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  • SMAD (protein)
  • sub-types of Smads: receptor-regulated Smads (R-Smads), common partner Smads (Co-Smads), and inhibitory Smads (I-Smads). The eight members of the Smad family

  • SMAD
  • nanoparticles SMAD (protein), proteins involved in cell signaling I-SMAD, inhibitory SMAD proteins R-SMAD, receptor regulated SMAD proteins Smad, Syria, a

  • R-SMAD
  • R-SMADs are receptor-regulated SMADs. SMADs are transcription factors that transduce extracellular TGF-β superfamily ligand signaling from cell membrane

  • TGF beta signaling pathway
  • receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where

  • Paracrine signaling
  • the TGF-β pathway in three ways. First, non-Smad signaling pathways phosphorylate the Smads. Second, Smads directly signal to other pathways by communicating

  • Mothers against decapentaplegic homolog 4
  • as WWTR1 (TAZ) interact with SMADs to promote their function. Once in the nucleus, the complex of SMAD4 and two R-SMADS binds to DNA and regulates the

  • I-SMAD
  • I-SMAD or Inhibitor SMAD is a subclass of SMADs that are involved in the modulation of transforming growth factor beta ligands. This class includes SMAD6

  • Upstream and downstream (transduction)
  • act on the R-Smads, Smad2/3. The phosphorylated R-Smads then form complexes and the signals are funneled through two regulatory Smad (R-Smad) channels (Smad1/5/8

  • Mothers against decapentaplegic homolog 2
  • transcript variants encoding the same protein have been observed. Like other SMADs, SMAD2 plays a role in the transmission of extracellular signals from ligands

  • Transforming growth factor beta
  • the case of Smad, receptor-activated Smads are phosphorylated by the type 1 TGF-β receptor kinase, and these go on to complex with other Smads, which is

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Astrological/horoscope meaning of smads. smads means: With a Life Path 2, your numbers are (11/2, 20/2). If you are blessed with the positive features of the life path number 2, you will have the ability to live a balanced, delicate and fair life. You like to examine clearly the full range of positions on every issue or situation, and for this reason, you are often seen as a mediator in challenging situations. In this function you are able to resolve conflicts with in an uninhibited and fair style. You have a genuine concern for others; Life path 2 people think the best of people, and want the best for them. They are honest and open in thought, word and deed. They stand out in some form of group activity, where his experience in handling and blending people can be used effectively. Manners and timeliness mark their way with others, and they are not one to dominate a group or situation. You are about to receive the master of compromise and harmony award in your area of expertise. As the main member of the team, you never need praise or recognition even when offered.In many ways, you are a creature of habit and routine, and you flourish in well known and familiar patterns. Your ability to analyze and to make accurate judgments is a wonderful natural function to bring the business community together. They strive for absolute precision and even perfection in their work. Maybe you're not a leader, but you are a visionary and talented person with innovative ideas.The Life Path 2 shows that you entered this life with a spiritual quality your make-up, which can cause you to always strive for peace in difficult circumstances. Your strengths come from your great ability to listen and absorb. You are a fixer, a mediator, and a very diplomatic type of person with great persuasion skills rather than forcefulness in your way in the world. You embrace their spiritual side, to show you are intuitive, modern, idealistic and visionary. These ends are made interesting with much to offer society. They have the potential to be a deep thinker, and certainly keen to understand many of the mysteries of life and fascinating facets.Life path 2 also has it's negatives. The nervous energy it generates may make one sometimes look a little extreme, but this is sometimes the zeal in you mainly expressing likes and dislikes. The stress can bring normality, and tolerance when in a state of emotional outrage, but it can also make you to seem so out of character. In fact, you can become sensitive to things. In some cases, this can even become weakness although generally a strength for the 2 life path. You can find it difficult to decide what you want to do sometimes. Twos often struggle with indecision. Decision and getting your life in gear, so to speak, can be a challenge. There is a tendency for many of 2s to cherish feelings of discomfort and dissatisfaction with the performance and personal progress in life. The biggest obstacle and difficulty that can be found, is the passivity and a state of apathy and lethargy. The negative 2 can be very pessimistic. If you live on the negative side of the 2, the lack of common sense can often make you unable to distinguish between fantasy and reality.Even the positive with 2 life path people prefer a more friendly and less competitive life, often to avoid the emotional and financial hardship. They can do better with the use their skills, advice and guidance from society in efforts to serve. Much of his idealism is people-oriented and very humanitarian in nature. They can expect a lot of themselves.

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    S: Meaning of S in the acronym smads means: S is a single strand that goes forward and backwards. It shows a willingness to explore. Friendliness, perceptiveness and accommodating are all S qualities. The ends pointing forward and backwards shows a conflicting nature with itself and a degree of puzzlement.

    M: Meaning of M in the acronym smads means: While M stands on two points, it has three projections pointing downwards. M is dracious, stable and temperamental. M could also be overwhelming with a great strenght of character and a strong in mind.

    A: Meaning of A in the acronym smads means: The letter A has two bars connected at a pointed edge and a cross bar holding them together. From an open end to a pointed edge signifies that all energies are trained to a point to achieve the most singularly important goal. The cross bar shows caution. Failure is avoided by stringing all required resources together. A also looks like a Pyramid with the peak as the apex of the Pyramid. Pyramids are iconic. A therefore symbolizes prominence and a desire to be recognized for ones achievements. The cross bar also represents a rung in ladder. To get to the top, one has to first step on the rung. It also means originality, a strong will power and an enterprising ability. The upper-case version consists of the two slanting sides of a triangle, crossed in the middle by a horizontal bar. It shows aspiration, the dominance to be successful, positive attitude, an optimistic world view and egotism.

    D: Meaning of D in the acronym smads means: D is a closed letter indicating self sufficiency. It displays self-reliance, a caring attitude and broadmindedness. It's broadmindedness can be seen in the fat that the letter D has a side that looks like an upright pole, it branches from the top and bottom to explore outwards, gain worldly knowledge, but its steady and slow, meticulous and self-reliance brings it back to itself.

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