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  • Wee1
  • Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular

  • Cell growth
  • balance of Wee1 and Cdc25 activity with changes in cell size is coordinated by the mitotic entry control system. It has been shown in Wee1 mutants, cells

  • G2 phase
  • employ such a mechanism, via Cdr2-mediated spatial regulation of Wee1 activity. Though Wee1 is a fairly conserved negative regulator of mitotic entry, no

  • G2-M DNA damage checkpoint
  • CyclinB-Cdc2 inhibitors, Wee1 and Myt1. Cdc25 activates the complex through the removal of phosphates from the active site while Wee1 inactivates the complex

  • Maturation promoting factor
  • phase, the CDK1 subunit of MPF is inactive due to an inhibitory enzyme, Wee1. Wee1 phosphorylates the Tyr-15 residue of CDK1, rendering MPF inactive. During

  • Cell cycle checkpoint
  • and reaches the G2/M transition, the kinase Plk1 phosphorylates Wee1, which targets Wee1 for degradation via the SCF ubiquitin ligase complex. An additional

  • Adavosertib
  • drug candidate. It is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. It is being developed

  • Wee1-like protein kinase
  • WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene. This gene encodes a nuclear protein, which is a

  • Tyrosine kinase inhibitor
  • based on early studies on TKIs aiming at VEGF receptors. Adavosertib is a Wee1 kinase inhibitor that is undergoing numerous clinical trials in the treatment

  • Schizosaccharomyces pombe
  • Pom1 inhibits Cdr2, preventing Cdr2 and Cdr1 from inhibiting Wee1, and allowing Wee1 to phosphorylate Cdk1, thus inactivating cyclin-dependent kinase

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Astrological/horoscope meaning of wee1. wee1 means: undefined

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    W: Meaning of W in the acronym wee1 means: W is an impressive characted. It has three projections pointing upwards and rests on two ends. It is nontraditional and energetic. More ends at the top indicated W is interested in travel, it is exciting, adventure seeking, willing enthusiastically, tasteful, and go-getting.

    E: Meaning of E in the acronym wee1 means: The letter E has three branches of equal lenghts. These all extend from it's left side. The equal lenghts show a degree of fairness to the outside world. They extend outwards indicating a willingness to learn, think broadly and be more vigorous in understanding. B also implies endowed with good writing abilities, eloquence, resourcefulness. It displays a unique artistic nature and strong enthusaism to get out and know more.

    1: Meaning of 1 in the acronym wee1 means: undefined

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