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  • Monomethyl auristatin E
  • Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked

  • Brentuximab vedotin
  • to three to five units of the antimitotic agent monomethyl auristatin E (MMAE, reflected by the 'vedotin' in the drug's name). The peptide-based linker

  • Tisotumab vedotin
  • monoclonal antibody against tissue factor, and monomethyl auristatin E (MMAE), a potent inhibitor of cell division. It is administered by infusion into

  • Hodgkin lymphoma
  • Brentuximab vedotin, a CD30 antibody conjugated with a cytotoxic component MMAE, and the checkpoint inhibitors, Nivolumab and Pembrolizumab. This has been

  • Seagen
  • protease-cleavable linker to MMAE. This ADC employs a linker system that is designed to be stable in the bloodstream but to release MMAE upon internalization

  • Antibody–drug conjugate
  • monomethyl auristatin E or MMAE, a synthetic antineoplastic agent, to human-specific CD30-positive malignant cells. MMAE inhibits cell division by blocking

  • Glembatumumab vedotin
  • Glembatumumab vedotin (also known as CDX-011 and CR011-vcMMAE) is an antibody-drug conjugate (ADC) that targets cancer cells expressing transmembrane glycoprotein

  • Enfortumab vedotin
  • to the monoclonal antibody part, and vedotin refers to the payload drug (MMAE) and the linker. The most common side effects include fatigue, peripheral

  • Triple-negative breast cancer
  • Cancer". 12 February 2015. Burris (2009). "A Phase I/II Study of CR011-vcMMAE (CDX-011), an Antibody-Drug Conjugate, in Patients with Locally Advanced

  • Indusatumab vedotin
  • to four molecules of the chemotherapeutic agent monomethyl auristatin E (MMAE). It was in Phase II clinical trials as of February 2016[update]. The trials

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Astrological/horoscope meaning of mmaes. mmaes means: With a Life Path 6, your numbers are (6, 15/6, 24/6, 33/6). The Life Path 6 suggests that you came into life with the tools to be the ultimate nurturer, and a beacon for truth, justice, righteousness, and domesticity. You have mature paternal or maternal instincts to nurture more than others your age. Whether at home or at work, you are the predominant caretaker and breadwinner. Beyond community tasks, life revolves around the home and immediate family, the internal numbers. Principles and conservative beliefs are deeply ingrained and define your character.You are idealistic and must be happy to feel useful. The main contribution you make, is that you like to provide advice and are always available serve and support. They are a prime humanitarian. It is your job to serve others, and you start in the home environment. They are very human and realistic about life, and you believe that the most important thing in your life is the home, family and friends.This is the life path to leadership by example and support related, so it is your duty to take responsibility and be ready to help. If you are like most with Life Path 6, you are the one who likes to wear a lot more than your fair share of all costs, and you are always there when needed. In this way, you take ownership and are often an authority on the situation.In romance, 6 are loyal and affectionate. You are able to attract partners that are slightly weaker and worse than yourself; You recommend and can provide protection. The main component of which must prevail in the relationship is complete harmony. They do not work well in stressful relationships, their challenges are to have others monitor for you. It's the same with friends, you are loyal and trustworthy. But there is a tendency for you to be dominant and controlling.It is likely that you feel compelled to function with strength and compassion. They are a friendly and kind person, generous with personal and material resources. Wisdom, balance and understanding are the cornerstones of your life, and tend to define your approach to life in general. Your extraordinary wisdom and the ability to understand other people's problems is likely to start at an early age. In this way you can easily cover the output gap and assume an important role in early life.The Life Path 6 actually has some negative examples, but there are pitfalls to clean the track. You can have a tendency to be overwhelmed by responsibilities and become a slave to others, especially your own family members or close friends. It's easy for you to fall into a pattern of being a helper to others in critical need; They also have a tendency to be too hard on yourself. Misuse of this life cycle generates tendencies to engage exaggeratedly about expansiveness and self-righteousness. Modesty and humility can not move easily. Imposing their views and interfering or meddling in people's matters may be a concern.The natural characteristics of this number are taking on heavy burdens, and on rare occasions, abdicated responsibility by persons with this Life Path 6. With this rejection of responsibility, you will feel very guilty and uncomfortable, and it is harmful on your relationships with others.

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    M: Meaning of M in the acronym mmaes means: While M stands on two points, it has three projections pointing downwards. M is dracious, stable and temperamental. M could also be overwhelming with a great strenght of character and a strong in mind.

    A: Meaning of A in the acronym mmaes means: The letter A has two bars connected at a pointed edge and a cross bar holding them together. From an open end to a pointed edge signifies that all energies are trained to a point to achieve the most singularly important goal. The cross bar shows caution. Failure is avoided by stringing all required resources together. A also looks like a Pyramid with the peak as the apex of the Pyramid. Pyramids are iconic. A therefore symbolizes prominence and a desire to be recognized for ones achievements. The cross bar also represents a rung in ladder. To get to the top, one has to first step on the rung. It also means originality, a strong will power and an enterprising ability. The upper-case version consists of the two slanting sides of a triangle, crossed in the middle by a horizontal bar. It shows aspiration, the dominance to be successful, positive attitude, an optimistic world view and egotism.

    E: Meaning of E in the acronym mmaes means: The letter E has three branches of equal lenghts. These all extend from it's left side. The equal lenghts show a degree of fairness to the outside world. They extend outwards indicating a willingness to learn, think broadly and be more vigorous in understanding. B also implies endowed with good writing abilities, eloquence, resourcefulness. It displays a unique artistic nature and strong enthusaism to get out and know more.

    S: Meaning of S in the acronym mmaes means: S is a single strand that goes forward and backwards. It shows a willingness to explore. Friendliness, perceptiveness and accommodating are all S qualities. The ends pointing forward and backwards shows a conflicting nature with itself and a degree of puzzlement.

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