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  • KMT2D

    • Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and sometimes MLL2 in humans and Mll4 in mice, is a major mammalian histone H3 lysine 4 (H3K4)

  • Kabuki syndrome

    • germline heterozygous loss of function variants in KMT2D (formerly known as the MLL2), located on human chromosome 12. It is estimated that between 55 and 80%

  • Extranodal NK/T-cell lymphoma, nasal type

    • MGA MAX dimerization protein ~8% tumor suppressor loss unknown unknown MLL2 MLL2 7–80% histone methyltransferase, tumor suppressor loss reduces cellular

  • Clear-cell renal-cell carcinoma

    • genes were discovered in CCRCC: VHL, KDM6A/UTX, SETD2, KDM5C/JARID1C and MLL2. PBRM1 is also commonly mutated in CCRCC.[citation needed] CCRCC is derived

  • Renal cell carcinoma

    • mutated genes were discovered in CCRCC; KDM6A/UTX, SETD2, KDM5C/JARID1C, and MLL2 CCRCC is derived from the proximal convoluted tubule Most commonly affects

  • Squamous-cell carcinoma of the lung

    • affect many tumor suppressor genes such as TP53 (mutated in 81% of cases), MLL2 (20%), CDKN2A (15%), KEAP1 (12%) and PTEN (8%). Recurrent loss-of-function

  • Medulloblastoma

    • well as Turcot syndrome. Recurrent mutations in the genes CTNNB1, PTCH1, MLL2, SMARCA4, DDX3X, CTDNEP1, KDM6A, and TBR1 were identified in individuals

  • Malformative syndrome

    • rearrangements gene mutations (monogenic malformative diseases) Kabuki mask syndrome: MLL2 Joubert syndrome, Meckel syndrome and related syndromes: TMEM216 cleft lip

  • Marginal zone lymphoma

    • cytokines; and 5) in ~40% of cases one or more of various other genes such as MLL2, SIN3A, ARID1A, EP300, CREBBP, and TBL1XR1) that have chromatin remodeling

  • Histone methyltransferase

    • methyltransferase activity include: ASH1L DOT1L EHMT1, EHMT2, EZH1, EZH2 MLL, MLL2, MLL3, MLL4, MLL5 NSD1 PRDM2 SET, SETBP1, SETD1A, SETD1B, SETD2, SETD3, SETD4

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Astrological/horoscope meaning of mll2. mll2 means: undefined

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    M: Meaning of M in the acronym mll2 means: While M stands on two points, it has three projections pointing downwards. M is dracious, stable and temperamental. M could also be overwhelming with a great strenght of character and a strong in mind.

    L: Meaning of L in the acronym mll2 means: The letter has a flat bottom and a vertically extending part that projects into the sky. L is aspiring, reckoning, methodical, logical and convincing. Its flat bottom on the earth shows desire for earthly things hence L is materialistics and active. L is flexible, successful, public, insightful and considerate.

    2: Meaning of 2 in the acronym mll2 means: undefined

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