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  • SWI/SNF
  • Yeast Human Drosophila Function SWI1 ARID1A, ARID1B OSA Contains LXXLL nuclear receptor binding motifs SWI2/SNF2 SMARCA2, SMARCA4 BRM ATP dependent chromatin

  • Selective estrogen receptor modulator
  • for an NR box motif contained in coactivators with the canonical sequence LXXLL (where L represents leucine or isoleucine and X is any amino acid). Unliganded

  • Human papillomavirus infection
  • Isabelle (8 February 2013). "Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins". Science. 339 (6120): 694–698

  • Androgen receptor
  • N-terminal FXXFL motif intramolecularly or coactivator proteins (containing the LXXLL or preferably FXXFL motifs) A ligand dependent nuclear export signal F)

  • Nuclear receptor
  • small part of the coactivator protein, the so-called NR box containing the LXXLL amino acid sequence motif. Antagonists occupy the same ligand binding cavity

  • JAK-STAT signaling pathway
  • Shuai, K. (2001). "A transcriptional corepressor of Stat1 with an essential LXXLL signature motif". Proceedings of the National Academy of Sciences. 98 (6):

  • Histone acetylation and deacetylation
  • along with a basic helix-loop-helix and PAS A and PAS B domains with a LXXLL receptor interacting motif in the middle. Another is ATF-2 which contains

  • Cyclin D1
  • domain for cyclin-dependent kinase (CDK) binding and CDK inhibitor binding; LxxLL binding motif for co-activator recruitment; PEST sequence that may mark

  • Nuclear receptor coactivator 1
  • 1074/jbc.M108132200. PMID 11574547. Litterst CM, Pfitzner E (Sep 2002). "An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1"

  • Thyroid hormone receptor beta
  • Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl

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Astrological/horoscope meaning of lxxll. lxxll means: With a Life Path 3, your numbers are (3, 12/3, 21,/3). The Life Path 3 shows you have a strong sense of creativity and wonderful communication skills. Your performance for most things comes through its ingenious expression. A truly gifted 3 has the extraordinary ability to innovate, usually in the verbal area, write, speak, act, or similar circumstances. They are great entertainers in the world, and their brightness sparkles with a very optimistic attitude. The positive side of this path stresses harmony, beauty and pleasure; their talents to share with the world of invention. The acquisition and capacity in creative self-expression is the highest level of performance for this type of life.Life path 3's live thier lives to fullest, often without much worry about tomorrow. They are not very good with money because of the general lack of concern in cautious spending. You spend it when you have it and not when you don't.3's like to connect with people. The characteristics of the 3 are warmth and friendliness, good conversationalist, social and open. A good speaker, both from the standpoint of being a joy to listen to, but more importantly, those who have to listen to other's ability. Thus the life path 3 persons are always a welcome addition to any social situation and always know how others feel at home. Their approach to life tends to be very positive. Their view is almost sunny, safe and open heart. They are happy and often inspired on the lookout for and need to stimulate and encourage others.There is a not so glamourous side the life path of 3 so to speak. This is a surprise for those who think they are well acquainted. 3 is actually a very sensitive soul. If injured, you can easily retreat into a shell of sullen silence for long periods. However, with the many setbacks that occur in life, they readily bounce back for more. It is usually easy for you to deal with the problems as they are free, the non-existence of problems can result in long periods of slow decline. You are very sensitive to the feelings, emotions and aspirations of others.In romance, 3 is a very passionate and faithful lover. Emotional experiences of all kinds deeply affect 3s in general and can take the form of drama in some cases. The emotional connection for 3s could be sometimes demanding to their partner or friends. As with most problems in life for life path 3 balance in relations is hard to achieve.The big test with a 3 Life path is in managing the ups and downs of life. They are not very well suited in any environment that requires routine or when placed under a dominant person. They are sometimes slow because they are contemplative in thought as they struggle to please people enough. This could sometimes be a frustrating affair when working with or among them.For the few to be on the negative side of this path of life, 3s live with the joy to feel impressed and be impressed. They may treat life frivolously and in a superficial way sometimes. It is possible to dispel their abilities and express little sense of concern. 3 may be a mystery, can be moody for no apparent reason and tend to withdraw. Escapist tendencies with the 3 life path is not unusual, and it is very difficult to stay in one place or position as they are grigarious and like to enjoy life. They hate to be critical to avoid negative energies, could be impatient, intolerant, or overly optimistic.

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    L: Meaning of L in the acronym lxxll means: The letter has a flat bottom and a vertically extending part that projects into the sky. L is aspiring, reckoning, methodical, logical and convincing. Its flat bottom on the earth shows desire for earthly things hence L is materialistics and active. L is flexible, successful, public, insightful and considerate.

    X: Meaning of X in the acronym lxxll means: X is a cross bettween two arms of exactly the same lenght. It also balances on two ends at the bottom. It looks like Y with the bottom ends merged in the middle. X is stable, responsible, gorgeous, and spiritual as it opens upwards. X also shows enlightenment as it seeks to explore by extending its arms.

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