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  • EME1
  • Crossover junction endonuclease EME1 is an enzyme that in humans is encoded by the EME1 gene. It forms a complex with MUS81 which resolves Holliday junctions

  • GEN1, Holliday junction 5' flap endonuclease
  • endonuclease shares redundancy with the EME1/MUS81 protein complex for DNA damage repair in mammalian cells. GEN1 and EME1/MUS81, in mice, have redundant functions

  • Endonuclease
  • stage of crosslink repair involves production of double-strand breaks. MUS81/EME1 is a structure specific endonuclease involved in converting interstrand crosslinks

  • List of human protein-coding genes 1
  • HGNC:27609 Q5UCC4 4916 EMCN HGNC:16041 Q9ULC0 4917 EMD HGNC:3331 P50402 4918 EME1 HGNC:24965 Q96AY2 4919 EME2 HGNC:27289 A4GXA9 4920 EMG1 HGNC:16912 Q92979

  • MUS81
  • West SC (Jul 2003). "Identification and characterization of the human mus81-eme1 endonuclease". The Journal of Biological Chemistry. 278 (27): 25172–8. doi:10

  • Stephen C. West
  • junction processing in human cells involving BLM-topoIIIα-RMI1-RMI2, MUS81-EME1 and GEN1. His laboratory discovered that the Holliday junction resolvase

  • Crossover junction endodeoxyribonuclease
  • bacteriophages (T7 endonuclease I), bacteria (RuvC), fungi (GEN1) and humans (hMus81-Eme1) have revealed that the enzymes function in dimers, and part of the resolution

  • ERCC1
  • comprising two subunits. Such nucleases include, for example, the MUS81-EME1 nuclease. The ERCC1–XPF complex is a structure-specific endonuclease. ERCC1-XPF

  • ERCC4
  • comprising two subunits. Such nucleases include, for example, the MUS81-EME1 nuclease. The ERCC1–XPF complex is a structure-specific endonuclease. ERCC1-XPF

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    E: Meaning of E in the acronym eme1 means: The letter E has three branches of equal lenghts. These all extend from it's left side. The equal lenghts show a degree of fairness to the outside world. They extend outwards indicating a willingness to learn, think broadly and be more vigorous in understanding. B also implies endowed with good writing abilities, eloquence, resourcefulness. It displays a unique artistic nature and strong enthusaism to get out and know more.

    M: Meaning of M in the acronym eme1 means: While M stands on two points, it has three projections pointing downwards. M is dracious, stable and temperamental. M could also be overwhelming with a great strenght of character and a strong in mind.

    1: Meaning of 1 in the acronym eme1 means: undefined

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