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  • Androgen receptor
  • ligand binding domain (LBD) in an intramolecular head-to-tail interaction FXXLF motif; where F = phenylalanine, L = leucine, and X = any amino acid residue

  • Selective androgen receptor modulator
  • to a FxxLF motif contained in coactivators. Conversely, antagonists destabilize the agonist conformation of H12 blocking the binding of the FXXLF coactivator

  • Vitamin D receptor
  • "Electrostatic Modulation in Steroid Receptor Recruitment of LXXLL and FXXLF Motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/MCB.23.6.2135-2150

  • MDN1
  • de Vos C, Trapman J, Jenster G (November 2009). "Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor

  • NCOA4
  • 0765. PMID 11818501. He B, Minges JT, Lee LW, Wilson EM (March 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators"

  • Estrogen receptor alpha
  • "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Molecular and Cellular Biology. 23 (6): 2135–2150. doi:10.1128/MCB

  • MAGEA11
  • promoting transcriptional through direct binding to the androgen receptor FXXLF motif region. This control is specific to primates, and is due to a mutation

  • RNF14
  • M108312200. PMID 11673464. He B, Minges JT, Lee LW, Wilson EM (Mar 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators"

  • Discovery and development of antiandrogens
  • containing various signature motifs. ARs seem to have a distinct preference for ‘FxxLF’ type of binding motifs (where F = phenylalanine, L = leucine, and X = any

  • Retinoic acid receptor alpha
  • "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Molecular and Cellular Biology. 23 (6): 2135–50. doi:10.1128/MCB

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    F: Meaning of F in the acronym fxxlf means: The letter F is like the letter E, but without the bottom rung. Even without this rung, F shows remarkable stability on its single leg. It means devotion, loving, uncomplaining, defensive, calm. F stands up straights and exemplifies straightforwardness, accountability and harmoniousness.

    X: Meaning of X in the acronym fxxlf means: X is a cross bettween two arms of exactly the same lenght. It also balances on two ends at the bottom. It looks like Y with the bottom ends merged in the middle. X is stable, responsible, gorgeous, and spiritual as it opens upwards. X also shows enlightenment as it seeks to explore by extending its arms.

    L: Meaning of L in the acronym fxxlf means: The letter has a flat bottom and a vertically extending part that projects into the sky. L is aspiring, reckoning, methodical, logical and convincing. Its flat bottom on the earth shows desire for earthly things hence L is materialistics and active. L is flexible, successful, public, insightful and considerate.

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