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FGF10

FGF10

humans is encoded by the FGF10 gene. It is a polypeptide of 208 amino acids. Human FGF10 gene is highly homologous (95.6%) to rat FGF10, where it was first

Apical ectodermal ridge

lateral mesoderm, restricting the expression of FGF10 through intermediate Wnt signals. Then, FGF10 in the lateral plate mesoderm signals to the surface

Lateral plate mesoderm

secretes FGF8 and FGF4 which maintains the FGF10 signal and induces proliferation in the mesoderm. The position of FGF10 expression is regulated by Wnt8c in

Limb bud

mesoderm. WNT2B and WNT8C stabilize this FGF10 expression in the forelimb and hindlimb, respectively. This FGF10 expression stimulates WNT3 expression in

Lung

fibroblast growth factors FGF10 and FGFR2b, and bone morphogenetic protein BMP4. FGF10 is seen to have the most prominent role. FGF10 is a paracrine signalling

Keratinocyte growth factor

complex and regulated by a variety of mechanisms in a tissue specific manner. FGF10 is also known as "keratinocyte growth factor 2". Palifermin Rotolo S, Ceccarelli

Turtle

signaled locally by proteins known as fibroblast growth factors that include FGF10. The shoulder girdle in turtles is made up of two bones, the scapula and

Paracrine signaling

produce Fgf10. Fgf10 then signals to the ectoderm to begin production of Fgf8, which also stimulates the production of Fgf10. Deletion of Fgf10 results

Limb development

and FGF4 which maintain the FGF10 signal and induce proliferation in the mesoderm.[citation needed] The position of FGF10 expression is regulated by two

Apert syndrome

Lana-Elola E, Rice DP, Sharpe J, Dickson C (February 2009). "Evidence that Fgf10 contributes to the skeletal and visceral defects of an Apert syndrome mouse