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What is the meaning of NPC1. Phrases containing NPC1
See meanings and uses of NPC1!
What is the meaning of NPC1. Phrases containing NPC1
See meanings and uses of NPC1!NPC1
NPC1
NPC1
type C1 (NPC1) is a membrane protein that mediates intracellular cholesterol trafficking in mammals. In humans the protein is encoded by the NPC1 gene (chromosome
Alzheimer's") is a lysosomal storage disease associated with mutations in NPC1 and NPC2 genes. Niemann–Pick type C affects an estimated 1:150,000 people
that Ebola virus cell entry and replication requires NPC1. When cells from patients lacking NPC1 were exposed to Ebola virus in the laboratory, the cells
infection by preventing viral envelope glycoprotein (GP) from binding to NPC1. Hence, NPC1 was shown to be critical to entry of this filovirus, because it mediates
sphingomyelinase, that breaks down the lipid sphingomyelin. Mutations in NPC1 or NPC2 cause Niemann–Pick disease, type C (NPC), which affects a protein
pharmaceutical drug that inhibits cholesterol absorption. It targets the NPC1-like intracellular cholesterol transporter 1. It reduces plasma levels of
cell via receptor mediated endocytosis. NPC2 works cooperatively with the NPC1 protein to facilitate the exportation of LDL-derived cholesterol out of the
Hawkins, John A; Gifford, Robert J (23 December 2015). "Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in
TMEM97 only in 2017. TMEM97 was shown to regulate the cholesterol transporter NPC1 and to be involved in cholesterol homeostasis. The sigma-2 receptor is a
receptor protein, Niemann-Pick C1 (NPC1). This "competition" by ansuvimab prevents Ebola virus from binding to NPC1 and "neutralizes" the virus's ability
NPC1
NPC1
NPC1
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NPC1
NPC1
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NPC1