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  • SOS1
  • sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene. SOS1 is a guanine nucleotide exchange factor (GEF) which interacts with

  • Son of Sevenless
  • each ommatidium fails to form. Similarly, the mammalian orthologues of Sos, SOS1 and SOS2, function downstream of many growth factor and adhesion receptors

  • Noonan syndrome
  • key ones being PTPN11 accounting for 50% of genetically diagnosed cases, SOS1 responsible for 10-13% of cases, and RAF1 or RIT1 - each contributing to

  • Hereditary gingival fibromatosis
  • mutation in the SOS1 gene localized on chromosome 2p21-p22 HGF2 - Caused by a mutation in the SOS1 gene localized on chromosome 5q13-q22[[[SOS1

  • Guanine nucleotide exchange factor
  • (SOS1) is an important GEF in the cell growth-regulatory MAPK/ERK pathway. SOS1 binds GRB2 at the plasma membrane after EGF receptor activation. SOS1 activates

  • Cardiofaciocutaneous syndrome
  • pathway at or above the level of SOS1. SOS1 in turn regulates the activities of RAS, RAF, MEK, ERK, and p90RSK. SOS1 has been demonstrated to be a target

  • Ribosomal s6 kinase
  • phosphorylation of SOS1 (Son of Sevenless) at Serines 1134 and 1161 creates 14-3-3 docking site. This interaction of phospho SOS1 and 14-3-3 negatively

  • 14-3-3 protein
  • cytoplasm, inhibiting their function. Raf-1 Bad – see Bcl-2 Bax Cdc25 Akt SOS1 – see RSK YWHAB – "14-3-3 beta" YWHAE – "14-3-3 epsilon" YWHAG – "14-3-3

  • Epidermal growth factor receptor
  • alpha, PLCG1, PLSCR1, PTPN1, PTPN11, PTPN6, PTPRK, SH2D3A, SH3KBP1, SHC1, SOS1, Src, STAT1, STAT3, STAT5A, UBC, and WAS, PAR2. In fruitflies, the epidermal

  • Signal transduction
  • small G proteins that activate guanine nucleotide exchange factors such as SOS1. Once activated, these exchange factors can activate more small G proteins

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    S: Meaning of S in the acronym sos1 means: S is a single strand that goes forward and backwards. It shows a willingness to explore. Friendliness, perceptiveness and accommodating are all S qualities. The ends pointing forward and backwards shows a conflicting nature with itself and a degree of puzzlement.

    O: Meaning of O in the acronym sos1 means: O is well carved with no pointed edges. It is smooth and closed. It shows deep in thought, well disciplined, down in the dumps and caring. The roundedness of the O with lookout in the middle indicates a peering nature into the outside. This means, lookout for the mysterious and be home-loving and enjoy the things that are close by. It is a traditionalist letter.

    1: Meaning of 1 in the acronym sos1 means: undefined

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