector Complexes". Frontiers in Molecular Biosciences. 7: 98. doi:10
Bio-layer_interferometry
Protein family
CRISPR functions. The CRISPR-Cas family of protein is also divided into 3 different types, Type I, Type II, Type III. Each of the 3 types of CRISPR-Cas
Cellular apoptosis susceptibility protein
Cellular_apoptosis_susceptibility_protein
Medical condition
number of studies are looking at gene therapy, exon skipping and CRISPR interference to offer hope for the future. Accurate determination through confirmed
Hypotrichosis with juvenile macular dystrophy
Hypotrichosis_with_juvenile_macular_dystrophy
Field of molecular biology
strength of putative enhancers are assayed by this method. Perturb-seq couples CRISPR mediated gene knockdowns with single-cell gene expression. Linear models
Functional_genomics
PMID 17387036. Brouns SJ, Jore MM, Lundgren M, et al. (August 2008). "Small CRISPR RNAs guide antiviral defense in prokaryotes". Science. 321 (5891): 960–4
List_of_RNAs
Wire CRISPR-Cas9 IP licensed to GE Dharmacon™ Edit-R™ Gene Engineering System | The Scientist Magazine® GE Healthcare Dharmacon Advances CRISPR Cas9 Gene
Dharmacon
Mobile genetic element in the genome of S. aureus
they enable it to keep pace with helper phage reproduction. Unlike the CRISPRs, which simply destroy infecting phages and thus totally block phage-mediated
SaPI
Process that prevents the expression of a gene
is the first approved food product to use this technique. CRISPR DNA-directed RNA interference Gene drive Gene knockdown PPRHs Redberry, Grace (2006). Gene
Gene_silencing
Infectious agent that replicates in cells
involve RNA interference from repetitive DNA sequences within archaean genomes that are related to the genes of the viruses. Most archaea have CRISPR–Cas systems
Virus
Species of prawn
application of CRISPR. His group established monosex biotechnologies in crustacean culture including the application of temporal RNA interference (RNAi) in
Macrobrachium_rosenbergii
Species of beetle
knock-down experiments. CRISPR technology has been shown to be useful in studying T. castaneum. In one experiment, researchers used CRISPR to knock out the E-cadherin
Red_flour_beetle
Family of large biological molecules
been shown to use regulatory RNA systems such as bacterial small RNAs and CRISPR. Fire and Mello were awarded the 2006 Nobel Prize in Physiology or Medicine
RNA
Dense cluser of restriction sites in DNA
diabetes. Multiple cloning sites play a central role in CRISPR gene editing systems. Many CRISPR-Cas9 plasmids feature MCSs immediately downstream of the
Multiple_cloning_site
Process of re-creating an extinct organism
has been rapidly advancing with the help of the CRISPR/Cas systems, particularly CRISPR/Cas9. The CRISPR/Cas9 system was originally discovered as part of
De-extinction
Cellular biology lab technique
Lastly, CITE-seq can be adapted to detect small molecules, RNA interference, CRISPR, and other gene editing techniques. Limitations: One of the limitations
CITE-Seq
American hematologist
His foundational research on BCL11A paved the way for the first approved CRISPR/Cas9-based gene-editing therapy, Casgevy, for sickle cell disease and β-thalassemia
Stuart_Orkin
French-American geneticist
to study conditions involving tissue wasting, such as cachexia. Pooled CRISPR/Cas9 screening methods were developed for Drosophila cell lines in collaboration
Norbert_Perrimon
Method in molecular genetics
for the Job: RNAi, TALEN, or CRISPR - ScienceDirect". Molecular Cell / Elsevier. Retrieved 2026-05-11. "RNA Interference (RNAi)". NCBI / U.S. National
Reverse_genetics
Disease
first-in-human study demonstrated that NTLA-2001, a therapeutic agent based on the CRISPR-Cas9 system, induces targeted knockout of the transthyretin protein. Permanent
Wild-type transthyretin amyloid
Wild-type_transthyretin_amyloid
Animal that has been genetically modified
from CRISPR). TALEN and CRISPR are the two most commonly used and each has its own advantages. TALENs have greater target specificity, while CRISPR is easier
Genetically_modified_animal
Starchy tuber used as a staple food
both to diploid potatoes (including a special line of S. tuberosum) by CRISPR-Cas9. Plants having a 'Sli' gene produce pollen which is compatible to its
Potato
British molecular cancer biologist (1964–2026)
Therapeutics Institute, aims to act as a hub for genetic screens, cancer models, CRISPR tool design, and computational approaches to big data to understand genetic
Gregory_Hannon
Foods produced from organisms that have had changes introduced into their DNA
GABA. CRISPR was first applied in tomatoes in 2014. Shortly afterwards, the first CRISPR-gene-edited marine animal/seafood and second set of CRISPR-edited
Genetically_modified_food
Organism altered by genetic engineering
host genome. Recent advancements using genome editing techniques, notably CRISPR, have made the production of GMOs much simpler. Herbert Boyer and Stanley
Genetically_modified_organism
Biomolecule
in length, similar to microRNA (miRNA), and operating within the RNA interference (RNAi) pathway. It interferes with the expression of specific genes with
Small_interfering_RNA
Public medical school in Worcester, Massachusetts, US
is chaired by molecular biologist Phillip D. Zamore and vice-chaired by CRISPR biologist Erik J. Sontheimer. The RTI brings together basic scientists and
UMass_Chan_Medical_School
Parasitic microorganism that causes giardiasis
critical virulence factor in host-pathogen interactions. Since 2022, the CRISPR-Cas9 system was established in Giardia. Constitutively expressed Cas9 nuclease
Giardia_duodenalis
Biological system protecting an organism against disease
and archaea) also possess acquired immunity, through a system that uses CRISPR sequences to retain fragments of the genomes of phage that they have come
Immune_system
Lysosomal storage disease
aged 2–5 years to evaluate its safety and efficacy.[circular reference] CRISPR-Cas9 gene editing technology is being explored to directly correct the defective
Cystinosis
Cell line derived from human embryonic kidney cells
equilibrative nucleoside transporter ENT1. The gene was knocked out using CRISPR-CAS9 and the cell line retains ENT2 expression. HEK 293 cells are straightforward
HEK_293_cells
well as to confirm genome modifications following genome editing (using CRISPR/TALENs/zinc fingers). The ability to discover and detect known and unknown
Surveyor_nuclease_assay
Infection following vaccine administration
administered outside this window are not compromised by maternal antibody interference. When an individual is vaccinated against a disease, the individual's
Breakthrough_infection
American scientist who co-discovered mTOR
screens in human cells, most notably through the use of RNA interference and the CRISPR-Cas9 system. 2009 Paul Marks Prize for Cancer Research 2014 NAS
David_M._Sabatini
American scientist and life sciences industry leader
S2CID 248668572. Martz, Lauren; Editor, Senior. "Alnylam's strategy to head off CRISPR threat". BioCentury. Retrieved 2021-09-09. {{cite web}}: |last2= has generic
John_Maraganore
American physician-scientist known for work in gene therapy
F. (March 11, 2022). "Promoterless Gene Targeting Approach Combined to CRISPR/Cas9 Efficiently Corrects Hemophilia B Phenotype in Neonatal Mice". Frontiers
Mark_A._Kay
Episode list for an American late-night talk show
7-Eleven commercial promoting safe sex in Norway Guests: Bobby Moynihan 136 17 CRISPR and genome editing July 1, 2018 (2018-07-01) 1.12 Other segment: Retirement
List of Last Week Tonight with John Oliver episodes
List_of_Last_Week_Tonight_with_John_Oliver_episodes
Milkweed butterfly in the family Nymphalidae
mutations into the same gene in the fruit fly Drosophila melanogaster using CRISPR-Cas9 genome editing. These fruit flies-turned monarch flies were completely
Monarch_butterfly
Domain of microorganisms
restriction modification systems that degrade foreign DNA and a system that uses CRISPR sequences to retain fragments of the genomes of phage that the bacteria
Bacteria
Viruses found in marine environments
involve RNA interference from repetitive DNA sequences within archaean genomes that are related to the genes of the viruses. Most archaea have CRISPR–Cas systems
Marine_viruses
Rod-shaped, gram-negative bacterium
November 2021. Shipman SL, Nivala J, Macklis JD, Church GM (July 2017). "CRISPR-Cas encoding of a digital movie into the genomes of a population of living
Escherichia_coli
Mammalian protein found in humans
results of ALN-PCS, which acts by means of RNA interference. In 2021, scientists demonstrated that CRISPR gene editing can decrease blood levels of LDL
PCSK9
Inherited neurodegenerative disorder
repair a genome with the erroneous gene that causes HD, using tools such as CRISPR/Cas9. PTC Therapeutics is evaluating small molecules that induce poison
Huntington's_disease
Scientific study of genes at the molecular level
alter/edit an organism's DNA. One way to due this is through the technique Crispr/Cas9, which was adapted from the genome immune defense that is naturally
Molecular_genetics
research. Unlike genetic perturbation technologies such as CRISPR–Cas editing and RNA interference, chemical probes provide rapid, reversible, and tunable
Chemical_probe
Drug discovery technique
full functional genomics capabilities (genome wide siRNA, shRNA, cDNA and CRISPR) which are complementary to small molecule efforts: Functional genomics
High-throughput_screening
affinity chromatography – x-ray diffraction – proteomics – mass spectrometry – CRISPR – gene therapy Genes, development, and evolution Apoptosis French flag model
Outline_of_biology
Biomedical and genomics research institute in New York, US
new types of treatments that utilize DNA and RNA based therapies, such as CRISPR, siRNA, RNA vaccines, and CAR T cells, and searching for novel drug targets
Icahn_Genomics_Institute
Annual award for scientific research
Higgs boson 2013: Cancer immunotherapy 2014: Rosetta comet mission 2015: CRISPR genome-editing method 2016: First observation of gravitational waves 2017:
Breakthrough_of_the_Year
Public university in Berkeley, California
campus, UCSF, established the Innovative Genomics Institute to develop CRISPR gene editing, and, in 2020, an anonymous donor pledged $252 million to help
University of California, Berkeley
University_of_California,_Berkeley
Type of electromagnetic spectroscopy
Red-shifted variants may address this. Other research attempts to pair TRFPs with CRISPR for targeted gene studies. Integration into clinical diagnostics, such as
Fluorescence_spectroscopy
Retracted study led by Gilles-Éric Séralini
industry-driven campaign and regard this as a concerning example of industry interference in the scientific process. At the time of the initial release, French
Séralini_affair
Electric light bulb with a resistively heated wire filament
commercial product that produced 29.8 lm/W. More advanced reflectors based on interference filters or photonic crystals can theoretically result in higher efficiency
Incandescent_light_bulb
Electronic circuit formed on a small, flat piece of semiconductor material
circuits offer smaller size and lower cost, but must account for signal interference. Prior to the late 1990s, radios could not be fabricated in the same
Integrated_circuit
CRISPR INTERFERENCE
CRISPR INTERFERENCE
Boy/Male
Greek
Anointed.
Girl/Female
Scottish Irish
Abbreviation of Christine. Follower of Christ.
Girl/Female
Hindu, Indian, Mexican, Russian
Crisp; Calm; Reserved
Girl/Female
Scottish Irish
Abbreviation of Christine. Follower of Christ.
Surname or Lastname
English
English : variant spelling of Crisp.
Boy/Male
American, Australian, British, Christian, Dutch, English, French, German, Greek, Hebrew, Latin, Portuguese, Swedish
Curly-haired
Surname or Lastname
English
English : variant spelling of Christie.
Male
Romanian
Pet form of Romanian Cristian, CRISTI means "Christian."
Surname or Lastname
English and French
English and French : from the Middle English, Old French personal name Crispin, Latin Crispinus, a family name derived from crispus ‘curly-haired’ (see Crisp). This name was especially popular in France in the early Middle Ages, having been borne by a saint who was martyred at Soissons in ad c. 285 along with a companion, Crispinianus (whose name is a further derivative of the same word).English and French : diminutive of Crisp.
Girl/Female
Spanish
Appointed one. A Christian.
Boy/Male
Latin
Curly-haired.
Male
Portuguese
Portuguese form of Latin Christophorus, CRISTÓVÃO means "Christ-bearer."Â
Surname or Lastname
English
English : occupational name for a maker of pouches, from the plural of Middle English crippes ‘pouch’.English : metathesized form of Crisp.German : variant spelling of Krips, a variant of Krebs.
Male
English
English name derived from Latin Crispinus, CRISPIN means "curly(-headed)."
Boy/Male
English Latin
Curly-haired. The 3rd century martyr St. Crispin is known as patron of shoemakers.
Male
Spanish
Spanish form of Latin Christophorus, CRISTÓBAL means "Christ-bearer."Â
Boy/Male
Latin
Curly-haired.
Girl/Female
Scottish American Irish
Abbreviation of Christine. Follower of Christ.
Surname or Lastname
English
English : nickname for a man with curly hair, from Middle English crisp, Old English crisp, cryps (Latin crispus), reinforced in Middle English by an Old French word also from Latin crispus.Americanized spelling of the German cognate Krisp, from Middle High German krisp, krispel ‘curly-haired man’.Americanized form of German Krisp, from a short form the medieval personal name Krispin (see Crispin).
Boy/Male
Indian, Latin
Curly Haired
CRISPR INTERFERENCE
CRISPR INTERFERENCE
Girl/Female
Christian & English(British/American/Australian)
Light
Boy/Male
Native American
Brave.
Girl/Female
American, Australian, British, English, Hebrew
Captivating; Bound; Form of Rebecca; Tied; Joined
Boy/Male
Muslim
Preserver of the religion
Girl/Female
Hindu, Indian
Hotness
Boy/Male
Hindu
Three eyed, After Lord Shiva
Girl/Female
Muslim
Sage, Intelligence
Boy/Male
Arabic, Muslim
Strong; Power
Girl/Female
Sikh
Face
Girl/Female
Hindu, Indian
Deepak; Light
CRISPR INTERFERENCE
CRISPR INTERFERENCE
CRISPR INTERFERENCE
CRISPR INTERFERENCE
CRISPR INTERFERENCE
a.
Brittle; crisp.
v. t.
to entrap into the military or naval service; as, to crimp seamen.
a.
Curling in stiff curls or ringlets; as, crisp hair.
n.
One who, or that which, crimps
imp. & p. p.
of Crisp
v. t.
To fold or plait in regular undulation in such a way that the material will retain the shape intended; to give a wavy appearance to; as, to crimp the border of a cap; to crimp a ruffle. Cf. Crisp.
a.
Crisp; brittle; as, a crispy pie crust.
a.
Brittle; friable; in a condition to break with a short, sharp fracture; as, crisp snow.
adv.
In a crisp manner.
v. t.
To cause to contract, or to render more crisp, as the flesh of a fish, by gashing it, when living, with a knife; as, to crimp skate, etc.
a.
Formed into short, close ringlets; frizzed; crisp; as, crispy locks.
a.
Having a crimped appearance; frizzly; as, the crimpy wool of the Saxony sheep.
a.
To cause to undulate irregularly, as crape or water; to wrinkle; to cause to ripple. Cf. Crimp.
a.
To make crisp or brittle, as in cooking.
n.
One who rises; as, an early riser.
n.
One who, or that which, crisps or curls; an instrument for making little curls in the nap of cloth, as in chinchilla.
n.
That which is crisp or brittle; the state of being crisp or brittle; as, burned to a crisp; specifically, the rind of roasted pork; crackling.
p. pr. & vb. n.
of Crisp
pl.
of Crisis
v. i.
To undulate or ripple. Cf. Crisp, v. t.